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Curcuma longa normalized cimetidine-induced pituitarytesticular dysfunction: Relevance in nutraceutical therapy

Animal Models and Experimental Medicine 2019年第3期2卷 191-200页

作者： Ngozi Joy Onwuemene christian eseigbe imafidon Abiodun Oladele Ayoka Department of Physiological Sciences Faculty of Basic Medical SciencesObafemi Awolowo UniversityIle‐IfeOsun StateNigeria Department of Physiology Faculty of Basic Medical and Health SciencesBowen UniversityIwoOsun StateNigeria

Background:The increasing incidence of chemically induced infertility is both a social threat and a threat to the continuation of life itself.Treatment or management therapy is often expensive.This study investigated the effects of acetone extract of a local plant(Curcuma longa)in a Wistar rat model of cimetidine‐induced pituitarytesticular dysfunction.Methods:Thirty‐five male Wistar rats were divided into 7 groups of 5 rats.After a phytochemical screening of an acetone extract of C.Longa,cimetidine and the extract at three doses,200,400 and 600 mg/kg,were orally co‐administered to the rats for 28 consecutive days.Comparisons were made(at P<0.05)against a control(2 mL/kg distilled water),a standard treatment group(cimetidine+50 mg/kg vitamin C),a toxic group(60 mg/kg cimetidine)and a group receiving extract alone.Results:Cimetidine administration was associated with deleterious alterations to sperm motility,sperm count and sperm viability,as well as derangements in the plasma levels of FSH,LH and testosterone(P<0.05).Both brain and testicular GSH and TBARS levels were significantly altered following cimetidine administration,and distortions were seen in the pituitary and testicular histoarchitecture.These changes were significantly normalized by co‐administration of graded doses of the extract,with an associated improvement of both pituitary and testicular histology.Conclusion:Acetone extract of C.Longa normalized cimetidine‐induced pituitarytesticular dysfunction in Wistar rats.This presents the extract as a potential nutraceutical choice against chemically induced reproductive toxicity.

关键词： Curcuma longa nutraceutics pituitary testis Wistar rats

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Animal Models and Experimental Medicine 2018年第4期1卷 295-304页

作者： Olaoluwa Sesan Olukiran Rufus Ojo Akomolafe Olutosin Samuel Ilesanmi christian eseigbe imafidon Quadri Kunle Alabi Department of Physiological Sciences Faculty of Basic Medical Sciences Obafemi Awolowo University Department of Biochemistry and Molecular Biology Faculty of Sciences Obafemi Awolowo University Department of Physiology Faculty of Basic Medical and Health Sciences Bowen University

Background: The study determined the fractions of proteins in the urine and plasma of rats at different ages, measured the plasma and urine concentrations of markers of renal function, with a view to determining the influence of proteinuria on renal function.Methods: Eighty Wistar rats were used for this study. Groups 1 and 2 each consisted of eight 1-month-old male and female rats; 3 and 4 had eight 3-month-old male and female rats; 5 and 6 had eight 6-month-old male and female rats; 7 and 8 had eight 9-month old male and female rats; and 9 and 10 had eight 12-month-old male and female rats.Results: A fraction of the molecular weight of protein in the urine of rats aged 1, 9 and 12 months was higher than that of 3 and 6 months. The total protein concentration in the urine of male and female rats aged 9 and 12 months was significantly higher than that of rats aged 1 and 3 months. The urine creatinine concentrations of male and female rats aged 9 months were significantly higher when compared with that of 1, 3, 6 and 12 months.Conclusion: Our results suggest that the 3-month-old rats seem less affected by proteinuria, because they had the least urine protein, and consistent and reduced plasma and urine concentrations of markers of renal function. The results of this study may provide a foundation for future mechanistic inquiries as to why this age group was the least affected by proteinuria.

关键词： creatinine electrophoresis protein rats urea

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