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Acute hepatitis induced by an Aloe vera preparation: A case report

World Journal of Gastroenterology 2005年第2期11卷 303-304页

作者： christian rabe Annemarie Musch Peter Schirmacher Wolfgang Kruis Robert Hoffmann Department of Medicine Evangelisches Krankenhaus Koeln KalkCologneGermany Institute of Pathology University of CologneCologneGermany

AIM: Aloe vera, plant extracts of Aloe barbadensis miller,is widely used in phytomedicine. The first case of acute hepatitis due to this compound was ***: Description of a clinical ***: Hepatitis in a 57-year old female could be linked to the ingestion of Aloe barbadensis miller compounds. The patient's hepatitis resolved completely after discontinuing this ***: The case emphasizes the importance of considering phytopharmaceutical over-the-counter drugs as causative agents of hepatitis.

关键词： Hepatitis Aloe vera Acute diseases

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Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice

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World Journal of Gastroenterology 2005年第28期11卷 4332-4336页

作者： Volker Schmitz Miroslaw Kornek Tobias Hilbert christian Dzienisowicz Esbher Raskopf christian rabe Tilman Sauerbruch Cheng Qian Wolfgang H Caselmann Medizinische Klinik und Poliklinik I Universitatsklinikum BonnGermany Universidad de Navarra Clinica Universitaria Pamplona Spain Bavarian State Ministry of the Environment Public Health and Consumer Protection Munich 81901 Germany

AIM： Tumor angiogenesis has been shown to be promoted by vascular endothelial growth factor （VEGF） via stimulating endothelial cell proliferation, migration, and survival. Blockade of VEGF signaling by different means has been demonstrated to result in reduced tumor growth and suppression of tumor angiogenesis in distinct tumor entities. Here, we tested a recombinant adenovirus, AdsFItl-3, that encodes an antagonistically acting fragment of the VEGF receptor 1 （Fit-l）, for systemic antitumor effects in pre-established subcutaneous CRC tumors in mice.METHODS： Murine colorectal carcinoma cells （CT26） were inoculated subcutaneously into Balb/c mice for in vivo studies. Tumor size and survival were determined. 293 cell line was used for propagation of the adenoviral vectors. Human lung cancer line A549 and human umbilical vein endothelial cells were transfected for in vitro experiments.RESULTS： Infection of tumor cells with AdsFlt1-3 resulted in protein secretion into cell supernatant, demonstrating correct vector function. As expected, the secreted sFlt1-3 protein had no direct effect on CT26 tumor cell proliferation in vitro, but endothelial cell function was inhibited by about 46% as compared to the AdLacZ control in a tube formation assay. When AdsFlt1-3 （5×10^9 PFU/animal） was applied to tumor bearing mice, we found a tumor inhibition by 72% at d 12 after treatment initiation, in spite of these antitumoral effects, the survival time was not improved. According to reduced intratumoral microvessel density in AdsFlt1-3-treated mice, the antitumor mechanism can be attributed to angiostatic vector effects. We did not detect increased systemic VEGF levels after AdsFlt1-3 treatment and liver toxicity was low as judged by serum alanine aminotransferase determination.CONCLUSION： In this study we confirmed the value of a systemic administration of AdsFItl-3 to block VEGF signaling as antitumor therapy in an experimental metastatic colorectal carcinoma model in mice.

关键词： Colorectal carcinomas Vascular endothelial growth factor Systemic inhibition

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Clinical characteristics and outcome of a cohort of 101 patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2001年第2期7卷 208-215页

作者： christian rabe Tillmann Pilz Christoph Klostermann Marc Berna Hans H.Schild Tilman Sauerbruch Wolfgang H.Caselmann Department of Medicine I Department of RadiologyUniversity of BonnGermany

AIM: To conduct a cohort study of 101 patients with hepatocellular carcinoma (HCC) presenting to a tertiary care medical referral center in Germany between 1997 and 1999. METHODS AND RESULTS: Data were retrospectively analyzed by chart review. In 95 cases (72 males and 23 females) sufficient data were available for analysis. Twenty five (29%) of 85 patients were HBsAg or anti HBc positive, 21/85 (25%) were anti HCV positive, and 6/85 (7%) were positive for both HBV and HCV-markers. Age was significantly lower in HBV positive patients than in the other two groups. Thirty one (34%) of 90 patients had histories of alcohol abuse. In 79/94 (84%) patients, cirrhosis was diagnosed. Of these cirrhotic patients, 29/79 (37%) belonged to Child Pugh's group (CHILD) A, 32/79 (40%) to CHILD B, and 18/79 (23%) to CHILD C. AFP was elevated in 61/91 (67%) patients. A single tumor nodule was found in 38/94 (40%), more than one nodule in 31/94 (34%), and 25/94 (26%) had a diffusely infiltrating tumor, i.e. the tumor margins could not be seen on imaging procedures. Portal vein thrombosis was present in 19/94 (20%). Imaging data consistent with lymph node metastases were found in 10/92 (11%), while distant metastases were found in 8/93 (9%). According to Okuda 28/94 (30%) were grouped to stage I, 53/94 (56%) were grouped to stage II, and 13/94 (14%) were grouped to stage II. Survival data were available for 83 patients. The Kaplan-Meier estimate for median survival was 8 4 months. Factors influencing survival were the Okuda score, the presence of portal vein thrombosis, and the presence of ascites. The presence of non complicated liver cirrhosis by itself, distant metastases, or infection with hepatitis viruses did not influence survival. AFP positivity by itself did not influence survival, though patients with an AFP value greater than 100 microg/L did experience shortened survival. Treatment besides tamoxifen or supportive care was associated with prolonged survival. The influence of

关键词： Adult Aged Aged, 80 and over Carcinoma, Hepatocellular Cohort Studies Female Germany Hepatitis B Hepatitis C Humans Liver Cirrhosis, Alcoholic Liver Neoplasms Male Middle Aged Research Support, Non-U.S. Gov't Retrospective Studies Risk Factors Survival Analysis

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ADAM10 sheddase activation is controlled by cell membrane asymmetry

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Journal of Molecular Cell Biology 2019年第11期11卷 979-993页

作者： Florian Bleibaum Anselm Sommer Martin Veit Bjorn rabe Jorg Andra Karl Kunzelmann christian Nehls Wilmar Correa Thomas Gutsmann Joachim Grotzinger Sucharit Bhakdi Karina Reiss Department of Dermatology University of Kiel24105 KielGermany Institute of Biochemistry University of KielOlshausenstraBe 4024098 KielGermany Hamburg University of Applied Science Ulmenliet 2021033 HamburgGermany Physiological Institute University of RegensburgUniversitatsstraBe 3193053 RegensburgGermany Forschungszentrum Borstel Leibniz-Zentrum fur Medizin und BiowissenschaftenParkallee 1023845 BorstelGermany

Dysregulation of the disintegrin-metalloproteinase ADAM10 may contribute to the development of diseases including tumorigenesis and Alzheimer's *** mechanisms underlying ADAM10 sheddase activation are incompletely ***,we show that transient exposure of the negatively charged phospholipid phosphatidylserine(PS)is necessarily *** soluble PS headgroup was found to act as competitive inhibitor of substrate *** of the Ca2+-dependent phospholipid scramblase Anoctamin-6(AN06)led to increased PS externalization and substrate *** with a constitutively active form of AN06 resulted in maximum sheddase activity in the absence of any ***-dependent ADAM10 activation could not be induced in lymphocytes of patients with Scott syndrome harbouring a missense mutation in AN06.A putative PS-binding motif was identified in the conserved stalk *** of this motif resulted in strong reduction of sheddase *** conjunction with the recently described 3D structure of the ADAM10 extracellular domain,a model is advanced to explain how surface-exposed PS triggers ADAM 10 sheddase function.

关键词： ADAM10 activation shedding Anoctamin-6 phosphatidylserine cell membrane asymmetry

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