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Spinal cord infarction attributed to SARS-CoV-2, with post-acute sequelae of COVID-19: A case report

World Journal of Clinical Cases 2023年第36期11卷 8542-8550页

作者： christina V Oleson Andrew C Olsen Suzanna Shermon Department of Physical Medicine and Rehabilitation Case Western Reserve UniversityMetroHealth Rehabilitation InstituteClevelandOH 44109United States

BACKGROUND While stroke and lower extremity venous thromboemboli have been commonly reported following acute infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),spinal cord infarction or ischemia has been extremely *** of long coronavirus disease(COVID)in this select population have not been *** SUMMARY We present the case of a 70-year-old female with sudden onset of trunk and lower extremity sensorimotor loss due to spinal cord infarction,attributed to acute infection with *** work up confirmed a T3 complete(ASIA impairment Scale A)paraplegia resulting from a thrombotic *** reported myalgias,neuropathic pain,spasticity,bladder spasms,and urinary tract infections exceeded the frequency and severity of many spinal cord injury(SCI)individuals of similar age and degree of neurologic *** her first year after contracting COVID-19,she underwent 2 separate inpatient rehabilitation courses,but also required acute hospitalization 6 additional times for subsequent infections or uncontrolled *** other complications of complete non-traumatic SCI(NTSCI),including neurogenic bowel and temperature hypersens-itivity,were mild,and pressure injuries were *** has now transitioned from the acute to chronic phase of spinal cord injury care,with subsequent development of post-acute sequelae of SARS-CoV-2 infection(PASC).CONCLUSION This individual experienced significant challenges with the combined effects of acute T3 NTSCI and acute COVID-19,with subsequent progression to *** Tip:Although stroke and venous thromboembolism have been frequently observed with acute coronavirus disease 2019(COVID-19),spinal cord infarction leading to paraplegia has rarely been *** report a case of spinal cord infarction shortly following infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Consequently,this individual has experienced severe neurologic disability,with subsequent developme

关键词： Spinal cord infarction Paraplegia COVID-19 SARS-CoV-2 Post-acute

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Long-term survivor of metastatic squamous-cell head and neck carcinoma with occult primary after cetuximab-based chemotherapy:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7092-7098页

作者： christina Große-Thie Claudia Maletzki Christian Junghanss Kathie Schmidt Department of Medicine Clinic III-HematologyOncologyPalliative MedicineRostock University Medical CenterRostock 18057Germany

BACKGROUND Cancer of unknown primary(CUP)is a histological proven malignant tumor whose origin cannot be detected despite careful *** cervical lymph node metastases in CUP(80%)will originate from head and neck sites,and 15%show infiltration of squamous carcinoma *** survival rates of CUP are poor:The 5-year-survival rate ranges from 10%to 15%.First-line treatment recommendation for advanced,inoperable squamous cell carcinoma of head/neck(HNSCC)was cetuximab plus platinum-fluorouracil chemotherapy until recently,when checkpoint inhibitors proved clinically beneficial *** SUMMARY Here,we report a case of a 42-year-old female patient with cervical and abdominal lymph node and distant bone metastases of an occult primary of the head and neck(squamous cell carcinoma,human papillomavirus positive).The cancer was diagnosed during pregnancy 10 years ago,and after giving birth,the patient was treated with cetuximab plus platinum-fluorouracil chemotherapy achieving complete remission(CR).CR lasted 26 mo when new metastases(abdominal lymph node,lumbar vertebral body)*** manifestations were *** then on,the patient has not received any further treatment,and her disease has remained *** years after the initial cancer diagnosis,the patient is still alive and in good health,representing an exceptional case of *** This case illustrates the exceptional clinical course and benefits of combined therapy approaches in advanced metastatic HNSCC with occult primary.

关键词： Squamous cell carcinoma of the head and neck Cancer of unknown primary Long-term survival Cetuximab Metastases Case report

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Corrosion-resistant Refractory Linings for Hazardous Waste Treatment inRotary Kilns

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China's Refractories 2021年第2期30卷 12-15页

作者： Chongchong NIU christina STIMPFL Danting ZHAO RHI Magnesita Dalian 116600China RHI Magnesita Shanghai 200021China

Mega trends like urbanization,industrialization and growing population drive the demand of daily necessaries and therefore result in increased refractory consumption for waste treatment carried out at elevated *** is estimated that for burning 1 t of waste about 5.5 kg of refractory materials need to be *** the present study,the corrosion resistance of refractory bricks based on alumina-chromia and alumina-silica was tested by exposing them to slag from hazardous waste *** from the cup test were investigated macroscopically and *** showed that alumina-chromia bricks had high corrosion resistance when in contact with the tested slags,while alumina-silica bricks containing silicon carbide showed an overall good performance.

关键词： hazardous waste treatment alumina-silica cup test

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Reading and the making of time in the eighteenth century

Reading and the making of time in the eighteenth century

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作者： christina Lupton.

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Sensory testing of the human gastrointestinal tract

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World Journal of Gastroenterology 2009年第2期15卷 151-159页

作者： christina Brock Lars Arendt-Nielsen Oliver Wilder-Smith Asbjφrn Mohr Drewes Mech-Sense Department of Gastroenterology Aalborg Hospital DK-9000 Aalborg Denmark Center for Sensory-Motor Interactions Department of Health Science and Technology Aalborg University DK-9000 Aalborg Denmark Pain and Nociception Research Group Department of Anaesthesiology Radboud University Nijmegen Medical Centrethe Netherlands Mech-Sense Department of Gastro-enterology Aalborg Hospital DK-9000 Aalborg Denmark Author

The objective of this appraisal is to shed light on the various approaches to screen sensory information in the human gut. Understanding and characterization of sensory symptoms in gastrointestinal disorders is poor. Experimental methods allowing the investigator to control stimulus intensity and modality, as well as using validated methods for assessing sensory response have contributed to the understanding of pain mechanisms. Mechanical stimulation based on impedance planimetry allows direct recordings of luminal cross-sectional areas, and combined with ultrasound and magnetic resonance imaging, the contribution of different gut layers can be estimated. Electrical stimulation depolarizes free nerve endings non-selectively. Consequently, the stimulation paradigm （single, train, tetanic） influences the involved sensory nerves. Visual controlled electrical stimulation combines the probes with an endoscopic approach, which allows the investigator to inspect and obtain small biopsies from the stimulation site. Thermal stimulation （cold or warm） activates selectively mucosal receptors, and chemical substances such as acid and capsaicin （either alone or in combination） are used to evoke pain and sensitization. The possibility of multimodal （e.g. mechanical, electrical, thermal and chemical） stimulation in different gut segments has developed visceral pain research. The major advantage is involvement of distinctive receptors, various sensory nerves and different pain pathways mimicking clinical pain that favors investigation of central pain mechanisms involved in allodynia, hyperalgesia and referred pain. As impairment of descending control mechanisms partly underlies the pathogenesis in chronic pain, a cold pressor test that indirectly stimulates such control mechanisms can be added. Hence, the methods undoubtedly represent a major step forward in the future characterization and treatment of patients with various diseases of the gut, which provides knowledge to dinicians

关键词： Endoscopy Intestine Experimental Neurophysiology Pain

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Tolerance to individual and joint effects of arsenic and Bacillus thuringiensis subsp, israelensis or Lysinibacillus sphaericus in Culex mosquitoes

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Insect Science 2014年第4期21卷 477-485页

作者： christina L. Mogren William E. Walton John T. Trumble Department of Entomology University of California Riverside CA 92521 USA

Arsenic contamination of global water supplies has come to the forefront in policy decisions in recent decades. However, the effects of arsenic on lower trophic levels of insects inhabiting contaminated ecosystems are not well understood. One approach to document both acute and sublethal effects of toxicants like arsenic is to assay them in combination with microbial pathogens to evaluate shifts in survival curves of the test organisms. Larvae of Culex quinquefasciatus and Culex tarsalis were reared in water containing 0 or 1 000μg/L of arsenate or arsenite. Fourth instars were then exposed to a range of doses of Bacillus thuringiensis subsp, israelensis （Bti） or Lysinibacillus sphaericus （Ls）, with shifts in lethal concentrations determined. Arsenic accumulation in 4th instars was also quantified, and a relative growth index （RGI） calculated for the treatments and compared to controls. Larvae of both species accumulated between 4 447 ± 169 ng As/g and 6 983 4- 367 ng As/g, though RGI values indicated accumulation did not affect growth and development. In all cases, the LC50＇s and LC90＇s of Cx. quinquefasciatus exposed jointly with arsenic and Bti/Ls were higher than Cx. tarsafis. Cx. tarsafis reared in arsenite showed a significant reduction in their Bti LC90 values compared to the control, indicating a sublethal effect of Bti. When exposed jointly with Ls, arsenite was more toxic than arsenate in Cx. tarsalis. Overall, these results indicate tolerance of these Culex species to arsenic exposures, and why this may occur is discussed.

关键词： arsenate arsenite Bsph Bti Culex tarsalis Culex quinquefasciatus

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Protocadherin gamma C3:a new player in regulating vascular barrier function

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Neural Regeneration Research 2023年第1期18卷 68-73页

作者： Victoria Kaupp Kinga G.Blecharz-Lang christina Dilling Patrick Meybohm Malgorzata Burek Department of Anesthesiology Intensive CareEmergency and Pain MedicineUniversity of WürzburgUniversity Hospital WürzburgWürzburgGermany Department of Experimental Neurosurgery Charité-UniversitätsmedizinBerlinGermany

Defects in the endothelial cell barrier accompany diverse malfunctions of the central nervous system such as neurodegenerative diseases,stroke,traumatic brain injury,and systemic diseases such as sepsis,viral and bacterial infections,and *** endothelial sealing leads to leaking blood vessels,followed by vasogenic *** edema as the most common complication caused by stroke and traumatic brain injury is the leading cause of *** microvascular endothelial cells,together with astrocytes,pericytes,microglia,and neurons form a selective barrier,the so-called blood-brain barrier,which regulates the movement of molecules inside and outside of the *** that regulate blood-brain barrier permeability in health and disease are complex and not fully *** newly discovered molecules that are involved in the regulation of cellular processes in brain microvascular endothelial cells have been described in the literature in recent *** of these molecules that are highly expressed in brain microvascular endothelial cells is protocadherin gamma *** this review,we discuss recent evidence that protocadherin gamma C3 is a newly identified key player involved in the regulation of vascular barrier function.

关键词： blood-brain barrier brain microvascular endothelial cells permeability protein interaction protocadherin gamma C3 protocadherins tight junctions

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Sexual selection for bright females prevails under light pollution

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Current Zoology 2021年第3期67卷 329-331页

作者： christina Elgert Topi K.LEHTOMEN Arja KAiTALA Ulrika Candolin Organismal and Evolutionary Biology University of HelsinkiHelsinkiPO Box 6500014Finland Tvarminne Zoological Station University of HelsinkiJ.A.Palmenin tie 260Hanko10900Finland Department of Ecology and Genetics University of OuluOuluPO Box 300000014Finland90014

The functions of sexually selected traits are particularly sensitive to changes in the environment because the traits have evolved to increase mating success under local environmental conditions(Rosenthal and Stuart-Fox 2012).When environmental conditions change,previously reliable signals may become less reliable or harder to detect and *** the correct expression,transmission,and interpretation of sexual signals typically influence mate choice outcomes,impediments to sexual signals can change both the strength and the direction of sexual selection(Rosenthal and Stuart-Fox 2012).Artificial light is a major anthropogenic disturbance that is intensifying around the world and has high potential to negatively impact wildlife,for example by hampering the expression and detection of sexual signals.

关键词： environmental change mate choice mate attraction reproduction sexual selection

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Development of a novel nano-biosorbent for the removal of fluoride from water

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Chinese Journal of Chemical Engineering 2015年第6期23卷 924-933页

作者： Evangeline christina Pragasam Viswanathan Renal Research Lab Bio Medical Research Center School of Biosciences and Technology VIT University

The study was designed to investigate the use of two sorbents namely(i) Fe3O4 nanoparticles immobilized in sodium alginate matrix(FNPSA) and(ii) Fe3O4 nanoparticles and saponified orange peel residue immobilized in sodium alginate matrix(FNPSOPR) as sorbents for fluoride removal from contaminated water. The synthesized nanoparticles were analyzed and characterized by dynamic light scattering, X-ray diffraction, vibrating sample magnetometry, and scanning electron microscopy with energy dispersive X-ray spectroscopy and Fourier transform-infrared spectrometry. The sorbent matrices were prepared in the form of beads and surface functionalized to enable enhanced sorption of fluoride ions. Batch sorption studies were carried out and the sorption isotherm and reaction kinetics were analyzed. Both the sorbents followed Langmuir model of isotherm and fitted well with Pseudo first order reaction. The maximum sorption capacity exhibited by FNPSA and FNPSOPR was58.24 mg·g-1and 80.33 mg·g-1respectively. Five sorption–desorption cycles exhibited 100%, 97.56%, 94.53%,83.21%, and 76.53% of regeneration of FNPSOPR. Accordingly, it is demonstrated that FNSOPR could be used as a promising sorbent for easy and efficient removal of fluoride from contaminated water with good *** current work suggests a simple and effective method to remove fluoride from contaminated water.

关键词： Adsorption capacity Fe3O4 nanoparticles Fluoride Functionalization Sorption

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作者： christina Henry.

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