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Overlap syndromes among autoimmune liver diseases

World Journal of Gastroenterology 2008年第21期14卷 3368-3373页

作者： christian rust Ulrich Beuers Department of Medicine Ⅱ Klinikum GrosshadernUniversity of MunichMunich 81377Germany Department of Gastroenterology & Hepatology Academic Medical CenterUniversity of AmsterdamAmsterdam NL-1100 DEThe Netherlands

The three major immune disorders of the liver are autoimmune hepatitis(AIH),primary biliary cirrhosis(PBC) and primary sclerosing cholangitis(PSC).Variant forms of these diseases are generally called overlap syndromes,although there has been no standardised *** with overlap syndromes present with both hepatitic and cholestatic serum liver tests and have histological features of AIH and PBC or *** AIH-PBC overlap syndrome is the most common form,affecting almost 10% of adults with AIH or *** cases of AIH and autoimmune cholangitis(AMA-negative PBC) overlap syndrome have also been *** AIH-PSC overlap syndrome is predominantly found in children,adolescents and young adults with AIH or ***,transitions from one autoimmune to another have also been reported in a minority of patients,especially transitions from PBC to AIH-PBC overlap *** syndromes show a progressive course towards liver cirrhosis and liver failure without *** for overlap syndromes is empiric,since controlled trials are not available in these rare *** therapy with ursodeoxycholic acid is usually combined with immunosuppressive therapy with corticosteroids and/or azathioprine in both AIH-PBC and AIH-PSC overlap *** end-stage disease,liver transplantation is the treatment of choice.

关键词： Autoimmune hepatitis Immunosuppressive agents Primary biliary cirrhosis Primary sclerosing cholangitis Ursodeoxycholic acid

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Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4^(-/-) mouse model

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World Journal of Hepatology 2016年第8期8卷 401-410页

作者： Florian P Reiter Ralf Wimmer Lena Wottke Renate Artmann Jutta M Nagel Manuel O Carranza Doris Mayr christian rust Peter Fickert Michael Trauner Alexander L Gerbes Simon Hohenester Gerald U Denk Department of Medicine Ⅱ Liver Center Munich University of Munich Institute of Pathology University of Munich Department of Medicine Ⅰ Krankenhaus Barmherzige Brüder Research Unit for Experimental and Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Hans Popper Laboratory of Molecular Hepatology Division of Gastroenterology and Hepatology Department of Internal Medicine Ⅲ Medical University of Vienna Transplant Center Munich of the University of Munich

AIM: To study the interleukin-1(IL-1) pathway as a therapeutic target for liver fibrosis in vitro and in vivo using the ATP-binding cassette transporter b4^(-/-)(Abcb4^(-/-)) mouse ***: Female and male Abcb4^(-/-) mice from 6 to 13 mo of age were analysed for the degree of cholestasis(liver serum tests), extent of liver fibrosis(hydroxyproline content and Sirius red staining) and tissue-specific activation of signalling pathways such as the IL-1 pathway [quantitative polymerase chain reaction(q PCR)]. For in vivo experiments, murine hepatic stellate cells(HSCs) were isolated via pronasecollagenase perfusion followed by density gradient centrifugation using female mice. Murine HSCs were stimulated with up to 1 ng/m L IL-1β with or without 2.5 μg/m L Anakinra, an IL-1 receptor antagonist, respectively. The proliferation of murine HSCs was assessed via the Brd U assay. The toxicity of Anakinra was evaluated via the fluorescein diacetate hydrolysis(FDH) assay. In vivo 8-wk-old Abcb4^(-/-) mice with an already fully established hepatic phenotype were treated with Anakinra(1 mg/kg body-weight daily intraperitoneally) or vehicle and liver injury and liver fibrosis were evaluated via serum tests, q PCR, hydroxyproline content and Sirius red staining. RESULTS: Liver fibrosis was less pronounced in males than in female Abcb4^(-/-) animals as defined by a lower hydroxyproline content(274 ± 64 μg/g vs 436 ± 80 μg/g liver, respectively; n = 13-15; P < 0.001; MannWhitney U-test) and lower m RNA expression of the profibrogenic tissue inhibitor of metalloproteinase-1(TIMP)(1 ± 0.41 vs 0.66 ± 0.33 fold, respectively; n = 13-15; P < 0.05; Mann-Whitney U-test). Reduced liver fibrosis was associated with significantly lower levels of F4/80 m RNA expression(1 ± 0.28 vs 0.71 ± 0.41 fold, respectively; n = 12-15; P < 0.05; Mann-Whitney U-test) and significantly lower IL-1β m RNA expression levels(1 ± 0.38 vs 0.44 ± 0.26 fold, respectively; n = 13-15; P < 0.001; Mann-Whitney U-te

关键词： Cholestasis Primary sclerosing cholangitis The ATP-binding cassette transporter b4 Liver fibrosis Interleukin-1

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The Metabolic Syndrome and Sexual Dysfunction in a State of Inflammation

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Advances in Sexual Medicine 2017年第2期7卷 82-96页

作者： Huseini Alidu W. K. B. A. Owiredu Nafiu Amidu Peter Paul Mwinsanga Dapare Ahmed Tijani Bawah christian Kofi Gyasi-Sarpong christian Obirikorang Department of Medical Laboratory Science University of Health and Allied Sciences Ho Ghana Department of Molecular Medicine Kwame Nkrumah University of Science & Technology Kumasi Ghana Department of Biomedical Laboratory Science University for Development Studies Tamale Ghana Department of Surgery (Urology Unit) Komfo Anokye Teaching Hospital Kumasi Ghana

Background: Diabetes is amongst the most researched diseases worldwide due to its debilitating effects on patients. Diabetics have a higher risk of developing erectile dysfunction. Evidence has linked erectile dysfunction severity to increased age, duration of diabetes, the metabolic syndrome and hypogonadism. However, the role of inflammatory markers in the pathogenesis of SD is still unclear. The contributions of hormonal parameters and adipokines to both macro and micro vascular complications are still poorly understood. This study was conducted to provide some evidence of an association between SD, the metabolic syndrome and inflammatory hormones. Method: A total of 130 diabetic males participated in this study. All participants were at least 18 years and were actively engaged in a stable heterosexual relationship for a minimum of two years before they were recruited for this study. The Diabetic men were evaluated using the Golombok rust Inventory of Sexual Satisfaction for males (GRISS-M). The NCEP-ATP III, IDF and WHO criteria were used to assess the metabolic syndrome. Blood samples were taken for biochemical and hormonal assays. Results: Participants with raised Triglyceride levels showed significantly higher leptin levels for NCEP-ATP III and IDF criteria. Participants with impotence showed significantly lower leptin/adiponectin ratio (p = 0.0184) whilst participant with non-sensuality showed significantly higher values of leptin/adiponectin ratio (p = 0.0103). A significantly higher levels of insulin (p = 0.0265) was recorded in participants with Dissatisfaction problems. Participants with Non communication problems showed significantly higher levels of insulin (p = 0.0419) and lower levels of adiponectin (p = 0.0438) whilst participants with infrequency showed significantly lower levels of adiponectin (p = 0.0042). Conclusion: The relative balance between pro inflammatory and anti-inflammatory mediators of endothelial dysfunction could possibly be essenti

关键词： Golombuk-rust Inventory for Sexual Satisfaction-Male Metabolic Syndrome Sexual Dysfunction

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