检索结果-南通市图书馆

检索条件"作者=Christian Kosan"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Defects in early lymphopoiesis contribute to sepsis-induced thymic atrophy

Defects in early lymphopoiesis contribute to sepsis-induced ...

引用

第九届全国免疫学学术大会

作者： Yaxian Kong Weimei Zhang Yajie Li Shaoxin Yuan René Winkler Ulrike Krhnert Peng Miao Beibei Wang Jianping Zhang Zhengya Yu christian kosan Hui Zeng Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical University Beijing Key Laboratory of Emerging Infectious Diseases Center for Molecular Biomedicine(CMB) Department of BiochemistryFriedrich-Schiller-University Jena Department of Surgery Beijing Tongren HospitalCapital Medical University

Sepsis is one of the most challenging clinical problems worldwide,and constitutes the leading cause of death in many intensive care ***-associated prolonged immunosuppression of innate and adaptive immunity is closely related to the morbidity and mortality of septic *** clinical studies have demonstrated that both a decrease in functional immune cells(such as granulocytopenia and lymphopenia)and expansion of immunosuppressive cells[such as regulatory T cells and myeloid-derived suppressor cells(MDSCs)]contribute to immunosuppression in septic patients,and are In contrast to enhanced granulopoiesis,impaired lymphopoiesis,especially impaired T lymphopoiesis,was commonly observed in the patients and animal models with *** studies have explored several intrathymic mechanisms that negatively affect thymopoiesis and subsequently contribute to sepsis-associated ***,the extrathymic mechanisms remain poorly *** line with previous studies,the mice subjected to cecal ligation and puncture developed severe T-cell ***,lower numbers of T cell receptor circles excision circles(TRECs)were detected in septic mice when compared with control mice,which suggested a decrease in T-cell output from the *** and histologic examinationsand total thymus cellularity were in agreement with decreased thymic ***,we investigated whether sepsis affected intrathymic *** was a dramatic decline in the proportions as well as absolute numbers of early Tlineage progenitors(ETPs,LinCD117CD44CD25CD127)in the thymi of septic ***,the percentage of ETPs correlated positively with the number of thymocytes(r=0.6481,p=0.0005).However,septic mice did not show a decrease in the number of bone marrow(BM)precursor ***,transwell migration assay exhibited that compared with cells from control mice,lymphoid-primed multipotent progenitors(LMPPs)and common lymphoid progenitors(CLPs)from septic

关键词： lymphopenia thymus atrophy early T-lineage progenitors(ETPs) lineage commitment

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：