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Personalising pancreas cancer treatment:When tissue is the issue

World Journal of Gastroenterology 2014年第24期20卷 7849-7863页

作者： Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor chris hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip NHMRC Clinical Trials Centre University of SydneySydney NSW 1450Australia Cancer Care Centre St George HospitalKogarah NSW 2217Australia The Kinghorn Cancer Centre and the Cancer Research ProgramGarvan Institute of Medical ResearchSydney NSW 2010Australia Macarthur Cancer Therapy Centre Campbelltown HospitalCampbelltown NSW 2560Australia St Vincents Hospital Clinical School Sydney UNSW 2010Australia Cancer Therapy Centre Liverpool HospitalLiverpool NSW 2170Australia St John of God Pathology Subiaco WA 6904Australia Department of Surgery Bankstown HospitalEldridge RoadBankstownSydney NSW 2200Australia Faculty of Medicine South Western Sydney Clinical SchoolUniversity of NSWLiverpool NSW 2170Australia Wolfson Wohl Cancer Research Centre Institute of Cancer SciencesUniversity of GlasgowGlasgow G61 1BDUnited Kingdom Department of Anatomical Pathology St.Vincent’s HospitalDarlinghurstSydney NSW 2010Australia West of Scotland Pancreatic Unit Glasgow Royal InfirmaryGlasgow G4 0SFUnited Kingdom Department of Medical Oncology The Canberra HospitalGarran ACT 2605Australia ANU Medical School Australian National UniversityActon ACT 2601Australia

The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved *** in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease *** has allowed identification of potentially actionable mutations that may be targeted by new biological *** heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the *** paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice.

关键词： Pancreatic neoplasms Molecular targeted therapy Genomics Tissue banks Chemotherapy

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