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Resin infiltration of deproteinised natural occlusal subsurface lesions improves initial quality of fissure sealing

International Journal of Oral Science 2017年第2期9卷 117-124页

作者： Andrej m Kielbassa ina Ulrich Rita Schmidl christoph Schuller Wilhelm Frank Vanessa D Werth Centre for Operative Dentistry Periodontology and Endodontology University of Dental Medicine and Oral Health Danube Private University (DPU) Krems Austria Department of Applied Genetics and Cell Biology UFT-Campus Tulln University of Natural Resources and Life Sciences (BOKU) Vienna Austria Centre for Preclinical Education Department of Biostatistics University of Dental Medicine and Oral Health Danube Private University (DPU) Krems Austria

The aim of this ex vivo study was to evaluate the infiltration capability and rate of microleakage of a low-viscous resin infiltrant combined with a flowable composite resin(RI/CR) when used with deproteinised and etched occlusal subsurface lesions(International Caries Detection and Assessment System code 2). This combined treatment procedure was compared with the exclusive use of flowable composite resin(CR) for fissure sealing. Twenty premolars and 20 molars revealing non-cavitated occlusal carious lesions were randomly divided into two groups and were meticulously cleaned and deproteinised using Na OCl(2%). After etching with HCl(15%), 10 premolar and 10 molar lesions were infiltrated(Icon/DmG; rhodamine B isothiocyanate(RITC)-labelled) followed by fissure sealing(G-?nial Flo/GC; experimental group, RI/CR). In the control group(CR), the carious fissures were only sealed. Specimens were cut perpendicular to the occlusal surface and through the area of the highest demineralisation(DIAGNOdent pen, Ka Vo). Using confocal laser-scanning microscopy, the specimens were assessed with regard to the percentage of caries infiltration, marginal adaption and internal integrity. Within the CR group, the carious lesions were not infiltrated. Both premolar(57.9% ± 23.1%) and molar lesions(35.3% ± 22.1%) of the RI/CR group were uniformly infiltrated to a substantial extent, albeit with significant differences(P = 0.034). moreover, microleakage(n = 1) and the occurrence of voids(n = 2) were reduced in the RI/CR group compared with the CR group(5 and 17 specimens,respectively). The RI/CR approach increases the initial quality of fissure sealing and is recommended for the clinical control of occlusal caries.

关键词： aprismatic enamel fissure sealing occlusal caries resin infiltration sodium hypochlorite

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Reproductive biology of an old endemic murid rodent of Australia, the Spinifex hopping mouse, Notomys alexis:adaptations for life in the arid zone

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Integrative Zoology 2011年第4期6卷 321-333页

作者： William G.BREED chris m.LEIGH Discipline of Anatomy and Pathology University of AdelaideAdelaideAustralia

The Spinifex hopping mouse(Notomys alexis Thomas,1922)is an arid adapted Australo–Papuan old endemic rodent that undergoes boom and bust population *** this communication,we review our findings on the timing of reproduction and the potential reproductive rate of this *** investigate the first question,the reproductive condition of adult females,and occurrence of immatures,in a population on a cattle station in central Australia was determined and,for the second,data from a laboratory colony compared to those previously published on closely related species in other *** findings show that,at least in the population at the times that monitoring was performed,reproductive activity was only taking place in spring and early summer,whereas the laboratory study indicates that females have a similar gestation length and litter size to those of most close relatives occurring in other *** have extremely small testes and store relatively few *** findings suggest that Notomys alexis might show some seasonality of reproduction at least in this region of central Australia and that this species does not have a higher reproductive rate than that of related species in other,more predictable,environments.

关键词： arid environment hopping mouse reproduction

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Cadmium in soybeans and the relevance to human exposure

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Journal of Environmental Sciences 2015年第11期27卷 157-162页

作者： as.ley m.Newbigging Xiaowen Yan X.chris Le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology University of Alberta

Introduction Cadmium is considered a human carcinogen by the International Agency for Research on Cancer（IARC,1993）and the US National Toxicology Program（NTP,1997）.Cadmium contamination of food crops is a persistent issue for both the agricultural industry as well as *** is an issue for agriculture because cadmium can be present in soils naturally or as a result of industrial processes and can contaminate foods that are consumed by ***

关键词： Cadmium metals Food safety Dietary exposure Agricultural products Uptake of cadmium from soil

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most ankle sprain research is either false or clinically unimportant:A 30-year audit of randomized controlled trials

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Journal of Sport and Health Science 2021年第5期10卷 523-529页

作者： chris m.Bleakley mark matthews James m.Smoliga School of Health Science Ulster UniversityCounty AntrimNorthern IrelandBT370QBUK School of Sport Ulster UniversityCounty AntrimNorthern IrelandBT370QBUK Department of Physical Therapy Congdon School of Health ScienceHigh Point UniversityHigh PointNC 27268USA

Background:Lateral ankle sprain is the most common musculoskeletal *** clinical research in this field is growing,there is a broader concern that clinical trial outcomes are often false and fail to translate into patient ***:We audited 30 years of experimental research related to lateral ankle sprain management(n=74 randomized controlled trials)to determine if reports of treatment effectiveness could be validated beyond statistical ***:A total of 77%of trials reported positive treatment effects,but there was a high risk of false *** trials were unregistered and relied solely on statistical significance,or lack of statistical significance,rather than on interpreting key measures of minimum clinical importance(e.g.,minimal detectable change,minimal clinically important difference).Conclusion:Future clinical trials must adopt higher standards of reporting and data *** includes consideration of the ethical responsibility to preregister their research and interpretation of clinical outcomes beyond statistical significance.

关键词： Ankle sprain False discovery mCID mDC

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Halogen-specific total organic halogen analysis： Assessment by recovery of total bromine

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Journal of Environmental Sciences 2017年第8期29卷 340-348页

作者： markus Langsa Sebastien Allard ina Kristiana Anna Heitz Cynthia A.Joll Curtin Water Quality Research Centre Department of Chemistry Curtin University Perth Western Australia 6102 Australia Department of Civil Engineering Curtin University Perth Western Australia 6102 Australia Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan AlamUniversitas PapuaManokwaripapua Barat 98314Indonesia

Determination of halogen-specific total organic halogen（TOX） is vital for studies of disinfection of waters containing bromide, since total organic bromine（TOBr） is likely to be more problematic than total organic chlorine. Here, we present further halogen-specific TOX method optimisation and validation, focusing on measurement of TOBr. The optimised halogen-specific TOX method was validated based on the recovery of model compounds covering different classes of disinfection by-products（haloacetic acids, haloacetonitriles,halophenols and halogenated benzenes） and the recovery of total bromine（mass balance of TOBr and bromide concentrations） during disinfection of waters containing dissolved organic matter and bromide. The validation of a halogen-specific TOX method based on the mass balance of total bromine has not previously been reported. Very good recoveries of organic halogen from all model compounds were obtained, indicating high or complete conversion of all organic halogen in the model compound solution through to halide in the absorber solution for ion chromatography analysis. The method was also successfully applied to monitor conversion of bromide to TOBr in a groundwater treatment plant. An excellent recovery（101%）of total bromine was observed from the raw water to the post-chlorination stage. Excellent recoveries of total bromine（92%–95%） were also obtained from chlorination of a synthetic water containing dissolved organic matter and bromide, demonstrating the validity of the halogen-specific TOX method for TOBr measurement. The halogen-specific TOX method is an important tool to monitor and better understand the formation of halogenated organic compounds, in particular brominated organic compounds, in drinking water systems.

关键词： Total organic bromine Dissolved organic matter Bromide Chlorination Drinking water Health effects

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Defining the effect of sweep tillage tool cutting edge geometry on tillage forces using 3D discrete element modelling

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Information Processing in Agriculture 2015年第2期2卷 130-141页

作者： mustafa Ucgul John m.Fielke chris Saunders Barbara Hardy Institute School of EngineeringUniversity of South AustraliaMawson LakesSA 5095Australia

The energy required for tillage processes accounts for a significant proportion of total energy used in crop *** many tillage processes decreasing the draft and upward vertical forces is often desired for reduced fuel use and improved penetration,*** studies have proved that the discrete element modelling(DEm)can effectively be used to model the soil–tool *** his study,Fielke(1994)[1]examined the effect of the various tool cutting edge geometries,namely;cutting edge height,length of underside rub,angle of underside clearance,on draft and vertical *** this paper the experimental parameters of Fielke(1994)[1]were simulated using 3D discrete element modelling *** the simulations a hysteretic spring contact model integrated with a linear cohesion model that considers the plastic deformation behaviour of the soil hence provides better vertical force prediction was *** parameters were determined by comparing the experimental and simulation results of angle of repose and penetration *** results of the study showed that the simulation results of the soil-various tool cutting edge geometries agreed well with the experimental results of Fielke(1994)[1].The modelling was then used to simulate a further range of cutting edge geometries to better define the effect of sweep tool cutting edge geometry parameters on tillage *** extra simulations were able to show that by using a sharper cutting edge with zero vertical cutting edge height the draft and upward vertical force were further reduced indicating there is benefit from having a really sharp cutting *** extra simulations also confirmed that the interpolated trends for angle of underside clearance as suggested by Fielke(1994)[1]where correct with a linear reduction in draft and upward vertical force for angle of underside clearance between the ranges of-25 and-5°,and between-5 and 0°.The good correlations give confidence to recommend further invest

关键词： DEm Cutting edge geometry

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Local geoid modeling in the central part of Java, Indonesia, using terrestrial-based gravity observations

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Geodesy and Geodynamics 2023年第3期14卷 231-243页

作者： Rahayu Lestari Brian Bramanto Kosasih Prijatna Arisauna m.Pahlevi Widy Putra Raa ina Sidrotul muntaha Febriananda Ladivanov Departement of Geodesy and Geomatics Engineering Faculty of Earth Sciences and TechnologyInstitut Teknologi BandungIndonesia Geodesy Research Group Faculty of Earth Sciences and TechnologyInstitut Teknologi BandungIndonesia Geodetic and Geodynamic Control Network Center Geospatial Information Agency of Indonesia(BIG)Indonesia

The Global Navigation Satellite System(GNSS)positioning method has been significantly developed in geodetic ***,the height obtained through GNSS observations is given in a geodetic height system that needs to be converted to orthometric height for engineering *** on geoid height,which can be calculated using the global geopotential mode,is required to convert such GNSS observations into orthometric ***,its accuracy is still insufficient for most engineering ***,a reliable geoid model is essential,especially in areas growing fast,e.g.,the central part of Java,*** this study,we modeled the local geoid model in the central part of Java,Indonesia,using terrestrial-based gravity *** Stokes'formula with the second Helmert's condensation method under the Remove-Compute-Restore approach was implemented to model the *** comparison between our best-performing geoid model and GNSS/leveling observations showed that the standard deviation of the geoid height differences was estimated to be 4.4 *** geoid result outperformed the commonly adopted global model of EGm2008 with the estimated standard deviation of geoid height differences of 10.7 cm.

关键词： Gravimetric geoid Stokes integration Second Helmert's condensation method GNSS/Leveling

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Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus

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World Journal of Gastroenterology 2014年第25期20卷 7993-8004页

作者： Augustine Chen Nattanan Panjaworayan T-Thienprasert chris m Brown Centre for Translational Cancer Research Department of BiochemistryUniversity of Otago710 Cumber-land StDunedin 9054New Zealand Department of Bio-chemistry Faculty of ScienceKasetsart UniversityLadyaow ChatuchakBangkok 10900Thailand Department of Biochemistry and Webster Centre for Infectious diseases University of Otago710 Cum-berland StDunedin 9054New Zealand

There is a continuing need for novel antivirals to treat hepatitis B virus (HBV) infection, as it remains a major health problem worldwide. Ideally new classes of antivirals would target multiple steps in the viral lifecycle. In this review, we consider the steps in which HBV RNAs are processed, exported from the nucleus and translated. These are often overlooked steps in the HBV life-cycle. HBV, like retroviruses, incorporates a number of unusual steps in these processes, which use a combination of viral and host cellular machinery. Some of these unusual steps deserve a closer scrutiny. They may provide alternative targets to existing antiviral therapies, which are associated with increasing drug resistance. The RNA post-transcriptional regulatory element identified 20 years ago promotes nucleocytoplasmic export of all unspliced HBV RNAs. There is evidence that inhibition of this step is part of the antiviral action of interferon. Similarly, the structured RNA epsilon element situated at the 5’ end of the polycistronic HBV pregenomic RNA also performs key roles during HBV replication. The pregenomic RNA, which is the template for translation of both the viral core and polymerase proteins, is also encapsidated and used in replication. This complex process, regulated at the epsilon element, also presents an attractive antiviral target. These RNA elements that mediate and regulate gene expression are highly conserved and could be targeted using novel strategies employing RNAi, miRNAs or aptamers. Such approaches targeting these functionally constrained genomic regions should avoid escape mutations. Therefore understanding these regulatory elements, along with providing potential targets, may also facilitate the development of other new classes of antiviral drugs.

关键词： Hepatitis B virus Translational control Antiviral Nuclear export Post-transcriptional control Nucleocytoplasmic export

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Rice:Reducing arsenic content by controlling water irrigation

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Journal of Environmental Sciences 2015年第4期27卷 129-131页

作者： as.ley m.Newbigging Rebecca E.Paliwoda X.chris Le University of Alberta

Arsenic has long been recognized as a *** in water supplies that are used for both drinking and crop irrigation can expose many people chronically to elevated levels of arsenic.

关键词： Arsenic Cadmium Rice Food Water irrigation metal contamination

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The current perspective of the PA 1957 gas well pillar study and its implications for longwall gas well pillars

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International Journal of mining Science and Technology 2021年第1期31卷 117-126页

作者： Peter Zhang Daniel Su chris mark CDC NIOSH Pittsburgh Mining Research DivisionPittsburghPA 15236USA mine Safety and Health Administration PittsburghPA 15217USA

many states rely upon the Pennsylvania 1957 Gas Well Pillar Study to evaluate the coal barrier surrounding gas *** study included 77 gas well failure cases that occurred in the Pittsburgh and Freeport coal seams over a 25-year *** the time,coal was mined using the room-and-pillar mining method with full or partial pillar recovery,and square or rectangle pillars surrounding the gas wells were left to protect the *** study provided guidelines for pillar sizes under different overburden depths up to 213 m(700 ft).The 1957 study has also been used to determine gas well pillar sizes in longwall mines since longwall mining began in the 1970 *** original study was developed for room-and-pillar mining and could be applied to gas wells in longwall chain pillars under shallow ***,under deep cover,severe deformations in gas wells have occurred in longwall chain ***,with a better understanding of coal pillar mechanics,new insight into subsidence movements induced by retreat mining,and advances in numerical modeling,it has become both critically important and feasible to evaluate the adequacy of the 1957 study for longwall gas well *** this paper,the data from the 1957 study is analyzed from a new perspective by considering various factors,including overburden depth,failure location,failure time,pillar safety factor(SF),and floor *** pillar SF and floor pressure are calculated by considering abutment pressure induced by full pillar recovery.A statistical analysis is performed to find correlations between various factors and helps identify the most significant factors for the stability of gas wells influenced by retreat *** analyzing the data from the 1957 study,the guidelines for gas well pillars in the 1957 study are evaluated for their adequacy for roomand-pillar mining and their applicability to longwall *** modeling is used to model the stability of gas wells by quantifying the mining-induced s

关键词： Gas well pillar Pennsylvania 1957 gas well pillar study Room-and-pillar mining Longwall mining

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