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Triose phosphate export from chloroplasts and cellular sugar content regulate anthocyanin biosynthesis during high light acclimation

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Plant Communications 2023年第1期4卷 42-61页

作者： Max-Emanuel Zirngibl Galileo Estopare Araguirang Anastasia kitashova kathrin Jahnke Tobias Rolka christine kühn Thomas Nägele Andreas S.Richter University of Rostock Institute for BiosciencesPhysiology of Plant MetabolismAlbert-Einstein-Strasse 318059 RostockGermany Humboldt-Universit€at zu Berlin Institute of BiologyPhysiology of Plant Cell OrganellesPhilippstrasse 1310115 BerlinGermany Ludwig-Maximilians-Universit€at M€unchen Faculty of BiologyPlant Evolutionary Cell Biology82152 Planegg-MartinsriedGermany

Plants have evolvedmultiple strategies to cope with rapid changes in the *** high light(HL)acclimation,the biosynthesis of photoprotective flavonoids,such as anthocyanins,is ***,the exact nature of the signal and downstreamfactors forHL induction of flavonoid biosynthesis(FB)is still under ***,we show that carbon fixation in chloroplasts,subsequent export of photosynthates by triose phosphate/phosphate translocator(TPT),and rapid increase in cellular sugar content permit the transcriptional and metabolic activation of anthocyanin biosynthesis during HL *** combination with genetic and physiological analysis,targeted and whole-transcriptome gene expression studies suggest that reactive oxygen species and phytohormones play only a minor role in rapid HL induction of the anthocyanin branch of *** addition to transcripts of FB,sugar-responsive genes showed delayed repression or induction in tpt-2 during HL treatment,and a significant overlapwith transcripts regulated by SNF1-related protein kinase 1(SnRk1)was observed,including a central transcription factor of *** of mutants with increased and repressed SnRk1 activity suggests that sugar-induced inactivation of SnRk1 is required for HL-mediated activation of anthocyanin *** study emphasizes the central role of chloroplasts as sensors for environmental changes as well as the vital function of sugar signaling in plant acclimation.

关键词： flavonoid biosynthesis acclimation sugar signaling high light anthocyanin SnRk1

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CBE Clima Tool:A free and open-source web application for climate analysis tailored to sustainable building design

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Building Simulation 2024年第3期17卷 493-508页

作者： Giovanni Betti Federico Tartarini christine Nguyen Stefano Schiavon Center for the Built Environment University of California BerkeleyBerkeleyUSA Berkeley Education Alliance for Research in Singapore SingaporeSingapore Heat and Health Research Incubator Faculty of Medicine and HealthThe University of SydneyCamperdownAustralia College of Letters and Sciences University of California BerkeleyBerkeleyUSA

Climate-responsive building design holds immense potential for enhancing comfort,energy efficiency,and environmental ***,many social,cultural,and economic obstacles might prevent the wide adoption of designing climate-adapted *** of these obstacles can be removed by enabling practitioners to easily access,visualize and analyze local climate *** CBE Clima Tool(Clima)is a free and open-source web application that offers easy access to publicly available weather files and has been created for building energy simulation and *** provides a series of interactive visualizations of the variables contained in the EnergyPlus Weather Files and several derived ones like the UTCI or the adaptive comfort *** is aimed at students,educators,and practitioners in the architecture and engineering *** its inception,Clima’s user base has exhibited robust growth,attracting over 25,000 unique users annually from across 70 *** tool is poised to revolutionize climate-adaptive building design,transcending geographical boundaries and fostering innovation in the architecture and engineering fields.

关键词： architectural design climate analysis sustainable building design web application building energy simulation open-source software

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Valuable Beyond Vulnerable: A Scoping Review on the Contributions of Older Forced Migrants in Post-migration Recovery

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International Journal of Disaster Risk Science 2024年第2期15卷 186-197页

作者： Prince Chiagozie Ekoh christine A.Walsh Faculty of Social Work University of CalgaryCalgaryAB T2N 1N4Canada Department of Social Work University of NigeriaNsukka 410001Nigeria

During times of crisis, including pandemics, climate change, and forced migration, much of the discourse in ageing research and intervention centers on the vulnerabilities of older adults. Unfortunately, the valuable contributions of older adults to post-disaster recovery and healing are often overlooked and undervalued. Our aim in this scoping review is to shed light on the critical contributions of older forced migrants to post-migration recovery. We set the scene by introducing the two significant global demographic changes of the twenty-first century: forced migration and ageing. We provide a discourse on older forced migrants, ageing in situations of forced migration, and some of the challenges faced by older forced migrants. We then present some of the substantial roles of older forced migrants in post-migration recovery, including building resilience, contributing to culture and language transfer, providing emotional support, offering mentorship and leadership, participating in community building, and fostering social integration. We close by highlighting some of the lessons that can be drawn from understanding the unique roles played by older adults in post-forced migration recovery and the key actions necessary to promote these roles.

关键词： Older displaced persons Older forced migrants Older refugees Post-forced migration recovery

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Benign stricture of bilioenteric anastomosis after Whipple withsynthetic polypropylene suture

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 103-105页

作者： A Michael Devane christine MG Schammel Department of Radiology Prisma Health UpstateGreenvilleUSA Department of Pathology Prisma Health UpstateGreenvilleUSA

To the Editor:Biliary stricture formation at the bilioenteric anastomosis is an infrequent complication(2%-3%)after pancreaticoduodenectomy;the average presentation is within 13-14 months(range from 1 month to 9 years)after surgery[1,2].While the etiology is unknown,development of biliary stricture has shown to be more likely if a bile leak occurs in the postoperative period[3,4]and with younger patients[5].

关键词： stricture anastomosis Whipple

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The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

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Neural Regeneration Research 2024年第6期19卷 1206-1211页

作者： Matihias T.Wyss christine Heuer Marina Herwerth Institute of Pharmacology and Toxicology University of Zurich Neuroscience Center Zurich (ZNZ) University of Zurich and ETH Zurich 3. Neurology Department University Hospital of Zurich

Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors(P1 and P2) with numerous subtypes. In the last few decades, there has been increasing evidence that purinergic signaling plays an important role in the regulation of immune functions. Mainly, signals mediated by P2 receptors have been shown to contribute to immune system-mediated pathologies. Thus, interference with P2 receptors may be a promising strategy for the modulation of immune responses. Although only a few clinical studies have been conducted in isolated entities with limited success, preclinical work suggests that the use of P2 receptor inhibitors may bear some promise in various autoimmune diseases. Despite the association of P2 receptors with several disorders from this field, the use of P2 receptor antagonists in clinical therapy is still very scarce. In this narrative review, we briefly review the involvement of the purinergic system in immunological responses and clinical studies on the effect of purinergic inhibition on autoimmune processes. We then open the aperture a bit and show some preclinical studies demonstrating a potential effect of purinergic blockade on autoimmune events. Using suramin, a non-specific purinergic inhibitor, as an example, we further show that off-target effects could be responsible for observed effects in immunological settings, which may have interesting implications. Overall, we believe that it is worthwhile to further investigate this hitherto underexplored area.

关键词： autoimmune diseases neurological disorders purinergic system P2 receptor inhibitors suramin

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Promoting Older Adults' Engagement in Disaster Settings: An Introduction to the Special Issue

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International Journal of Disaster Risk Science 2024年第2期15卷 181-185页

作者： Haorui Wu christine AWalsh Julie LDrolet kyle Breen Faculty of Health School of Social WorkDalhousie UniversityHalifaxNS B3H 4R2Canada Faculty of Social Work University of CalgaryCalgaryAB T2N 1N4Canada Faculty of Social Work Central&Northern Alberta RegionUniversity of CalgaryEdmontonAB T5J 4P6Canada

1 Introduction Globally, surging extreme events and the escalating aging population present ongoing and severe challenges to the full spectrum of international community development(for example, social, health, and ec... 详细信息

关键词： extreme challenges economic

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Trehalose:A sugar molecule involved in temperature stress management in plants

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The Crop Journal 2024年第1期12卷 1-16页

作者： Ali Raza Savita Bhardwaj Md Atikur Rahman Pedro García-Caparrós Madiha Habib Faisal Saeed Sidra Charagh christine H.Foyer kadambot H.M.Siddique Rajeev k.Varshney College of Agriculture Fujian Agriculture and Forestry University(FAFU)Fuzhou 350002FujianChina Department of Botany School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara 144411India Department of Botany MCM DAV CollegeKangraHimachal Pradesh 176001India Grassland and Forage Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000Republic of Korea Agronomy Department of Superior School Engineering University of AlmeríaAlmeríaSpain National Institute for Genomics and Advanced Biotechnology National Agricultural Research CentrePark Rd.Islamabad 45500Pakistan Agriculture Health and Environment DepartmentNatural Resources InstituteFaculty of Engineering&ScienceUniversity of GreenwichKent ME44TBUK State key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhouZhejiangChina School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK The UWA Institute of Agriculture The University of Western AustraliaCrawleyPerth 6009Australia WA State Agricultural Biotechnology Centre Centre for Crop and Food InnovationFood Futures InstituteMurdoch UniversityMurdochWA 6150Australia

Trehalose(Tre)is a non-reducing disaccharide found in many species,including bacteria,fungi,invertebrates,yeast,and even plants,where it acts as an osmoprotectant,energy source,or protein/membrane *** relatively small amounts in plants,Tre concentrations increase following exposure to abiotic ***-6-phosphate,a precursor of Tre,has regulatory functions in sugar metabolism,crop production,and stress *** the various abiotic stresses,temperature extremes(heat or cold stress)are anticipated to impact crop production worldwide due to ongoing climate *** small amounts of Tre can mitigate negative physiological,metabolic,and molecular responses triggered by temperature *** also interacts with other sugars,osmoprotectants,amino acids,and phytohormones to regulate metabolic reprogramming that underpins temperature stress *** plants expressing Tre-synthesis genes accumulate Tre and show improved stress ***-wide studies of Tre-encoding genes suggest roles in plant growth,development,and stress *** review discusses the functions of Tre in mitigating temperature stress—highlighting genetic engineering approaches to modify Tre metabolism,crosstalk,and interactions with other molecules—and in-silico approaches for identifying novel Tre-encoding genes in diverse plant *** consider how this knowledge can be used to develop temperature-resilient crops essential for sustainable agriculture.

关键词： Abiotic stress Gene expression Genetic engineering Osmolyte Trehalose-6-phosphate

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Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective

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Neural Regeneration Research 2024年第5期19卷 957-958页

作者： Prashant Sharma Jenny Serra-Vinardell Wendy J.Introne May christine V.Malicdan NIH Undiagnosed Diseases Program Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Human Biochemical Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular *** acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate *** in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular *** energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological ***,a conserved catabolic process,requires extensive lysosomal *** plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关键词： homeostasis lysosomal removing

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At the Dog Park

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小学生时代（大嘴英语） 2024年第7期 50-53页

作者： christine Schneider(图) 不详

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Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis

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World Journal of Gastroenterology 2024年第8期30卷 811-816页

作者： Mike de Jong Foke van Delft christine Roozen Erwin-Jan van Geenen Tanya Bisseling Peter Siersema Marco Bruno Department of Gastroenterology and Hepatology Radboud University Medical CenterNijmegen 6525 GANetherlands Department of Gastroenterology and Hepatology Erasmus University Medical CenterRotterdam 3015 GDNetherlands

Endoscopic ultrasound(EUS)with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and auto-immune pancreatitis or to analyze cyst *** most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis,which is likely induced by the same pathophysiological mechanisms as after en-doscopic retrograde cholangiopancreatography(ERCP).According to the current European Society of Gastrointestinal Endoscopy guideline,nonsteroidal anti-inflammatory drugs are administered prior to ERCP as a scientifically proven treatment to reduce post-ERCP pancreatitis incidence rate.A single suppository of diclofenac or indomethacin prior to EUS guided tissue acquisition(TA)is harm-less in healthy *** it is associated with low costs and,most important,may prevent a dreadsome complication,we strongly recommend the adminis-tration of 100 mg diclofenac rectally prior to *** will explain this recom-mendation in more detail in this review as well as the risk and pathophysiology of post-EUS TA pancreatitis.

关键词： Pancreatitis Endoscopic ultrasound Tissue acquisition Nonsteroidal antiinflammatory drugs Pancreatic cancer

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