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ASSESSMENT OF THE PRIMARY STRUCTURE OF SLABS AND THE INFLUENCE ON HOT- AND COLD-ROLLED STRIP STRUCTURE

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ASSESSMENT OF THE PRIMARY STRUCTURE OF SLABS AND THE INFLUEN...

Ecological intensification of agriculture through biodiversity management:introduction

1～(st) Chinese-German Seminar on Fundamentals of Iron and Steelmaking

作者： Hubert Presslinger Michael Mayr Ernst Tragl christian bernhard voestalpine Division Stahl Linz Austria voestalpine Division Stahl Linz Austria voestalpine Division Stahl Linz Austria Montanuniversitt Leoben Austria

＜正＞voestalpine Linz is an Austrian steel producer delivering mainly strip material to the automotive, the household appliance and the construction *** quality of the delivered strips depends - among other things - on the internal structure of the slabs. Solidification phenomena as micro - and macro-segregation are of particular importance. This paper deals with the micro - and macro-segregations in slabs of the steel grades DP and S355. The method for the investigation of segregations based on electron probe microanalysis is described in brief. Characteristic values of segregations are derived from quantitative element distribution *** results serve as a basis for decisions on further processing steps in the hot and cold rolling mill.

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Journal of Plant Ecology 2023年第6期16卷 1-4页

作者： bernhard Schmid christian Schöb Department of Geography Remote Sensing LaboratoriesUniversity of ZurichWinterthurerstrasse 1908057 ZürichSwitzerland Universidad Rey Juan Carlos Calle Tulipán s/n28933 MóstolesSpain

A major feature of humans is that they can attain much higher population densities than any non-domestic animal species of similar body size(Damuth 1987).This is most likely due to the invention of agriculture(Herrera and Garcia-Bertrand 2018),which allowed humans to manage ecosystems in such a way that as much biomass as possible is converted into food(Vitousek et al.1986).

关键词： Ecological likely agriculture

Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation

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World Journal of Gastroenterology 2006年第23期12卷 3729-3735页

作者： christian U Riedel Francis Foata David Philippe Oskar Adolfsson bernhard J Eikmanns Stephanie Blum Department of Microbiology and Biotechnology University of Ulm89068 UlmGermany Immunology GroupNutrition and Health Dept.Nestlé Research CenterPO Box 44CH-1026 LausanneSwitzerland Immunology Group Nutrition and Health Dept.Nestlé Research CenterPO Box 44CH-1026 LausanneSwitzerland Department of Microbiology and Biotechnology University of Ulm89068 UlmGermany

AIM： Different strains of bifidobacteria were analysed for their effects on HT-29 intestinal epithelial cells （IECs） in in vitro models both of the non-inflamed and inflamed intestinal epithelium. METHODS： A reporter gene system in HT-29 cells was used to measure levels of NF-KB activation after challenge with bifidobacteria or after bacterial pre-treatment following LPS challenge. IL-8 protein and pro-inflammatory gene expression was investigated using normal HT-29 cells. RESULTS： None of the bifidobacteria tested induced activation of nuclear factor κB （NF-κB） indicating that bifidobacteria themselves do not induce inflammatory events in IECs. However, six out of eight bifidobacteria tested inhibited lipopolysaccharide- （LPS-） induced NF-κB activation in a dose- and strain-dependent manner. In contrast, NF-κB activation in response to challenge with tumor necrosis factor-α （TNF-α） was affected by none of the tested bifidobacteria, indicating that the inhibitory effect of bifidobacteria is specific for LPS-induced inflammation in IECs. As shown with two of the six inhibitionpositive bifidobacteria, LPS-induced inhibition of NF-κB activation was accompanied by a dose-dependent decrease of interleukin 8 （IL-8） secretion and by lower mRNA levels for IL-8, TNF-α, cyclooxygenase 2 （Cox-2）, and intercellular adhesion molecule 1（ICAM-1）. CONCLUSION： Some strains of bifidobacteria are effective in inhibiting LPS-induced inflammation and thus might be appropriate candidates for probiotic intervention in chronic intestinal inflammation.

关键词： NF-κB Bifidobacteria Anti-inflammatory LPS

Design and simulation of gas burner ejectors

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Carbon Resources Conversion 2021年第1期4卷 28-35页

作者： Mario Pichler Florian Wesenauer christian Jordan Stefan Puskas bernhard Streibl Franz Winter Michael Harasek Institute of Chemical Environmental&Bioscience EngineeringTU WienGetreidemarkt 9/1661060 ViennaAustria Wienerberger AG Wienerbergerplatz 11100 ViennaAustria DrS3–Strömungsberechnung und Simulation e.U. Simmeringer Hauptstraße 397/1411110 ViennaAustria

Ignition within gas burner ejectors can lead to off design conditions and has significant influence on the burner *** ignition in the ejector should be *** the present study the influence of combustion reactions on the performance of gas burner injectors is *** investigate if ignition is possible,simulated ignition delay times,using a detailed reaction mechanism,are compared to predicted mean residence times of the gas in the *** burner ejectors are designed using one dimensional analytic equations,based on energy and momentum conservation equations and conventional isentropic equations.1D results are compared to 2D computational fluid dynamics(CFD)simulations,to take into account non-ideal mixing effects along the *** are validated with experiments with air at room temperature.1D results show very good agreement not only with CFD simulations for the case of non-reactive flows,but also with performed *** is shown that the assumption of ideal mixing along the ejector and thus the comparison of the ignition delay time to the gas mean residence time,to predict ignition in the ejector,is not *** in the ejector is possible,even if the ignition delay time is more than thirty times higher than the mean residence *** addition to that,it is shown,that ignition and the choice of reaction mechanism have significant influence on the predicted gas burner ejector ***,the accurate prediction of ignition delay time and the use of a detailed reaction kinetic are mandatory to correctly predict the burner ejector behavior.

关键词： Self-ignition Flammability limits Reacting jet Ejector Jet pump Computational fluid dynamics

Event segmentation in ADHD:neglect of social information and deviant theta activity point to a mechanism underlying ADHD

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General Psychiatry 2024年第3期37卷 431-439页

作者： Astrid Prochnow Xianzhen Zhou Foroogh Ghorbani Veit Roessner bernhard Hommel christian Beste Cognitive Neurophysiology Department of Child and Adolescent PsychiatryFaculty of MedicineTU DresdenDresdenGermany Faculty of Psychology Shandong Normal UniversityJinanShandongChina

Background Attention-deficit/hyperactivity disorder(ADHD)is one of the most frequently diagnosed psychiatric conditions in children and *** the symptoms appear to be well described,no coherent conceptual mechanistic framework integrates their occurrence and variance and the associated problems that people with ADHD *** The current study proposes that altered event segmentation processes provide a novel mechanistic framework for understanding deficits in *** Adolescents with ADHD and neurotypically developing(NT)peers watched a short movie and were then asked to indicate the boundaries between meaningful segments of the *** recorded electroencephalography(EEG)data were analysed for differences in frequency band activity and effective connectivity between brain *** Compared with their NT peers,the ADHD group showed less dependence of their segmentation behaviour on social information,indicating that they did not consider social information to the same extent as their unaffected *** divergence was accompanied by differences in EEG theta band activity and a different effective connectivity network architecture at the source ***,NT adolescents primarily showed error signalling in and between the left and right fusiform gyri related to social information processing,which was not the case in the ADHD *** the ADHD group,the inferior frontal cortex associated with attentional sampling served as a hub instead,indicating problems in the deployment of attentional *** This study shows that adolescents with ADHD perceive events differently from their NT peers,in association with a different brain network architecture that reflects less adaptation to the situation and problems in attentional sampling of environmental *** results call for a novel conceptual view of ADHD,based on event segmentation theory.

关键词： instead meaningful primarily

CT-guided high-dose-rate brachytherapy in the interdisciplinary treatment of patients with liver metastases of pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 530-538页

作者： Gero Wieners Alexander christian Schippers Federico Collettini Dirk Schnapauff Bernd Hamm Peter Wust Hanno Riess bernhard Gebauer Department of Diagnostic and Interventional Radiology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Department of Radiation Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum Department of Oncology Charité-Universit?tsmedizin Berlin Campus Virchow-Klinikum

BACKGROUND： CT-guided high-dose-rate brachytherapy（CT-HDRBT） is an interventional radiologic technique for local ablation of primary and secondary malignomas applying a radiation source through a brachycatheter percutaneously into the targeted lesion. The aim of this study was to assess local tumor control, safety and efficacy of CT-HDRBT in the treatment of liver metastases of pancreatic cancer. METHODS： Twenty consecutive patients with 49 unresectable liver metastases of pancreatic cancer were included in this retrospective trial and treated with CT-HDRBT, applied as a single fraction high-dose irradiation（15-20 Gy） using a 192 Irsource. Primary endpoint was local tumor control and secondary endpoints were complications, progression-free survival and overall ***： The mean tumor diameter was 29 mm（range 10-73）. The mean irradiation time was 20 minutes（range 7-42）. The mean coverage of the clinical target volume was 98%（range 88%-100%）. The mean D100 was 18.1 Gy and the median D100 was 19.78 Gy. Three major complications occurred with post-interventional abscesses, three of which were seen in 15 patients with biliodigestive anastomosis（20%）and overall 15%. The mean follow-up time was 13.7 months（range 1.4-55.0）. The median progression-free survival was 4.9 months（range 1.4-42.9, mean 9.4）. Local recurrence occurred in 5（10%） of 49 metastases treated. The median overall survival after CT-HDRBT was 8.6 months（range 1.5-55.3）. Eleven patients received chemotherapy after ablation with a median progression-free survival of 4.9 months（mean 12.9）. Nine patients did not receive chemotherapy after intervention with a median progression-free survival of 3.2 months（mean 5.0）. The rate of local tumor control was 91% in both groups after 12 ***： CT-HDRBT was safe and effective for the treatment of liver metastases of pancreatic cancer.

关键词： brachytherapy pancreatic cancer liver metastases CT intervention

Simulated patient methodology as a“gold standard”in community pharmacy practice:Response to criticism

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World Journal of Methodology 2024年第2期14卷 172-174页

作者： christian Kunow bernhard Langer Department of Health NursingManagementNeubrandenburg University of Applied SciencesNeubrandenburg 17033Germany

The simulated patient methodology(SPM)is considered the“gold standard”as covert participatory *** is attracting increasing interest for the investigation of community pharmacy practice;however,there is criticism that SPM can only show a small picture of everyday pharmacy practice and therefore has limited external *** the one hand,a certain design and application of the SPM goes hand in hand with an increase in external *** if,on the other hand,this occurs at the expense of internal validity due to the trade-off situation,the justified criticism of the SPM for investigating community pharmacy practice can be countered.

关键词： Simulated patient methodology Community pharmacy Gold standard Covert participatory observation Internal validity External validity

The global significance of biodiversity science in China:an overview

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National Science Review 2021年第7期8卷 34-58页

作者： Xiangcheng Mi Gang Feng Yibo Hu Jian Zhang Lei Chen Richard T.Corlett Alice C.Hughes Stuart Pimm bernhard Schmid Suhua Shi Jens-christian Svenning Keping Ma State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau and Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and Environment Inner Mongolia University Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Zhejiang Tiantong Forest Ecosystem National Observation and Research Station School of Ecological and Environmental Sciences East China Normal University Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Center of Conservation Biology Core Botanical Gardens Chinese Academy of Sciences Nicholas School of the Environment Duke University Department of Geography Remote Sensing Laboratories University of Zurich State Key Laboratory of Biocontrol Guangdong Key Laboratory of Plant Resources Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes School of Life Sciences Sun Yat-Sen University Center for Biodiversity Dynamics in a Changing World (BIOCHANGE) and Section for Ecoinformatics and Biodiversity Department of Biology Aarhus University University of Chinese Academy of Sciences

Biodiversity science in China has seen rapid growth over recent decades, ranging from baseline biodiversity studies to understanding the processes behind evolution across dynamic regions such as the Qinghai-Tibetan Plateau. We review research, including species catalogues; biodiversity monitoring; the origins, distributions, maintenance and threats to biodiversity; biodiversity-related ecosystem function and services; and species and ecosystems’ responses to global change. Next, we identify priority topics and offer suggestions and priorities for future biodiversity research in China. These priorities include(i) the ecology and biogeography of the Qinghai-Tibetan Plateau and surrounding mountains, and that of subtropical and tropical forests across China;(ii) marine and inland aquatic biodiversity; and(iii) effective conservation and management to identify and maintain synergies between biodiversity and socio-economic development to fulfil China’s vision for becoming an ecological civilization. In addition, we propose three future strategies:(i) translate advanced biodiversity science into practice for biodiversity conservation;(ii) strengthen capacity building and application of advanced technologies, including high-throughput sequencing, genomics and remote sensing; and(iii) strengthen and expand international *** on the recent rapid progress of biodiversity research, China is well positioned to become a global leader in biodiversity research in the near future.

关键词： biodiversity inventory biodiversity maintenance biodiversity monitoring biodiversity origins biodiversity-ecosystem functioning

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Asian Journal of Andrology 2007年第3期9卷 299-304页

作者： Raft Henkel Gesa Maaβ Andreas Jung Gerhard Haidl Wolf-bernhard Schill Hans-christian Schuppe Department of Medical Biosciences University of the Western Cape Bellville 7535 South Africa Centre for Dermatology and Andrology Justus Liebig University 35385 Giessen Germany Department of Dermatology Rheinische Friedrich-Wilhelms University 53105 Bonn Germany

Aim： To investigate age-related inflammatory events in the male genital tract. Methods： In a total of 4 265 randomly collected patients attending the andrological outpatient clinic of the Center for Dermatology and Andrology, University of Giessen, Germany, ejaculate volume, pH-value, sperm concentration, total and progressive sperm motility, concentration of polymorphonuclear （PMN） elastase, number of peroxidase-positive cells and fructose were measured and correlated with patient＇s age. Results： While ejaculate volume, motility and fructose all correlated negatively with age, sperm concentration, PMN elastase and the pH-value showed a positive correlation. The prevalence of male genital tract inflammation （as defined by PMN elastase 〉 250 ng/mL） and its severity increased significantly. PMN elastase did not correlate with sperm motility. Fructose as a marker of seminal vesicle function showed a significant negative relationship with the PMN elastase levels, the number of peroxidase-positive cells and sperm motility. Conclusion： The significant increases of PMN elastase levels as marker of male genital tract inflammation in older men appear to be indicative of age-related changes in local immunoregulatory mechanisms. Because there is no association of PMN elastase with sperm motility, a direct inhibitory effect of this enzyme can be excluded.

关键词： aging men male genital tract inflammation polymorphonuclear elastase leukocytes infertility human semen