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A Meta-Analysis of the Prognostic and Clinicopathological Significance of circZFR in Human Gastrointestinal Cancers

International Journal of Clinical Medicine 2024年第3期15卷 134-144页

作者： christian cedric bongolo Erick Thokerunga Yu Zhang Jian-Cheng Tu Wuhan Life Origin Biotech Joint Stock Co Ltd. Wuhan China College of Life Sciences and Technology Huazhong Agricultural University Wuhan China Department & Program of Clinical Laboratory Medicine and Center for Gene Diagnosis Zhongnan Hospital of Wuhan University Wuhan China

Background: Studies of gastrointestinal (GIT) cancers have shown that circZFR could be involved in the development and progression of various GIT cancers. However, small sample sizes limit the clinical significance of these studies. Here, a meta-analysis was conducted to ascertain the actual involvement of circZFR in the development and prognosis of GIT cancers. Methods: PubMed, Embase, Web of Science, and the Cochrane Library were searched up to December 31, 2023. Hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to evaluate the association between circZFR expression and overall survival (OS). Publication bias was measured using the funnel plot and Egger’s test. Results: 10 studies having 659 participants were enrolled for meta-analysis. High circZFR expression was associated with poor OS (HR = 1.4, 95% CI: 1.20, 1.70). High circZFR expression also predicted larger tumor size (OR = 4.38, 95% CI 2.65, 7.25), advanced clinical stage (OR = 5.33, 95% CI 3.10, 9.16), and tendency for distant metastasis (OR = 2.89, 95% CI: 1.62, 5.11), but was not related to age, gender, and histological grade. Conclusions: In summary, high circZFR expression was associated with poor OS, larger tumor size, advanced stage cancer and tendency for distant metastasis. These findings suggested that circZFR could be a prognostic marker for GIT cancers.

关键词： CircZFR Gastrointestinal Prognostic Significance Meta-Analysis

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Preliminary Results of Cochlear Implantation in Underdeveloped Countries: The Experience of Cameroon

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International Journal of Otolaryngology and Head & Neck Surgery 2023年第4期12卷 232-249页

作者： Andjock Nkouo Yves christian Lekassa Pierrette Meva’a Biouele Roger christian Kuifo cedric Nanci Eliane Ngono Ateba Gladys Abdelaziz Raji Njock Richard Djomou Francois Ndjolo Alexis Ophthalmology-Ear-Nose-Throat (ENT)-Stomatology Department Faculty of Medicine and Biomedical Sciences University of Yaounde I Yaounde Cameroon ENT-Cervico-Facial-Surgery (CFS) Service Yaounde General Hospital Yaounde Cameroon ENT-CFS Service Miltary Teaching Hospital Libreville Gabon ENT-CFS Service Yaounde Central Hospital Yaounde Cameroon ENT-CFS Service Douala General Hospital Douala Cameroon Anesthesiology and Reanimation Service Douala General Hospital Douala Cameroon ENT-CFS Mohammed VI Marrakech Teaching Hospital Marrakecch Morroco ENT-CFS Service Yaounde Teaching Hospital Yaounde Cameroon

Introduction: Deafness, is the most common neurosensory deficit in humans. The origins can be diverse: congenital or acquired and sometimes of an etiology that is difficult to specify. The main risk is social exclusion. The advent of cochlear implants is a solution of choice for severe to profound sensorineural hearing loss. This innovative therapeutic modality is new to Cameroon, so we proposed to evaluate the preliminary results of cochlear implantation at the General Hospitals of Yaoundé and Douala, by addressing the epidemiological, clinical and paraclinical, surgical, and prosthetic aspects. Methodology: We conducted a descriptive and prospective cross-sectional study over a period of two years and eight months, from January 2019 to 31 August 2021. The study sites were: the general hospitals of Yaounde and Douala, as well as the private practices of speech therapists in the said cities. We collected socio-demographic, clinical, paraclinical variables and data on surgical, prosthetic and speech therapy management which were processed. Results: We recruited 15 cochlear implant patients, one adult and 14 children. The sex ratio was 1.14 in favour of girls, the average age of the child population was 4.9 years and one subject was 57 years old. These children were mostly in school (85.7%) and mostly (86.7%) living in urban areas. The average period of sound deprivation was 3.9 years. The deafness of the children was 100% prelingual and the acquired cause was evoked in front of the risk factors (prematurity, low birth weight, neonatal asphyxia, jaundice, meningitis, neuromalaria) for 57.7% of them. The adult deafness was postlingual and post-traumatic. The associated clinical conditions found in 4 (26.8%) of the patients were an ocular refraction disorder, a chronic otitis media sequelae, cerebral palsy and minor head trauma injuries. There was no syndromic or malformative picture. The deafness was bilateral in all cases, asymmetric in 22.2% of cases and severe to pr

关键词： Cochlear Implants Deafness Cameroon

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小额信贷的变迁——一个危机与发展并存的行业

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金融发展评论 2013年第3期 51-69页

作者： cedric Lutzenkirchen christian Weistroffer 田天驰德意志银行

很长时间以来人们都认为,小额信贷可以同时实现社会和金融两重目标而互不产生矛盾。随着获取金融服务的人数稳步增加,小额信贷行业越来越趋向商业化并且转变成为一个越来越财务高效的行业。而那一时期对于小额信贷市场的发展是否具有可... 详细信息

很长时间以来人们都认为,小额信贷可以同时实现社会和金融两重目标而互不产生矛盾。随着获取金融服务的人数稳步增加,小额信贷行业越来越趋向商业化并且转变成为一个越来越财务高效的行业。而那一时期对于小额信贷市场的发展是否具有可持续性却鲜有质疑。2008年的国际金融危机以及随之而来的全球经济衰退。

关键词：小额信贷机构客户群体非政府组织商业化金融危机贫困人口投资组合风险借贷偏远地区非银行金融机构

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An Integrated Systems Biology Approach Identifies ZIKV and DENV Replication

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 108-122页

作者： Guang Song Emily M.Lee Jianbo Pan Miao Xu Hee-Sool Rho Yichen Cheng Nadia Whitt Shu Yang Jennifer Kouznetsova Carleen Klumpp-Thomas Samuel G.Michael cedric Moore Ki-Jun Yoon Kimberly M.christian Anton Simeonov Wenwei Huang Menghang Xia Ruili Huang Madhu Lal-Nag Hengli Tang Wei Zheng Jiang Qian Hongjun Song Guo-li Ming Heng Zhu Department of Pharmacology&Molecular Sciences Johns Hopkins School of MedicineBaltimoreMD 21205USA Department of Biological Science Florida State UniversityTallahasseeFL 32306USA Department of Ophthalmology Johns Hopkins School of MedicineBaltimoreMD 21205USA National Center for Advancing Translational Sciences National Institutes of HealthBethesdaMD 20892USA Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Institute for Cell Engineering Johns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Neuroscience and Mahoney Institute for Neurosciences Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Cell and Developmental Biology Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Institute for Regenerative Medicine Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA The Epigenetics Institute Perelman School for MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA

The Zika virus(ZIKV)and dengue virus(DENV)flaviviruses exhibit similar replicative processes but have distinct clinical outcomes.A systematic understanding of virus–host protein–protein interaction networks can reveal cellular pathways critical to viral replication and disease *** we employed three independent systems biology approaches toward this ***,protein array analysis of direct interactions between individual ZIKV/DENV viral proteins and20,240 human proteins revealed multiple conserved cellular pathways and protein complexes,including proteasome ***,an RNAi screen of 10,415 druggable genes identified the host proteins required for ZIKV infection and uncovered that proteasome proteins were crucial in this ***,high-throughput screening of 6016 bioactive compounds for ZIKV inhibition yielded 134 effective compounds,including six proteasome inhibitors that suppress both ZIKV and DENV *** analyses of these orthogonal datasets pinpoint proteasomes as critical host machinery for ZIKV/DENV *** study provides multi-omics datasets for further studies of flavivirus–host interactions,disease pathogenesis,and new drug targets.

关键词： Protein–protein interaction RNAi screening Chemical genetics screening Multi-omics

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Corrigendum to“An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication"[Genomics Proteomics Bioinformatics 19(1)(2021)108-122]

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Genomics, Proteomics & Bioinformatics 2022年第4期20卷 808-809页

作者： Song, Guang Lee, Emily M. Pan, Jianbo Xu, Miao Rho, Hee-Sool Cheng, Yichen Whitt, Nadia Yang, Shu Kouznetsova, Jennifer Klumpp-Thomas, Carleen Michael, Samuel G. Moore, cedric Yoon, Ki-Jun christian, Kimberly M. Simeonov, Anton Huang, Wenwei Xia, Menghang Huang, Ruili Lal-Nag, Madhu Tang, Hengli Zheng, Wei Qian, Jiang Song, Hongjun Ming, Guo-li Zhu, Heng Department of Pharmacology & Molecular Sciences Johns Hopkins School of Medicine Baltimore MD 21205 USA Department of Biological Science Florida State University Tallahassee FL 32306 USA Department of Ophthalmology Johns Hopkins School of Medicine Baltimore MD 21205 USA National Center for Advancing Translational Sciences National Institutes of Health Bethesda MD 20892 USA Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 China Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA Department of Neuroscience and Mahoney Institute for Neurosciences Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA Department of Cell and Developmental Biology Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA Institute for Regenerative Medicine Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA The Epigenetics Institute Perelman School for Medicine University of Pennsylvania Philadelphia PA 19104 USA

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