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Risk of second primary cancers after testicular cancer in East and West Germany： a focus on contralateral testicular cancers

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Asian Journal of Andrology 2014年第2期16卷 285-289,I0010,I0011页

作者： Carsten Rusner Brigitte Streller christa stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang Institute of Clinical Epidemiology Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Common Cancer Registry of Berlin Berlin Saarland Cancer Registry Saarbrucken Institute of Medical Epidemiology Biostatistics and Informatics Medical Faculty Martin-Luther-University of Halle-Wittenberg Halle (Saale) Germany Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD Department of Epidemiology Scfloof of Public Heaftfl Boston University Boston MA USA.

Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation therapy are potentially carcinogenic. The purpose of this study was to estimate the risk of developing second primary cancers including the risk associated with primary histologic type （seminoma and non-seminoma） among testicular cancer survivors in Germany. We identified 16 990 and 1401 cases of testicular cancer in population-based cancer registries of East Germany （1961-1989 and 1996-2008） and Saarland （a federal state in West Germany; 1970-2008）, respectively. We estimated the risk of a second primary cancer using standardized incidence ratios （SIRs） with 95% confidence intervals （95% Cls）. To determine trends, we plotted model-based estimated annual SIRs. In East Germany, a total of 301 second primary cancers of any location were observed between 1961 and 1989 （SIR： 1.9; 95% Ch 1.7-2.1）, and 159 cancers （any location） were observed between 1996 and 2008 （SIR： 1.7; 95% Ch 1.4-2.0）. The SIRs for contralateral testicular cancer were increased in the registries with a range from 6.0 in Saarland to 13.9 in East Germany. The SIR for seminoma, in particular, was higher in East Germany compared to the other registries. We observed constant trends in the model-based SIRs for contralateral testicular cancers. The majority of reported SIRs of other cancer sites including histology-specific risks showed low precisions of estimated effects, likely due to small sample sizes. Testicular cancer patients are at increased risk especially for cancers of the contralateral testis and should receive intensive follow-ups.

关键词： cancer registry incidence neoplasms second primary testicular neoplasms

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Adiponectin,a key adipokine in obesity related liver diseases

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World Journal of Gastroenterology 2011年第23期17卷 2801-2811页

作者： christa Buechler Josef Wanninger Markus Neumeier Department of Internal Medicine I University Hospital of RegensburgD-93042 RegensburgGermany

Non-alcoholic fatty liver disease (NAFLD) comprising hepatic steatosis,non-alcoholic steatohepatitis (NASH),and progressive liver fibrosis is considered the most common liver disease in western *** liver is more prevalent in overweight than normal-weight people and liver fat positively correlates with hepatic insulin *** steatosis is regarded as a benign stage of NAFLD but may progress to NASH in a subgroup of *** liver biopsy no diagnostic tools to identify patients with NASH are available,and no effective treatment has been *** obesity is a main risk factor for NAFLD and inappropriate storage of triglycerides in adipocytes and higher concentrations of free fatty acids may add to increased hepatic lipid storage,insulin resistance,and progressive liver *** of the adipose tissue-derived proteins are elevated in obesity and may contribute to systemic inflammation and liver *** is highly abundant in human serum but its levels are reduced in obesity and are even lower in patients with hepatic steatosis or *** antagonizes excess lipid storage in the liver and protects from inflammation and *** review aims to give a short survey on NAFLD and the hepatoprotective effects of adiponectin.

关键词： Hepatic steatosis Non-alcoholic steatohepatitis Adiponectin Obesity Adipose tissue

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Pathogenic and therapeutic role of exosomes in neurodegenerative disorders

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Neural Regeneration Research 2024年第1期19卷 75-79页

作者： christa C.Huber Hongmin Wang Division of Basic Biomedical Sciences Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming *** therapies exist to aid in symptomatic relief,effective treatments that can stop or reve rse the progress of each neurodegenerative disease are ***,research on the role of extracellular vesicles as disease markers and therapeutics has been intensively ***,30-150 nm in diameter,are one type of extracellular vesicles facilitating cell-to-cell *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,such as Alzheimer's disease,Parkinson s disease,and amyotrophic lateral ***,the exosomes derived from the patients are an invaluable source of disease *** the other hand,exosomes,especially those derived from stem cells,could serve as a therapeutic for these disorders,as seen by a rapid increase in clinical trials investigating the therapeutic efficacy of exosomes in different neurological *** review summarizes the pathological burden and therapeutic approach of exosomes in neurodegenerative *** also highlight how heat shock increases the yield of exosomes while still maintaining their therapeutic ***,this review concludes with outstanding questions that remain to be addressed in exosomal research.

关键词： aging Alzheimer's disease biomarker drug exosome extracellular vesicle neurodegenerative disease Parkinson's disease therapy

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Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3632-3634页

作者： christa E.Muller Tobias Claff PharmaCenter Bonn and Pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnAn der Immenburg 453121 BonnGermany

n a recent study published in Science,1 Tansley,Khoutorsky et *** a novel mechanism by which activated microglia can induce pain and pain *** involves the degradation of perineural nets(PNNs)around neurons in the spin... 详细信息

关键词： pain al. neural

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Surgical management in pediatric neuroblastoma diagnosis and treatment:a 20-year,single-center experience

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World Journal of Pediatrics 2022年第2期18卷 120-125页

作者： Brianna Spencer Akshilkumar Patel Robert Cilley christa N.Grant Department of Surgery Penn State Health Milton SHershey Medical Center500 University DriveHersheyPA 17033USA Pennsylvania State University College of Medicine HersheyPAUSA Division of Pediatric Surgery Penn State Health Milton SHershey Medical CenterHersheyPAUSA

Background The currently utilized International Neuroblastoma Risk Group(INRG)staging system developed in 2009 uses image-defined risk factors as a measure of surgical risk,separating resectable neuroblastoma from those best preceded by *** previous International Neuroblastoma Staging System was based primarily on surgical *** hypothesized there would be a change to the role of the surgeon in neuroblastoma treatment in the more recent *** This is a single center 20-year retrospective analysis of 104 patients with International Classification of Diseases-9 and-10 codes for *** demographics,tumor site,cancer treatment modality,survival,biopsy technique,surgical intervention,and pathology staging were *** was analyzed by analysis of variance(ANOVA)and Student’s t *** There was a decrease in open surgeries for extra-adrenal neuroblastomas in the later decade(77%,31%,P=0.01).There was a narrowing of the time interval to surgery in the later cohort,likely as a result of uniformity in surgical timing on treatment protocols relying on INRG *** Our findings mirror changes in practice patterns *** found an increase in minimally invasive approaches but did not find a difference in the role of the surgeon under the INRG staging system.

关键词： International Neuroblastoma Risk Group International Neuroblastoma Staging System MYCN Neuroblastoma Resection

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Glucocorticoid receptor gene haplotype structure and steroid therapy outcome in IBD patients

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World Journal of Gastroenterology 2010年第31期16卷 3888-3896页

作者： Jessica Mwinyi christa Wenger Jyrki J Eloranta Gerd A Kullak-Ublick Division of Clinical Pharmacology and Toxicol-ogy University Hospital Zurich

AIM: To study whether the glucocorticoid receptor (GR/ NR3C1) gene haplotypes influence the steroid therapy outcome in inflammatory bowel disease (IBD). METHODS: We sequenced all coding exons and flanking intronic sequences of the NR3C1 gene in 181 IBD patients, determined the single nucleotide polymorphisms, and predicted the NR3C1 haplotypes. Furthermore, we investigated whether certain NR3C1 haplotypes are significantly associated with steroid therapy outcomes. RESULTS: We detected 13 NR3C1 variants, which led to the formation of 17 different haplotypes with a certainty of > 95% in 173 individuals. The three most commonly occurring haplotypes were included in the association analysis of the influence of haplotype on steroid therapy outcome or IBD activity. None of the NR3C1 haplotypes showed statistically signifi cant association with glucocorticoid therapy success. CONCLUSION: NR3C1 haplotypes are not related to steroid therapy outcome.

关键词： Inflammatory bowel disease Steroid therapy Glucocorticoid receptor Pharmacogenetics Haplotype analysis

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First report of colonoscopic closure of a gastrocolocutaneous PEG migration with over-the-scope-clip-system

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World Journal of Gastroenterology 2014年第32期20卷 11439-11442页

作者： Reto Bertolini christa Meyenberger Michael Christian Sulz Department of Gastroenterology and Hepatology 9000 St. Gallen Switzerland

Percutaneous endoscopic gastrostomy(PEG) is a common practice for long-term nutrition of patients who are unable to take oral food. We report of an 85-year old man with a history of recurrent larynx carcinoma and hemicolectomy many years ago due to unknown reason. Laryngectomy was indicated. Preoperatively a PEG was inserted endoscopically after an abdominal ultrasonography without abnormal findings. Few months after PEG insertion, the patient was evaluated for diarrhea and insufficient feeding without signs of infection or peritonism. An upper endoscopy and computed tomography scan confirmed a buried bumper syndrome with migration of the PEG tube into the colon as a rare complication. He underwent successful colonoscopic removal of the internal bumper and closure of the colonic orifice of the fistula with the over-the-scope-clip system(OTSC). OTSC is an endoscopic device for treatment of bleeding, perforation, leak and fistula in the gastrointestinal tract. To the best of our knowledge, this is the first report of the use of OTSC for colonoscopic closure of a gastrocolocutaneous fistula due to a buried bumper syndrome with transcolonic PEG tube migration.

关键词： Over-the-scope-clip Over-the-scope-clip system Enterocutaneous fistula Colon Buried bumper Percutaneous endoscopic gastrostomy Complication Migration

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Phenotyping Tomato Root Developmental Plasticity in Response to Salinity in Soil Rhizotrons

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Plant Phenomics 2021年第1期3卷 14-27页

作者： Jacinto Gandullo Safarina Ahmad Essam Darwish Rumyana Karlova christa Testerink Section of Plant Physiology and Plant Cell Biology Swammerdam Institute for Life ScienceUniversity of AmsterdamScience Park 9041098 XH AmsterdamNetherlands Departamento de Biología Vegetal y Ecología Área de Fisiología VegetalFacultad de BiologíaUniversidad de SevillaSevilleSpain Plant Physiology Section Agricultural Botany DepartmentFaculty of AgricultureCairo University12613 GizaEgypt Laboratory of Plant Physiology Plant Sciences GroupWageningen University and Research6708PB WageningenNetherlands

Plants have developed multiple strategies to respond to salt *** order to identify new traits related to salt tolerance,with potential breeding application,the research focus has recently been shifted to include root system architecture(RSA)and root *** a simple but effective root phenotyping system containing soil(rhizotrons),RSA of several tomato cultivars and their response to salinity was *** observed a high level of root plasticity of tomato seedlings under salt *** general root architecture was substantially modified in response to salt,especially with respect to position of the lateral roots in the *** the soil surface,where salt accumulates,lateral root emergence was most strongly *** the set of tomato cultivars,H1015 was the most tolerant to salinity in both developmental stages studied.A significant correlation between several root traits and aboveground growth parameters was observed,highlighting a possible role for regulation of both ion content and root architecture in salt stress resilience.

关键词： soil cultivar breeding

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Are heat stroke and physical exhaustion underestimated causes of acute hepatic failure?

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World Journal of Gastroenterology 2007年第2期13卷 306-309页

作者： Kilian Weigand Carina Riediger Wolfgang Stremmel christa Flechtenmacher Jens Encke Department of Gastroenterology and Hepatology Medicine Ⅳ University of Heidelberg 69120 Heidelberg Germany Department of Pathology University of Heidelberg 69120 Heidelberg Germany

While cardiopulmonary symptoms are common in patients undergoing dassical or, due to physical exercise, exertional heat stroke, the failure of other organs is a rarely described phenomenon. Here we present two cases of acute hepatic failure, one due to classic heat shock, while the other occurred while the patient was doing a marathon-type running. Both cases presented with very high transaminases and significantly elevated international normalized ratio （INR）. No other causes for liver failure could be identified but physical exhaustion and hyperthermia.

关键词： Heat stroke Acute hepatic failure Heat shock Liver failure Hyperthermia

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Comparison of energy consumption and economic performance of organic and conventional soybean production——A case study from Jilin Province, China

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Journal of Integrative Agriculture 2015年第8期14卷 1561-1572页

作者： ZHANG Li-wei Til Feike Jirko Holst christa Hoffmann Reiner Doluschitz Institute of Farm Management (410c) University of Hohenheim Institute for Strategies and Technology Assessment Julius Kühn-Institut Federal Research Centre for Cultivated Plants

Modern agriculture heavily depends on energy consumption, especially fossil energy, but intensive energy input increases the production cost for producers and results in environmental *** agricultural production is considered a more sustainable system, but there is lack of scientific research on the energy consumption between organic and conventional systems in *** analysis and comparison of energy use between the two systems would help decision-makers to establish economic, effective and efficient agricultural ***, the objectives of the present study are to analyze energy inputs, outputs, energy efficiency, and economic benefits between organic and conventional soybean（Glycine max（L.） Merrill） production.A total of 24 organic farmers and 24 conventional farmers in Jilin Province, China, were chosen for investigation in 2010 production *** energy input was 71.55 GJ ha–1 and total energy output was 96.18 GJ ha–1 in the organic system, resulting in an energy efficiency（output/input） of *** energy input was 9.37 GJ ha–1 and total energy output was 113.4 GJ ha–1 in the conventional system, resulting in the energy efficiency of *** huge discrepancy in energy inputs and respective efficiencies lies in the several times higher nutrient inputs in the organic compared to the conventional production ***, the production costs ha–1 were 33% higher, and the net income ha–1 25% lower in the organic compared to the conventional soybean production *** is recommended to improve fertilizer management in organic production to improve its energetic and economic performance.

关键词： energy consumption fossil energy economic benefit organic agriculture soybean production Jilin Province China

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