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No evidence for enzootic plague within black-tailed prairie dog(Cynomys ludovicianus)populations

Integrative Zoology 2021年第6期16卷 834-851页

作者： Rebecca E.COLMAN R.Jory BRINKERHOFF Joseph D.BUSCH chris ray Adina DOYLE Jason W.SAHL Paul KEIM Sharon K.COLLINGE David M.WAGNER Pathogen and Microbiome Institute Northern Arizona UniversityFlagstaffArizonaUSA Environmental Studies Program University of Colorado at BoulderBoulderColoradoUSA

Yersinia pestis,causative agent of plague,occurs throughout the western United States in rodent populations and periodically causes epizootics in susceptible species,including black-tailed prairie dogs(Cynomys ludovicianus).How *** persists long-term in the environment between these epizootics is poorly understood but multiple mechanisms have been proposed,including,among others,a separate enzootic transmission cycle that maintains *** without involvement of epizootic hosts and persistence of *** within epizootic host populations without causing high mortality within those *** live-trapped and collected fleas from black-tailed prairie dogs and other mammal species from sites with and without black-tailed prairie dogs in 2004 and 2005 and tested all fleas for presence of *** was not detected in 2126 fleas collected in 2004 but was detected in 294 fleas collected from multiple sites in 2005,before and during a widespread epizootic that drastically reduced black-tailed prairie dog populations in the affected *** and spatial patterns of *** occurrence in fleas and genotyping of *** present in some infected fleas suggest *** was introduced multiple times from sources outside the study area and once introduced,was dispersed between several *** conclude *** likely was not present in these black-tailed prairie dog colonies prior to epizootic activity in these *** we did not identify likely enzootic hosts,we found evidence that deer mice(Peromyscus maniculatus)may serve as bridging hosts for *** between unknown enzootic hosts and black-tailed prairie dogs.

关键词： black-tailed prairie dog Cynomys ludovicianus plague prairie dogs Yersinia pestis

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精心准备步步为营——访Solid Works总裁John McEleney,副总裁Jeff ray,chris Garcia

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机械设计与制造工程 2006年第8期 58-60页

作者：崔荣会 John McEleney Jeff ray chris Garcia Solid Works

造就PLM 3D主流市场一代霸主记者:达索是SolidWorks公司的母体,在PLM市场以及三维CAD主流市场中,二者分别扮演了怎样的角色?

关键词：副总裁中华人民共和国 SolidWorks John McEleney Jeff ray,chris Garcia Solid Works

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精心准备步步为营——访Solid Works总裁John McEleney,副总裁Jeff ray,chris Garcia

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中国制造业信息化（应用版） 2006年第4期35卷 58-60页

作者：崔荣会 John McEleney Jeff ray chris Garcia Solid Works

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Systematic review of periprosthetic tibia fracture after total knee arthroplasties

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World Journal of Orthopedics 2015年第8期6卷 649-654页

作者： Nabil A Ebraheim Joseph R ray Meghan E Wandtke Grant S Buchanan chris G Sanford Jiayong LiuZ Department of Orthopaedic Surgery University of Toledo Medical Center

AIM: To investigate the known incidences, treatment options, and related outcomes of periprosthetic tibia fractures after total knee arthroplasty(TKA).METHODS: A literature search was done to identify studies that fit the inclusion criteria. The database search yielded 185 results, which were further reduced by the exclusion criteria to 13 papers, totaling 157 patients that met these criteria. Incidence rates of the different types of periprosthetic tibia fractures were determined and their treatments were subsequently analyzed based on the fracture's subclass, with patient outcomes being overall ***: Of the 144 documented patients, 54(37.5%) had a subclass C fracture, which are frequently seen in revision arthroplasties or when using cement intraoperatively. The fractures of subclasses A and B occur postoperatively. There were 90 subclass A and B fractures with incidences of 18.75% and 43.75% respectively. When broken down by type, 62(55.36%) were type 1, 24(21.4%) were type 2, 24(21.4%) were type 3, and 2(1.8%) were type 4. Furthermore, from the studies that included origin of injury, the types were further classified as having non-traumatic or traumatic origins. Type 1 had 78%(40/51) non-traumatic origin and 22%(11/51) traumatic origin. Fifteen fractures were type 2, but 5 were falls and 1 through a motor vehicle accident, giving a trauma causation of 40%(6/15). Of the 24 type 3 fractures, 12 were falls and 2 vehicular accidents, leading to a trauma causation of 58%(14/24).CONCLUSION: Type 1 fractures were the most common. Subclass A was treated with locking plates, B required a revision TKA, and C was treated intraoperatively or nonoperatively.

关键词： Periprosthetic fractures Literature review Tibia fractures

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Using a fluvial archive to place extreme flood sediment(dis)connectivity dynamics in context of a longer-term record

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International Journal of Sediment Research 2022年第4期37卷 447-456页

作者： Kirstie Fryirs chris Thompson Damian Gore School of Natural Sciences Macquarie University Seqwater

The aim of this study was to establish the source and provenance of sediments deposited in a large floodplain sink during extreme floods in the Lockyer Creek catchment, Australia, in 2011 and 2013. We place the sediment source patterns in context of the longer-term record to determine whether coarsegrained sediment sources(i.e., very fine sand to very coarse sand) and the spatio-temporal pattern of(dis)connectivity have changed over time. We do this by matching the geochemical properties and age structure of a sediment profile located in a downstream floodplain sink to the elemental composition of source sediments. One hundred and fifty-seven sediment samples from 20 sites across the catchment are analysed using X-ray fluorescence(XRF) spectrometry to compare the elemental ratio composition of the downstream floodplain sink to its source materials. We use Optically Stimulated Luminescence(OSL)dating to determine the age structure of the sediments in the floodplain sink. The northern tributaries and parts of the Lockyer River trunk stream are the primary sources of coarse sediment. These areas are connected(coupled) to the lower trunk stream and floodplain sediment sink. Southern tributaries are largely disconnected(decoupled) and supply little sediment to the floodplain sediment sink. This pattern of sediment source contribution has remained similar over the last 6.8 ka at least. Sediment sources as observed in the 2011 flood have predominated over the mid-late Holocene whilst those in the 2013 flood are rare.

关键词： Sediment provenance Geomorphology Sediment source Sediment sink Lockyer Valley

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单管球囊腔内治疗和组织间插植治疗早期乳腺癌的剂量和临床比较

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中华放射医学与防护杂志 2007年第2期27卷 145-149页

作者：修霞 ray Lin Colin Chu chris Issa Prabhakar Tripuraneni 卫生部北京医院放疗科 100730 Scripps Green Hospital CA USA

目的比较单管球囊腔内治疗（MammoSite）和组织间插植两种高剂量率（HDR）后装技术行早期乳腺癌保乳术后局部乳腺加速照射的剂量学优缺点、早晚期毒副作用及美容评估。方法自2004年1月至12月，10例乳腺癌在肿瘤局部扩大切除后使用了高... 详细信息

目的比较单管球囊腔内治疗（MammoSite）和组织间插植两种高剂量率（HDR）后装技术行早期乳腺癌保乳术后局部乳腺加速照射的剂量学优缺点、早晚期毒副作用及美容评估。方法自2004年1月至12月，10例乳腺癌在肿瘤局部扩大切除后使用了高剂量率^192Ir加速照射（APBI），其中组织间插植6例、MammoSite4例。全部息者均在手术中植入施源器，组织间插植组瘤腔距皮肤〉0．5～0．7cm，MammoSite中1例瘤腔距皮肤0．65cm，其余3例均大于1cm。治疗靶区组织间插植组为瘤腔外2cm（皮肤和胸壁方向根据实际情况略小），MammoSite组为球囊外1cm。组织间插植组中位剂量均匀指数（DHI）为0．77，MammoSite组中位DHI为0．73。结果全部患者随诊12～24个月，中位随诊18个月，随诊率为100％。治疗期间两组无一例发生Ⅲ级以上急性反应，仅发生红斑、水肿、乳腺触痛和感染，均为1～2级。晚期毒性（皮肤纤维化、乳腺触痛、脂肪坏死）组织间插植组较MammoSite组略高。美容效果达到极好和良好的在治疗结束时为100％，随诊12个月时组织间插植组患者和医生评估分别是100％和83％，MammoSite组均为100％。无一例局部复发。结论组织间插植剂量分布较MammoSite均匀而且治疗体积大；MammoSite重复性好、操作简单，早晚期毒副作用及美容效果相同。

关键词：早期乳腺癌单管球囊腔内治疗组织间插植近距离治疗

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160岁的圣斯克航海传奇

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游艇业 2009年第11期 102-107页

作者： ray Bulman chris Davis（图）

两位加起来已经160岁的老人，因一部007电影激起了重战英吉利海峡的豪情。如同他们所说，“驾驶圣斯克古董艇重回大海？我们简直是疯了。”

关键词：传奇航海英吉利海峡驾驶

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Hardfacing steel with nanostructured coatings of Stellite-6 by supersonic laser deposition

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Light(Science & Applications) 2012年第1期1卷 112-117页

作者： Rocco Lupoi Andrew Cockburn chris Bryan Martin Sparkes Fang Luo William O’Neill Institute for Manufacturing Department of EngineeringUniversity of CambridgeCambridge CB30FSUK College of Zhijiang Zhejiang University of TechnologyHangzhou 310024China

The ability to manufacture coatings is critical to engineering design. Many components require the application of additional layers toenhance mechanical properties and protect against hostile environments. Supersonic laser deposition (SLD) is a novel coating methodbased on cold spray (CS) principles. In this technique, the deposition velocities can be significantly lower than those required foreffective bonding in CS applications. The addition of laser heat energy permits a change in the thermodynamic experience of impactingparticles, thereby offering a greater opportunity for efficient bonding at lower velocities as compared with the CS process. The workreported in this paper demonstrates the ability of the SLD process to deliver hardfacing materials to engineering surfaces. Stellite-6 hasbeen deposited on low-carbon steel tubes over a range of process parameters to establish the appropriate target power and traversespeeds for the coating formation. The coating properties and parameters were examined to determine the primary characteristics andgrain structure size. Their morphology and performance were studied through optical microscopy, scanning electron microscope(SEM), X-ray diffraction, hardness measurements and wear testing. The results have shown that SLD is capable of depositing layers ofStellite-6, with properties that are superior to those of their conventionally manufactured counterparts.

关键词： cold spray laser supersonic laser deposition(SLD) Stellite wear

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Machine-learned interatomic potentials by active learning:amorphous and liquid hafnium dioxide

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npj Computational Materials 2020年第1期6卷 803-810页

作者： Ganesh Sivaraman Anand Narayanan Krishnamoorthy Matthias Baur christian Holm Marius Stan Gábor Csányi chris Benmore Álvaro Vázquez-Mayagoitia Leadership Computing Facility Argonne National LaboratoryArgonneIL 60439USA Institute for Computational Physics Universität StuttgartAllmandring 3Stuttgart 70569Germany Helmholtz-Institute Münster:Ionics in Energy Storage(IEK-12) Forschungszentrum Jülich GmbHCorrensstrasse 46Münster 48149Germany Applied Materials Division Argonne National LaboratoryArgonneIL 60439USA Department of Engineering University of CambridgeTrumpington StreetCambridge CB21PZUK X-ray Science Division Argonne National LaboratoryArgonneIL 60439USA Computational Science Division Argonne National LaboratoryArgonneIL 60439USA

We propose an active learning scheme for automatically sampling a minimum number of uncorrelated configurations for fitting the Gaussian Approximation Potential(GAP).Our active learning scheme consists of an unsupervised machine learning(ML)scheme coupled with a Bayesian optimization technique that evaluates the GAP *** apply this scheme to a Hafnium dioxide(HfO2)dataset generated from a“melt-quench”ab initio molecular dynamics(AIMD)*** results show that the active learning scheme,with no prior knowledge of the dataset,is able to extract a configuration that reaches the required energy fit ***,molecular dynamics(MD)simulations performed using this active learned GAP model on 6144 atom systems of amorphous and liquid state elucidate the structural properties of HfO2 with near ab initio precision and quench rates(i.e.,1.0 K/ps)not accessible via *** melt and amorphous X-ray structural factors generated from our simulation are in good agreement with *** addition,the calculated diffusion constants are in good agreement with previous ab initio studies.

关键词： amorphous dioxide scheme

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Intracellular in situ labeling of Ti02 nanoparticles for fluorescence microscopy detection

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Nano Research 2018年第1期11卷 464-476页

作者： Koshonna Brown Ted Thurn Lun Xin William Liu Remon Bazak Si Chen Barry Lai Stefan Vogt chris Jacobsen Tatjana Paunesku Gayle E. Woloschak Department of Radiation Oncology Feinberg School of Medicine Northwestern University Chicago Illinois 60611 USA X-ray Science Division Advanced Photon Source Argonne National Laboratory 9700 South Cass Avenue Argonne Illinois 60439 USA Department of Physics & Astronomy Weinberg College of Arts and Sciences 2145 Sheridan Road Evanston Illinois 60208 USA

Titanium dioxide （TiO2） nanoparticles are produced for many different purposes, including development of therapeutic and diagnostic nanoparticles for cancer detection and treatment, drug delivery, induction of DNA double-strand breaks, and imaging of specific cells and subcellular structures. Currently, the use of optical microscopy, an imaging technique most accessible to biology and medical patholog36 to detect TiO2 nanoparticles in cells and tissues ex vivo is limited with low detection limits, while more sensitive imaging methods （transmission electron microscopy, X-ray fluorescence microscop~ etc.） have low throughput and technical and operational complications. Herein, we describe two in situ post- treatment labeling approaches to stain TiO2 nanoparticles taken up by the cells. The first approach utilizes fluorescent biotin and fluorescent streptavidin to label the nanoparticles before and after cellular uptake; the second approach is based on the copper-catalyzed azide-alkyne cycloaddition, the so-called Click chemistry, for labeling and detection of azide-conjugated TiO2 nanoparticles with alkyne- conjugated fluorescent dyes such as Alexa Fluor 488. To confirm that optical fluorescence signals of these nanoparticles match the distribution of the Ti element, we used synchrotron X-ray fluorescence microscopy （XFM） at the Advanced Photon Source at Argonne National Laboratory. Titanium-specific XFM showed excellent overlap with the location of optical fluorescence detected by confocal microscopy. Therefore, future experiments with TiO2 nanoparticles may safely rely on confocal microscopy after in situ nanoparticle labeling using approaches described here.

关键词： TiO2 nanoparticles anatase Click reaction biotin-streptavidin synchrotron X-ray fluorescence microscopy

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