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Mitochondrial DNA mutations-candidate biomarkers for breast cancer diagnosis in Bangladesh

Chinese Journal of Cancer 2012年第9期31卷 449-454页

作者： Gazi Nurun Nahar Sultana Atiqur Rahman Abu Din Ahmed Shahinuzzaman Rowshan Ara Begum chowdhury faiz hossain Centre for Advanced Research in Sciences University of DhakaDhaka 1000Bangladesh Department of Microbiology University of DhakaDhaka 1000Bangladesh Department of Genetic Engineering and Biotechnology University of DhakaDhaka 1000Bangladesh National Cancer Research Institute and Hospital MohakhaliDhaka 1212Bangladesh East West University MohakhaliDhaka 1212Banglades

Breast cancer is a major health problem that affects more than 24% of women in Bangladesh. Furthermore, among low-income countries including Bangladesh, individuals have a high risk for developing breast cancer. This study aimed to identify candidate mitochondrial DNA (mtDNA) biomarkers for breast cancer diagnosis in Bangladeshi women to be used as a preventive approach. We screened the blood samples from 24 breast cancer patients and 20 healthy controls to detect polymorphisms in the D-loop and the ND3-and ND4-coding regions of mtDNA by direct sequencing. Among 14 distinct mutations, 10 polymorphisms were found in the D-loop, 3 were found in the ND3-coding region, and 1 was found in the ND4-coding region. The frequency of two novel polymorphisms in the D-loop, one at position 16290 (Tins) and the other at position 16293 (A-del), was higher in breast cancer patients than in control subjects (position 16290: odds ratio = 6.011, 95% confidence interval = 1.2482 to 28.8411, P = 0.002; position 16293: odds ratio = 5.6028, 95% confidence interval = 1.4357 to 21.8925, P = 0.010). We also observed one novel mutation in the ND3-coding region at position 10316 (A > G) in 69% of breast cancer patients but not in control subjects. The study suggests that two novel polymorphisms in the D-loop may be candidate biomarkers for breast

关键词：线粒体DNA突变生物标志物孟加拉国乳腺癌诊断基因编码区基因多态性 D-loop区

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Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys: A review

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Journal of Magnesium and Alloys 2023年第9期11卷 3038-3058页

作者： chowdhury Ahmed Shahed faiz Ahmad Ebru Günister Farhana Mohd Foudzi Saad Ali Khurshid Malik Wan Sharuzi Wan Harun Department of Mechanical Engineering Universiti Teknologi PETRONAS(UTP)32610Seri IskandarPerakMalaysia Faculty of Engineering and Natural Sciences Department of Mechanical EngineeringIstanbul Health and Technology UniversityIstanbulTurkey Department of Mechanical and Manufacturing Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Faculty of Mechanical&Automotive Engineering Technology Universiti Malaysia Pahang26600 PekanPahangMalaysia

Benefits achieved by the biodegradable magnesium(Mg) and zinc(Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver(Ag), copper(Cu), lithium(Li), and gallium(Ga). Copper ions(Cu^(2+)) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion(Ag^(+)) kills bacteria by creating bonds with the thiol group. Gallium ion(Ga^(3+)) inhibits ferric ion(Fe^(3+)) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species(ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions.

关键词： Biodegradable materials Biomedical implants Antibacterial mechanism Cytotoxicity Reactive oxygen species

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