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D-Dimer: Predictor of Postpartum Hemorrhage among Pre-Eclampsia at Kilimanjaro christian Medical Centre

Open journal of Obstetrics and Gynecology 2024年第6期14卷 923-937页

作者： Husna Silim Ally Nyasatu G. Chamba Raziya Gaffur Nasra Batchu Glory Mangi Pendo S. Mlay Bariki Mchome Mtoro j. Mtoro Thomas j. Kakumbi Rafiki N. Mjema Doris Rwenyagila Eusebius Maro Fredrick Mbise Gilleard Masenga Patricia S. Swai Department of Obstetrics and Gynaecology KCMC Hospital Moshi Tanzania Department of Obstetrics and Gynaecology Kilimanjaro Christian Medical University College (KCMUCo) Moshi Tanzania

Background: Postpartum hemorrhage (PPH) is the major contributor to maternal mortality and morbidity worldwide as well as in Tanzania. Studies have shown Pre-eclampsia as a risk indicator for Postpartum hemorrhage and D-dimer tends to rise in women with pre-eclampsia. Few studies that have shown the association between D-dimer and PPH have been controversial and differ according to ethnicity and lifestyle. Hence there is no suitable reference interval for D-dimer in predicting Postpartum hemorrhage among women with pre-eclampsia. Broad Objective: This study aimed to assess the association, sensitivity, and specificity of D-dimer as a laboratory predictor of postpartum hemorrhage among women with pre-eclampsia at KCMC hospital. Methodology: This was a hospital-based analytical cross-sectional study conducted at KCMC Hospital in Northern Tanzania from September 2022 to March 2023. A total of 195 women with pre-eclampsia were included in this study. Plasma D-dimer levels were taken from women with pre-eclampsia pre-delivery. Haematocrit was compared before and after delivery, and a fall of 10% was considered as Postpartum hemorrhage together with clinical assessment of the patient. Participants were divided among those who had severe features and those who did not have severe features and were further categorized into those who had PPH and those who did not have PPH. Logistic regression was used to determine the association between D-dimer and PPH adjusting for other factors. The Receiver Operating Curve (ROC) was used to evaluate the predictive value. Results: Higher median D-dimer levels were seen among women who had PPH compared to those who had no PPH. D-dimer was seen to be associated with PPH, thus for every unit increase of µg/ml of D-dimer among women who had pre-eclampsia without severe features there was a 14% significant increase in the odds of having postpartum hemorrhage and a 45% significant increase of having postpartum hemorrhage among those who had pre

关键词： D-Dimer Preeclampsia Postpartum Hemorrhage Tanzania

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Reply to comments by ***(2015) and A.j.(Tom) van Loon(2015) on “3D palaeogeographic reconstructions of the Phanerozoic versus sea-level and Sr-ratio variations”

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journal of Palaeogeography 2015年第3期4卷 248-250页

作者： christian Vérard Institute for Environmental Science University of Geneva

I use to say that in science, one cannot say what is right, but one can say what is wrong. And a model is, by definition, wrong, otherwise it is not a modet, it is the truth. Being aware that a model aims to mimic the truth but witl never be the truth, the onty worth questions asking to a model are：（1） How wrong are we？ And （2） Why are we wrong？ The tatter questions the foundations of the model, and is mainty the concerns of A. j. （Tom） van Loon＇s comments （2015, this issue）. The first questions the accuracy of the outcomes, and corresponds more to G. Shanmugam＇s comments （2015, this issue）. I am grad that our paper has aroused so rapidty as much feedbacks and comments, sometimes even before the manuscript is definitely pubtished. We hope this paper witl keep on inspiring various axes of research and opening new avenues in geosciences. Detaited answers to the comments raised by A. j. （Tom） van Loon and G. Shanmugam among others would certainty deserve a book, so my repty witl just focus herein around the two aforementioned questions.

关键词： modet topography pataeogeographicreconstruction plate tectonics geoscience

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Bestimmung des regionalen Blutvolumens (rBV) in Meningeomen: Vergleich von Echoplanar-und Gradientenechosequenzen

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journal of Huazhong University of Science and Technology(Medical Sciences) 2004年第6期24卷 610-614页

作者：吴仁华 Roland Bruening christian Berchtenbreiter jügen Weber 郎志谨 Maximilian Reiser Abteilung für Radiologie Medizinische Fakultt der Universitt ShantouShantou 515041ChinaInstitut für Diagnostische RadiologieKlinikum GrophadernLudwig-Maximilians-UniversittMünchen 81377Germany Institut für Diagnostische Radiologie Klinikum GrophadernLudwig-Maximilians-UniversittMünchen 81377Germany Abteilung für Radiologie Medizinische Universitt DalianDalian 116011

Summary: The purpose of this study was to evaluate relative regional blood volume (rCBV) in meningioma and compare the utility of reconstruction using both gradient-echo sequence and echo-planar-imaging (EPI) *** patients with meningiomas were studied on a Siemens 1.5-T scanner. During the gradient-echo sequence (n=12) and EPI sequence (n=6), a bolus ^(0.2 mmol/kg) of Gd-DTPA was injected mechanically with a flow rate of 5 ml/second. Image processing of dynamic data was performed on a pixel-by-pixel basis. The ratio of tumor rCBV/gray matter rCBV was 3.01±1.18 (3.07 ± 1.39 in gradient sequence and 2.84 ± 0.94 in EPI sequence). The ratio of gray matter/ white matter as the reference tissue had a mean of 2.79 ± 0.76 using the FLASH sequence, and a mean of 3.04 ± 1.31 using EPI. These differences were not statistically signifcant (P>0.5, t-test). According to the ratio of tumor rCBV/gray matter rCBV, a mean value, 14.5 ml/100 g, of rCBV in meningiomas was calculated. Compared with gray matter, increased inhomogeneous rCBV was observed in meningioma. Based on the two different sequences, no bias can be observed in our rCBV reconstruction.

关键词： magnetic resonance imaging meningioma blood volume

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Highly efficient passive Tesla valves for microfluidic applications

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Microsystems & Nanoengineering 2022年第5期8卷 125-136页

作者： Sebastian Bohm Hai Binh Phi Ayaka Moriyama Erich Runge Steffen Strehle jörg König christian Cierpka Lars Dittrich Theoretical Physics I Technische Universität IlmenauWeimarer Straße 2598693 IlmenauGermany Research and Development 5microns GmbHMargarethenstraße 698693 IlmenauGermany Institute of Micro-and Nanotechnologies Gustav-Kirchhoff-Straße 798693 IlmenauGermany Microsystems Engineering Technische Universität IlmenauMax-Planck-Ring 1298693 IlmenauGermany Physics and Astronomy Carleton CollegeOne North CollegeNorthfield 55057 MinnesotaUSA Engineering Thermodynamics Technische Universität IlmenauAm Helmholtzring 198693 IlmenauGermany

A multistage optimization method is developed yielding Tesla valves that are efficient even at low flow rates,characteristic,e.g.,for almost all microfluidic systems,where passive valves have intrinsic advantages over active *** report on optimized structures that show a diodicity of up to 1.8 already at flow rates of 20μl s^(−1) corresponding to a Reynolds number of *** of the design is a topological optimization based on the finite element *** is set-up to yield easy-to-fabricate valve structures with a small footprint that can be directly used in microfluidic *** numerical two-dimensional optimization takes into account the finite height of the channel approximately by means of a so-called shallow-channel *** on the threedimensionally extruded optimized designs,various test structures were fabricated using standard,widely available microsystem manufacturing *** manufacturing process is described in detail since it can be used for the production of similar cost-effective microfluidic *** the experimentally fabricated chips,the efficiency of the different valve designs,i.e.,the diodicity defined as the ratio of the measured pressure drops in backward and forward flow directions,respectively,is measured and compared to theoretical predictions obtained from full 3D calculations of the Tesla *** agreement is *** addition to the direct measurement of the diodicities,the flow profiles in the fabricated test structures are determined using a two-dimensional microscopic particle image velocimetry(μPIV)***,a reasonable good agreement of the measured flow profiles with simulated predictions is observed.

关键词： backward Highly optimization

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Bistability theorem in a cancer model

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International journal of Biomathematics 2018年第1期11卷 61-98页

作者： jens christian Larsen Vanlcse Alle 50 2. mr. tv2720 VanlCse Copenhagen Denmark

In this paper, I continue the study of the mathematical models presented in [j. C. Larsen, Models of cancer growth, j. Appl. Math. Comput. 53 (1–2) (2015) 613–645] and [j. C. Larsen, The bistability theorem in a model of metastatic cancer, to appear in Appl. Math. ]. I shall prove the bistability theorem for the ODE model from [Larsen, 2015]. It is a mass action kinetic system in the variables C cancer, GF growth factor and GI growth inhibitor. This theorem says that for some values of the parameters, there exist two positive singular points c ∗ + = ( C ∗ + , GF ∗ , GI ∗ + ) , c ∗ − = ( C ∗ − , GF ∗ , GI ∗ − ) of the vector field. Here C ∗ − < C ∗ + and c ∗ − is stable and c ∗ + is unstable, see Sec. 2. There is also a discrete model in [Larsen, 2015], it is a linear map ( T ) on three-dimensional Euclidean vector space with variables ( C , GF , GI ) , where these variables have the same meaning as in the ODE model above. In [Larsen, 2015], I showed that one can sometimes find affine vector fields on three-dimensional Euclidean vector space whose time one map is T . I shall also show this in the present paper in a more general setting than in [Larsen, 2015]. This enables me to find an expression for the rate of change of cancer growth on the coordinate hyperplane C = 0 in Euclidean vector space. I also present an ODE model of cancer metastasis with variables C , C M , GF , GI , where C is primary cancer and C M is metastatic cancer and GF, GI are growth factors and growth inhibitors, respectively.

关键词：数学模型癌症定理欧几里德几何学生长因素向量空间运动系统分离模型

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Electronic structure modulation with ultrafine Fe_(3)O_(4) nanoparticles on 2D Ni-based metal-organic framework layers for enhanced oxygen evolution reaction

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journal of Energy Chemistry 2022年第2期31卷 78-88页

作者： Wei Huang Chao Peng jing Tang Fangyuan Diao Murat Nulati Yesibolati Hongyu Sun christian Engelbrekt jingdong Zhang Xinxin Xiao Kristian S.Mølhave Department of Chemistry Technical University of DenmarkDK-2800 Kongens LyngbyDenmark DTU Nanolab-National Center for Nanofabrication and Characterization Technical University of DenmarkDK-2800 Kongens LyngbyDenmark Multiscale Crystal Materials Research Center Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina

Two-dimensional(2D)metal organic frameworks(MOFs)are emerging as low-cost oxygen evolution reaction(OER)electrocatalysts,however,suffering aggregation and poor operation ***,ultrafine Fe_(3)O_(4) nanoparticles(diameter:6±2 nm)are homogeneously immobilized on 2D Ni based MOFs(Ni-BDC,thickness:5±1 nm)to improve the OER *** structure modulation for enhanced catalytic activity is studied via adjusting the amount of Fe_(3)O_(4) nanoparticles on *** optimal Fe_(3)O_(4)/Ni-BDC achieves the best OER performance with an overpotential of 295 mV at 10 mA cm^(-2),a Tafel slope of 47.8 mV dec^(-1) and a considerable catalytic durability of more than 40 h(less than 5 h for Ni-BDC alone).DFT calculations confirm that the active sites for Fe_(3)O_(4)/Ni-BDC are mainly contributed by Fe species with a higher oxidation state,and the potential-determining step(PDS)is the formation of the adsorbed O*species,which are facilitated in the composite.

关键词： Fe_(3)O_(4)nanoparticles 2D Ni-BDC Aggregation Electronic structure modulation Oxygen evolution reaction

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STING palmitoylation as a therapeutic target

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Cellular & Molecular Immunology 2019年第3期16卷 236-241页

作者： Anne Louise Hansen Kojiro Mukai Francisco j.Schopfer Tomohiko Taguchi christian K.Holm Department of Biomedicine Aarhus University8000 Aarhus CDenmark Laboratory of Organelle Pathophysiology Department of Integrative Life SciencesGraduate School of Life SciencesTohoku UniversitySendai 980-8578 MiyagiJapan Department of Pharmacology and Chemical Biology University of PittsburghPittsburghPA 15213USA

Gain-of-function mutations in the STING-encoding gene TMEM173 are central to the pathology of the autoinflammatory disorder STING-associated vasculopathy with onset in infancy(SAVI).Furthermore,excessive activity of the STING signaling pathway is associated with autoinflammatory diseases,including systemic lupus erythematosus and Aicardi–Goutières syndrome(AGS).Two independent studies recently identified pharmacological inhibitors of ***,both types of compounds are reactive nitrocontaining electrophiles that target STING palmitoylation,a posttranslational modification necessary for STING *** a consequence,the activation of downstream signaling molecules and the induction of type I interferons were *** compounds were effective at ameliorating inflammation in a mouse model of AGS and in blocking the production of type I interferons in primary fibroblasts from SAVI *** mini-review focuses on the roles of palmitoylation in STING activation and signaling and as a pharmaceutical target for drug development.

关键词： STING Palmitoylation Inflammation SAVI Interferonopathies

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Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C

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World journal of Gastroenterology 2011年第44期17卷 4883-4889页

作者： Elke Kaemmerer Anne Peuscher Andrea Reinartz christian Liedtke Ralf Weiskirchen jürgen Kopitz Nikolaus Gassler Department of Pediatrics RWTH Aachen UniversityAachenGermany Institute of Pathology RWTH Aachen University Department of Plant Biotechnology Fraunhofer Institute for Molecular Biology and Applied Ecology (IME) Institute of Pathology RWTH Aachen University Department of Medicine Ⅲ RWTH Aachen University Institute of Clinical Chemistry and Pathobiochemistry RWTH Aachen University Institute of Pathology University of Heidelberg

AIM:To investigate whether human acyl-CoA synthetase 5(ACSL5) is sensitive to the ACSL inhibitor triacsin ***:The ACSL isoforms ACSL1 and ACSL5 from rat as well as human ACSL5 were cloned and recombinantly expressed as 6xHis-tagged *** 2+-affinity purified recombinant enzymes were assayed at pH 7.5 or pH 9.5 in the presence or absence of triacsin *** addition,ACSL5 transfected CaCo2 cells and intestinal human mucosa were ***5 expression in cellular systems was verified using Western blot and *** ACSL assay mix included TrisHCl(pH 7.4),ATP,CoA,EDTA,DTT,MgCl 2,[9,103 H] palmitic acid,and triton *** 200 μL reaction was initiated with the addition of solubilized,purified recombinant proteins or cellular *** were terminated after 10,30 or 60 min of incubation with Doles ***:Expression of soluble recombinant ACSL proteins was found after incubation with isopropyl betaD-1-thiogalactopyranoside and after ultracentrifugation these were further purified to near homogeneity with Ni 2+-affinity *** C selectively and strongly inhibited recombinant human ACSL5 protein at pH 7.5 and pH 9.5,as well as recombinant rat ACSL1(sensitive control),but not recombinant rat ACSL5(insensitive control).The IC50 for human ACSL5 was about 10 μmol/*** inhibitory triacsin C effect was similar for different incubation times(10,30 and 60 min) and was not modified by the N-or C-terminal location of the *** order to evaluate ACSL5 sensitivity to triacsin C in a cellular environment,stable human ACSL5 CaCo2 transfectants and mechanically dissected normal human intestinal mucosa with high physiological expression of ACSL5 were *** both models,ACSL5 peak activity was found at pH 7.5 and pH 9.5,corresponding to the properties of recombinant human ACSL5 *** the presence of triacsin C(25 μmol/L),total ACSL activity was dramatically diminished in human ACSL5 transfectants as well as in AC

关键词：酰基辅酶A 肠道黏膜敏感性抑制剂合成酶重组表达亲和纯化 Triton

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Nonlinear integrated photonics

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Photonics Research 2018年第5期6卷 I0024-I0025页

作者： ERIC CASSAN christian GRILLET DRAGOMIR N.NESHEV DAVID j.MOSS Centre for Nanosciences and Nanotechnologies (C2N) Paris-Sud University CNRS Senior research fellow continuing position Institut des Nanotechnologies de Lyon (INL)Ecole centrale de Lyon Nonlinear Physics Centre Australian National University Director of the Center for Micro-Photonics (CMP) Swinburne University of Technology

The field of nonlinear photonics is in full development. This special issue of Photonics Research takes you through the current issues of this fast-growing field of research, drawing on the current state of the art an... 详细信息

关键词： Nonlinear integrated photonics

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A framework to express variant and invariant functional spaces for binary logic

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Frontiers of Electrical and Electronic Engineering in China 2010年第2期5卷 163-172页

作者： jeffrey Zhi j.ZHENG christian H.ZHENG Department of Information Security School of SoftwareYunnan UniversityKunming 650200China Conjugate Systems Kunming Ltd.Co. Kunming 650032China Department of Electrical and Electronic Engineering School of EngineeringThe University of MelbourneParkvilleVictoria 3010Australia

A new framework has been developed to express variant and invariant properties of functions operating on a binary vector *** framework allows for manipulation of dynamic logic using basic operations and *** representations of binary functional spaces are *** ideas of binary functional spaces are extended and additional conditions are added to describe new function representation schemes:F code and C *** of the proposed functional space representation schemes were *** was found that the complete representation for any set of functions operating on a binary sequence of numbers is larger than previously *** complete representation can only be described using a structure having a space of size 2^(2n)×2^(n)!for any given space of functions acting on a binary sequence of length *** framework,along with the proposed coding schemes provides a foundational theory of variant and invariant logic in software and electricelectronic technology and engineering,and has uses in the analysis of the stability of rule-based,dynamic binary systems such as cellular automata.

关键词： two-dimensional(2D)organization conjugate symmetry cellular automata(CA) permutation meta-state vector space truth table(TT) variant table(VT) invariant table(IVT) variant logic optimization global coding vector function space

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