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Viral hepatitis:A brief introduction,review of management,advances and challenges

World Journal of Meta-Analysis 2021年第2期9卷 139-152页

作者： Olga Fagan Paul Amstrong Kevin Van Der Merwe Daniela Crosnoi chris steele Julia Sopena-Falco VikrantParihar Department of Gastroenterology Letterkenny University HospitalLetterkenny F92 AE81Ireland Department of Gastroenterology Saint Vincent’s University HospitalDublin 04Ireland

Viral hepatitis represents a major public health hazard and is associated withsignificant global mortality. Over the last decade, there have been significantdevelopments in the prevention and treatment of viral hepatitis. These changeshave led to a situation whereby global elimination has become a realistic goal,fully endorsed by the World Health Organization (WHO). By 2030, the WHOaims to reduce viral hepatitis mortality by 65% and reduce new infections by 90%by 2030. These are ambitious targets and will only be met through a sustainedprogramme. This will require expertise from hepatologists and virologists and thefields of public health and primary care. In this article, we review the causes ofviral hepatitis, its management through prevention and treatments, and the mostpressing challenges and recent advances.

关键词： Viral Hepatitis Management Direct-acting antivirals Advances Challenges

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Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen chris R.Burke Jennie E.Pryce Nicole M.steele Peter R.Amer Susanne Meier Claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-Massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler Markov-chain Monte Carlo(MCMC) Puberty

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Event

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明日风尚 2010年第1期 200-207页

作者： chris Zhang

上海旁氏专业护肤中心正式落成旁氏专业护肤中心全球网络的新成员——上海旁氏专业护肤中心于最近宣告正式落成。这个研究机构,把屡获殊荣的科学家聚集到上海。为护肤品的科学创新,与研究组建立起精英团队。该中心拥有先进的全新设施,... 详细信息

上海旁氏专业护肤中心正式落成旁氏专业护肤中心全球网络的新成员——上海旁氏专业护肤中心于最近宣告正式落成。这个研究机构,把屡获殊荣的科学家聚集到上海。为护肤品的科学创新,与研究组建立起精英团队。该中心拥有先进的全新设施,对于具有前瞻性思维的专业人士来说,是一项富挑战性的工作。旁氏全球副总裁David steele出席了开幕礼,同时发表了讲话。

关键词：研究机构副总裁广告奖施华洛 Event 周大精英团队国际广告高级定制浦江两岸

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