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Cellular & Molecular Immunology 2010年第4期7卷 323-326页

作者： Ho-Kee Koon Kwok-Wai Lo Kwok-Nam Leung Maria Li Lung chris chi-kwong chang Ricky Ngok-Shun Wong Wing-Nang Leung Nai-Ki Mak Department of Biology Hong Kong Baptist UniversityKowloonHong Kong Department of Anatomical and Cellular Biology and State Key Laboratory in Oncology in South china Prince of Wales HospitalShatinHong Kong Department of Biochemistry and Food and nutritional Sciences Programme The Chinese University of Hong KongShatinHong Kong Department of Biology Hong Kong University of Science and TechnologyHong Kong Department of Chemistry Hong Kong University of Science and TechnologyKowloonHong Kong School of chinese Medicine The Chinese University of Hong KongShatinHong Kong

Nasopharyngeal carcinoma(NPC)is a malignant disease associated with Epstein–Barr virus(EBV)*** study aims to examine the effects of EBV infection on the production of proinflammatory cytokines in NPC cells after the Zn-BC-AM photodynamic therapy(PDT)*** were treated with the photosensitiser Zn-BC-AM for 24 h before light *** ELISA was used to evaluate the production of *** the same experimental condition,HK-1-EBV cells produced a higher basal level of IL-1a(1561 pg/ml),IL-1b(16.6 pg/ml)and IL-8(422.9 pg/ml)than the HK-1 *** the light dose of 0.25–0.5 J/cm2,Zn-BC-AM PDT-treated HK-1-EBV cells were found to produce a higher level of IL-1a and IL-1b than the HK-1 *** production of IL-1b appeared to be mediated via the IL-1b-converting enzyme(ICE)-independent *** contrast,the production of angiogenic IL-8 was downregulated in both HK-1 and HK-1-EBV cells after Zn-BC-AM *** results suggest that Zn-BC-AM PDT might indirectly reduce tumour growth through the modulation of cytokine production.

关键词： Photodynamic therapy nasopharyngeal carcinoma cytokines Epstein-Barr virus

A retrospective study on use of palliative care for patients with alcohol related end stage liver disease in United States

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World Journal of Hepatology 2022年第9期14卷 1817-1829页

作者： Kamesh Gupta Bandhul Hans Ahmad Khan Syed Hamza Sohail Devika Kapuria chris chang Department of Gastroenterology UMass Chan Medical School-BaystateSpringfieldMA 01199United States Department of Internal Medicine Allegheny General HospitalPittsburghPA 15212United States Department of Gastroenterology Case Western UniversityClevelandOH 44106United States Department of Internal Medicine UMass Chan Medical School-BaystateSpringfieldMA 01199United States Department of Gastroenterology Washington UniversitySt.LouisMO 63110United States Department of Gastroenterology University of New MexicoAlberquerqueNM 46111United States

BACKGROUND Palliative care(PC)has been shown to be beneficial in end stage liver disease(ESLD),yet the hospitalization data for PC utilization is *** To identify the trend of PC utilization for the special population of alcoholassociated ESLD patients,factors affecting its use and ascertain its impact on healthcare *** We analyzed around 78 million discharges from the 2007-2014 national inpatient sample and 2010-2014 national readmission database including adult patients admitted for decompensated alcohol-associated *** identified patients with PC consultation as a secondary *** ratios(OR)and means were adjusted for confounders using multivariate regression analysis *** Out of the total 1421849 hospitalizations for decompensated liver cirrhosis,62782(4.4%)hospitalizations had a PC consult,which increased from 0.8%(1258)of all alcohol-associated ESLD hospitalizations in 2007 to 6.6%in 2014(Pching institution,urban location,length of stay>3 d,prolonged ventilation,and administration of total parenteral nutrition(all P<0.01).Palliative encounters in alcohol-associated ESLD and acute-onchronic liver failure(ACLF)score were associated with increased odds of discharge to a rehabilitation facility,but significantly lower odds of 30-d readmissions(aOR:0.35,95%CI:0.31-0.41),lower total hospitalization charges and lower mean hospitalization days(all P<0.01).CONCLUSION Inpatient PC is sparingly used for patients with decompensated alcohol related liver disease,however it has increased over the past *** consultation is associated with lower 30-d readmission rates on multivariate analysis,and lower hospitalization cost and length of stay in patients with ACLF score≥2.

关键词： Alcohol-associated cirrhosis Palliative care End stage liver disease National inpatient sample National readmission database

智能电网中分布式光伏逆变器的基本功能组件(英文)

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中国电机工程学报 2013年第34期33卷 83-90页

作者：邵日明 Mary KAYE chris DIDUCH 张榴晨新布伦瑞克大学电气与计算机工程系

智能电网环境中,光伏系统作为分布式发电机应用时,必须满足并网标准的各种要求。逆变器作为光伏阵列与电网的连接机构,应该具备分布式发电机入网的必要功能。文章重点介绍了光伏逆变器的必要功能组件,提出光伏逆变器的基本功能算法,包... 详细信息

智能电网环境中,光伏系统作为分布式发电机应用时,必须满足并网标准的各种要求。逆变器作为光伏阵列与电网的连接机构,应该具备分布式发电机入网的必要功能。文章重点介绍了光伏逆变器的必要功能组件,提出光伏逆变器的基本功能算法,包括基于空间矢量脉宽调制的电流控制算法、基于黄金分割搜索的最大功率跟踪算法、加速式自动移相孤岛检测算法等。这些新技术构成并网型光伏逆变器的一个完整技术方案。随着智能电网的发展,更多分布式发电装置将在虚拟电站的控制环境中运行。为此,探讨了光伏逆变器的通讯和电力系统控制功能。这些附加功能使光伏系统能够参与电力系统的调度和服务,从而创造更高的经济价值。

关键词：光伏逆变器脉宽调制最大功率跟踪孤岛检测系统控制

Feature Patch Illumination Spaces and Karcher Compression for Face Recognition via Grassmannians

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Advances in Pure Mathematics 2012年第4期2卷 226-242页

作者： Jen-Mei chang chris Peterson Michael Kirby Department of Mathematics Colorado State University Fort Collins USA Departmentof Mathematics and Statistics California State University Long Beach USA

Recent work has established that digital images of a human face, when collected with a fixed pose but under a variety of illumination conditions, possess discriminatory information that can be used in classification. In this paper we perform classification on Grassmannians to demonstrate that sufficient discriminatory information persists in feature patch (e.g., nose or eye patch) illumination spaces. We further employ the use of Karcher mean on the Grassmannians to demonstrate that this compressed representation can accelerate computations with relatively minor sacrifice on performance. The combination of these two ideas introduces a novel perspective in performing face recognition.

关键词： Grassmannians Karcher Mean Face Recognition Illumination Spaces Compressions Feature Patches Principal Angles

Personalising pancreas cancer treatment:When tissue is the issue

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World Journal of Gastroenterology 2014年第24期20卷 7849-7863页

作者： Katrin M Sjoquist Venessa T chin Lorraine A Chantrill Chelsie O'Connor chris Hemmings David K chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip NHMRC Clinical Trials Centre University of SydneySydney NSW 1450Australia Cancer Care Centre St George HospitalKogarah NSW 2217Australia The Kinghorn Cancer Centre and the Cancer Research ProgramGarvan Institute of Medical ResearchSydney NSW 2010Australia Macarthur Cancer Therapy Centre Campbelltown HospitalCampbelltown NSW 2560Australia St Vincents Hospital Clinical School Sydney UNSW 2010Australia Cancer Therapy Centre Liverpool HospitalLiverpool NSW 2170Australia St John of God Pathology Subiaco WA 6904Australia Department of Surgery Bankstown HospitalEldridge RoadBankstownSydney NSW 2200Australia Faculty of Medicine South Western Sydney Clinical SchoolUniversity of NSWLiverpool NSW 2170Australia Wolfson Wohl Cancer Research Centre Institute of Cancer SciencesUniversity of GlasgowGlasgow G61 1BDUnited Kingdom Department of Anatomical Pathology St.Vincent’s HospitalDarlinghurstSydney NSW 2010Australia West of Scotland Pancreatic Unit Glasgow Royal InfirmaryGlasgow G4 0SFUnited Kingdom Department of Medical Oncology The Canberra HospitalGarran ACT 2605Australia ANU Medical School Australian National UniversityActon ACT 2601Australia

The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved *** in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease *** has allowed identification of potentially actionable mutations that may be targeted by new biological *** heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the *** paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice.

关键词： Pancreatic neoplasms Molecular targeted therapy Genomics Tissue banks Chemotherapy

A semi-analytical rate-transient analysis model for light oil reservoirs exhibiting reservoir heterogeneity and multiphase flow

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Petroleum Science 2023年第1期20卷 309-321页

作者： Jin-chang Li Bin Yuan christopher R.Clarkson Jian-Quan Tian Key Laboratory of Unconventional Oil&Gas Development(china University of Petroleum(East china)) Ministry of EducationQingdao266580ShandongPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Department of Geoscience University of CalgaryABT2L2N5Canada

Rate-transient analysis(RTA)has been widely applied to extract estimates of reservoir/hydraulic fracture ***,the majority of RTA techniques can lead to misdiagnosis of reservoir/fracture information when the reservoir exhibits reservoir heterogeneity and multiphase flow *** work proposes a practical-yet-rigorous method to decouple the effects of reservoir heterogeneity and multiphase flow during TLF,and improve the evaluation of reservoir/fracture properties.A new,general,semi-analytical model is proposed that explicitly accounts for multiphase flow,fractalbased reservoir heterogeneity,anomalous diffusion,and pressure-dependent fluid *** is achieved by introducing a new Boltzmann-type transformation,the exponent of which includes reservoir heterogeneity and anomalous *** order to decouple the effects of reservoir heterogeneity and multiphase flow during TLF,the modified Boltzmann variable allows the conversion of three partial differential equations(PDE's)(i.e.,oil,gas and water diffusion equations)into ordinary differential equations(ODE's)that are easily solved using the Runge-Kutta(RK)method.A modified time-power-law plot is also proposed to estimate the reservoir and fracture properties,recognizing that the classical square-root-of-time-plot is no longer valid when various reservoir complexities are exhibited *** the slope of the straight line on the modified time-power-law plot,the linear flow parameter can be estimated with more ***,because of the new Boltzmann-type transformation,reservoir and fracture properties can be derived more efficiently without the need for defining complex pseudo-variable *** the new semi-analytical model,the effects of multiphase flow,reservoir heterogeneity and anomalous diffusion on rate-decline behavior are *** the case of approximately constant flowing pressure,multiphase flow impacts initial oil rate,which is a funct

关键词： Transient linear flow Multiphase flow Reservoir heterogeneity Unconventional reservoirs

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中国新零售

商业周刊（中文版） 2018年第22期 32-33页

作者： Rachel chang chris Philpot(插图)

面对渴望新奇和能快速适应新技术的消费者，中国的零售商比西方同行更有可能去冒险，推出一些可能仍处在测试阶段、在更注重隐私保护的市场可能会遭到抵制的模式和功能。在阿里巴巴集团和腾讯控股有限公司等科技巨头的带领下，中国企业... 详细信息

面对渴望新奇和能快速适应新技术的消费者，中国的零售商比西方同行更有可能去冒险，推出一些可能仍处在测试阶段、在更注重隐私保护的市场可能会遭到抵制的模式和功能。在阿里巴巴集团和腾讯控股有限公司等科技巨头的带领下，中国企业正在测试一系列新概念，如人脸识别支付系统和全自动便利商店。它们吸引了全世界的目光。

关键词：中国企业零售商阿里巴巴集团测试阶段隐私保护便利商店支付系统人脸识别

分布式发电反孤岛控制的自动加速相移方法（英文）

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电力科学与技术学报 2014年第3期 5-12页

作者：张榴晨 Mary Kaye chris Diduch 尹俊纽布伦斯维克大学电气与计算机工程系

分布式发电反孤岛技术的最新研究进展表明,相移法能有效用于具有逆变器的分布式发电系统反孤岛保护。介绍滑模频率偏移(SMS)、主动频率偏移(AFD)和带正反馈的主动频率偏移(AFDPF)。自动相移法(APS)是一种改进的SMS法,减少了SMS的测区盲... 详细信息

分布式发电反孤岛技术的最新研究进展表明,相移法能有效用于具有逆变器的分布式发电系统反孤岛保护。介绍滑模频率偏移(SMS)、主动频率偏移(AFD)和带正反馈的主动频率偏移(AFDPF)。自动相移法(APS)是一种改进的SMS法,减少了SMS的测区盲区(NDZ)。但稳定孤岛效应的频率确定困难,而且APS运行慢,并可能在某些特定条件下失效。基于目前存在的难题,该文提出一种改进的自动加速相移算法(AAPS),矫正孤岛效应下的附加相位漂移,评价总电压相位漂移对电压周期的影响。该算法在孤岛发生时,会引起快速的相移,但在电网互联时只会引起极小的相位。孤岛发生时,该算法通过逆变器相移正反馈实现。仿真和实验结果证明了AAPS算法的有效性。先进的AAPS已经被应用于风能和太阳能系统的商业并网逆变器中,并符合UL/CSA认证标准要求。各种条件下的认证测试结果表明APPS算法可以在极短的时间内断开逆变器。

关键词：分布式发电电网互联反孤岛自动移相逆变器

西藏恰功铁矿岩浆演化序列及斑岩出溶流体特征

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地质学报 2009年第12期83卷 1869-1886页

作者：谢玉玲李应栩 Zhaoshan chang David R. COOKE chris G. RYAN Jamie LAIRD 白劲松刘云飞李光明张丽北京科技大学土木与环境工程学院资源工程系北京100083 塔斯马尼亚大学优秀矿床研究中心 TAS7001澳大利亚澳大利亚联邦科工组织(CSIRO)矿业勘查研究院墨尔本大学物理学院VIC3010澳大利亚国土资源部成都地质矿产研究所矿产资源室成都610081

冈底斯成矿带是碰撞造山过程形成的最重要的成矿带,恰功矽卡岩铁(铜)矿床即位于冈底斯成矿带中部。本文在详细的野外地质填图和室内研究基础上确定了恰功铁矿与成矿有关的斑岩体为二长花岗斑岩,锆石的U-Pb定年结果为68.8±2.2Ma,明显早... 详细信息

冈底斯成矿带是碰撞造山过程形成的最重要的成矿带,恰功矽卡岩铁(铜)矿床即位于冈底斯成矿带中部。本文在详细的野外地质填图和室内研究基础上确定了恰功铁矿与成矿有关的斑岩体为二长花岗斑岩,锆石的U-Pb定年结果为68.8±2.2Ma,明显早于冈底斯东部与后碰撞伸展有关的斑岩型矿床和主碰撞期形成的矽卡岩型矿床,其应代表了冈底斯一次尚未被充分认识到的成矿事件。通过对成矿斑岩的岩石学、岩石化学、岩浆出溶流体的包裹体岩相学、显微测温分析及包裹体成分的LRM、LA-ICP-MS和PIXE分析,本文探讨了与该矽卡岩矿床有关的斑岩的岩浆起源、斑岩侵位机制及出溶流体特征。结果表明,成矿斑岩为矿区最早的侵入岩单元,具有壳幔源混源特征,其常量元素组成与冈底斯东部斑岩铜矿带的埃达克质岩相近,但稀土和微量元素组成与东部斑岩明显不同,为地幔物质上涌并诱发角闪岩相下地壳熔融的产物,岩体侵位深度大(>7km)、剥蚀程度高。早期岩浆出溶的流体为高温、高压、高盐度流体,其中富含Fe、Pb、Zn、Cu等成矿金属,与世界其他斑岩铜矿床相比,相对富铁、铅而贫铜。流体的沸腾作用发生于钾硅化阶段,形成了一套富气、高盐、高固相和气液包裹体组合,不同于早期出溶流体的包裹体组合。从岩浆起源和出溶流体性质可以看出,该斑岩具有形成与斑岩有关的铁铅多金属矿床的成矿潜力,但从该矿区地表出露的蚀变和包裹体测压结果可以看出,该斑岩体目前剥蚀深度较大,对斑岩型矿床保存不利,对该斑岩体及与成矿关系的认识对理解该区内的矿床成因和指导区域找矿具有重要的指示意义。

关键词：冈底斯成矿带恰功铁矿斑岩岩石化学流体包裹体 PIXE

Microdebrider complications in sinus surgery:Analysis of the openFDA database

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第4期9卷 328-332页

作者： Elias S.Saba Jacob Hoerter Jeremy chang David W.Chou chris Xiao Jacob G.Eide Rijul S.Kshirsagar James N.Palmer Nithin D.Adappa Department of Head and Neck Surgery Kaiser Permanente Oakland Medical CenterOaklandCaliforniaUSA Department of Otorhinolaryngology‐Headand Neck Surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Otolaryngology‐Head and Neck Surgery Mount Sinai Medical CenterNew YorkNew YorkUSA Department of Otorhinolaryngology‐Head and Neck Surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:Functional endoscopic sinus surgery is a commonly performed otolaryngologic procedure that often uses the microdebrider device for tissue *** the ubiquitous nature of the instrument,we sought to better define the patterns of device failure using the postmarket surveillance openFDA ***:The openFDA database was queried for all microdebrider‐related adverse events from January 1,2000 to November 1,*** information on the nature of device failure and any associated patient injury was *** not directly related to device failure were excluded from the ***:A total of 641 events were included in the *** most common device failure was overheating(n=348,54.3%),followed by material separation(n=173,27%),and inconsistent device activation(n=52,8.1%).Of the reported events,the vast majority did not result in patient harm(n=579,90.3%).On review of the remaining cases,only 24 events(3.7%)resulted in true harm to the patient,defined as a temporary or permanent injury or>30 min of additional anesthesia *** these cases,the need to reschedule surgical cases(n=5,0.8%),retained foreign body(n=5,0.8%),and thermal tissue injury(n=3,0.5%)were the most *** patients suffered an injury due to surgeon error unrelated to device malfunction(n=5,0.8%).Conclusions:Microdebrider device failures are extremely *** they do occur,less than 10%result in patient *** cases of patient harm related to microdebrider failure,preoperative testing of the device before use could prevent many of the reported malfunctions.

关键词： device failure microdebrider openFDA outcomes sinus