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Building Simulation 2024年第3期17卷 493-508页

作者： Giovanni Betti Federico Tartarini christine Nguyen Stefano Schiavon Center for the Built Environment University of California BerkeleyBerkeleyUSA Berkeley Education Alliance for Research in Singapore SingaporeSingapore Heat and Health Research Incubator Faculty of Medicine and HealthThe University of SydneyCamperdownAustralia College of Letters and Sciences University of California BerkeleyBerkeleyUSA

Climate-responsive building design holds immense potential for enhancing comfort,energy efficiency,and environmental ***,many social,cultural,and economic obstacles might prevent the wide adoption of designing climate-adapted *** of these obstacles can be removed by enabling practitioners to easily access,visualize and analyze local climate *** CBE Clima Tool(Clima)is a free and open-source web application that offers easy access to publicly available weather files and has been created for building energy simulation and *** provides a series of interactive visualizations of the variables contained in the EnergyPlus Weather Files and several derived ones like the UTCI or the adaptive comfort *** is aimed at students,educators,and practitioners in the architecture and engineering *** its inception,Clima’s user base has exhibited robust growth,attracting over 25,000 unique users annually from across 70 *** tool is poised to revolutionize climate-adaptive building design,transcending geographical boundaries and fostering innovation in the architecture and engineering fields.

关键词： architectural design climate analysis sustainable building design web application building energy simulation open-source software

Valuable Beyond Vulnerable: A Scoping Review on the Contributions of Older Forced migrants in Post-migration Recovery

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International Journal of Disaster Risk Science 2024年第2期15卷 186-197页

作者： Prince Chiagozie Ekoh christine A.Walsh Faculty of Social Work University of CalgaryCalgaryAB T2N 1N4Canada Department of Social Work University of NigeriaNsukka 410001Nigeria

During times of crisis, including pandemics, climate change, and forced migration, much of the discourse in ageing research and intervention centers on the vulnerabilities of older adults. Unfortunately, the valuable contributions of older adults to post-disaster recovery and healing are often overlooked and undervalued. Our aim in this scoping review is to shed light on the critical contributions of older forced migrants to post-migration recovery. We set the scene by introducing the two significant global demographic changes of the twenty-first century: forced migration and ageing. We provide a discourse on older forced migrants, ageing in situations of forced migration, and some of the challenges faced by older forced migrants. We then present some of the substantial roles of older forced migrants in post-migration recovery, including building resilience, contributing to culture and language transfer, providing emotional support, offering mentorship and leadership, participating in community building, and fostering social integration. We close by highlighting some of the lessons that can be drawn from understanding the unique roles played by older adults in post-forced migration recovery and the key actions necessary to promote these roles.

关键词： Older displaced persons Older forced migrants Older refugees Post-forced migration recovery

Benign stricture of bilioenteric anastomosis after Whipple withsynthetic polypropylene suture

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 103-105页

作者： A michael Devane christine mG Schammel Department of Radiology Prisma Health UpstateGreenvilleUSA Department of Pathology Prisma Health UpstateGreenvilleUSA

To the Editor:Biliary stricture formation at the bilioenteric anastomosis is an infrequent complication(2%-3%)after pancreaticoduodenectomy;the average presentation is within 13-14 months(range from 1 month to 9 years)after surgery[1,2].While the etiology is unknown,development of biliary stricture has shown to be more likely if a bile leak occurs in the postoperative period[3,4]and with younger patients[5].

关键词： stricture anastomosis Whipple

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

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Neural Regeneration Research 2024年第6期19卷 1206-1211页

作者： matthias T.Wyss christine Heuer marina Herwerth Institute of Pharmacology and Toxicology University of ZurichZürichSwitzerland Neuroscience Center Zurich(ZNZ) University of Zurich and ETH ZurichZürichSwitzerland Neurology Department University Hospital of ZurichZürichSwitzerland

Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of *** is also reflected by the widespread expression of two families of purinergic receptors(P1 and P2)with numerous *** the last few decades,there has been increasing evidence that purinergic signaling plays an important role in the regulation of immune ***,signals mediated by P2 receptors have been shown to contribute to immune system-mediated ***,interference with P2 receptors may be a promising strategy for the modulation of immune *** only a few clinical studies have been conducted in isolated entities with limited success,preclinical work suggests that the use of P2 receptor inhibitors may bear some promise in various autoimmune *** the association of P2 receptors with several disorders from this field,the use of P2 receptor antagonists in clinical therapy is still very *** this narrative review,we briefly review the involvement of the purinergic system in immunological responses and clinical studies on the effect of purinergic inhibition on autoimmune *** then open the aperture a bit and show some preclinical studies demonstrating a potential effect of purinergic blockade on autoimmune *** suramin,a non-specific purinergic inhibitor,as an example,we further show that off-target effects could be responsible for observed effects in immunological settings,which may have interesting ***,we believe that it is worthwhile to further investigate this hitherto underexplored area.

关键词： autoimmune diseases neurological disorders purinergic system P2 receptor inhibitors suramin

Silvery fullerene in Ag102 nanosaucer

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National Science Review 2024年第7期11卷 158-167页

作者： Zhi Wang Yuchen Wang Chengkai Zhang Yan-Jie Zhu Ke-Peng Song christine m.Aikens Chen-Ho Tung Di Sun School of Chemistry and Chemical Engineering Shandong University Department of Chemistry Kansas State University

Despite the discovery of a series of fullerenes and a handful of noncarbon clusters with the typical topology of Ih-C60, the smallest fullerene with a large degree of curvature, C20, and its other-element counterparts are difficult to isolate experimentally. In coinage metal nanoclusters（NCs）, the first all-gold fullerene, Au32, was discovered after a long-lasting pursuit, but the isolation of similar silvery fullerene structures is still challenging. Herein, we report a flying saucer-shaped 102-nuclei silver NC（Ag102） with a silvery fullerene kernel of Ag32, which is embraced by a robust cyclic anionic passivation layer of（KPO4）10. This Ag32kernel can be viewed as a non-centered icosahedron Ag12encaged into a dodecahedron Ag20, forming the silvery fullerene of Ag12@Ag20. The anionic layer（KPO4）10is located at the interlayer between the Ag32kernel and Ag70shell, passivating the Ag32silvery fullerene and templating the Ag70shell. The ~tBuPhS-and CF3COO-ligands on the silver shell show a regioselective arrangement with the 60 ~tBuPhS-ligands as expanders covering the upper and lower of the flying saucer and 10 CF3COO-as terminators neatly encircling the edges of the structure. In addition, Ag102 shows excellent photothermal conversion efficiency（η） from the visible to near-infrared region（η = 67.1% ± 0.9% at 450 nm, 60.9% ± 0.9% at 660 nm and 50.2% ± 0.5% at 808 nm）, rendering it a promising material for photothermal converters and potential application in remote laser ignition. This work not only captures silver kernels with the topology of the smallest fullerene C20, but also provides a pathway for incorporating alkali metal（m） into coinage metal NCs via m-oxoanions.

关键词： silvery fullerene >Ag102 nanosaucer cyclic anionic passivation layer photothermal conversion DFT calculation

Promoting Older Adults' Engagement in Disaster Settings: An Introduction to the Special Issue

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International Journal of Disaster Risk Science 2024年第2期15卷 181-185页

作者： Haorui Wu christine AWalsh Julie LDrolet Kyle Breen Faculty of Health School of Social WorkDalhousie UniversityHalifaxNS B3H 4R2Canada Faculty of Social Work University of CalgaryCalgaryAB T2N 1N4Canada Faculty of Social Work Central&Northern Alberta RegionUniversity of CalgaryEdmontonAB T5J 4P6Canada

1 Introduction Globally, surging extreme events and the escalating aging population present ongoing and severe challenges to the full spectrum of international community development(for example, social, health, and ec... 详细信息

关键词： extreme challenges economic

Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective

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Neural Regeneration Research 2024年第5期19卷 957-958页

作者： Prashant Sharma Jenny Serra-Vinardell Wendy J.Introne may christine V.malicdan NIH Undiagnosed Diseases Program Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Human Biochemical Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular *** acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate *** in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular *** energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological ***,a conserved catabolic process,requires extensive lysosomal *** plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关键词： homeostasis lysosomal removing

Trehalose:A sugar molecule involved in temperature stress management in plants

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The Crop Journal 2024年第1期12卷 1-16页

作者： Ali Raza Savita Bhardwaj md Atikur Rahman Pedro García-Caparrós madiha Habib Faisal Saeed Sidra Charagh christine H.Foyer Kadambot H.m.Siddique Rajeev K.Varshney College of Agriculture Fujian Agriculture and Forestry University(FAFU)Fuzhou 350002FujianChina Department of Botany School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara 144411India Department of Botany MCM DAV CollegeKangraHimachal Pradesh 176001India Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Agronomy Department of Superior School Engineering University of AlmeríaAlmeríaSpain National Institute for Genomics and Advanced Biotechnology National Agricultural Research CentrePark Rd.Islamabad 45500Pakistan Agriculture Health and Environment DepartmentNatural Resources InstituteFaculty of Engineering&ScienceUniversity of GreenwichKent ME44TBUK State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhouZhejiangChina School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK The UWA Institute of Agriculture The University of Western AustraliaCrawleyPerth 6009Australia WA State Agricultural Biotechnology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochWA 6150Australia

Trehalose(Tre)is a non-reducing disaccharide found in many species,including bacteria,fungi,invertebrates,yeast,and even plants,where it acts as an osmoprotectant,energy source,or protein/membrane *** relatively small amounts in plants,Tre concentrations increase following exposure to abiotic ***-6-phosphate,a precursor of Tre,has regulatory functions in sugar metabolism,crop production,and stress *** the various abiotic stresses,temperature extremes(heat or cold stress)are anticipated to impact crop production worldwide due to ongoing climate *** small amounts of Tre can mitigate negative physiological,metabolic,and molecular responses triggered by temperature *** also interacts with other sugars,osmoprotectants,amino acids,and phytohormones to regulate metabolic reprogramming that underpins temperature stress *** plants expressing Tre-synthesis genes accumulate Tre and show improved stress ***-wide studies of Tre-encoding genes suggest roles in plant growth,development,and stress *** review discusses the functions of Tre in mitigating temperature stress—highlighting genetic engineering approaches to modify Tre metabolism,crosstalk,and interactions with other molecules—and in-silico approaches for identifying novel Tre-encoding genes in diverse plant *** consider how this knowledge can be used to develop temperature-resilient crops essential for sustainable agriculture.

关键词： Abiotic stress Gene expression Genetic engineering Osmolyte Trehalose-6-phosphate

Enabling low-cost decentralized power reserves adopting carbon dioxide for green methane exchange in stabilized clathrate adsorbent

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Journal of Energy Chemistry 2024年第10期97卷 438-443,I0009页

作者： Lucas Hanssens maarten Houlleberghs C.Vinod Chandran Geert Watson Sambhu Radhakrishnan Pascal Van Der Voort Joeri F.m.Denayer christine E.A.Kirschhock Johan A.martens Eric Breynaert Centre for Surface Chemistry and Catalysis-Characterization and Application Team(COK-KAT) 3001 LeuvenBelgium NmR/X-Ray Platform for Convergence Research(NmRCoRe) 3001 LeuvenBelgium Centre for Ordered materials Organometallics and Catalysis(COMOC)Department of ChemistryGhent University9000 GhentBelgium Department of Chemical Engineering Vrije Universiteit Brussel1050 BrusselBelgium

*** circular methane energy systems In recent decades,methane-based energy systems have rapidly gained traction across the globe because of the increasing availability of low-cost methane production ***,fossil methane... 详细信息

关键词： Long duration energy storage Green methane Carbon neutrality Confined clathrate hydrates CH_(4)/CO_(2) exchange Direct gas exchange