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A decision framework for identifying models to estimate forest ecosystem services gains from restoration

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Forest Ecosystems 2016年第2期3卷 126-137页

作者： Zachary L. christin.Kenneth J. Bagstad Michael A. Verdone Earth Economics 107 N Tacoma Ave Tacoma WA 98403 USA. U.S. Geological Survey Geosciences & Environmental Change Science Center Box 25046 MS 980 Denver CO 80225 USA. International Union for the Conservation of nature 1630 Connecticut Ave. NW #300 Washington DC 20009 USA.

Restoring degraded forests and agricultural lands has become a global conservation priority. A growing number of tools can quantify ecosystem service tradeoffs associated with forest restoration. This evolving ＂tools landscape＂ presents a dilemma： more tools are available, but selecting appropriate tools has become more challenging. We present a Restoration Ecosystem Service Tool Selector （RESTS） framework that describes key characteristics of 13 ecosystem service assessment tools. Analysts enter information about their decision context, services to be analyzed, and desired outputs. Tools are filtered and presented based on five evaluative criteria： scalability, cost, time requirements, handling of uncertainty, and applicability to benefit-cost analysis. RESTS uses a spreadsheet interface but a web-based interface is planned. Given the rapid evolution of ecosystem services science, RESTS provides an adaptable framework to guide forest restoration decision makers toward tools that can help quantify ecosystem services in support of restoration.

关键词： Decision support Ecosystem services Forest restoration Modeling Valuation Comparative toolsassessment

Root canal morphology and configuration of 123 maxillary second molars by means of micro-CT

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International Journal of Oral Science 2017年第1期9卷 33-37页

作者： Thomas Gerhard Wolf Frank Paqué Anja-christin.Woop Brita Willershausen Benjamín Briseno-Marroquín Department of Operative Dentistry Johannes Gutenberg University Medical CenterMainzGermany Division of Endodontology Department of Preventive DentistryPeriodontology and CariologyUniversity of ZurichZurichSwitzerland

The aim of this study was to investigate the root canal configuration, accessory canals and number of main foramina of 123 maxillary second molars by means of micro-computed tomography. The teeth were scanned and reproduced with 3D software imaging. The root canal configuration and number of main foramina were evaluated by means of a four-digit system. The morphological complexity of human maxillary second molars is depicted by the number of accessory and connecting canals. The most frequently observed root canal configurations in the mesiobuccal root were 2-2-2/2 （19.5%）, 2-2-1/1 （14.6%） and 2-1-1/1 （13.0%）. A 1-1-1/1 configuration was observed in 93.5% and in 96.7% in the distobuccal and palatal roots, respectively. The MB1 mot canal had one accessory canal （18.7%）, and 8.9% of the MB2 root canal had one or two accessory canals. The distobuccal （11.3%） and palatal （14.6%） root canals had at least one accessory canal, and connecting canals were observed in 16.3% of mesiobuccal roots. The MB1, MB2, distobuccal and palatal root canals had one main foramen in 99.2%, 43.1%, 98.4% and 99.2% of samples, respectively. In the mesiobuccal root, one accessory foramen was detected in 14.6%, two were detected in 7.3%, and three were detected in 5.7%. The distobuccal root showed one or two accessory foramina in 9.1% of samples. The root canal configuration of maxillary second molars is quite heterogeneous; the mesiobuccal root has predominantly two root canal entrances （58.4%, 1 in 41.1%） with one main foramen （54.4%）. Two main foramina were observed in 43.0%. Morphological variations, connecting and accessory canals were observed in all apical thirds.

关键词： accessory and connecting canals apical foramina maxillary second molar micro-CT morphology root canal configuration

Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis

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World Journal of Gastroenterology 2009年第44期15卷 5558-5562页

作者： Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann christin.Meltzer Franz Leidl norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand Department of Internal Medicine University Medical Center RegensburgD-93042 RegensburgGermany Department of Psychiatry University Medical Center RegensburgD-93042 RegensburgGermany

AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ***:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). COnCLUSIOn:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP.

关键词： Monocyte chemotactic protein-1 Chemokines Spontaneous bacterial peritonitis Polymorphism Livercirrhosis

CYLD deletion triggers nuclear factor-κB-signaling and increases cell death resistance in murine hepatocytes

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World Journal of Gastroenterology 2014年第45期20卷 17049-17064页

作者： Toni Urbanik Bruno Christian Koehler Laura Wolpert christin.Elbner Anna-Lena Scherr Thomas Longerich nicole Kautz Stefan Welte nadine Hovelmeyer Dirk Jager Ari Waisman Henning Schulze-Bergkamen national Center for Tumor Diseases Department of Medical Oncology University Clinic of Heidelberg 69120 HeidellbergBade-WuerrtembergGermany Institute of Pathology University Hospital Heidelberg 69120 HeidelbergBaden-WuerrtembergGermany Institute for Molecular Medicine Johannes Gutenberg-University Mainz 55131 MainzRheinland-PalatlnateGemany

AIM:To analyze the role of CYLD for receptor-mediated cell death of murine hepatocytes in acute liver injury ***:Hepatocyte cell death in CYLD knockout mice(CYLD-/-)was analyzed by application of liver injury models for CD95-(Jo2)and tumor necrosis factor(TnF)-α-[D-Gal n/lipopolysaccharide(LPS)]induced *** injury was assessed by measurement of serum transaminases and histological *** induction was quantified by cleaved PARP staining and Western blotting of activated *** factor(nF)-κB,ERK,Akt and jun amino-terminal kinases signaling were *** Hepatocytes were isolated by two step-collagenase perfusion and treated with recombinant TnF-αand with the CD95-ligand *** viability was analyzed by ***:Livers of CYLD-/-mice showed increased anti-apoptotic nF-κB *** both applied liver injury models CYLD-/-mice showed a significantly reduced apoptosis *** D-Gal n/LPS treatment CYLD-/-mice exhibited significantly lower levels of alanine aminotransferase(ALT)(295 U/L vs 859 U/L,Pnd aspartate aminotransferase(AST)(560 U/L vs 1025 U/L,Pnjection CYLD-/-mice showed 2-fold lower ALT(50 U/L vs 110 U/L,Pnd lower AST(250 U/L vs 435 U/L,Pn,isolated CYLD-/-primary murine hepatocytes(PMH)were less sensitive towards death receptor-mediated apoptosis and showed increased levels of Bcl-2,XIAP,c IAP1/2,survivin and c-FLIP expression upon TnF-and CD95-receptor triggering,*** of nF-κB activation by the inhibitor of nF-κB phosphorylation inhibitor BAY 11-7085 inhibited the expression of antiapoptotic proteins and re-sensitized CYLD-/-PMH towards TnF-and CD95-receptor mediated cell ***:CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling nF-κB dependent anti-apoptotic signaling.

关键词： CYLD Apoptosis nuclear factor-κB Tumo rnecrosis factor-α CD95 Liver

Dose-efficient scanning Compton X-ray microscopy

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Light(Science & Applications) 2023年第6期12卷 1141-1152页

作者： Tang Li JLukas Dresselhaus nikolay Ivanov Mauro Prasciolu Holger Fleckenstein Oleksandr Yefanov Wenhui Zhang David Pennicard Ann-christin.Dippel Olof Gutowski Pablo Villanueva-Perez Henry n.Chapman Saša Bajt The Hamburg Centre for Ultrafast Imaging 22761 HamburgGermany Center for Free-Electron Laser Science CFEL Deutsches ElektronenSynchrotron DESY22607 HamburgGermany Deutsches Elektronen Synchrotron DESY 22607 HamburgGermany Synchrotron Radiation Research and nanoLund Lund University22100 LundSweden Department of Physics Universität Hamburg22761 HamburgGermany

The highest resolution of images of soft matter and biological materials is ultimately limited by modification of the structure,induced by the necessarily high energy of short-wavelength *** the inelastically scattered X-rays at a photon energy of 60 keV(0.02 nm wavelength)offers greater signal per energy transferred to the sample than coherent-scattering techniques such as phase-contrast microscopy and projection *** present images of dried,unstained,and unfixed biological objects obtained by scanning Compton X-ray microscopy,at a resolution of about 70 *** microscope was realised using novel wedged multilayer Laue lenses that were fabricated to sub-ångström precision,a new wavefront measurement scheme for hard X rays,and efficient pixel-array *** doses required to form these images were as little as 0.02%of the tolerable dose and 0.05%of that needed for phase-contrast imaging at similar resolution using 17 keV photon *** images obtained provide a quantitative map of the projected mass density in the sample,as confirmed by imaging a silicon *** on these results,we find that it should be possible to obtain radiation damage-free images of biological samples at a resolution below 10 nm.

关键词： wedge dried scattered

Benefit of Growth Hormone Replacement in Adults Older than 60 Years

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Open Journal of Endocrine and Metabolic Diseases 2013年第3期3卷 166-178页

作者： Kristin Arp Christian Schwahn nele Friedrich Thomas Kohlmann Jorn Moock Maria Koltowska-Haggstrom Matthias nauck Michael Buchfelder Henri Wallaschofski christin.Spielhagen Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany Community Medicine University Medicine GreifswaldGreifswaldGermany KIGS/KIMS/ACROSTUDY Medical Outcomes Pfizer Endocrine CareSollentunaSweden Department of neurosurgery University of ErlangenErlangenGermany

Objective: Benefits of replacement therapy in growth hormone deficiency (GHD) are well documented in younger and middle-aged patients. The aim of our investigation was to prove the benefit of GH replacement for patients older than 60 years especially in terms of health-related quality of life (HRQoL) of age as well. Design: Data of 743 consecutively recruited patients (394 men, 349 women) with GHD aged 20 - 49 (n = 606) and 60 - 69 (n = 137) years enrolled from KIMS Germany (Pfizer International Metabolic Database) were compared. Treatment effects over the 12 months dose-finding and the subsequent phase up to three years were analysed using mixed models. Serum insulin-like growth factor I (IGF-I), fasting blood glucose, fasting serum total cholesterol and low-density lipoprotein cholesterol (LDL-C) as well as body mass index (BMI) at baseline and at last visit were studied. HRQoL was assessed using the Quality of Life-Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA). Results: For both age groups and genders the IGF-I level and standardized IGF-I increased over the dose-finding phase. In women, the overall QoL-AGHDA score at the baseline examination was 8.7 (95% CI: 7.7 - 9.7) and decreased to 6.3 (95% CI: 5.1 - 7.6) at the end of the dose-finding phase (p n men, the corresponding values were 8.8 (95% CI: 7.8 - 9.8) and 6.4 (95% CI: 5.1 - 7.6;p nces between the age groups. The therapy benefit for elderly was supported by the non-impairment after the dose-finding phase. In total cholesterol, LDL-C and fasting blood glucose, no significant changes were detected, whereas an increase in BMI did not differ between age groups. Conclusion: We could show positive effects of GH replacement on HRQoL in patients older than 60 years of age. Therefore, GH replacement should be considered in elderly GHD adults without difference compared to younger age groups.

关键词： Growth Hormone Deficiency Quality of Life Growth Hormone IGF-I

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丹麦国家海事博物馆

城市环境设计 2019年第2期118卷 142-159页

作者： John Pries Jensen Henrik Kania Ariel Joy norback Wallner Rasmus Pedersen Annette Jensen Dennis Rasmussen Jan Magasanik Jeppe Ecklon Karsten Hammer Hansen Rasmus Rodam Rune Hansen Alina Tamosiunaite Alysen Hiller Ana Merino Armen Menendian Andy Yu Andreas Johansen Baptiste Blot Christian Alvarez christin.Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Eskild nordbud Felicia Guldberg Finn n?rkj?r Gül Ertekin Jan Borgstr?m James Schrader Johan Cool Jonas M?nster Kirstine Ragnhild Malte Kloe Michael Andersen Michal Kristof Marc Jay Maria Mavriku Masatoshi Oka Oana Simionescu Pablo Labra Peter Rieff Qianyi Lim Sara Sosio Sebastian Latz Tina Lund H?jgaard Tina Troster Todd Bennet Xi Chen Xing Xiong Xu Li Zoltan Kalaszi Iwan Baan Rasmus Hjortshoj Luca Santiago Mora Dragoer Luftfoto Jens Lindhe Lorenzon Boddi Thiks Wolzak 陈子钰

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强... 详细信息

丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强有力的结构作为海事博物馆中心。将博物馆这样设置,使它在成为与克伦堡城堡和邻近的文化庭院相联系的文化环境的一部分的同时,彰显自身,成为一个独立

关键词：海事博物馆铝覆层 Section 重钢结构