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A Systematic Review on Antituberculosis Drug Discovery and Antimycobacterial Potential of Biologically Synthesized Silver Nanoparticles:Overview and Future Perspectives

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Infectious Microbes & Diseases 2022年第4期4卷 139-148页

作者： christian k.ezeh Chibuzor N.Eze Uju M.E.Dibua Stephen C.Emencheta Department of Microbiology University of NigeriaNsukkaEnugu StateNigeria Department of Pharmaceutical Microbiology University of NigeriaNsukkaEnugu StateNigeria

Rapid emergence and quick evolution of drug-resistant and aggressive mycobacterial strains have resulted in the present antimycobacterial drug crisis and the persistence of tuberculosis as a major public health ***/biological nanotechnologies constitute an interesting area of research for discovering antimycobacterial *** review focused on the biological(green)synthesis of silver nanoparticles(AgNPs)as an alternative source of antimycobacterial *** for this study were searched and screened from three electronic databases(Google Scholar,PubMed and ScienceDirect)following the Preferred Reporting Items for Systematic Reviews and Meta-analyses *** from in total 17 eligible studieswere reported in this systematic *** of the 17 studies used plants to fabricate AgNPs,whereas the remaining five studies used microorganisms(bacteria and/or fungi).Silver as part of silver nitrate(AgNO3)was themetal precursor reported for the synthesis of AgNPs in these *** nanoparticles were mostly spherical,with sizes ranging from12 *** minimum inhibitory concentrations varied between studies and were divided into three groups:(i)those more effective than the antibiotic(controls),(ii)those more effective than plant extracts,and(iii)those less effective than the antibiotic *** addition,little or no cytotoxicity effects were *** nanoparticles were also shown to be highly specific or selective toward mycobacterial *** systematic review highlights the antimycobacterial potential of biologically synthesized AgNPs,underscoring the possibility of discovering/developing new antimycobacterial agents using biological synthesis approaches with less toxicity and high selectivity.

关键词： antimycobacterial activity silver nanoparticles cytotoxicity biological synthesis tuberculosis mycobacterial

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Occurrence of False-Positive Tests and Cross-reactions Between COVID-19 and Dengue With Implications During Diagnosis:A Mixed Evidence Synthesis

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Infectious Microbes & Diseases 2023年第2期5卷 64-75页

作者： Daniel C.Digwo Chidinma P.Elebe Vincent N.Chigor Stella N.Madueke christian k.ezeh Anthony C.Ike Department of Microbiology University of NigeriaNsukkaEnugu StateNigeria.

This review aimed to assess the occurrence of false-positive serological reaction between dengue and coronavirus disease 2019(COVID-19)and its implications for *** syntheses were conducted by systematically reviewing available literature using multiple databases,including Web of Science,PubMed,Google Scholar and *** a total of 16 presented cases from clinical settings,cross-reaction to COVID-19 serological tests was observed in two(12.5%)dengue-positive patients,while 14 patients(87.5%)confirmed positive for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)showed a cross-reaction with dengue serological tests,leading to misdiagnosis and mismanagement by attending *** 1789 SARS-CoV-2-positive sera,cross-reaction to dengue serological tests was observed in 180 sera(10%),which is higher than the cross-reaction observed for SARS-CoV-2 in archived pre-COVID-19 sera positive for a dengue infection(75 of 811,9.2%,P=0.674).Clinicians in tropical regions are therefore advised to interpret serological tests with caution and use a more pragmatic approach to triage these infections.

关键词： COVID-19 cross-reaction dengue SARS-CoV-2

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