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破译Am制造工艺的密码

现代制造 2015年第2期 68-70页

作者： christina m. Fuges

将车间内的添加法制造工艺（Am）提高到新的水平，不只是采用几台机床的问题，对于制造商来说，还需要提高对客户的服务，教育和培训水平。

关键词：制造工艺密码 Am 破译添加法制造商

Laser Heating and Infrared Thermography of Building materials

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Journal of Building Construction and Planning Research 2021年第3期9卷 223-229页

作者： Aschalew Kassu Carlton Farley III christina P. Tsoli Department of mechanical Civil Engineering and Construction Management Alabama A & M University Huntsville AL USA Department of Physics Chemistry and Mathematics Alabama A & M University Huntsville AL USA Department of Chemistry National and Kapodistrian University Athens Greece

In this work, a 532 nm diode CW laser is used to heat samples used as building materials at a 1 meter standoff distance while using an FLIR (Forward-Looking Infrared) thermal camera to monitor and record the heating and then cooling of each sample after lasers are switched off. The data is then analyzed using FLIR proprietary software. Since the absorption spectra of materials are unique, using multiple lasers of different wavelengths to simultaneously shine onto the sample at different locations would give enough thermal data to successfully characterize the samples within a reasonable amount of time. The results are very promising for applications involving non-destructive detection and classification of materials.

关键词： Infrared Thermography NIR Thermal Laser Heating Remote Detection

A Single Institutional Experience with Panitumumab in metastatic Colorectal Cancer

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Journal of Cancer Therapy 2012年第6期3卷 948-955页

作者： Sigurdis Haraldsdottir Jeffrey S. Rose christina Wu Lai Wei Richard m. Goldberg Tanios Bekaii-Saab The Ohio State University Comprehensive Cancer Center Columbus USA.

Introduction: Panitumumab is an EGFR inhibitor approved for use in metastatic refractory colorectal cancer. It is unclear whether patients who have progressed on cetuximab may benefit from subsequent panitumumab therapy. This retrospective analysis was conducted to describe the experience at The Ohio State University with panitumumab including in patients who have progressed on cetuximab. methods: Patients who received at least 1 dose of panitumumab between September 2006 and December 2011 were identified using the hospital’s pharmacy database. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 was used to assess responses and Kaplan-meier curves were used to estimate progression-free survival (PFS) and overall survival (OS). Results: Eighty-seven patients (median age 61 years) were identified. Sixty-seven percent of patients had tumors with wild-type KRAS, 3.4% had tumors with mutated KRAS and the KRAS status was unknown in 29.9%. Twenty-four percent of the patients had an ECOG performance status of 2 or above and 59.8% of patients had received ≥ 2 prior lines of chemotherapy. Thirty-two percent of patients received single-agent panitumumab while 68% received it in combination with chemotherapy. Of the patients with KRAS wild-type tumors, 10 (17.2%) had objective responses (3 complete, 7 partial) and 26 (44.8%) had stable disease. median PFS and OS were 5.0 and 9.0 months. The presence of a rash, improved ECOG performance status and coadministration with either irinotecan or FOLFIRI, led to a significantly better OS in univariate analysis. Among patients who had clinical benefit with cetuximab, 71% had subsequent clinical benefit with panitumumab therapy. Conclusions: In our single institution analysis of patients who received panitumumab, the number of prior lines of therapy did not significantly affect OS, suggesting that panitumumab retains its efficacy in the 2nd and 3rd line setting. Additionally, panitumumab can benefit patients who previously had clin

关键词： Panitumumab Cetuximab EGFR Inhibitor metastatic Colorectal Cancer

中国非物质文化遗产与市场:自我经营的非遗传承人

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文化遗产 2021年第5期 32-38页

作者： [德]Philipp Demgenski [德]christina maags 张煜(译) 浙江大学社会学系人类学研究所英国谢菲尔德大学浙江农林大学文法学院浙江杭州311300

从江苏省和山东省的田野调查来看,官方认可的非遗标志以及政治资本和社会网络都给非物质文化遗产传承人带来了机会,使得他们能通过非物质文化遗产市场化,从中获得经济利益。同时,在中国更大的发展和现代化计划背景下,非物质文化遗产的... 详细信息

从江苏省和山东省的田野调查来看,官方认可的非遗标志以及政治资本和社会网络都给非物质文化遗产传承人带来了机会,使得他们能通过非物质文化遗产市场化,从中获得经济利益。同时,在中国更大的发展和现代化计划背景下,非物质文化遗产的概念如何帮助非遗传承人积极参与国家经济发展,并从中获益。非遗使文化制度化,将从业者与国家联系起来,并提供了更多市场化的机会,让从业者在保护下实现自我经营。不能把政治经济问题、结构性不平等和权力等级制度都归咎于非遗。因为无论有没有非遗,这些问题依旧存在。

关键词：中国非物质文化遗产市场化非遗传承人经济发展

Prosecution records reveal pangolin trading networks in China, 2014–2019

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Zoological Research 2021年第5期42卷 666-670页

作者： Xiang-Qin Huang Chris Newman christina D.Buesching mei-Ling Shao Yun-Chun Ye Sha Liu David W.macdonald Zhao-min Zhou Key Laboratory of Southwest China Wildlife Resources Conservation(ministry of Education) China West Normal UniversityNanchongSichuan 637002China Wildlife Conservation Research Unit The Recanati-Kaplan CentreDepartment of ZoologyUniversity of OxfordOxford OX135QLUK Cook’s Lake Farming Forestry and Wildlife Inc.(Ecological Consultancy)Queens CountyNova Scotia B0J 2H0Canada Department of Biology Irving K.Barber Faculty of ScienceThe University of British Columbia/OkanaganKelownaBC V1V 1V7Canada Key Laboratory of Environmental Science and Biodiversity Conservation(Sichuan Province) China West Normal UniversityNanchongSichuan 637002China

In a precautionary response to the current coronavirus(COVID-19)pandemic,China’s ministries permanently banned eating and trading in terrestrial wild(non-livestock)animals on 24 February 2020,and extensively updated the list of Fauna under Special State Protection(LFSSP)in 2020 and 2021,in which pangolins(manidae spp.)were upgraded to the highest protection *** 509 pangolin prosecution records from China Judgements online prior to these changes(01/01/14–31/12/19),we identified that Guangdong,Guangxi and Yunnan Provinces were hotspots for trade in whole pangolins and their scales.

关键词： trading networks mining

Establishment,functional and genetic characterization of three novel patient-derived rectal cancer cell lines

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World Journal of Gastroenterology 2018年第43期24卷 4880-4892页

作者： michael Gock christina S mullins Carina Bergner Friedrich Prall Robert Ramer Anja Goder Oliver H Kramer Falko Lange Bernd J Krause Ernst Klar michael Linnebacher Department of General Surgery University Medical CenterRostock 18055Germany Section of molecular Oncology and Immunotherapy University MedicalCenterRostock 18055Germany Department of Nuclearmedicine University Medical CenterRostock 18055Germany Institute of Pathology University MedicalCenterRostock 18055Germany Institute of Pharmacology University Medical CenterRostock 18055Germany Institute of Toxicology University Medical Center MainzMainz 55131Germany Oscar-Langendorff-Institute of Physiology University Medical CenterRostock 18055Germany

AIm To establish patient-individual tumor models of rectal cancer for analyses of novel biomarkers, individual response prediction and individual therapy *** Establishment of cell lines was conducted by direct in vitro culturing and in vivo xenografting with subsequent in vitro culturing. Cell lines were in-depth characterized concerning morphological features, invasive and migratory behavior, phenotype, molecular profile including mutational analysis, protein expression, and confirmation of origin by DNA fingerprint. Assessment of chemosensitivity towards an extensive range of current chemotherapeutic drugs and of radiosensitivity was performed including analysis of a combined radioand chemotherapeutic treatment. In addition, glucose metabolism was assessed with 18 F-fluorodeoxyglucose(FDG) and proliferation with 18 *** We describe the establishment of ultra-low passage rectal cancer cell lines of three patients suffering from rectal cancer. Two cell lines(HROC126, HROC284 met) were established directly from tumor specimens while HROC239 T0 m1 was established subsequent to xenografting of the tumor. molecular analysis classified all three cell lines as CImP-0/non-mSI-H(sporadic standard) type. mutational analysis revealed following mutational profiles: HROC126: APC^(wt), TP53^(wt), KRAS^(wt), BRAF^(wt), PTEN^(wt); HROC239 T0 m1: APC^(mut), P53^(wt), KRAS^(mut), BRAF^(wt), PTEN^(mut) and HROC284 met: APC^(wt), P53^(mut), KRAS^(mut), BRAF^(wt), PTEN^(mut). All cell lines could be characterized as epithelial(EpCAm+) tumor cells with equivalent morphologic features and comparable growth kinetics. The cell lines displayed a heterogeneous response toward chemotherapy, radiotherapy and their combined application. HROC126 showed a highly radio-resistant phenotype and HROC284 met was more susceptible to a combined radiochemotherapy than HROC126 and HROC239 T0 m1. Analysis of 18 F-FDG uptake displayed a markedly reduced FDG uptake of all th

关键词： Patient-derived tumor model Rectal cancer ^(18)F-fluorodeoxyglucose ^(18)F-fluorothymidine FOLFOX FOLFIRI Personalized medicine

Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups

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World Journal of Gastroenterology 2015年第9期21卷 2759-2769页

作者： christina m Hester Venkatakrishna R Jala morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu Department of Family medicine Research Division University of Kansas Medical CenterKansas CityKS 66160United States University of Kansas Cancer Center University of Kansas medical Center Kansas CityKS 66160United States James Graham Brown Cancer Center and Department of microbiology and Immunology University of LouisvilleLouisvilleKY 40202United States Department of Pharmacology Dalhousie UniversityHalifaxNS B3H 4R2Canada Department of molecular and Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160United States

AIm:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White ***:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA ***,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the *** used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all ***:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic *** also found that participant microbial profiles differed by racial/ethnic *** Americans had significantly more Firmicutes than Whites,with enriched *** Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of *** also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in ***:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions.

关键词： Colorectal cancer Short chain fatty acids Racial/e

Genome-wide microRNA Expression Profiles in COPD: Early Predictors for Cancer Development

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 162-171页

作者： Andreas Keller Tobias Fehlmann Nicole Ludwig mustafa Kahraman Thomas Laufer christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart meese Robert Bals Clinical Bioinformatics Saarland University 66123 Saarbriieken Germany Department of Human Genetics Saarland University Hospital 66421 Homburg Germany Hummingbird Diagnostics GmbH 69120 Heidelberg Germany Department of Internal medicine Division for Pulmonary Diseases Philipps University of Marburg 35043 Marburg Germany Institute for Biostatistics Hannover Medical School 30625 Hanover Germany Department of Internal medicine V- Pulmonology AlIergology Intensive Care Medicine Saarland University Hospital 66421 Homburg Germany Institute and Outpatient Clinic for Occupational Social and Environmental Medicine Comprehensive Pneumology Center Munich (CPC-M) Ludwig-Maximilians-University Munich Member of the German Center for Lung Research ( DZL) 80539 Munich Germany Bioinformatics Saarland University 66123 Saarbrucken Germany Center for Bioinformatics Saarland University 66123 Saarbrucken Germany

Chronic obstructive pulmonary disease （COPD） significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork （COSYCONET） study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA （miRNA） profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance （two-tailed unpaired t-test adjusted for multiple testing P 〈 0.05）, including members of the miR-320 family. The identified miRNAs regulate different cancer-related pathways including the mAPK pathway （P - 2.3 × 10 -5）. We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer.

关键词： microRNA Cancer COPD Lung Biomarker COSYCONET