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Nitroglycerin reduces augmentation index and central blood pressure independent of effects on cardiac preload

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Journal of pharmaceutical Analysis 2009年第2期21卷 114-119页

作者： Mike Saddon Karen McNeil philip chowienczyk Cardiovascular Division King's College London School of MedicineSt Thomas' Hospital

Objective To determine whether reduction in central pressure augmentation and central systolic blood pressure by nitroglycerine (NTG) results from effects on pre-load or is due to arterial dilation. Methods We compared effects of NTG with those of lower body negative pressure (LBNp). Hemodynamic measurements were made at rest,during LBNp (10,20 and 30 mmHg,each for 15 min) and after NTG (10,30 and 100 μg/min,each dose for 15 min) in ten healthy volunteers. Cardiac pre-load,stroke volume and cardiac output were assessed by echocardiography. Central pressure augmentation and central systolic pressure were obtained by radial tonometry using a transfer function. Results LBNp (20 mmHg) and NTG (30 μg/min) reduced pre-load (as measured by the peak velocity of the S wave in the superior vena cava) to a similar degree [by (26.8±3.8)% and (23.9±3.4)%,respectively]. Compared to LBNp,NTG reduced systemic vascular resistance [by (32.9±7.5)%,pperipheral and central pressure augmentation [by (20.8±3.4)% units and (12.9±2.9)% units,respectively,each ppre-load does not explain reduction in pressure augmentation and central systolic blood pressure by NTG and that these effects are mediated through arterial dilation.

关键词： augmentation index central blood pressure nitroglycerine cardiac preload lower body negative pressure

心脏前负荷减低对主动脉压及主动脉扩增指数的影响

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西安交通大学学报（医学版） 2009年第1期30卷 74-78页

作者：刘保民牛小麟 JIANG Ben-yu SADDON Mike MCNEIL Karen chowienczyk philip 西安交通大学医学院第二附属医院心内科陕西西安710004 英国国王学院临床药理心血管中心伦敦SE1 7EH英国

目的了解心脏前负荷减低对中心动脉压及主动脉扩增指数的影响。方法10例健康志愿者,行下肢负压(LB-Np)抽吸造成不同程度前负荷减低。采用超声心动图检测心输出量的变化;采用中心动脉压力分析系统(SphymoCor)检测桡动脉压力波形,经平均... 详细信息

目的了解心脏前负荷减低对中心动脉压及主动脉扩增指数的影响。方法10例健康志愿者,行下肢负压(LB-Np)抽吸造成不同程度前负荷减低。采用超声心动图检测心输出量的变化;采用中心动脉压力分析系统(SphymoCor)检测桡动脉压力波形,经平均转换功能形成中心动脉压力波形。结果①随着下肢负压的加大,上腔静脉血流进行性减低,在-30mmHg阶段,S波减低22.4%,VTIs+d减低了15.8%,同时SV减少24.7%,CO减少18.7%;②中心动脉收缩压(CSBp)除在-30mmHg阶段轻度下降外,在-10及-20mmHg阶段没有明显改变,中心动脉舒张压(CDBp)在各个负压阶段没有明显改变;③主动脉压力波p1在各个负压阶段均明显下降,在-30mmHg阶段,p1减少了19.6%[(28.2±5.02)mmHgvs.(22.65±3.08)mmHg,ppR)在各负压阶段均较基础阶段明显升高,在-30mmHg阶段升高21.3%[(16.0±2.9)(***)/Lvs.(20.3±3.4)(***)/L,pp1降低,同时使TpR升高,由于TpR的升高抵消了p1的降低,因而AI保持不变。

关键词：前负荷中心动脉压扩增压扩增指数下肢负压主动脉压总外周阻力

旅英华人与当地白人血管内皮功能的对比性研究

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中华高血压杂志 2010年第1期18卷 50-53页

作者：张晓东 Maniou Z chowienczyk phil Jiang B 福建医科大学附属厦门市第一医院超声科福建厦门361004 Department of Clinical pharmacology St.Thomas' HospitalKing's College of London

目的研究旅英华人和当地白人血管内皮功能有无差异。方法选取年龄、性别相似的旅英华人和当地白人各40名(男女各20名),检测体质量、身高、腰围、血压、血脂、血糖、血流介导的内皮依赖性血管舒张功能(FMD)等,比较两组检测结果,并分析心... 详细信息

目的研究旅英华人和当地白人血管内皮功能有无差异。方法选取年龄、性别相似的旅英华人和当地白人各40名(男女各20名),检测体质量、身高、腰围、血压、血脂、血糖、血流介导的内皮依赖性血管舒张功能(FMD)等,比较两组检测结果,并分析心血管危险因素、种族与FMD的相关性。结果旅英华人的舒张压、FMD较当地白人高[舒张压(80.2±9.1)比(75.1±11.3)mmHg;FMD(6.76±2.95)%比(5.52±2.13)%,均ppp<0.05)。结论旅英华人的血管内皮功能优于当地白人,可能与种族因素、饮食习惯相关。

关键词：血流介导的内皮依赖性血管舒张功能旅英华人白人

Hypertension：健康人的血压是由酶nNOS调节的

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现代生物医学进展 2017年第11期17卷 I0003-I0004页

作者： Husain Shabeeh Sitara Khan Benyu Jiang Sally Brett Narbeh Melikian Barbara Casadei philip J. chowienczyk Ajay M. Shah From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.). From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.). From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.). From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.). From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.). From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.). From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.). From the King’s College London British Heart Foundation Centre Cardiovascular Division United Kingdom (H.S. S.K. B.J. S.B. N.M. P.J.C. A.M.S.) and Department of Cardiovascular Medicine University of Oxford United Kingdom (B.C.).

在一项新的研究中。来自英国伦敦国王学院的研究人员发现调节血压的一氧化氮（NO）是在神经组织中而不是在血管壁中形成的。这一发现可能导致人们开发出更加有效地治疗高血压的方法。

关键词：高血压 nNOS 健康人神经组织一氧化氮研究人员酶血管壁

British Journal of General practice论文摘要汇编——2000—2017年肺癌表现症状的变化:英国初级保健观察记录的横断面研究

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中国全科医学 2020年第15期23卷 1960-1960页

作者：本刊编辑部(整理) chowienczyk S pRICE SHAMILTON W College of Medicine and Health University of Exeter Exeter. College of Medicine and Health University of Exeter Exeter. College of Medicine and Health University of Exeter Exeter.

背景大多数被诊断出肺癌的患者都有临床症状。目前尚不清楚出现每种症状的患者比例是否随时间推移而发生变化。确定肺癌的症状趋势对于肺癌医学教育和肺癌早期诊断都具有重要意义。目的确定首次报告的可能的肺癌症状(索引症状),并计算20... 详细信息

背景大多数被诊断出肺癌的患者都有临床症状。目前尚不清楚出现每种症状的患者比例是否随时间推移而发生变化。确定肺癌的症状趋势对于肺癌医学教育和肺癌早期诊断都具有重要意义。目的确定首次报告的可能的肺癌症状(索引症状),并计算2000-2017年每种索引症状的患者百分比是否发生变化。设计与场所采用英国临床实践研究数据链(CpRD)数据和癌症登记数据,进行连续的横断面观察研究。方法2000-01-01至2017-12-31,确定肺癌患者的索引症状。搜索美国国立卫生研究院(NICE)疑似癌症转诊指南中的癌症症状。搜索时间限定在确诊前一年。使用广义线性模型(具有二项函数)检验2000-2017年每种症状的患者百分比是否发生变化。结果咳嗽〔OR=1.01,95%CI(1.00,1.02),pppp<0.0001)。结论在2000-2017年,具有咳嗽或呼吸困难症状的肺癌患者比例增加,而具有咯血症状的患者比例下降。这种趋势对肺癌医学教育和肺癌症状认知具有启示作用。

关键词：呼吸困难症状医学教育初级保健肺癌早期诊断广义线性模型横断面研究咯血临床实践

Relation of ventricular structure and function to arterial stiffness in healthy women

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Relation of ventricular structure and function to arterial s...

中国超声医学工程学会第十四届全国超声心动图学术会议

作者： Jing Zhang Benyu Jiang Mingxing Xie Jing Wang Haotian Gu Tim Spector phil J.chowienczyk Department of Ultrasonography Union Hospital of Tongji Medical Collegehuazhong University of Science and TechnologyHubei Provincial Key Laboratory of Molecular Imaging King's College London British Heart Foundation Centre Department of Clinical Pharmacology

Amis:To examine the relationship between arterial stiffness and ventricular structure and function in healthy *** and Results:Healthy women from the Twins UK cohort(n=147,mean ± SD age 54.1 ±11.9 years) were *** stiffness was evaluated by carotid-femoral pulse wave velocity(cf-pWV).Left ventricular(LV) structure and function were assessed by two dimensional speckle tracking ***-pWV was significantly associated with most measures of LV geometry and function,including relative wall thickness(RWT),global circumferential and radial strain,apical rotation and LV twist(each ppressure and heart rate,cf-pWV was significantly correlated with RWT,global circumferential strain,apical rotation and LV twist(β=0.011,)0.484,1.167 and 1.089,respectively,each p ptation to increased arterial stiffening.

关键词： Arterial stiffness Left ventricular hypertrophy Left ventricular twist Speckle tracking echocardiography

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超声在血管内皮功能研究中的应用

中华医学超声杂志（电子版） 2010年第5期7卷 12-15页

作者：张晓东 Maniou Z chowienczyk phil Jiang B 厦门大学附属第一医院超声科厦门361004 Department of Clinical pharmacology St Thomas＇ Hospital King＇ s College of London

目的探讨超声在血管内皮功能研究中的应用价值。方法选取年龄、性别匹配的旅英华人和当地白人各40名,检测体重、腰围、体重指数(BMI)、血压、血脂、血糖,并采用超声检测血流介导的肱动脉内径扩张值(FMD),对两组检测结果进行比较,并分析... 详细信息

目的探讨超声在血管内皮功能研究中的应用价值。方法选取年龄、性别匹配的旅英华人和当地白人各40名,检测体重、腰围、体重指数(BMI)、血压、血脂、血糖,并采用超声检测血流介导的肱动脉内径扩张值(FMD),对两组检测结果进行比较,并分析心血管危险因素、种族与FMD值的相关性。结果华人组的舒张压、FMD值较白人组高(ppp<0.05),种族因素与FMD值具有相关性。结论超声检测FMD值法是一种无创、可靠、简便易行的检测血管内皮功能的方法。规范检查方法是保证检查质量的关键。

关键词：超声检查血流介导的肱动脉扩张值法血管内皮

Evaluation of global cardiac systolic performance and diastolic filling in central hypovolumia by lower body negative pressure with Doppler echocardiography

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Journal of Nanjing Medical University 2007年第4期21卷 227-232页

作者： Baomin Liu Xiaolin Niu Benyu Jiang Mike Seddon Keren McNeil philip chowienczyk Department of cardiology the second hospital of Xi＇n Jiaotong university Xi＇an 710004 Shanxi Province China Department of Clinical pharmacology St. Thomas hospital of King＇s College London SEI 7EH U.K.

Objective ：To overall evaluate the change of global cardiac systolic performance and diastolic filling in hypovoleamia by LBNp, Methods：10 healthy male subjects were placed in a standard LBNp chamber. Baseline haemodynamic and echocardiographic measurements were made after a period of least 10 min resting supine within the chamber. pressure was then decreased to -10,-20 and -30 mmHg, with each pressure maintained for 15 rain. The indices of four transvalvular and SVC flow were measured using Doppler echocardiography. Results ：The results showed that S wave, Re wave ,and VTI of SVC progressively decreased with increasing LBNp. At -30 mmHg stage, S wave decreased by 35.4 % （change of 0.21±0.03 m/s, p 〈 0.001）. This reduction in pre-load Was associated with a progressive decrease in SV（by 21.5 ± 4.5 ml at -30 mmHg,p 〈 0.001 ）, decrease in CO（by 1.2 ± 0.2 L min^-1 at -30 mmHg LBNp,p 〈 0.001 ）. The diastolic filling of mitral and tricuspid flow also reduced significantly. At -30 mmHg stage, the E wave of MVF and TVF decreased 31% and 32% respectively （change of 0.23 ± 0.05 m/s,p 〈 0.001 and 0.18 ± 0.01 m/s,p 〈 0.001）. VTI of MVF and TVF decreased 27% and 27.7% respectively（change of 5.55 ± 1.41cm,p 〈 0.01 and 4.25 ± 0.44 cm,p 〈 0.01）. A wave of both sides did not change significantly. Conclusion：Doppler indices changes in different LBNp stage can roughly reflect the degree of hypovoleamia caused by blood volume redistribution. The indices of Doppler echocardiography are more sensitive than traditional physiological indexes in evaluating cardiovascular responses of LBNp. Echocardiography techniques overall can evaluate the global cardiac function including systolic performance and diastolic filling.

关键词： function heart echocardiography lower body negative pressure

口服抗氧化剂raxofelast可降低男性Ⅱ型糖尿病患者的氧化应激及改善内皮功能

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Oncology and Translational Medicine 2001年第6期 17-18页

作者： p.J.chowienczyk,S.E.Brett,N.K.Gopaul,D.Meeking,M.Marchetti,D.L.Russell-Jones,E.E.(?)ngg(?)rd,J.M.Ritter,袁刚 Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road Department of Clinical pharmacology St Thomas’Hospital Lambeth palace Road 华中科技大学同济医学院附属同济医院 London SE1 7EH UK London SE1 7EH UK London SE1 7EH UK London SE1 7EH UK London SE1 7EH UK London SE1 7EH UK London SE1 7EH UK London SE1 7EH UK

Ⅱ型糖尿病以氧化应激增加和内皮功能紊乱为特征。二者在动脉粥样硬化性疾病发生和发展中起重要作用。短期动脉注射维生素C能增加Ⅱ型糖尿病患者内皮依赖的血管舒张反应,提示内皮功能障碍继发于氧化应激增加,可能原因为活性氧族如过氧... 详细信息

Ⅱ型糖尿病以氧化应激增加和内皮功能紊乱为特征。二者在动脉粥样硬化性疾病发生和发展中起重要作用。短期动脉注射维生素C能增加Ⅱ型糖尿病患者内皮依赖的血管舒张反应,提示内皮功能障碍继发于氧化应激增加,可能原因为活性氧族如过氧化物阴离子阻断内皮来源的NO。为了解口服抗氧化剂能否降低Ⅱ型糖尿病患者氧化应激及改善内皮功能,我们研究一种新的类维生素E的水溶性抗氧化剂raxofelast在糖尿病及正常人中的作用。检测血浆8-epi-pGF2α浓度表示氧化应激,输注乙酰胆碱后血管的反应性表示内皮功能。

关键词： Ⅱ型糖尿病二型糖尿病氧化应激内皮功能患者抗氧化剂