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A Concise Review of Gold Nanoparticles-Based Photo-Responsive Liposomes for Controlled Drug Delivery

Nano-Micro Letters 2018年第1期10卷 85-94页

作者： Malathi Mathiyazhakan christian wiraja Chenjie Xu School of Chemical and Biomedical Engineering Nanyang Technological University

The focus of drug delivery is shifting toward smart drug carriers that release the cargo in response to a change in the microenvironment due to an internal or external trigger. As the most clinically successful nanosystem, liposomes naturally come under the spotlight of this trend. This review summarizes the latest development about the design and construction of photo-responsive liposomes with gold nanoparticles for the controlled drug release. Alongside, we overview the mechanism involved in this process and the representative applications.

关键词： Photo-responsive liposome Controlled release Drug delivery Gold nanoparticles

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Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2937-2944页

作者： Xiaoyu Ning christian wiraja Wan Ting Sharon Chewa Chen Fan Chenjie Xu NTU Institute for Health Technologies Interdisciplinary Graduate GroupNanyang Technological UniversitySingapore 639798Singapore School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore Skin Research Institute of Singapore 8A Biomedical GroveSingapore 138648Singapore Department of Biomedical Engineering City University of Hong KongHong Kong SAR 999077China

Hypertrophic scars are unfavorable skin diseases characterized by excessive collagen deposition.Although systemic treatments exist in clinic to manage hypertrophic scars,they pose significant side effects and tend to lose efficacy over prolonged applications.Traditional Chinese medicine(TCM)offers as a promising candidate to treat pathological scars.A large number of TCMs have been studied to show anti-scarring effect,however,the natural barrier of the skin impedes their penetration,lowering its therapeutic efficacy.Herein,we reported the use of dissolvable hyaluronic acid(HA)microneedles(MNs)as a vehicle to aid the transdermal delivery of therapeutic agent,a model TCM called shikonin for the treatment of hypertrophic scars.Here,shikonin was mixed with HA to make MNs with adequate mechanical strength for skin penetration,making its dosage controllable during the fabrication process.The therapeutic effect of the shikonin MNs was studied in vira using HSFs and then further verified with quantitative reverse transcriptase polymerase chain reaction.Our data suggest that the shikonin HA MNs significantly reduce the viability and proliferation of the HSFs and downregulate the fibrotic-related genes(i.e.,TGFβ1,FAP-αand COL1 A1).Furthermore,we observed a localized therapeutic effect of the shikonin HA MNs that is beneficial for site-specific treatment.

关键词： Traditional Chinese medicine Shikonin Hyaluronic acid Microneedle Hypertrophic scarring Drug delivery Transdermal delivery Skin

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One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

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Nano Research 2020年第6期13卷 1592-1596页

作者： Mingyue Cui christian wiraja Lim Wei Qi Sharon Chew Wan Ting Deblin Jana Mengjia Zheng Xiao Hu Chenjie Xu Nanyang Environment&Water Research Institute Interdisciplinary Graduate ProgrammeNanyang Technological UniversitySingapore637141Singapore School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore637457Singapore School of Materials Science and Engineering Nanyang Technological UniversitySingapore639798Singapore Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore National Dental Centre of Singapore 5 Second Hospital AveSingapore168938Singapore Department of Biomedical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina

Silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility,controllable morphology and so on.They can be used both as the drug carrier and imaging vehicle.Here,an aminated ultra-small silica nanoparticle based system is developed with various functionalities.Multiple molecules including fluorophore,folic acid,and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

关键词： silica nanoparticles one-step synthesis surface modification bacterial&cell labelling

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