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Omotesando时尚博物馆

城市环境设计 2010年第9期 177-179页

作者： christian j.lange Ingeborg M.Rocker

时尚博物馆项目位于东京的Omotesando改造区。它一方面坐落于低层区域,成为城市的地标,另一方面通过这种明显的差异产生对比的效果。常规的塔配置会有等级制度。为了避免断裂和空间的离散,设计采用可扩展的概念和可微分的带状结构做成... 详细信息

时尚博物馆项目位于东京的Omotesando改造区。它一方面坐落于低层区域,成为城市的地标,另一方面通过这种明显的差异产生对比的效果。常规的塔配置会有等级制度。为了避免断裂和空间的离散,设计采用可扩展的概念和可微分的带状结构做成了一个连续的组织。带状结构类似一个三叶草结,回应了时尚的历史,并且难以被割裂。斜坡为残疾人提供了便捷的入口,坡度为6%。这个斜坡系统存在于整个塔楼,提供了一个连续的用户使用界面,使得人们能够感受到从20世纪初到21世纪初的时尚产业发展年表。

关键词：博物馆 Omotesando 博物院文化机构流线系统时尚

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“城市转换器”

城市环境设计 2010年第9期 184-185页

作者： christian j.lange Ingeborg M.Rocker

位于香港的城市家具有多种功能,每个都属于不同的表达方式。当香港的混搭风格很明显的时候,城市就会缺乏统一性和正式的表达,香港也失去了城市特征。这个设计概念是一种暂时性的城市长椅,解决长期存在的街道装置设计冷冰冰的感觉。与仅... 详细信息

位于香港的城市家具有多种功能,每个都属于不同的表达方式。当香港的混搭风格很明显的时候,城市就会缺乏统一性和正式的表达,香港也失去了城市特征。这个设计概念是一种暂时性的城市长椅,解决长期存在的街道装置设计冷冰冰的感觉。与仅提供一个简单的设计不同,这个计划建议根据环境的不同采用多种合适的解决手段。"城市转换器"项目从电子参数化模型转化而来。其核心是利用项目地点的信息和方案明确的数据以反映环境和与环境互动。他们一起构成了一个没有止境的城市椅子家族,而不是一个固定形式的家庭成员,可以适应不同立地条件和方案需求。当所有的设计都能够成为可落座的单元时,有些其他的参数化值被加入,比如垃圾箱、花盆或者广告灯箱。这些功能性的表面使得落座者可以获得额外的交流体验。

关键词：转换器变换器仪表参数化

Using an ILU/Deflation Preconditioner for Simulation of a PEMFuel Cell Cathode Catalyst Layer

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Communications in Computational Physics 2013年第8期14卷 537-573页

作者： Kyle j.lange Pang-Chieh Sui Ned Djilali Institute of Integrated Energy Systems University of VictoriaBCCanada Department of Mechanical Engineering University of VictoriaBCCanada Currently at Lawrence Livermore National Laboratory LivermoreCAUSA

Numerical aspects of a pore scale model are investigated for the simulation of catalyst layers of polymer electrolyte membrane fuel *** heat,mass and charged species transport together with reaction kinetics are taken into account using parallelized finite volume simulations for a range of nanostructured,computationally reconstructed catalyst layer *** effectiveness of implementing deflation as a second stage preconditioner generally improves convergence and results in better convergence behavior than more sophisticated first stage *** behavior is attributed to the fact that the two stage preconditioner updates the preconditioning matrix at every GMRES restart,reducing the stalling effects that are commonly observed in restarted GMRES when a single stage preconditioner is *** addition,the effectiveness of the deflation preconditioner is independent of the number of processors,whereas the localized block ILU preconditioner deteriorates in quality as the number of processors is *** total number of GMRES search directions required for convergence varies considerably depending on the preconditioner,but also depends on the catalyst layer microstructure,with low porosity microstructures requiring a smaller number of *** improved model and numerical solution strategy should allow simulations for larger computational domains and improve the reliability of the predicted transport *** preconditioning strategies presented in the paper are scalable and should prove effective for massively parallel simulations of other problems involving nonlinear equations.

关键词： Deflation PEM fuel cell catalyst layer pore scale model porous media preconditioner

Syndesmotic Internal Brace^(TM) for anatomic distal tibiofibular ligament augmentation

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World journal of Orthopedics 2017年第4期8卷 301-309页

作者： Markus Regauer Gordon Mackay Mirjam lange christian Kammerlander Wolfgang Bocker SportOrtho Rosenheim Praxis für Orthopadie und Unfallchirurgie Klinik für Allgemeine Unfall-und WiederherstellungschirurgieKlinikum der Ludwig-Maximilians-Universitat München Faculty of Health Sciences and Sport University of Stirling

Reconstruction of unstable syndesmotic injuries is not trivial, and there is no generally accepted treatment guidelines. Thus, there still remain considerable controversies regarding diagnosis, classification and treatment of syndesmotic injuries. Syndesmotic malreduction is the most common indication for early re-operation after ankle fracture surgery, and widening of the ankle mortise by only 1 mm decreases the contact area of the tibiotalar joint by 42%. Outcome of ankle fractures with syndesmosis injury is worse than without, even after surgical syndesmotic stabilization. This may be due to a high incidence of syndesmotic malreduction revealed by increasing postoperative computed tomography controls. Therefore, even open visualization of the syndesmosis during the reduction maneuver has been recommended. Thus, the most important clinical predictor of outcome is consistently reported as accuracy of anatomic reduction of the injured syndesmosis. In this context the Tight Rope~?system is reported to have advantages compared to classical syndesmotic screws. However, rotational instability of the distal fibula cannot be safely limited by use of 1 or even 2 Tight Ropes~?. Therefore, we developed a new syndesmotic Internal Brace^(TM) technique for improved anatomic distal tibiofibular ligament augmentation to protect healing of the injured native ligaments. The Internal Brace^(TM) technique was developed by Gordon Mackay from Scotland in 2012 using Swive Locks~? for knotless aperture fixation of a Fiber Tape~? at the anatomic footprints of the augmented ligaments, and augmentation of the anterior talofibular ligament, the deltoid ligament, the spring ligament and the medial collateral ligaments of the knee have been published so far. According to the individual injury pattern,patients can either be treated by the new syndesmotic Internal Brace^(TM) technique alone as a single anterior stabilization, or in combination with one posteriorly directed Tight Rope~? as a doub

关键词： Syndesmosis injury Rotational instability Stabilization Anatomic repair Internal Brace^(TM) Surgical technique

Biophotonic sensors with integrated Si_(3)N_(4)-organic hybrid (SiNOH) lasers for point-of-care diagnostics

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Light(Science & Applications) 2021年第4期10卷 648-659页

作者： Daria Kohler Gregor Schindler Lothar Hahn johannes Milvich Andreas Hofmann Kerstin lange Wolfgang Freude christian Koos Institute of Photonics and Quantum Elearo nics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstrasse 576131 KarlsruheGermany lnstitute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Robert Bosch GmbH Robert-Bosch-Campus 171272 RenningenGermany lnstitute for Autom ation and Applied Informatics(IAI) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Early and efficient disease diagnosis with low-cost point-of-care devices is gaining importance for personalized medicine and public health *** this context,waveguide-(WG)-based optical biosensors on the siliconnitride(Si_(3)N_(4))platform represent a particularly promising option,offering highly sensitive detection of indicative biomarkers in multiplexed sensor arrays operated by light in the visible-wavelength ***,while passive Si_(3)N_(4)-based photonic circuits lend themselves to highly scalable mass production,the integration of low-cost light sources remains a *** this paper,we demonstrate optical biosensors that combine Si_(3)N_(4)sensor circuits with hybrid on-chip organic *** Si_(3)N_(4)-organic hybrid(SiNOH)lasers rely on a dye-doped cladding material that are deposited on top of a passive WG and that are optically pumped by an external light *** of the devices is simple:The underlying Si_(3)N_(4)WGs are structured in a single lithography step,and the organic gain medium is subsequently applied by dispensing,spin-coating,or ink-jet printing processes.A highly parallel read-out of the optical sensor signals is accomplished with a simple *** our proof-of-concept experiment,we demonstrate the viability of the approach by detecting different concentrations of fibrinogen in phosphate-buffered saline solutions with a sensor-length(L-)-related sensitivity of S/L=0.16 rad nM^(-1)mm^(-1).To our knowledge,this is the first demonstration of an integrated optical circuit driven by a co-integrated low-cost organic light *** expect that the versatility of the device concept,the simple operation principle,and the compatibility with cost-efficient mass production will make the concept a highly attractive option for applications in biophotonics and point-of-care diagnostics.

关键词： passive waveguide pumped

Glycolysis in the control of blood glucose homeostasis

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Acta Pharmaceutica Sinica B 2012年第4期2卷 358-367页

作者： Xin Guo Honggui Li Hang Xu Shihlung Woo Hui Dong Fuer Lu Alex j.lange Chaodong Wu Intercollegiate Faculty of Nutrition Department of Nutrition and Food ScienceTexas A&M UniversityCollege StationTX 77843USA Institute of Integrated Chinese and Western Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China Department of Biochemistry Molecular Biology and Biophysicsthe University of MinnesotaMinneapolisMN 55405USA

Glycolysis,a simple pathway of glucose metabolism,critically regulates insulin secretion and metabolic functions of various *** on cell types,rates of glycolysis are determined at various steps of glycolysis that are subjected to the control of key metabolic and regulatory enzyme(S),which include glucokinase,6-phosphofructo-I-kinase,and 6-phosphofructo-2-kinase/fructose-2,*** enzymes are regulated by both nutritional and hormonal signals at the levels of transcription,translation,and post-translational *** hepatocytes,glycolysis is involved in the control of hepatic glucose *** latter,when excessive,contributes to hyperglycemia in *** pancreatic β cells,glycolysis couples glucose-stimulated insulin *** or relatively low levels of circulating insulin causes *** adipocytes,glycolysis generates metabolites for lipogenesis and channels fatty acids from excessive oxidation to triglyceride synthesis,thereby reducing oxidative *** increased proinflammatory status,adipocytes produce pro-hyperglycemic factors and bring about hyperglycemia and insulin *** hypotha lamic neurons,glycolysis conveys nutrient sensing that is related to feeding *** of glycolysis occurs in conditions of insulin deficiency or resistance,and is attributable to inappropriate amount and/or activities of metabolic and regulatory enzymes of *** key metabolic and regulatory enzymes to enhance glycolysis may offer viable approaches for treatment of diabetes.

关键词： Glycolysis Diabetes Insulin resistance Liver Pancreatic beta cells Adipose tissue Hypothalamus Inflammatory response

Event-Based Semantics of UML 2.X Concurrent Sequence Diagrams for Formal Verification

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journal of Computer Science & Technology 2022年第1期37卷 4-28页

作者： Inès Mouakher Fatma Dhaou j.christian Attiogbé Faculty of Sciences of Tunis University of Tunis El Manar1068TunisTunisia Institute of Technology University of Nantes44322NantesFrance

UML 2.X sequence diagrams(SD)are among privileged scenarios-based approaches dealing with the complexity of modeling the behaviors of some current ***,there are several issues related to the standard semantics of UML 2.X SD proposed by the Object Management Group(OMG).They mainly concern ambiguities of the interpretation of SDs,and the computation of causal relations between events which is not specifically laid ***,SD is a semi-formal language,and it does not support the verification of the modeled *** justifies the considerable number of research studies intending to define formal semantics of UML *** proposed in our previous work semantics covering the most popular combined fragments(CF)of control-flow ALT,OPT,LOOP and SEQ,allowing to model alternative,optional,iterative and sequential behaviors *** proposed semantics is based on partial order theory relations that permit the computation of the precedence relations between the events of an SD with nested *** also addressed the issue of the evaluation of the interaction constraint(guard)for guarded CFs,and the related synchronization *** this paper,we first extend our semantics,proposed in our previous work;indeed,we propose new rules for the computation of causal relations for SD with PAR and STRICT CFs(dedicated to modeling concurrent and strict behaviors respectively)as well as their ***,we propose a transformational semantics in *** modeling approach emphasizes computation of causal relations,guard handling and transformational semantics into *** transformation of UML 2.X SD into the formal method Event-B allows us to perform several kinds of verification including simulation,trace acceptance,verification of properties,and verification of refinement relation between SDs.

关键词： UML 2.X sequence diagram formal semantics nested combined fragment partial order theory Event-B

Tea in cardiovascular health and disease:a critical appraisal of the evidence

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Food Science and Human Wellness 2022年第3期11卷 445-454页

作者： Klaus W.lange Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

The findings of various epidemiological studies,interventions using randomized controlled trials and mechanistic experiments have suggested a protective role of tea and its bioactive components in cardiovascular *** potential of tea in the prevention of cardiovascular diseases(CVDs)has therefore attracted increasing research ***,in particular flavonoids,found in both green and black tea,have been suggested to play a primary role in the reduction of CVD *** promising results regarding the effects of tea on blood pressure and other CVD-related biomarkers have been found in preclinical experiments,the effects demonstrated in human studies are modest and less *** discrepancy may be explained,at least in part,by different research strategies used in human and animal ***,since tea is globally one of the most commonly consumed beverages,even small beneficial effects in humans may shift the population distribution of CVD risk,with major implications for public ***,research conducted to date does not yield sufficiently robust evidence to allow a recommendation as to an optimal level of tea consumption as an element of health policies seeking to prevent hypertension and improve cardiovascular health.

关键词： Tea Cardiovascular diseases Health Prevention Treatment

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Green tea, epigallocatechin gallate and the prevention of Alzheimer’s disease: clinical evidence

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Food Science and Human Wellness 2022年第4期11卷 765-770页

作者： Klaus W.lange Katharina M.lange Yukiko Nakamura Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Given its increasing global prevalence,Alzheimer’s disease(AD)has become a major public health challenge *** symptomatic treatments available for AD have shown no significant efficacy,and no disease-modifying interventions are capable of slowing the progression of the *** potential of lifestyle-related factors,including diet,is increasingly recognized as an important consideration in the primary prevention of *** mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea,such as(-)-epigallocatechin-3-gallate,as well as their preventive efficacy against AD,have been elucidated in preclinical ***,in contrast to the abundance of mechanistic findings in animals,clinical results demonstrating efficacy in humans are *** epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD,a causal relationship cannot be established on the basis of these *** clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory.A role of green tea in the prevention of AD cannot be recommended until well-designed,randomized,placebo-controlled clinical trials using standardized formulations confirm the purported beneficial effects of green tea.

关键词： Green tea Epigallocatechin gallate Alzheimer’s disease Neurodegeneration Prevention

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