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Prospective Study on the Results of the Tuboplasty in Rural Region in germany

International Journal of Otolaryngology and Head & Neck Surgery 2025年第1期14卷 1-11页

作者： Peter R. Issing Hendrik Tebben Emad Alsabbagh christian Issing Department of Otorhinolaryngology Head- Neck- and Facial Plastic Surgery Klinikum Bad Hersfeld GmbH Bad Hersfeld Germany Department of Ophthalmology Klinikum Bad Hersfeld GmbH Bad Hersfeld Germany Department of Otorhinolaryngology Johann-Wolfgang von Goethe University Frankfurt Germany

1) Introduction: Ventilation disorders of the middle ear play a major role in everyday clinical ENT-practice and sometimes represent a major therapeutic challenge. In addition to the conventional therapy of tympanostomy tube insertion, tuboplasty (TP) offers a less invasive option for treating this problem. The study should examine whether TP can be performed in a rural setting. 2) Material and methods: This is a prospective, monocentric study of patients scheduled for TP because of tubal ventilation disorder (TVD) in a rural region of germany. The diagnosis was established after a thorough clinical examination and by assessing the possibility of performing the Valsalva maneuver, the tympanogram type, recording the middle ear pressure and air-bone gap. The subjective impairment caused by the TVD was evaluated using the EDTQ-7 questionnaire pre- and approximately 3 months postoperatively. 3) Results: Sixty-two patients with 92 TP were included with a mean age of 44.1 years. The EDTQ-7 score decreased highly significantly from 3.6 to 1.7 (p g with parameters such as age, sex, BMI, allergies or smoking. Middle ear pressure fell in average by −87 daPa, resulting in an improvement of the tympanogram type. The preoperative air-bone gap of 10.2 dB also was reduced significantly in most patients to 8.0 dB after the procedure. No notable complications occurred beside a sore throat due to the use of a laryngeal mask for ventilation during anesthesia in two cases. 4) Conclusion: In our experience, TP represents a less invasive and, in many cases, successful alternative to the established tympanostomy tube insertion with the advantage of an intact eardrum. It can also be offered and successfully performed in a rural setting.

关键词： Eustachian Tube Dysfunction Tuboplasty Eustachian Tube Valsalva Maneuver grommet

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Design and Optimization of Terracotta Tube-Based Direct Evaporative Cooling Exchanger: An Analytical Approach to Heat and Mass Transfer

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Open Journal of Applied Sciences 2025年第1期15卷 352-373页

作者： Windnigda Zoungrana Makinta Boukar Ousmane Coulibaly guy christian Tubreoumya Antoine Bere Laboratoire dEnergtique dElectronique dElectrotechnique dAutomatique et dinformatique Industrielle Universit Abdou Moumouni Niamey Niger Laboratoire de Physique et de Chimie de lEnvironnement Universit Joseph Ki Zerbo Ouagadougou Burkina Faso

This study develops an analytical model to evaluate the cooling performance of a porous terracotta tubular direct evaporative heat and mass exchanger. By combining energy and mass balance equations with heat and mass transfer coefficients and air psychrometric correlations, the model provides insights into the impact of design and operational parameters on the exchanger cooling performance. Validated against an established numerical model, it accurately simulates cooling behavior with a Root Mean Square Deviation of 0.43 - 1.18˚C under varying inlet air conditions. The results show that tube geometry, including equivalent diameter, flatness ratio, and length significantly influences cooling outcomes. Smaller diameters enhance wet-bulb effectiveness but reduce cooling capacity, while increased flatness and length improve both. For example, extending the flatness ratio of a 15 mm diameter, 0.6 m long tube from 1 (circular) to 4 raises the exchange surface area from 0.028 to 0.037 m2, increasing wet-bulb effectiveness from 60% to 71%. Recommended diameters range from 5 mm for tubes under 0.5 m to 1 cm for tubes 0.5 to 1 m in length. Optimal air velocities depend on tube length: 1 m/s for tubes under 0.8 m, 1.5 m/s for lengths of 0.8 to 1.2 m, and up to 2 m/s for longer tubes. This model offers a practical alternative to complex numerical and CFD methods, with potential applications in cooling tower optimization for thermal and nuclear power plants and geothermal heat exchangers.

关键词： Analytical Modeling Porous Terracotta Tube Direct Evaporative Cooling Heat and Mass Exchanger Performance Optimization

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Primary intestinal lymphangiectasia in an adult patient:A case report and review of literature

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World Journal of gastroenterology 2020年第48期26卷 7707-7718页

作者： Rudolf huber georg Semmler Alexander Mayr Felix Offner christian Datz Department of Internal Medicine General Hospital OberndorfTeaching Hospital of the Paracelsus Medical University SalzburgOberndorf 5110Austria Department of Pathology General Hospital FeldkirchFeldkirch 6800Austria

BACKgROUND Primary intestinal lymphangiectasia(PIL),first described in 1961,is a rare disorder of unknown etiology resulting in protein-losing *** disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia,hypogammaglobulinemia,and *** the severity and location of lymph vessels being affected can vary considerably,the range of associated symptoms is wide from mild lower-limb edema to generalized edema,abdominal and/or pleural effusion,and recurrent diarrhea,among *** usually developing in early childhood,we present the case of a 34-yearold woman with ***,we performed a literature review systematically assessing clinical presentation,and provide a practical approach to facilitate diagnosis and therapy of PIL in *** SUMMARY Our patient presented with unspecific symptoms of abdominal discomfort,fatigue,nausea,and recurrent edema of the lower ***,a striking collinearity of clinical symptoms with female hormone status was ***,polyglobulia,hypoalbuminemia,hypogammaglobulinemia,and transient lymphocytopenia were *** to suspicion of a bone marrow disease,an extensive diagnostic investigation was carried out excluding secondary causes of polyglobulinemia and *** diagnosis of primary intestinal lymphangiectasia was established after 22 wk by histological analysis of biopsy samples obtained via ***,the patient was put on a high-protein and low-fat diet with medium-chain triglycerides supplementation leading to significant improvement of clinical symptoms until 2 years of *** PIL can be the reason for cryptogenic hypoalbuminemia,hypogammaglobulinemia,and lymphopenia in *** to difficulty in correct diagnosis,treatment initiation is often delayed despite being effective and *** leads to a significant disease burden in affected *** is increasingly been

关键词： Primary intestinal lymphangiectasia Waldmann´s disease Protein losing enteropathy Hypoproteinemia Case report

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还有悬念吗？

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摩托车 2025年第03期 90-95页

作者：李琳 christian Bourget

有些人经历了梦魇般的冬测，有些人在黑暗摸索中找到了一丝曙光，2025赛季的MotogP即将打响。出师未捷从杜卡迪阵营转投阿普利亚阵营的上届冠军豪尔赫·马丁本来就已经在赛车上获得了卫冕后发优势，而在赛季前的雪邦测试中，他又让自己...

有些人经历了梦魇般的冬测，有些人在黑暗摸索中找到了一丝曙光，2025赛季的MotogP即将打响。出师未捷从杜卡迪阵营转投阿普利亚阵营的上届冠军豪尔赫·马丁本来就已经在赛车上获得了卫冕后发优势，而在赛季前的雪邦测试中，他又让自己本就不富裕的卫冕希望雪上加霜——在测试的第一天便送上了两次摔车，饭点儿都没到就已经去了医院，查出手脚骨折之后本次测试便只得草草收场。

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稳定制胜

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摩托车 2025年第1期 88-95页

作者：李琳 christian Bourget

赛季前瞻中，我们曾经问，哪个厂牌可以挑战杜卡迪，杜卡迪阵营中，又有谁能阻挡厂队的步伐。第一个问题我们知道，没有人可以挑战杜卡迪，第二个问题我们知道，世界冠军属于独立车队车手豪尔赫·马丁。神仙打架巴尼亚亚的赛季开局是美...

赛季前瞻中，我们曾经问，哪个厂牌可以挑战杜卡迪，杜卡迪阵营中，又有谁能阻挡厂队的步伐。第一个问题我们知道，没有人可以挑战杜卡迪，第二个问题我们知道，世界冠军属于独立车队车手豪尔赫·马丁。神仙打架巴尼亚亚的赛季开局是美好而又地狱的,如果你只看揭幕战,虽然冲刺赛差强人意,但在自己一向得意的正赛中巴尼亚亚胜似闲庭信步。可如果把赛季开局展开到前三站,也就是传统欧洲赛季开启前,那么巴尼亚亚的开局可谓地狱,冲刺赛一次都没上过领奖台,正赛除了一个冠军剩下两场属于白给和基本白给。

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco gutierrez gonzalez Daniel Refai gerald R.Rodts christian Mustroph David gimbel Jonathan grossberg Daniel L.Barrow Matthew F.gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Antidiabetic and antioxidant properties of Fagara zanthoxyloides root-bark ethyl acetate fraction:in-vitro enzyme inhibition and gC-MS analysis

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Life Research 2025年第1期8卷 32-43页

作者： christian Amah Parker Joshua Ikechukwu Okoro Favour Iyidiegwu Chibuike Brendan Linus Nsude Ugochukwu Nweke Department of Biochemistry Faculty of Natural and Applied SciencesState University of Medical and Applied SciencesNsukka 412111Nigeria Department of Biochemistry Faculty of Biological SciencesUniversity of NigeriaNsukka 410001Nigeria Department of Medical Biochemistry College of Health SciencesDavid Umahi Federal University of Health SciencesUburueUburu 491105Nigeria Department of Chemical Sciences Faculty of Natural and Applied SciencesSpiritan University NneochiNneato RoadLeru 441111Nigeria Department of genetics and Biotechnology Faculty of Natural and Applied SciencesState University of Medical and Applied Sciences Igbo-EnoNsukka 412111Nigeria Department of Pharmacognosy and Natural Medicine University of UyoUyo 520003Nigeria

The application of therapeutic herbs in treatment of common infections and diseases has gained popularity in developing nations due to its cost-effectiveness and purported lower side effects compared to synthetic *** zanthoxyloides Lam also known as Zanthoxylum zanthoxyloides,is an indigenous plant used widely as chewing stick for tooth cleaning in West *** root-bark macerations,decoctions or infusions are the most valuable organs widely taken to treat malaria and diabetes by local populations,traditional healers and local pharmaceutical *** alternative,more efficient,safer,and less expensive anti-diabetic natural products from plants has received great attention,hence this research delved into the inhibitory effects of the ethyl acetate fraction of *** root-bark(EAFFZRB)on in-vitroα-amylase andα-glucosidase *** biochemical methods were used to extract and assess the in-vitro antioxidant such as 2,2-diphenyl-1-picrylhydrazl(DPPH),total antioxidant capacity(TAC)and Ferric Reducing Antioxidant Power(FRAP).The sample was combined at different concentrations(10,20,40,80,160,320,and 640μl/dl).Theα-amylase,andα-glucosidase activities of EAFFZRB sample was combined at different concentrations(0.2,0.4,0.6,0.8 and 1.0 mg/mL).The phyto-constituents in EAFFZRB were identified using gas Chromatography-Mass Spectrometry(gC-MS)*** plant fraction showed a significant(Pglucosidase IC50=0.877 at varying concentrations,comparable to the reference drug Acarbose IC50=0.728 and IC50=0.852 *** demonstrated significant(PgC-MS analysis of EAFFZRB revealed a total of 12 volatile organic compounds such as;Phenol-3-methoxy-2,5,6-trimethyl,2-Hydroxy-5-nitrobenzylbromide,2,6-Dimethyl-4-(3-nitrophenyl)py

关键词： Fagara zanthoxyloides α-amylase andα-glucosidase anti-oxidant gC-MS

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Inter-and transdisciplinary perspective on the integration of ecological processes into ecosystem services analysis in a mountain region

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Ecological Processes 2014年第1期3卷 172-185页

作者： Robert huber Simon Briner Harald Bugmann Che Elkin christian Hirschi Roman Seidl Rebecca Snell Andreas Rigling Forest Dynamics Swiss Federal Research Institute WSLZürcherstrasse 111CH-8903 BirmensdorfSwitzerland Department of Environmental Systems Science Agri-food and Agri-environmental Economics GroupETH ZurichCH-8092 ZurichSwitzerland Department of Environmental Systems Science Forest EcologyETH ZurichCH-8092 ZurichSwitzerland Department of Environmental Systems Science Environmental Policy and EconomicsETH ZurichCH-8092 ZurichSwitzerland Department of Environmental Systems Science Natural and Social Science InterfaceETH ZurichCH-8092 ZurichSwitzerland.

Introduction:Ecosystem goods and services(EgS)studies have had little impact on policy processes and real-world decision-making due to limited understanding of the interactions and feedbacks among ecological,social and economic *** we present an inter-and transdisciplinary analysis of global change impacts on EgS provision in a European mountain *** aim is to evaluate the projected influence of ecological,economic and social drivers on future EgS provision and to show possible ways to address the predominant limitations of EgS ***:The integrated findings from ecological experiments,mechanistic models of landscape dynamics,socio-economic land-use models,policy analysis and transdisciplinary stakeholder interactions are presented *** regionally downscaled global change scenarios,for a case study region near Visp,Switzerland(350 km2),were used to examine the impacts of climate and socio-economic changes on four ecosystem services,i.e.,food provision,timber production,net greenhouse gas emissions and protection from natural ***:Our simulation results reveal four key aspects that influence the future provision of mountain ***,we show the high spatial and temporal heterogeneity of EgS provision even in a small case study ***,we find that climate change impacts are much more pronounced for forest EgS,while changes to agricultural EgS result primarily from shifts in economic ***,our modeling results reveal the complex trade-offs associated with the different ***,simulations illustrate the importance of interactions between environmental shifts and economic *** discuss our simulation results with respect to both existing policy networks and transdisciplinary stakeholder ***:We describe a framework based on experiments and observations that effectively supports the integration of ecological processes into an integrative modeling chain of EgS provisio

关键词： Interdisciplinary research Ecosystem services Modeling Scenario analysis Policy process Transdisciplinary research Mountain regions

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Numerical Analysis of a System of Singularly Perturbed Convection-Diffusion Equations Related to Optimal Control

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Numerical Mathematics(Theory,Methods and Applications) 2011年第4期4卷 562-575页

作者： Hans-görg Roos christian Reibiger Technische Universität Dresden Institut für Numerische Mathematik01062 DresdenGermany

We consider an optimal control problem with an 1D singularly perturbed differential state *** solving such problems one uses the enhanced system of the state equation and its adjoint ***,we obtain a system of two convectiondiffusion *** linear finite elements on adapted grids we treat the effects of two layers arising at different boundaries of the *** proof uniform error estimates for this method on meshes of Shishkin *** present numerical results supporting our analysis.

关键词： Convection-diffusion linear finite elements a priori analysis layer-adapted meshes singular perturbed optimal control

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Study of Ionospheric Anomalies at the Koudougou Station during the Moderate geomagnetic Activity of Co-Rotation during the Solar Cycle 24

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International Journal of geosciences 2025年第1期16卷 20-30页

作者： Idrissa Sourabié Abidina Diabaté Emmanuel Wambi Sawadogo Bruno Korgo christian Zoundi Allain Doua gnabahou Denis Ouédraogo Frédéric Ouattara Laboratoire de Chimie Analytique de Physique Spatiale et nergtique (L@CAPSE) Dpartement de Physique Universit Norbert ZONGO Koudougou Burkina Faso Laboratoire dEnergies Thermiques REnouvelables (L.E.T.RE) Dpartement de Physique Universit Joseph KI-ZERBO Ouagadougou Burkina Faso

This article is part of the ongoing study of the moderate geomagnetic activity of corotation. The aim here is to examine ionospheric anomalies through variations in Total Electronic Content (TEC) recorded at the Koudougou gPS station over solar cycle 24 during periods of corotation activity. Through the diurnal variations by solar phase, we observed a TEC peak at 14:00 TL. The TEC data analysed revealed winter, annual and semi-annual anomalies. However, the equinoctial anomaly was insignificant during corotation activity at the Koudougou station during solar cycle 24.

关键词： geomagnetic Activity Total Electronic Content Ionospheric Anomalies Equinoctial Corotation Activity

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