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Baccaurea ramiflora: Isolation of Aldehydes and in Vitro Biological Investigations

Pharmacology & Pharmacy 2020年第7期11卷 147-157页

作者： Sangita Debnath Puja choudhury mahmood hasan Monira Ahsan Department of Pharmaceutical Chemistry University of Dhaka Dhaka Bangladesh

The stem bark of Baccaurea ramiflora was studied. Four aldehydes named as 3 methoxy 4 hydroxy-cinnamaldehyde (coniferyl aldehyde);3, 4, 5 trimethoxy cinnamaldehyde;3, 4, 5 trimethoxy benzaldehyde and 3,4 dimethoxy benzaldehyde) (veratraldehyde) have been isolated and then identified by NMR spectroscopy. All of them are first time reported for this plant. Here in vitro biological investigations include antioxidant and cytotoxicity study. Among all fractions, the chloroform soluble fraction exhibited strong free radical scavenging activity having IC50 value of 12.87 μg/ml compared to BHT (IC

关键词： Baccaurea ramiflora Aldehyde NMR Spectroscopy Antioxidant Cytotoxicity

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Flavonoids from the Leaves of Bridelia stipulariswith in VitroAntioxidant and Cytotoxicity Activity

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Pharmacology & Pharmacy 2020年第7期11卷 137-146页

作者： Sangita Debnath Puja Kazi Ruhullah Shahriar choudhury mahmood hasan Monira Ahsan Department of Pharmaceutical Chemistry University of Dhaka Dhaka Bangladesh Department of Pharmacy State University of Bangladesh Dhaka Bangladesh

Methanolic extract of the leaves of Bridelia stipularis was studied. From this study, we isolated three known flavonoids. They were identified as 7-O-methyl luteolin, apigenin and 5, 7, 2’, 5’ tetrahydroxyflavone by NMR spectroscopic studies. All of them are first time documented for this plant. Different solvent fractions were subjected to in vitro antioxidant and cytotoxicity studies. Both apigenin and ethyl acetate soluble fraction of Bridelia stipularis showed strong antioxidant activity having IC50 value of 8.005, 8.77 μg/mL respectively. Chloroform soluble fraction of Bridelia stipularis exerted the highest toxicity to brine shrimp and petroleum ether soluble fraction showed moderate toxicity having LC50 value of 1.05, 1.71 μg/mL respectively.

关键词： Bridelia stipularis Flavonoid Antioxidant Cytotoxicity

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Isolation of Two Furanoditerpenes and Two Triterpenes from the Stem Bark of Dalbergia lanceolariaL.f.

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Pharmacology & Pharmacy 2019年第12期10卷 519-527页

作者： Sharmin Sultana Fakir Shahidullah Tareq Khondaker Miraz Rahman choudhury mahmood hasan Department of Pharmacy University of Asia Pacific Dhaka Bangladesh Department of Pharmacy Manarat International University Dhaka Bangladesh School of Cancer & Pharmaceutical Sciences King’s College London London UK Department of Pharmaceutical Chemistry University of Dhaka Dhaka Bangladesh

Stem bark of Dalbergia lanceolaria was subjected to methanolic extraction and extensive phytochemical separation. The process yielded four known compounds namely Jateorin (1), Columbin (2), β-sitosterol (3), and Lupeol (4). The compounds were identified using nuclear magnetic resonance spectral data namely 1H NMR, 13C NMR, 1H-1H COSY, HMBC, and DEPT-135 and verified by comparing the data with previous literature. All four compounds are being reported for the first time from the species D. lanceolaria. Furthermore, two furanoditerpenes namely Jateorin and Columbin are reported for the first time from the genus Dalbergia. This may lead to potential identification of a new chemotaxonomic marker for this genus.

关键词： Dalbergia lanceolaria Fabaceae Jateorin Columbin Furanoditerpene 1HNMR

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Antioxidant, Cytotoxic, Thrombolytic and Antimicrobial Activity of Zanthoxylum rhetsaRoot Bark with Two Isolated Quinolone Alkaloids

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Pharmacology & Pharmacy 2019年第3期10卷 137-145页

作者： Fatema Tuz Zohora Sheikh Nazrul Islam Shibbir Ahmed Khan choudhury mahmood hasan Monira Ahsan Department of Pharmaceutical Chemistry University of Dhaka Dhaka-1000 Bangladesh Department of Pharmacy Manarat International University Dhaka Bangladesh Institute of Nutrition and Food Science University of Dhaka Dhaka-1000 Bangladesh

The background of this study was to investigate the antioxidant, cytotoxic, thrombolytic and antimicrobial activity of the petroleum ether (PE), carbon tetrachloride (CTC), chloroform (CF) and aqueous (AQ) soluble fractions of crude methanolic Zanthoxylum rhetsa root bark with two isolated quinolone alkaloids, 8-methoxy-n-methylflindersine (1) and zanthodioline (2). Structures were characterized by 1D NMR analyses. Antioxidant activity was assessed by using DPPH assay and antimicrobial activity was screened by disc diffusion method. An in vitro thrombolytic model was used to evaluate the clot lysis effect of different extracts of root bark of Z. rhetsa along with streptokinase as a positive control and distilled water as a negative control and the cytotoxic activity of different extracts of Z. rhetsa root bark was evaluated by Brine Shrimp Lethality Bioassay. AQ fraction exhibited strongest antioxidant, cytotoxic and thrombolytic activity among four fractions. The CTC and CF soluble fractions exhibited significant antioxidant, cytotoxic and thrombolytic activity. CTC and AQ fractions gave highest anti-bacterial activity against Vibrio cholera and Klebsiella pneumonia respectively. Compound 1 showed significant activity at a concentration of 100 μgm/disc against Sarcina lutea, Staphylococcus aureus and Salmonella paratyphi-A, Shigella dysenteriae, Shigella boydii and Shigella sonnei with high antioxidant activity. The antioxidant, thrombolytic and antimicrobial activity of 8-methoxy-n-methylflindersine and zanthodioline are the first record from root bark of this plant.

关键词： Zanthoxylum rhetsa Antioxidant Thrombolytic Antimicrobial 8-Methoxy-n-Methylflindersine Zanthodioline

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