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Journal of geoscience and Environment Protection 2019年第7期7卷 202-221页

作者： Vincent T.Assoma Martial Z.Konan christian g.adon Fernand K.Kouamé Laboratory of Science and Technology of Water and Environment University of Félix Houphouet-BoignyAbidjanCote d’Ivoire

The present work applied the HydrogeoSphere (HgS) model in humid tropical area to Koué watershed scale to simulate flows in porous and fractured area of crystalline aquifers. It integrates rainfall, physiographic, fractures, hydraulic drilling and hydrodynamic data. The simulation of flows in porous area concerned 5 test zones. The input database of the model is implemented on a triangular grid in porous area using gridbuilder software and interactive block grid in fractured area. In order to use the model in these two environments, boundary condition was set. The infiltrations rate of the earth layers is estimated in the order to 10-5 ms-1. The model simulates the pumping with a good reproductivity of the drawdown profiles of groundwater at the drillings. The storage coefficients vary between 9.9 × 10-4 and 2 × 10-3. The hydraulic conductivities vary from 8.5 × 10-6 to 2 × 10-5. 73.9% of the drillings studied has a high hydraulic conductivity and shows a strong drawdown of the groundwater table. The study of the static levels of the ground water allowed indicating the distribution of the water resources in the drillings: 57% are deep in the first 10 meters, 36% between 10 and 20 m, and 7% in the higher level to 20 m deep in the earth.

关键词： Crystalline Aquifer Hydrogeological Modelling HydrogeoSphere Water Resource Koué Watershed Cote d’Ivoire

Many faces of neuronal activity manipulation in Drosophila

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Neural Regeneration Research 2025年第9期20卷 2574-2576页

作者： Amber Krebs Steffen Kautzmann christian Klämbt Institut für Neuro-und Verhaltensbiologie MünsterGermany

Animals exhibit complex responses to external and internal *** information is computed by interconnected neurons that express numerous ion channels,which modulate the neuronal membrane *** can neuronal activity orchestrate complex motor patterns or allow learning from previous experience?To answer such questions,we need the ability not only to record,but also to modulate neuronal activity in both space(e.g.,neuronal subsets)and time.

关键词： manipulation potential. neuronal

Numerical Analysis of a System of Singularly Perturbed Convection-Diffusion Equations Related to Optimal Control

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Numerical Mathematics(Theory,Methods and Applications) 2011年第4期4卷 562-575页

作者： Hans-görg Roos christian Reibiger Technische Universität Dresden Institut für Numerische Mathematik01062 DresdenGermany

We consider an optimal control problem with an 1D singularly perturbed differential state *** solving such problems one uses the enhanced system of the state equation and its adjoint ***,we obtain a system of two convectiondiffusion *** linear finite elements on adapted grids we treat the effects of two layers arising at different boundaries of the *** proof uniform error estimates for this method on meshes of Shishkin *** present numerical results supporting our analysis.

关键词： Convection-diffusion linear finite elements a priori analysis layer-adapted meshes singular perturbed optimal control

Anticancer Properties and Mechanism of Action of Oblongifolin C,guttiferone K and Related Polyprenylated Acylphloroglucinols

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Natural Products and Bioprospecting 2021年第6期11卷 629-641页

作者： christian Bailly gérard Vergoten Scientific Consulting Office OncoWitan59290 LilleWasquehalFrance Inserm INFINITE-U1286Facultéde PharmacieUniversity of LilleInstitut de Chimie Pharmaceutique Albert Lespagnol(ICPAL)3 rue du Professeur LaguesseBP-8359006 LilleFrance

Polyprenylated acylphloroglucinols represent an important class of natural products found in many *** them,the two related products oblongifolin C(Ob-C)and guttiferone K(gt-K)isolated from garcinia species(notably from edible fruits),have attracted attention due to their marked anticancer *** two compounds only differ by the nature of the C-6 side chain,prenyl(gt-K)or geranyl(Ob-C)on the phloroglucinol *** origin,method of extraction and biological properties are presented here,with a focus on the targets and pathways implicated in their anticancer *** compounds markedly reduce cancer cell proliferation in vitro,as well as tumor growth and metastasis in *** are both potent inducer of tumor cell apoptosis,and regulation of autophagy flux is a hallmark of their mode of *** distinct mechanism leading to autophagosome accumulation in cells and the implicated molecular targets are *** specific role of the chaperone protein HSPA8,known to interact with Ob-C,is *** models of gt-K and Ob-C bound to HSPA8 provide a structural basis to their common HSPA8-binding recognition *** review shed light on the mechanism of action of these compounds,to encourage their studies and potential development.

关键词： Anticancer Autophagy HSPA8 Natural products Polyprenylated acylphloroglucinols

Transfer learning applications for autoencoder-based anomaly detection in wind turbines

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Energy and AI 2024年第3期17卷 1-10页

作者： Cyriana M.A.Roelofs christian gück Stefan Faulstich Fraunhofer IEE Joseph-Beuys-Straße 834117 KasselGermany

Anomaly detection in wind turbines typically involves using normal behaviour models to detect faults *** behaviour models are often implemented through the use of neural networks,of which autoencoders are particularly popular in this ***,training autoencoder models for each turbine is time-consuming and resource ***,transfer learning becomes essential for wind turbines with limited data or applications with limited computational *** study examines how cross-turbine transfer learning can be applied to autoencoder-based anomaly ***,autoencoders are combined with constant thresholds for the reconstruction error to determine if input data contains an *** models are initially trained on one year’s worth of data from one or more source wind *** are then fine-tuned using small amounts of data from the target wind *** methods for fine-tuning are investigated:adjusting the entire autoencoder,only the decoder,or only the threshold of the *** performance of the transfer learning models is compared to baseline models that were trained on one year’s worth of data from the target wind *** results of the tests conducted in this study indicate that models trained on data of multiple wind turbines do not improve the anomaly detection capability compared to models trained on data of one source wind *** addition,modifying the model’s threshold can lead to comparable or even superior performance compared to the baseline,whereas fine-tuning the decoder or autoencoder further enhances the models’performance.

关键词： Condition monitoring Transfer learning Autoencoder Anomaly detecti on Wind turbines Fault detection

Perceptual lateralization of vocal stimuli in goats

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Current Zoology 2019年第1期65卷 67-74页

作者： Luigi Baciadonna christian Nawroth Elodie F. Briefer Alan g. McELLigOTT Biological and Experimental Psychology School of Biological and Chemical Sciences Queen Mary University of London Mile End Road London E1 4NS UK Institute of Behavioural Physiology Leibniz Institute for Farm Animal Biology Dummerstorf Germany Institute of Agricultural Sciences ETH Zurich Universitatstrasse 2 8092 Zurich Switzerland Department of Life Sciences University of Roehampton London SW15 4JD UK

Functional asymmetries, for example, the preferential involvement of 1 brain hemisphere to process stimuli, may increase brain efficiency and the capacity to carry out tasks simultaneously. We investigated which hemisphere was primarily invoIved in processing acoustic stimuli in goats using a headorienting paradigm. Three playbacks using goat vocalizations recorded in different contexts: food anticipation (positive), isolation (negative), food frustration (negative), as well as 1 playback involving dog barks (negative) were presented on the left and right sides of the test subjects simultaneously. The head-orienting response (left or right) and latency to resume feeding were recorded. The direction of the head-orienting response did not differ between the various playbacks. However, when the head-orienting response was tested against chanee level, goats showed a right bias regardless of the stimuli presented. goats responded more to dog barks than to food frustration calls, whereas responses to food anticipation and isolation calls were intermediate. In addition, the latency to resume feeding, an indicator of fear reaction, was not affected by the kind of vocalization presented. These results provide evidence for asymmetries in goat vocal perceptio n of emotional-li nked con specific and heterospecific calls. They also suggest involvement of the left brain hemisphere for processing acoustic stimuli, which might have been perceived as familiar and non -threate ning.

关键词： auditory processing brain asymmetry emotions lateralization social cognition vocal communication

Anisotropic deformation for local shape control

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Computational Visual Media 2017年第4期3卷 305-313页

作者： Matteo Colaianni christian Siegl Jochen Süвmuth Frank Bauer günther greiner Computer graphics group University Erlangen-Nuremberg Adidas Ag

We present a novel approach to mesh deformation that enables simple context sensitive manipulation of 3 D geometry. The method is based on locally anisotropic transformations and is extended to global control directions. This allows intuitive directional modeling within an easy to implement framework. The proposed method complements current sculpting paradigms by providing further possibilities for intuitive surface-based editing without the need for additional host geometries. We show the anisotropic deformation to be seamlessly transferable to free boundary parameterization methods, which allows us to solve the hard problem of flattening compression garments in the domain of apparel design.

关键词： anisotropy modeling as-rigid-aspossible(ARAP) deformation parameterization

Skeletal microstructures of cheilostome bryozoans(phylum Bryozoa,class gymnolaemata):crystallography and secretion patterns

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Marine Life Science & Technology 2024年第3期6卷 405-424页

作者： christian grenier Erika griesshaber Wolfgang Schmahl Björn Berning Antonio g.Checa Departamento de Estratigrafía y Paleontología Universidad de Granada18071 GranadaSpain Instituto Andaluz de Ciencias de La Tierra CSIC-Universidad de Granada18100 ArmillaSpain Department of Earth and Environmental Sciences Ludwig-Maximilians Universität80333 MunichGermany Institute for geology University of Hamburg20146 HamburgGermany

gymnolaemata bryozoans produce CaCO3 skeletons of either calcite,aragonite,or *** extensive research,their crystallography and biomineralization patterns remain *** present a detailed study of the microstructures,min-eralogy,and crystallography of eight extant cheilostome species using scanning electron microscopy,electron backscatter diffraction,atomic force microscopy,and micro-computed *** distinguished five basic microstructures,three calcitic(tabular,irregularly platy,and granular),and two aragonitic(granular-platy and fibrous).The calcitic microstruc-tures consist of crystal aggregates that transition from tabular or irregularly platy to granular *** aragonite consists of fibers arranged into *** all cases,the crystallographic textures are axial,and stronger in aragonite than in calcite,with the c-axis as the fiber *** reconstruct the biomineralization sequence in the different species by considering the distribution and morphology of the growth fronts of crystals and the location of the secretory *** bimineralic species,calcite formation always predates aragonite *** interior compound walls,growth proceeds from the cuticle toward the zooecium *** conclude that,with the exception of tabular calcite,biomineralization is remote and occurs within a relatively wide extrapallial space,which is consistent with the inorganic-like appearance of the *** biomineralization mode is rare among invertebrates.

关键词： Biomineralization Bryozoan Skeleton Calcite Aragonite Electron backscatter diffraction

Probabilistic approach for open pit bench slope stability analysis——A mine case study

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International Journal of Mining Science and Technology 2019年第4期29卷 629-640页

作者： christian Obregon Hani Mitri Department of Mining and Materials Engineering McGill University

The geotechnical slope design of an open pit wall starts at the bench scale *** this scale,the rock slope stability is governed primarily by the geological discontinuities within the rock mass and as a result,structurally-controlled failures(***,wedge or toppling)are most likely to *** probabilistic approach offers a major advantage over the traditional deterministic method in that it accounts for the different degrees of variability and uncertainty often encountered in rock *** paper presents a bench slope stability assessment for an open pit mine in Peru using a probabilistic-based approach by coupling a kinematic analysis based on stereographic projection techniques followed by a kinetic analysis by means of the limit equilibrium ***,these two probabilities are combined to provide an overall measure of the probability of failure(PoF)of the bench slope *** case study is characterized by significant scatter in the geometrical and mechanical properties of the *** surface mapping was conducted at 36 different sites following the ISRM suggested *** direct shear tests were carried *** is shown that by combining field and laboratory measurements and engineering judgment,the probability density functions(PDF)of the discontinuity parameters can be *** are then used in a Monte Carlo simulation process to compute both kinematic and kinetic probabilities of *** overall probability of failure aims to provide the design engineer with a tool to critically evaluate the bench performance from a geotechnical risk perspective and to provide a basis for future bench design optimization.

关键词： Mine safety Rock slope stability Kinematic analysis Probability of failure Limit equilibrium analysis Case study

geodynamic evolution of the Earth over the Phanerozoic:Plate tectonic activity and palaeoclimatic indicators

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Journal of Palaeogeography 2015年第2期4卷 167-188页

作者： christian Vérard Cyril Hochard Peter O.Baumgartner gérard M.Stampfli Université de Lausanne (UNIL) Institut des Sciences de la Terre (ISTE)

During the last decades, numerous local reconstructions based on field geol- ogy were developed at the University of Lausanne （UNIL）. Team members of the UNIL partici- pated in the elaboration of a 600 Ma to present global plate tectonic model deeply rooted in geological data, controlled by geometric and kinematic constraints and coherent with forces acting at plate boundaries. In this paper, we compare values derived from the tectonic model （ages of oceanic floor, production and subduction rates, tectonic activity） with a combination of chemical proxies （namely CO2, 87Sr/86Sr, glaciation evidence, and sea-level variations） known to be strongly in- fluenced by tectonics. One of the outstanding results is the observation of an overall decreas- ing trend in the evolution of the global tectonic activity, mean oceanic ages and plate velocities over the whole Phanerozoic. We speculate that the decreasing trend reflects the global cooling of the Earth system. Additionally, the parallel between the tectonic activity and CO2 together with the extension of glaciations confirms the generally accepted idea of a primary control of CO2 on climate and highlights the link between plate tectonics and CO2 in a time scale greater than 107 yr. Last, the wide variations observed in the reconstructed sea-floor production rates are in contradiction with the steady-state model hypothesized by some.

关键词： geodynamic plate tectonics plate model Phanerozoic palaeoclimate CO2,strontium glaciation