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Experiences with a violence and mental health safety protocol for a randomized controlled trial to support youth living with HIV

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Global Health Research and Policy 2021年第1期6卷 87-96页

作者： Katherine G.Merrill Jonathan K.Mwansa Sam Miti Virginia M.Burke Elizabeth A.Abrams christiana frimpong Michele R.Decker Jacquelyn C.Campbell Julie A.Denison Department of International Health Johns Hopkins Bloomberg School of Public Health615 N.Wolfe StreetBaltimoreMD 21205USA Arthur Davison Children’s Hospital NdolaZambia Department of Population Family and Reproductive HealthJohns Hopkins Bloomberg School of Public HealthBaltimoreMDUSA Department of Community-Public Health Johns Hopkins School of NursingBaltimoreMDUSA Present Address:Department of Medicine University of Illinois at ChicagoChicagoILUSA

Background:Safety protocols are an essential component of studies addressing violence and mental health but are rarely described in the published literature from Sub-Saharan *** designed and implemented a safety protocol within Project YES!(Youth Engaging for Success),which enrolled 276 youth living with HIV(ages 15–24 years)in a randomized controlled trial of a peer-mentoring intervention across four HIV clinics in Ndola,***:Youth who reported severe violence and/or suicidal thoughts on research surveys or during meetings with youth peer mentors(YPM)were referred to designated healthcare providers(HCP).We explored experiences with the safety protocol using:a)monitoring data of referrals,and b)in-depth interviews with youth(n=82),HCP(n=10),YPM(n=8),and staff(n=6).Descriptive statistics were generated and thematic analysis of coded transcripts and written memos ***:Nearly half of youth enrolled(48%of females,41%of males)were referred to a HCP at least *** first referral was most often for sexual violence(35%)and/or suicidal ideation/depression(29%).All referred youth aged 15–17 years and over 80%of referred youth aged 18+agreed to see a *** referred 15%for additional services outside the ***-nine youth,all HCP,all YPM,and all staff interviewed discussed the safety *** youth felt“encouraged,”“helped,”“unburdened,”and“relieved”by their meetings with HCP;some expressed concerns about meeting with *** safety protocol helped HCP recognize the need to integrate care for violence and mental health with medication adherence ***,YPM,and study staff raised implementation challenges,including youth choosing not to open up to HCP,time and resource constraints,deficiencies in HCP training,and stigma and cultural norms inhibiting referrals outside the clinic for emotional trauma and mental ***:Implementing a safety protocol within an HIV clinic-based research study is possible and beneficial for

关键词： Safety protocol Referral Violence Mental health HIV Youth Zambia

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Impulse force reductions and their effects on WBV exposures in high impact shovel loading operations

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International Journal of Mining Science and Technology 2018年第3期28卷 423-435页

作者： Danish Ali Samuel frimpong Mining & Nuclear Engineering Department Missouri University of Science and Technology

When shovels load the dump trucks with over 100-ton passes under gravity dumping conditions, they will create a large impact force on the dump truck body which generates high frequency shock waves which expose the operators to whole body vibrations （WBV）. The main cause of such truck vibrations is the large impact force due to the gravity dumping of large tonnage passes. Therefore a rigorous mathematical model has been developed for the impact force containing all the necessary factors upon which it depends. Latter, a thorough analysis shows that percentage reduction of 7.19%, 9.40%, 13.27%, 14.8%, 17.30% and 18.13% can he achieved by reducing the dumping distance to 6.33 m, 6.0 m, 5.5 m, 5.33 m, 5.0 m and 4.9 m, respectively, as compared to when the dumping distance was 7.33 m. Even more reduction in the magnitude of impact force can he observed if the shovel pass gets divided into more than two sub-passes. Therefore, these models can he used to figure out the number of sub-passes into which a single ore pass can he divided and/or the extent to which the dumping distance can he reduced which would reduce the impact force significantly enough to obtain safer yet economic operations.

关键词： Impact force HISLO Mathematical modeling Dumping distance Shovel ore sub-passes

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Kinematic Analysis of an Under-actuated,Closed-loop Front-end Assembly of a Dragline Manipulator

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International Journal of Automation and computing 2020年第4期17卷 527-538页

作者： Muhammad AWardeh Samuel frimpong Department of Mining and Nuclear Engineering Missouri University of Science and TechnologyRolla 65409USA Center for Infrastructure Engineering Studies Missouri University of Science and TechnologyRolla 65409USADepartment of Mining and Nuclear EngineeringMissouri University of Science and TechnologyRolla 65409USA

Dragline excavators are closed-loop mining manipulators that operate using a rigid multilink framework and rope and rigging system,which constitute its front-end *** arrangements of dragline front-end assembly provide the necessary motion of the dragline bucket within its operating *** assembly resembles a five-link closed kinematic chain that has two independent generalized coordinates of drag and hoist ropes and one dependent generalized coordinate of dump *** models failed to represent the actual closed loop of dragline front-end assembly,nor did they describe the maneuverability of dragline ropes under imposed geometric ***,a three degrees of freedom kinematic model of the dragline front-end is developed using the concept of generalized *** contains all relevant configuration and kinematic constraint conditions to perform complete digging and swinging *** model also uses three inputs of hoist and drag ropes linear and a rotational displacement of swinging along their *** inverse kinematics is resolved using a feedforward displacement algorithm coupled with the Newton-Raphson method to accurately estimate the trajectories of the *** trajectories are solved only during the digging phase and the singularity was eliminated using Baumgarte's stabilization technique(BST),with appropriate inequality constraint *** is shown that the feedforward displacement algorithm can produce accurate trajectories without the need to manually solve the inverse kinematics from the *** research findings are well in agreement with the dragline real operational limits and they contribute to the efficiency and the reduction in machine downtime due to better control strategies of the dragline cycles.

关键词： Dragline mining manipulator underactuated closed-loop mechanism generalized speeds Baumgarte's stabilization technique(BST) feedforward displacement

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Effects of selective logging on tree diversity and some soil characteristics in a tropical forest in southwest Ghana

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Journal of Forestry Research 2014年第1期25卷 171-176页

作者： Alex Asase Bismark K.Asiatokor Kwasi Ofori-frimpong Department of Botany University of Ghana Environmental Science Programme University of Ghana Cocoa Research Institute of Ghana (CRIG)

We investigated the effects of selective logging disturbances on tree diversity and soil characteristics in the Bia Conservation Area in southwest Ghana. The study was conducted in unlogged, 29-35 years post-logged and swamp forests using ten 25 m× 25 m plots. In total, we identified 310 individual trees belonging to 87 species. Mean Shannon-Weiner index was highest in the post-logged forest but there were no significant differences in tree density, dominance, or DBH size class distributions between these forests. Soil physical properties such as pH and bulk density up to 30 cm depth were similar in the two of forests In terms of soil nutrient status, available P, exchangeable K and total N contents were all similar in the unlogged and post-logged forests. Our findings suggest that the effects of logging on tree diversity are compara-tively long-term, in contrast to its short-term effects on some top soil physical and chemical characteristics.

关键词： tropical forest deforestation plant diversity soil propertiesGhana

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Mechanical properties of coppiced and non-coppiced Pterocarpus erinaceus boles and their industrial application

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Journal of Forestry Research 2019年第5期30卷 1973-1980页

作者： Charles Antwi-Boasiako Frederick Amin Anthonio Kwasi frimpong-Mensah Kwame Nkrumah University of Science and Technology

Rosewood(Pterocarpus erinaceus Poir.)is valued for flooring,ornaments,musical instruments and furniture-making due to its durability,strength,beauty and acoustic *** coppices easily which could boost its continual *** parallel to grain,Modulus of Elasticity(MOE)and Modulus of Rupture(MOR)within coppiced and non-coppiced boles were *** properties decreased along both types of *** values for the heartwood were also greater than those for the sapwood of each type of ***,MOR and compression for non-coppiced stems were greater than those from the coppiced *** differences were significant(p<0.05).Mechanical properties from the coppiced and non-coppiced boles are *** have strength properties comparable with those of species widely used for railway sleepers,structural supports,flooring,veneer,furniture,cabinetry,truss and mine ***,coppiced wood could supplement non-coppiced wood for industrial applications which require strength.

关键词： Coppicing Wood density Mechanical property Rosewood Structural application

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Systematic literature review on the applications,impacts,and public perceptions of autonomous vehicles in road transportation system

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第6期10卷 1037-1060页

作者： Isaac Oyeyemi Olayode Bo Du Alessandro Severino Tiziana Campisi frimpong Justice Alex SMART Infrastructure Facility University of WollongongWollongongNSW 2522Australia Department of Civil Engineering and Architecture University of CataniaCatania 95131Italy Faculty of Engineering and Architecture Kore University of EnnaEnna 94100Italy School of Automotive Engineering Wuhan University of TechnologyWuhan 430070China

As the advancement of driverless technology,together with information and communication technology moved at a fast pace,autonomous vehicles have attracted great attention from both industries and academic sectors during the past *** is evident that this emerging technology has great potential to improve the pedestrian safety on roads,mitigate traffic congestion,increase fuel efficiency,and reduce greenhouse gas ***,there is limited systematic research into the applications and public perceptions of autonomous vehicles in road *** purpose of this systematic literature review is to synthesise and analyse existing research on the applications,implications,and public perceptions of autonomous vehicles in road transportation *** is found that autonomous vehicles are the future of road transportation and that the negative perception of humans is rapidly changing towards autonomous ***,to fully deploy autonomous vehicles in a road transportation system,the existing road transportation infrastructure needs significant *** systematic literature review contributes to the comprehensive knowledge of autonomous vehicles and will assist transportation researchers and urban planners to understand the fundamental and conceptual framework of autonomous vehicle technologies in road transportation systems.

关键词： Autonomous vehicles Autonomous mobility Public perception Road transportation Traffic safety

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Liposome-based delivery of biological drugs

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Chinese Chemical Letters 2022年第2期33卷 587-596页

作者： Kosheli Thapa Magar George frimpong Boafo Xiaotong Li Zhongjian Chen Wei He Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Biological drugs are attracting tremendous attention in disease treatment. However, their application is significantly limited by their inherent properties, such as high hydrophilicity, poor membranepermeability, low stability, and larger size. Liposome-based drug delivery systems are emerging as promising tools to improve their delivery, owing to their ability to reduce toxicity, improve bioavailability,and enhance the therapeutic efficacy of the drug by optimizing delivery to the specific target site. Here,we reviewed the types of liposomes and their applications as carriers for biological drugs to treat various diseases, emphasized the commercial products, and ultimately provided perspectives in this field.

关键词： Liposomes Drug delivery Biological drugs Endocytosis Toxicity

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Physical and mechanical properties of Klainedoxa gabonensis with engineering potential

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Journal of Forestry Research 2017年第3期28卷 629-636页

作者： K.Boakye Boadu C.Antwi-Boasiako K.frimpong-Mensah Department of Wood Science&Technology Faculty of Renewable Natural ResourcesKwame Nkrumah University of Science&TechnologyKumasiGhana

Adequate information is sparse for many tropical timbers on their engineering applications, which make their international promotion difficult. The physical and mechanical properties of Klainedoxa gabonensis Pierre ex Engl. （a lesserutilized species） and Entandrophragma cylindricum were compared. K. gabonensis contained more moisture with greater density at 12 % moisture content than E. cylindricum and had a tangential-radial ratio for swelling and shrinkage of 1.31-1.38 and 1.58-1.63, respectively, within acceptable thresholds for engineering/structural timbers. For K. gabonensis, shear parallel to grain was 32.2 ± 0.4-33.5 ±1 N mm^-2; compressive parallel to grain, 80.7 ± 1.4-90.6± 1 N mm^-2; modulus of rupture, 204± 4.0-214 ± 4.0 N mm^-2 and modulus of elasticity, 28,932 ± 664-29,493 ±822 N mm^-2. These properties were superior to those of E. cylindricum [（15.5 ± 0.9）- （15.6 ± 0.6）, （56.4 ± 4.5）-（63.6 ± 1.2）, （99.4 ± 4.7）- （121.3 ± 10.6）, and （9987.4 ± 207）-（10,051 ± 258） N mm^-2, respectively] and compared well with those of several traditional timbers for conslruction and furniture production. Its use would contribute to minimize pressure on the primary timbers in the forests and widen the raw material base for wooden products.

关键词： Density Dimensional stability Timberengineering Mechanical property Tangential-radialratio Traditional timber

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Pulmonary delivery of siRNA against acute lung injury/acute respiratory distress syndrome

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Acta Pharmaceutica Sinica B 2022年第2期12卷 600-620页

作者： Makhloufi Zoulikha Qingqing Xiao George frimpong Boafo Marwa A.Sallam Zhongjian Chen Wei He Department of Pharmaceutics School of PharmacyChina Pharmaceutical UniversityNanjing 211198China Department of Industrial Pharmacy Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

The use of small interfering RNAs(si RNAs)has been under investigation for the treatment of several unmet medical needs,including acute lung injury/acute respiratory distress syndrome(ALI/ARDS)wherein si RNA may be implemented to modify the expression of pro-inflammatory cytokines and chemokines at the m RNA *** properties such as clear anatomy,accessibility,and relatively low enzyme activity make the lung a good target for local si RNA ***,the translation of si RNA is restricted by the inefficient delivery of si RNA therapeutics to the target cells due to the properties of naked si ***,this review will focus on the various delivery systems that can be used and the different barriers that need to be surmounted for the development of stable inhalable si RNA formulations for human use before si RNA therapeutics for ALI/ARDS become available in the clinic.

关键词： Pulmonary administration Drug delivery Nanoparticles siRNA Cellular uptake Endosomal escape Inflammatory diseases ALI/ARDS

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Multifunctional nanoparticle-mediated combining therapy for human diseases

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Signal Transduction and Targeted Therapy 2024年第2期9卷 343-375页

作者： Xiaotong Li Xiuju Peng Makhloufi Zoulikha George frimpong Boafo Kosheli Thapa Magar Yanmin Ju Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 2111198PR China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013PR China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and *** preclinical investigations,combined effect of certain known drugs has been well established in treating extensive human *** to synergistic effects by targeting various disease pathways and advantages,such as reduced administration dose,decreased toxicity,and alleviated drug resistance,combinatorial treatment is now being pursued by delivering therapeutic agents to combat major clinical illnesses,such as cancer,atherosclerosis,pulmonary hypertension,myocarditis,rheumatoid arthritis,inflammatory bowel disease,metabolic disorders and neurodegenerative *** therapy involves combining or co-delivering two or more drugs for treating a specific ***(NP)-mediated drug delivery systems,i.e.,liposomal NPs,polymeric NPs and nanocrystals,are of great interest in combinatorial therapy for a wide range of disorders due to targeted drug delivery,extended drug release,and higher drug stability to avoid rapid clearance at infected *** review summarizes various targets of diseases,preclinical or clinically approved drug combinations and the development of multifunctional NPs for combining therapy and emphasizes combinatorial therapeutic strategies based on drug delivery for treating severe clinical ***,we discuss the challenging of developing NP-codelivery and translation and provide potential approaches to address the *** review offers a comprehensive overview for recent cutting-edge and challenging in developing NP-mediated combination therapy for human diseases.

关键词： drugs diseases prevention

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