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*** tissues bank for vision health research

Annals of Eye Science 2018年第1期 499-499页

作者： Kim Santerre Mathieu Thériault Sylvain Chemtob Lucie Germain Claude Giasson Sylvain Guérin Solange Landreville Patrick Jrochette christian rochette Mike Sapieha Élodie Boisselier Vincent Pernet Stéphanie Proulx Centre de Recherche du CHU de Québec-UniversitéLaval Axe Médecine RégénératriceQuébecQCCanada Centre de Recherche en Organogénèse Expérimentale de l'UniversitéLaval/LOEX QuébecQCCanada Département d'Ophtalmologie et d'Oto-Rhino-Laryngologie-Chirurgie Cervico-Faciale Facultéde MédecineUniversitéLavalQuébecQCCanada Département d’ophtalmologie Universitéde MontréalQCCanada Maisonneuve-Rosemont Hospital Research Center MontrealQCCanada Département de chirurgie Facultéde MédecineUniversitéLavalQuébecQCCanada École d’optométrie Universitéde MontréalQuébecQCCanada

Background:This infrastructure delivers biological material necessary for several research projects to Vision Health Research Network investigators(VHRN).Methods:Héma-Québec is the organism in charge obtaining consent and retrieving donor eyes for patient treatment or for *** Quebec City,donor eyes are sent to the eye bank of the“Centre Universitaire d’Ophtalmologie”(CUO)of Saint-Sacrement *** at the eye bank evaluate the quality of the *** unfit for graft are transferred to the infrastructure where the coordinator encodes samples prior to their ***:Between 2013 and 2017,27 fundamental investigators,clinical investigators and collaborators supported by 60 students,trainees and laboratory assistants used this infrastructure to move forward their *** 2013,results from those projects generated 21 scientific publications and 232 *** infrastructure helped VHRN investigators obtain near 4 million dollars in grants from many organisms(CIHR,NSERC,Foundations,etc.).These grants allowed recruitment and formation of highly qualified *** year(April 2016 to March 2017),189 corneas and 23 eyes transited through the ***:This infrastructure is available for all investigators that are members of the *** original projects have been elaborated thanks to the human ocular tissues provided by this *** projects will advance our knowledge in vision health.A better understanding of eye functions will lead to new treatments for eye diseases.

关键词： Human ocular tissues for research fresh tissues

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*** database of clinical data and biological material for research on uveal melanoma

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Annals of Eye Science 2018年第1期 453-453页

作者： Solange Landreville Frédéric Mouriaux Patrick J.rochette christian Salesse Mohib W.Morcos Claudine Bellerive Sylvain Guérin Centre de recherche du CHU de Québec-UniversitéLaval Hôpital du Saint-SacrementQuébecQCCanada Département d’ophtalmologie et d’ORL-CCF Facultéde médecineUniversitéLavalQuébecQCCanada Centre de recherche en organogénèse expérimentale de l’UniversitéLaval/LOEX QuébecQCCanada Département d'ophtalmologie Facultéde médecineUniversitéde Rennes 1RennesFrance Service d’ophtalmologie CHU de RennesRennesFrance

Background:Sharing biological material and clinical data from patients with uveal ***:Uveal melanoma is the most common intraocular malignancy in the adult *** uveal melanoma is primarily a sporadic cancer and familial cases are rare,it is difficult to prevent or detect *** effective treatment of ocular tumors,more than 50%of patients develop incurable liver metastases mainly in the 5-10 years following the detection of the primary *** cancer is relatively rare and the obtained biopsies are very *** 20 samples are taken each year in *** provincial infrastructure is made of biological material from donors with uveal melanoma and a large clinical *** tumor biopsies are used for culturing cell lines and the creation of a DNA/RNA library used for genomic and genetic ***:This infrastructure plays an important role in the achievement of various research programs for a better understanding of genetic and environmental factors involved in the development of melanoma and the spread of *** allows collaboration with other researchers at a provincial,national and international level in order to make progress in basic and clinical research on uveal ***:The biological material and clinical data of this infrastructure are available upon request to VHRN members whose research project was approved by the ethics committee of the institution.

关键词： Uveal melanoma tumor biopsies blood clinical data

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