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Bridging Healthcare and Health IT

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Journal of Health Science 2017年第5期5卷 236-238页

作者： christina m. Perez Community Family medicine Clinic University of the Incarnate Word San Antonio Texas 78228 USA

Health IT （Information Technology） is new to the healthcare industry, even though the term surfaced in 2008 the true meaning of what it is and how data aggregation, evaluation, and validation of patient data and information drives a successful quality healthcare organization. Understanding of key factors, what quality is and how it is measured, helps bridge together healthcare and technology for an organization to be successful in reporting quality measures for the best patient care.

关键词： Health information technology accountable care organizations office of national coordinator data aggregation cybersecurity.

Characterizing the patient experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma:A qualitative study

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1175-1186页

作者： Lena Stevens Zachary J Brown Ryan Zeh christina monsour Sharla Wells-Di Gregorio Heena Santry Aslam m Ejaz Timothy michael Pawlik Jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of General Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Center for Palliative CareThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Neoadjuvant therapy(NT)has increasingly been utilized for patients with localized pancreatic ductal adenocarcinoma(PDAC).It is the recommended approach for borderline resectable(BR)and locally advanced(LA)cancers and an increasingly utilized option for potentially resectable(PR)*** its increased use,little research has focused on patient-centered metrics among patients undergoing NT,including patient experiences,preferences,and recommendations.A better understanding of all aspects of the patient experience during NT may identify opportunities to design interventions aimed at improving quality of life;it may also facilitate the completion of NT and receipt of surgery,ultimately optimizing long-term *** To understand the experience of patients initiating and receiving NT to identify opportunities to improve neoadjuvant cancer care *** Semi-structured interviews of patients with localized PDAC during NT were conducted to explore their experience initiating and receiving *** took place between August 2020 and October *** to the descriptive nature of the research,questions were open *** were conducted over the phone,audio recorded and then *** interviews were coded by two independent researchers using NVivo 12,iteratively identifying themes until thematic saturation was *** integrative approach to qualitative analysis was used,utilizing both inductive and deductive *** A total of 12 patients with localized PDAC were *** with BR(n=7),PR(n=2),and LA(n=3)cancers participated in the *** patients indicated that choosing NT was the doctor’s recommendation,while most reported not being familiar with the concept of NT(n=11)and that NT was presented as the only option(n=8).Five themes describing the patient experience emerged:physical symptoms,emotional symptoms,coping mechanisms,access to care,and life *** most commonly cited recommendation for

关键词： Pancreatic ductal adenocarcinoma Neoadjuvant therapy Patient experience Patient-centered care Quality of life Qualitative research

Emerging Techniques for Cardiovascular PET

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Cardiovascular Innovations and Applications 2019年第B4期4卷 13-24页

作者： Austin A.Robinson,mD jamieson m.Bourque,mD,mHS Cardiovascular Division and the Cardiovascular Imaging Center Department of MedicineUniversity of Virginia Health SystemCharlottesvilleVAUSA Department of Radiology University of Virginia Health SystemCharlottesvilleVAUSA

Positron emission tomography(PET)has been successfully applied to an increasing number of cardiovascular *** review will highlight the status of cardiovascular PET,including the present state of the art and the expanding pool of clinical evidence guiding its ***,we highlight upcoming developments in the fi eld,including the development of new tracers and applications of PET to novel indications within cardiovascular medicine.

关键词： positron emission tomography(PET) absolute blood fl ow metabolic imaging novel tracers coronary artery disease(CAD) coronary microvascular dysfunction cardiac infection congestive heart failure

Pentacene-based nanorods on Au（111） single crystals： Charge transfer, diffusion, and step-edge barriers

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Nano Research 2013年第6期6卷 449-459页

作者： Sabine-Antonia Savu Sabine Abb Simon Schundelmeier Jonathan D. Saathoff James m. Stevenson christina Tonshoff Holger F. Bettinger Paulette Clancy m. Benedetta Casu Thomas Chasse Institute of Physical and Theoretical Chemistry University of Tuebingen Aufder Morgenstelle 18 72076 Tuebingen Germany School of Chemical and Biomolecular Engineering Cornel/University Ithaca New York 14853 USA Institute of Organic Chemistry University of Tuebingen Auf der Morgenstelle 18 72076 Tuebingen Germany

We investigate nanorod assemblies of two 64-substituted pentacenes, namely （2,3-X2-9,10-Y2）-substituted pentacenes with X -- Y = OCH3 （mOP） and with X = F, Y-- OCH3 （mOPF）, grown on Au（111） single crystals. By using a multi-technique approach based on ultraviolet photoelectron spectroscopy X-ray photoelectron spectroscopy; and X-ray absorption, we find evidence for charge transfer screening at the interface with gold. Furthermore, the mOP and mOPF nanorods show a rough surface morphology, which was investigated with atomic force microscopy. We use molecular simulation techniques to investigate the energetic barriers to diffusion and to traverse step-edges to estimate their influence on the nanorod roughness. We find that barriers to surface diffusion on a terrace are anisotropic and that their direction favors the formation of nanorods in these materials.

关键词： nanorod assembly substituted pentacene electronic structures/ processes/mechanisms organic electronics charge transfer diffusion and step-edge barrier

Quantities of comorbidities affects physical, but not mental health related quality of life in type 1 diabetes with confirmed polyneuropathy

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World Journal of Diabetes 2019年第2期10卷 87-95页

作者： Anne-marie L Wegeberg Theresa meldgaard Sofie Hyldahl Poul Erik Jakobsen Asbjφrn m Drewes Birgitte Brock christina Brock mech-Sense Department of Gastroenterology and HepatologyAalborg University Hospital and Clinical InstituteAalborg UniversityAalborg 9000Denmark Steno Diabetes Center North Judland Region NordjyllandAalborg 9000Denmark Steno Diabetes Center Copenhagen Region HovedstadenGentofte 2820Denmark

BACKGROUND A large number of adults with long-term type 1 diabetes are affected by symmetrical peripheral *** complications increase socioeconomic expenses and diminish the individual quality of *** 36-Item Short Form Health Survey(SF-36)is a generic patient reported questionnaire,measuring mental and physical health related quality of *** hypothesized that diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and that clinical appearance may be associated with the *** To investigate if diabetic neuropathy would decrease physical and mental quality of life measured with SF-36,and if clinical appearance may be associated with the *** Forty-eight adults[age 50±9 years,10 females,disease duration 32(14-51)years]with verified diabetic symmetrical peripheral neuropathy and 21 healthy participants(age 51±6 years,6 females)underwent standardised nerve conduction testing and completed the SF-36 ***,disease duration,number of comorbidities,both diabetes related and nondiabetes related,vibration perception threshold,number of hypoglycaemic events,HbA1c and administration way of insulin was *** In comparison to healthy subjects,patients’mental composite score was not significantly diminished(51.9±8.9 vs 53.1±5.5,P=0.558),while the physical composite score was(46.3±11.7 vs 54.6±3.3,P=0.002).As expected,the overall physical health related symptoms in patients were associated to total number of comorbidities(Pmorbidities relation to diabetes(P=0.0002)and HbA1c(P=0.005)as well as comorbidities not related to diabetes(P=0.0006).CONCLUSION The finding of this study emphasises the importance of focusing on quality of life in adults with diabetes and especially in those with multiple comorbidities as well as the possibility of HbA1c as a biomarker for severe complication.

关键词： Quality of life 36-Item Short Form Health Survey(SF-36) Diabetes mellitus,Type 1 Diabetic neuropathies Comorbidity

Short lessons in basic life support improve self-assurance in performing cardiopulmonary resuscitation

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World Journal of Emergency medicine 2016年第4期7卷 255-262页

作者： mario Kobras Sascha Langewand christina murr Christiane Neu Jeannette Schmid Department of Anaesthesiology Intensive Care and Emergency Medicine Asklepios Western Clinical Centre 20 Suurheid City of Hamburg 22559 Federal Republic of Germany Academy of the Rescue Service Cooperation in Schleswig-Holstein 50 Esmarch Street City of Heide 25746 Federal Republic of Germany Regio Clinical Center GmbH Sana Group 71 75 Ramskamp Elmshorn 25337 County of Pinneberg Federal Republic of Germany Executive Committee of the Goethe University Frankfurt a.m. City of Frankfurt 60323 Federal Republic of Germany

BACKGROUND:There are several reasons why resuscitation measures may lead to inferior results:difficulties in team building,delayed realization of the emergency and interruption of chest *** study investigated the outcome of a new form of in-hospital cardiopulmonary resuscitation(CPR) training with special focus on changes in self-assurance of potential helpers when faced with emergency ***:Following a 12-month period of CPR training,questionnaires were distributed to participants and *** non-participants who intended to undergo the training at a later date served as control ***:The study showed that participants experienced a significant improvement in selfassurance,compared with their remembered self-assurance before the *** self-assurance also was significantly greater than that of the control group of ***:Short lessons in CPR have an impact on the self-assurance of medical and non-medical personnel.

关键词： Basic life support Simulation training Non-technical skills Cardiopulmonary resuscitation

Human enteric viruses–potential indicators for enhanced monitoring of recreational water quality

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Virologica Sinica 2015年第5期30卷 344-353页

作者： Erin Allmann Updyke Zi Wang Si Sun christina Connell marek Kirs mayee Wong Yuanan Lu Department of Public Health Sciences University of Hawai‘i at Mānoa Water Resources Research Center University of Hawai‘i at Mānoa

Recreational waters contaminated with human fecal pollution are a public health concern, and ensuring the safety of recreational waters for public use is a priority of both the Environmental Protection Agency(EPA) and the Centers for Disease Control and Prevention(CDC). Current recreational water standards rely on fecal indicator bacteria(FIB) levels as indicators of human disease risk. However present evidence indicates that levels of FIB do not always correspond to the presence of other potentially harmful organisms, such as viruses. Thus, enteric viruses are currently tested as water quality indicators, but have yet to be successfully implemented in routine monitoring of water quality. This study utilized enteric viruses as possible alternative indicators of water quality to examine 18 different fresh and offshore recreational waters on O‘ahu, Hawai‘i, by using newly established laboratory techniques including highly optimized PCR, real time PCR, and viral infectivity assays. All sample sites were detected positive for human enteric viruses by PCR including enterovirus, norovirus genogroups I and II, and male specific FRNA coliphage. A six time-point seasonal study of enteric virus presence indicated significant variation in virus detection between the rainy and dry seasons. Quantitative PCR detected the presence of norovirus genogroup II at levels at which disease risk may occur, and there was no correlation found between enteric virus presence and FIB counts. Under the present laboratory conditions, no infectious viruses were detected from the samples PCR-positive for enteric viruses. These data emphasize both the need for additional indicators for improved monitoring of water quality, and the feasibility of using enteric viruses as these indicators.

关键词： human enteric virus indicator recreational water q

Ternary Ni-Co-Fe oxyhydroxide oxygen evolution catalysts:Intrinsic activity trends,electrical conductivity,and electronic band structure

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Nano Research 2019年第9期12卷 2288-2295页

作者： michaela Burke Stevens Lisa J. Enman Ester Hamal Korkus Jeremie Zaffran christina D. m. Trang James Asbury matthew G. Kast maytal Caspary Toroker Shannon W. Boettcher Department of Chemistry & Biochemistry and the materials Science Institute University of OregonEugeneOR 97403USA Department of materials Science & Engineering and The Nancy & Stephen Grand Technion Energy Program Technion Israel Institute of TechnologyHaifa 3200003Israel

Nickel-,cobalt-,and iron-based(oxy)hydroxides comprise the most-commonly studied electrocatalysts for the oxygen-evolution reaction(OER)in alkaline solution.A fundamental understanding of composition-structure-activity relationships for mixed-metal Ni-Co and Ni-Co-Fe(oxy)hydroxides is important to guide the design of advanced OER *** we use cyclic voltammetry,chronopotentiometry,inductively-coupled plasma-optical emission spectroscopy,and in situ electrical conductivity measurements to characterize the properties and activity of various compositions of Ni-Co-Fe(oxy)hydroxides prepared by cathodic *** with previous studies,we find Fe is essential for the mixed-metal(oxy)hydroxides to achieve high OER *** the rigorous absence of Fe(achieved by using specially cleaned electrolytes),the most-active Ni-Co(oxy)hydroxide composition has an OER turn-over frequency only twice that ofpure Co(oxy)hydroxide,suggesting minimal synergism between the two *** addition of Co to Ni-Fe(oxy)hydroxides shifts the onset of electrical conductivity to lower potentials,but has little effect on the intrinsic OER activity,with the most-active Ni-Co-Fe(oxy)hydroxide having an OER turn-over frequency only -1.5 times that of the Ni-Fe(oxy)*** magnitudes of the electrical conductivities are similar for all the compositions ***-functional-theory-calculated projected density of states show a significant contribution of all chemical elements at the valence band edge of the mixed-metal oxyhydroxide electronic structure,demonstrating significant electronic hybridization between the *** calculations suggest the involvement of all the elements in modulating the electronic structure at putative Fe-based active sites that are probably located at edges or defects in the two-dimensional oxyhydroxide sheets.

关键词： electrocatalysis heterogeneous catalysis water electrolysis oxygen evolution density functional theory

Recent advances in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms

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World Journal of Gastrointestinal Surgery 2022年第5期14卷 383-396页

作者： meng Dai christina S mullins Lili Lu Guido Alsfasser michael Linnebacher Clinic of General Surgery Molecular Oncology and ImmunotherapyRostock University Medical Center18057 RostockGermany Clinic of General Surgery Rostock University Medical Center18057 RostockGermany

Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are a rare group of tumors originating from neuroendocrine cells of the digestive *** incidence has increased over the last *** specific pathogenetic mechanisms underlying GEP-NEN development have not been completely *** GEP-NENs are usually asymptomatic;some grow slowly and thus impede early diagnosis,which ultimately results in a high rate of ***,many GEP-NEN patients present with later staged *** hereby,research attention for diagnosis and treatment for GEP-NENs increased in recent *** result of which is great progress in clinical diagnosis and *** to the most recent clinical guidelines,improved grading standards can accurately define poorly differentiated grade 3 neuroendocrine tumors and neuroendocrine carcinomas(NECs),which are subclassified into large and small cell *** different functional imaging methods facilitates precise *** expression of somatostatin receptors helps to predict *** analyses of mutations affecting death domain associated protein(DAXX),multiple endocrine neoplasia type 1(mEN 1),alpha thalassemia/intellectual disability syndrome X-linked(ATRX),retinoblastoma transcriptional corepressor 1(RB 1),and mothers against decapentaplegic homolog 4(SmAD 4)help distinguishing grade 3 NENs from poorly differentiated *** aim of this review is to summarize the latest research progress on diagnosis and treatment of GEP-NENs.

关键词： GEP-NENs Functional imaging Peptide receptor radionuclide therapy Targeting agents Immune checkpoint inhibitors Genetic mutations