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Adenylate cyclase activity of TIR1/AFB links cAMP to auxin-dependent responses

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Molecular Plant 2022年第12期15卷 1838-1840页

作者： Aloysius Wong Xuechen Tian Yixin Yang chris Gehring Department of Biology College of Science and TechnologyWenzhou-Kean University88 Daxue RoadOuhaiWenzhou 325060Zhejiang ProvinceChina Wenzhou Municipal Key Lab for Applied Biomedical and Biopharmaceutical Informatics OuhaiWenzhou 325060Zhejiang ProvinceChina Zhejiang Bioinformatics International Science and Technology Cooperation Center OuhaiWenzhou 325060Zhejiang ProvinceChina Department of Chemistry Biology&BiotechnologyUniversity of PerugiaPerugia 06121Italy

The phytohormone auxin is essential for plant growth and development as well as cellular and systemic responses to environmental *** auxin receptor TRANSPORT INHIBITOR RESPONSE 1/AUXIN-SIGNALING F-BOX(TIR1/AFB)lies within an E3 ubiquitin ligase complex(SCF^(TIR1/AFB))consisting of Skp,Cullin,and F-box *** brings together TIR1/AFB and the transcriptional repressor Auxin/INDOLE-3-ACETIC ACID(Aux/IAA),which allows the SCF^(TIR1/AFB) complex to transfer activated ubiquitin to Aux/IAA,thereby targeting it for proteasomal *** liberates the transcription factors AUXINRESPONSE FACTORs for auxin-dependent transcription(Lavy and Estelle,2016).

关键词： complex AFB of

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萨塔玛活动中心芬兰科特卡

世界建筑导报 2024年第2期39卷 77-81页

作者： Juho Grönholm Antti Nousjoki Samuli Woolston Sampo Honkala chris Morris Ricardo Cruz Recalde Mirja Sillanpää Niklas Mahlberg Thomas Miyauchi Stephanie Polochowitz Tuomas Uusheimo(摄影) ALA建筑师事务所不详

新开业的萨塔玛活动中心位于科特卡市最古老的港口坎塔萨塔玛,距离著名的维拉莫海事中心(已在港口区立足15年)只有几步之遥。该活动中心与目前正在建设的芬兰东南应用科技大学新校区大楼和未来酒店位于同一地块。这三座新建筑将有助于... 详细信息

新开业的萨塔玛活动中心位于科特卡市最古老的港口坎塔萨塔玛,距离著名的维拉莫海事中心(已在港口区立足15年)只有几步之遥。该活动中心与目前正在建设的芬兰东南应用科技大学新校区大楼和未来酒店位于同一地块。这三座新建筑将有助于加强港口与城市中心之间的视觉和功能联系。该活动中心是举办各种文化、体育和商务活动的理想场所。ALA建筑师事务所的设计工作侧重于将极具吸引力的建筑与功能性和环境目标相结合。其建筑特征来源于环境和项目目标。

关键词：活动中心建筑师事务所大学新校区港口区科特萨塔功能性芬兰

Reliability Investigation of BiCGStab and IDR Solvers for the Advection-Diffusion-Reaction Equation

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Communications in Computational Physics 2022年第6期32卷 156-188页

作者： chris Schoutrop Jan ten Thije Boonkkamp Jan van Dijk Department of Applied Physics Eindhoven University of TechnologyThe Netherlands Department of Mathematics and Computer Science Eindhoven University of TechnologyThe Netherlands

The reliability of BiCGStab and IDR solvers for the exponential scheme discretization of the advection-diffusion-reaction equation is *** resulting discretization matrices have real *** consider BiCGStab,IDR(S),BiCGStab(L)and various modifications of BiCGStab,where S denotes the dimension of the shadow space and L the degree of the polynomial used in the polynomial *** implementations of BiCGStab exist which are equivalent in exact arithmetic,however,not in finite precision *** modifications of BiCGStab we consider are;choosing a random shadow vector,a reliable updating scheme,and storing the best intermediate *** is shown that the Local Minimal Residual algorithm,a method similar to the“minimize residual”step of BiCGStab,can be interpreted in terms of a time-dependent advection-diffusion-reaction equation with homogeneous Dirichlet boundary conditions for the residual,which plays a key role in the convergence *** to the real eigenvalues,the benefit of BiCGStab(L)compared to BiCGStab is shown to be modest in numerical ***-sparse(*** random)shadow residual turns out to be essential for the reliability of *** reliable updating scheme ensures the required tolerance is truly *** the best intermediate solution has no significant *** is to modify BiCGStab with a random shadow residual and the reliable updating scheme,especially in the regime of large P´eclet and small Damk¨ohler *** alternative option is IDR(S),which outperforms BiCGStab for problems with strong advection in terms of the number of matrix-vector *** MATLAB code used in the numerical experiments is available on GitLab:https://***/chrisSchoutrop/krylov-adr,a C++implementation of IDR(S)is available in the Eigen linear algebra library:http://***.

关键词： BiCGStab IDR shadow residual advection-diffusion-reaction equation

High-performance solutions of geographically weighted regression in R

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Geo-Spatial Information Science 2022年第4期25卷 536-549页

作者： Binbin Lu Yigong Hu Daisuke Murakami chris Brunsdon Alexis Comber Martin Charlton Paul Harris School of Remote Sensing and Information Engineering Wuhan UniversityWuhanChina Department of Data Science Institute of Mathematical StatisticsTokyoJapan National Centre for Geocomputation Maynooth UniversityMaynoothIreland School of Geography University of LeedsLeedsUK Sustainable Agriculture Sciences North Wyke Rothamsted ResearchOkehamptonUK

As an established spatial analytical tool,Geographically Weighted Regression(GWR)has been applied across a variety of ***,its usage can be challenging for large datasets,which are increasingly prevalent in today’s digital *** this study,we propose two high-performance R solutions for GWR via Multi-core Parallel(MP)and Compute Unified Device Architecture(CUDA)techniques,respectively GWR-MP and *** compared GWR-MP and GWR-CUDA with three existing solutions available in Geographically Weighted Models(GWmodel),Multi-scale GWR(MGWR)and Fast GWR(FastGWR).Results showed that all five solutions perform differently across varying sample sizes,with no single solution a clear winner in terms of computational ***,solutions given in GWmodel and MGWR provided acceptable computational costs for GWR studies with a relatively small sample *** a large sample size,GWR-MP and FastGWR provided coherent solutions on a Personal Computer(PC)with a common multi-core configuration,GWR-MP provided more efficient computing capacity for each core or thread than *** cases when the sample size was very large,and for these cases only,GWR-CUDA provided the most efficient solution,but should note its I/O cost with small *** summary,GWR-MP and GWR-CUDA provided complementary high-performance R solutions to existing ones,where for certain data-rich GWR studies,they should be preferred.

关键词： Non-stationarity big data parallel computing Compute Unified Device Architecture(CUDA) Geographically Weighted models(GWmodel)

Optimisation of alloy composition for highly-formable magnesium sheet

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International Journal of Minerals,Metallurgy and Materials 2022年第7期29卷 1388-1395页

作者： Zhuoran Zeng Mingzhe Bian Shiwei Xu Weineng Tang chris Davies Nick Birbilis Jianfeng Nie College of Engineering and Computer Science Australian National UniversityACT.2601Australia Department of Materials Science and Engineering Monash UniversityVIC 3800Australia State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China Research Institute(R&D Center) Baosteel Group CorporationShanghai 201999China Department of Mechanical and Aerospace Engineering Monash UniversityVIC 3800Australia

The effectiveness of Ca or Gd addition on ductility and formability of Mg-Zn-Zr based dilute alloys in deep drawing has not been systematically compared *** this study,formable Mg-Zn-Gd-Zr and Mg-Zn-Ca-Zr sheet alloys are produced by hot *** sheets have similarly weakened basal texture,but the sheet of the Mg-Zn-Gd-Zr alloys has higher ductility and formability than that of Mg-Zn-Ca-Zr *** combined addition of 0.2wt%Ca and 0.4wt%Gd to the Mg-1Zn-0.5Zr(wt%)alloy leads to a Mg-1Zn-0.4Gd-0.2Ca-0.5Zr alloy that has even better ductility,and its formability during deep drawing is comparable to the benchmark Al6016 *** increase in Ca content from 0.2wt%to 0.5wt%leads to decreased sheet ductility and formability,predominantly due to grain boundary embrittlement.

关键词： magnesium sheet alloy texture microstructure formability solute segregation

The occurrence,inheritance,and segregation of complex genomic structural variation in synthetic Brassica napus

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The Crop Journal 2024年第2期12卷 515-528页

作者： Dandan Hu Jin Lu Wenwen Li Yinghui Yang Junxiong Xu Han Qin Hao Wang Yan Niu Huaiqi Zhang Qingqing Liu Xiangxiang He Annaliese S.Mason Jchris Pires Zhiyong Xiong Jun Zou National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Agronomy Henan Agricultural UniversityZhengzhou 450002HenanChina Key Laboratory of Herbage and Endemic Crop Biotechnology Inner Mongolia UniversityHohhot 010070Inner MongoliaChina Plant Breeding Department University of BonnBonn 53115Germany Department of Soil and Crop Sciences Colorado State UniversityFort CollinsCO 80523USA

"Synthetic"allopolyploids recreated by interspecific hybridization play an important role in providing novel genomic variation for crop *** synthetic allopolyploids often undergo rapid genomic structural variation(SV).However,how such SV arises,is inherited and fixed,and how it affects important traits,has rarely been comprehensively and quantitively studied in advanced generation synthetic lines.A better understanding of these processes will aid breeders in knowing how to best utilize synthetic allopolyploids in breeding ***,we analyzed three genetic mapping populations(735 DH lines)derived from crosses between advanced synthetic and conventional Brassica napus(rapeseed)lines,using whole-genome sequencing to determine genome *** observed high tolerance of large structural variants,particularly toward the telomeres,and preferential selection for balanced homoeologous exchanges(duplication/deletion events between the A and C genomes resulting in retention of gene/chromosome dosage between homoeologous chromosome pairs),including stable events involving whole chromosomes("pseudoeuploidy").Given the experimental design(all three populations shared a common parent),we were able to observe that parental SV was regularly inherited,showed genetic hitchhiking effects on segregation,and was one of the major factors inducing adjacent novel and larger ***,novel SV occurred at low frequencies with no significant impacts on observed fertility and yield-related traits in the advanced generation synthetic ***,incorporating genome-wide SV in linkage mapping explained significantly more genetic variance for *** results provide a framework for detecting and understanding the occurrence and inheritance of genomic SV in breeding programs,and support the use of synthetic parents as an important source of novel trait variation.

关键词： Allopolyploid Large Genome structural variation Linkage mapping Synthetic polyploids Inheritance and segregation

Optical clearing of the mouse skull

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Light(Science & Applications) 2022年第10期11卷 2267-2268页

作者： chris Xu School of Applied and Engineering Physics Cornell UniversityIthacaNY 14853USA

High spatial resolution imaging of the mouse brain through the intact skull is challenging because of the skull-induced aberration and *** research group of Dan Zhu from Huazhong University of Science and Technology has developed a skull-clearing technique that provides a long-term(~weeks),stable,transparent window for high resolution optical imaging over a large field of view.

关键词： scattering. transparent Optical

Time to treat the climate and nature crisis as one in divisible global health emergency

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General Psychiatry 2023年第5期36卷 440-442页

作者： chris Zielinski Centre for Global Health University of WinchesterWinchesterUK

Over 200 health journals call on the United Nations(UN),political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to pres... 详细信息

关键词： catastrophe global preserve

INF-γ and IL-2 Profile as Therapeutic Markers in Tuberculosis Patients at the Jamot Hospital of Yaounde-Cameroon

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Journal of Tuberculosis Research 2024年第2期12卷 119-128页

作者： Alexandra Emmanuelle Membangbi Jacky Njiki-Bikoï Esther Del-Florence Moni Ndedi Donatien Serge Mbaga Elsa Nguiffo Makue André chris Mikangue Mbongue Koko-Ta Ladiff Sharonne Martha Mesembe Justin Olivier Essindi Aïcha Ngoutane Arnaud Franck Elang Sabine Aimée Touangnou-Chamda George Ikomey Mondinde Eric Walter Perfura-Yone Marie Joseph Nkodo Mindimi Sara Honorine Riwom Essama Department of Microbiology The University of Yaound 1 Yaound Cameroon Center for the Study and Control of Communicable Diseases (CSCCD) Yaound Cameroon The Institute for Medical Research and Medicinal Plants Studies Yaound Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaound I Yaound Cameroon The Pneumology Department Jamot Hospital of Yaound Yaound Cameroon

Background: Tuberculosis (TB) is one of the top lethal infectious diseases worldwide. In recent years, interferon-γ (INF-γ) release assays (IGRAs) have been established as routine tests for diagnosing TB infection. However, produced INF-γ assessment cannot permit to distinguish active ATB from latent TB infection (LTBI), especially in TB epidemic areas. In addition to IFN-γ, interleukin-2 (IL-2), secreted by activated T cells, is involved in immune response against Mycobacterium tuberculosis. This could be involved in the follow up of treatment response. The aim of our study was to determine IFN-γ and IL2 cytokines profiles of patients under antituberculosis treatment. Materials and Methods: A six months’ cross-sectional study was conducted at the Jamot Hospital of Yaoundé, from May to August 2021. Sociodemographic and clinical data as well as 5 mL of blood were collected from each participant. INF-γ and IL-2 were determined using indirect Enzyme linked Immuno-Sorbent Assay (ELISA) according to the manufacturer’s recommendations and spectrum exam in combination with radiography and GeneXpert were used as standard. P-values Results: The results showed that men were more infected 14/61 (31.8%) with a high presence in active and resistant TB groups. The mean age was 41.3 ± 13.1 years with a 95% CI = [38.2 - 44.7], the age group with the highest infection rate was ranged between 31 and 40 years. The IL-2 and INF-γ means were respectively 327.6 ± 160.6 pg/mL and 26.6 ± 13.0 pg/mL in ATB patients, 251.1 ± 30.9 pg/mL and 21.4 ± 9.2 pg/mL in patients with resistant tuberculosis, while it was 149.3 ± 93.3 pg/mL and 17.9 ± 9.4 pg/mL in cured patients, 15.1 ± 8.4 pg/mL and 5.3 ± 2.6 pg/mL in participants presumed healthy (p γ and IL-2rates were observed between the different groups. Conclusion: Monitoring the serum levels of INF-γ and IL-2 would be useful for the follow-up of anti-tuberculosis patients, particularly in the both cytokines association case.

关键词： Tuberculosis Antituberculosis Treatment INF-γ IL-2 ELISA