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Pancreatic parenchymal injection of ethanol and octreotide to induce focal pancreatic fibrosis in rats: Strategies to eliminate postoperative pancreatic fistula

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 81-85页

作者： Soo Ho lee tae Ho Hong Department of Surgery Uijeongbu St.Mary’s Hospital College of Medicine The Catholic University of Korea Department of Surgery Seoul St.Mary’s Hospital College of Medicine The Catholic University of Korea

Background: Postoperative pancreatic fistula(POPF) is more likely to occur in a soft pancreas compared to a hard pancreas in which fibrosis has progressed. There is almost no leakage at the anastomosis site or cut surface of a hard pancreas. The aim of this study was to induce localized fibrosis at the cut surface of the pancreas in a rat ***: Thirty-six rats were divided into three groups(group S: normal saline group; group E: ethanol group; and group O: octreotide group). Each rat was directly injected with a particular compound at the duodenal lobe of the pancreatic parenchyma. Each group was divided into three subgroups according to the time of post-injection sacrifice(1, 2, or 4 weeks). The hardness, suture holding capacity(SHC), and histological fibrosis grade of each pancreas were ***: The hardness, SHC, and fibrosis grade of groups E and O were increased at week 1, with greater increases in group E(all P < 0.001). In a subgroup comparison, the hardness, SHC, and fibrosis grade of group E tended to decrease gradually over time, with no regular pattern evident in group O. A comparison between the injected site(duodenal lobe) and non-injected site(splenic lobe) of the pancreas revealed increases in the three parameters of group E only in the duodenal lobe, with increases in group O at both the duodenal and splenic ***: Parenchymal injection of ethanol and octreotide increased pancreatic fibrosis. Unlike octreotide, ethanol provoked localized fibrosis that was maintained over time. It is expected that ethanol injection could eliminate POPF during pancreatic surgery.

关键词： Ethanol Octreotide Pancreatic fibrosis Pancreatic fistula Rat model

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Estimation of deformed laser heat sources and thermal analysis on laser assisted turning of square member

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Journal of Central South University 2012年第2期19卷 402-407页

作者： KIM Jae-hyun KIM Kwang-sun CHOI Jun-young lee choon-man Department of Mechanical Design and Manufacturing Engineering Changwon National University

Laser assisted machining （LAM） has difficulties in estimating temperature after applying a LAM process due to its very small heat input area, large energy and movement. In particular, in the case of laser assisted turning （LAT） process, it is more difficult to estimate the temperature after preheating because it has a shape of ellipse when a laser heat source is rotated. A prediction method and thermal analysis method for heat source shapes were proposed as a square shaped member was preheated. The temperature distribution was calculated according to the rotation of the member. Compared with the results of the former study, the maximum temperature of the calculation results, 1 407.1 ℃, is 8.5 ℃ higher than that of the square member, which is 1 398.6 ℃. In a LAT process for a square member, the maximum temperature is 1 850.8 ℃. It is recognized that a laser power control process is required because square members show a maximum temperature that exceeds a melting temperature at around a vertex of the member according to the rotation.

关键词： laser assisted machining laser assisted turning laser preheating laser power control

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Analysis of Determinants for an Enhanced and Long-lasting Coastal Convective System by Means of a Case Study(26 July 2011)

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Advances in Atmospheric Sciences 2019年第12期36卷 1327-1339页

作者： Jung-tae lee Dong-In lee Shingo SHIMIZU Cheol-Hwan YOU New and Renewable Energy Resource Center Korea Institute of Energy ResearchDaejeon 34129Republic of Korea Department of Environmental Atmospheric Science Pukyong National UniversityBusan 48513Republic of Korea Storm Floodand Landslide Research DepartmentNational Research Institute for Earth Science and Disaster ResilienceTsukuba 305-0006Japan

A precipitation system developed continuously along the western coastline of the Korean Peninsula and created considerable precipitation both along the coast and inland on 26 July 2011. In this study, the causes for this nearshore convective system are investigated from observations and the results of model experiments. Three-dimensional radar fields clearly show that a change of wind at the surface border played an important role in the development of the nearshore convection system. The simulation results, which are very similar to the observations, show that the surface border generated and maintained the convergence zone. The roughness change enhanced the convergence, and the interaction between the deepening cold pool and downward flow maintained the convergence zone. The surface mechanical discontinuity affected by the roughness change between sea and land formed the convergence (gradient of wind stress), which induced momentum transfer to the upper layer. The cold pool created a steep gradient of potential temperature and provided the reason for the propagated convergence zone with the downward flow. The maximum value of the surface change factor, which comprises the influencing factors for the long-lasting convective system, reflects the enhancement of the system at the coast.

关键词： coastal precipitation roughness convergence zone cold pool propagation downward flow

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Adaptive Functional Projective Lag Synchronization of a Hyperchaotic Rossler System

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Chinese Physics Letters 2009年第9期26卷 69-72页

作者： tae H. lee Ju H. Park Nonlinear Dynamics Group Department of Electrical Engineering Yeungnam University 214-1 Dae-Dong Kyongsan 712-749 Republic of Korea

We explain the functional projective lag synchronization of a hyperchaotic Rossler system with four unknown parameters, where the output of the master system lags behind the output of the slave system proportionally. Based on Lyapunov stability theory, an active control method and adaptive control law are employed to make the states of two hyperchaotic Rossler systems asymptotically synchronized. Finally, some numerical examples are provided to show the effectiveness of our results.

关键词： No English Keyword

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Discovering High-Quality Threaded Discussions in Online Forums

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Journal of Computer Science & Technology 2014年第3期29卷 519-531页

作者： Jung-tae lee Min-Chul Yang Hae-Chang Rim Department of Computer and Radio Communications Engineering Korea UniversitySeoul 136-713Korea

Archives of threaded discussions generated by users in online forums and discussion boards contain valuable knowledge on various topics. However, not all threads are useful because of deliberate abuses, such as trolling and flaming, that are commonly observed in online conversations. The existence of various users with different levels of expertise also makes it difficult to assume that every discussion thread stored online contains high-quality contents. Although finding high-quality threads automatically can help both users and search engines sift through a huge amount of thread archives and make use of these potentially useful resources effectively, no previous work to our knowledge has performed a study on such task. In this paper, we propose an automatic method for distinguishing high-quality threads from low-quality ones in online discussion sites. We first suggest four different artificial measures for inducing overall quality of a thread based on ratings of its posts. We then propose two tasks involving prediction of thread quality without using post rating information. We adopt a popular machine learning framework to solve the two prediction tasks. Experimental results on a real world forum archive demonstrate that our method can significantly improve the prediction performance across all four measures of thread quality on both tasks. We also compare how different types of features derived from various aspects of threads contribute to the overall performance and investigate key features that play a crucial role in discovering high-quality threads in online discussion sites.

关键词： online forum discussion board thread quality

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High resolution impedance manometric findings in dysphagia of Huntington's disease

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World Journal of Gastroenterology 2012年第14期18卷 1695-1699页

作者： tae Hee lee Joon Seong lee Wan Jung Kim Institute for Digestive Research Soon Chun Hyang College of MedicineSeoul 140-743South Korea

Conventional manometry presents significant challenges,especially in assessment of pharyngeal swallowing,because of the asymmetry and deglutitive movements of oropharyngeal *** only provides information about intraluminal pressure and thus it is difficult to study functional details of esophageal motility *** technology of solid high resolution impedance manometry(HRIM),with 32 pressure sensors and 6 impedance sensors,is likely to provide better assessment of pharyngeal swallowing as well as more information about esophageal motility ***,the clinical usefulness of application of HRIM in patients with oropharyngeal dysphagia or esophageal dysphagia is not *** experienced a case of Huntington's disease presenting with both oropharyngeal and esophageal dysphagia,in which HRIM revealed the mechanism of oropharyngeal dysphagia and provided comprehensive information about esophageal dysphagia.

关键词： Dysphagia Esophagus High resolution impedance manometry Huntington's disease Oropharynx

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Mechanical properties of high-strength concrete subjected to high temperature by stressed test

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中国有色金属学会会刊：英文版 2009年第B9期19卷 128-133页

作者： Gyu-Yong KIM Young-Sun KIM tae-Gyu lee Division of Architecture Engineering Chun gnam National University

Recently, the effects of high temperature on compressive strength and elastic modulus of high strength concrete were experimentally investigated. The present study is aimed to study the effect of elevated temperatures ranging from 20 ℃ to 700 ℃ on the material mechanical properties of high-strength concrete of 40, 60 and 80 MPa grade. During the strength test, the specimens are subjected to a 25% of ultimate compressive strength at room temperature and sustained during heating, and when the target temperature is reached, the specimens are loaded to failure. The tests were conducted at various temperatures (20-700 ℃) for concretes made with W/B ratios of 46%, 32% and 25%, respectively. The results show that the relative values of compressive strength and elastic modulus decrease with increasing compressive strength grade of specimen.

关键词：高强混凝土高温作用力学性能测试抗压强度温度升高弹性模量强度试验

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Arterial stiffness expressed as brachial–ankle pulse wave velocity and gait assessment independent of lower extremity strength:a cross-sectional study in the older men population

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Journal of Geriatric Cardiology 2023年第2期20卷 91-99页

作者： tae Kyung Yoo Seunghee lee Sae-Jong Park Jong-Young lee Department of Medicine MetroWest Medical CenterFraminghamUSA Department of Physical Education Korea UniversitySeoulSouth Korea Division of Sports Science Korea Institute of Sport ScienceSeoulSouth Korea Division of Cardiology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea

BACKGROUND Older men are more vulnerable to fatal falls than women,and gait disturbances contribute to the risk of *** have assessed the association between arterial stiffness and gait dysfunction,but the results have been *** study aimed to conduct a cross-sectional analysis to evaluate the association between brachial–ankle pulse wave velocity(baPWV)and gait assessment in older *** Data from the 2014–2015 Korea Institute of Sport Science Fitness Standards project were used for the *** inclusion criteria were men aged>65 years with gait assessment[the 30-s chair stand test(30s-CST),the timed up and go(TUG)test,the figure-of-8 walk(F8W)test,the 2-min step test(2MST),and the 6-min walk test(6MWT)]and baPWV measurement *** linear regression analysis was conducted with multiple confounding factor adjustments,including lower extremity isometric *** A total of 291 participants were included in the *** mean age was 71.38±4.40 *** mean values were as follows:(1)30s-CST,17.48±5.00;(2)TUG test,6.01±1.10 s;(3)F8W test,25.65±4.71 s;(4)2MST,102.40±18.83 per 2 min;and(5)6MWT,500.02±85.65 *** multivariable adjustment,baPWV was associated with the 6MWT(β=−0.037,95%CI:−0.072–−0.002),TUG test(β=0,95%CI:0.000–0.001),and F8W test(β=0.002,95%CI:0.000–0.004).baPWV was not associated with the 30s-CST and *** The current study showed a statistically significant association between gait assessments and arterial stiffness,independent of lower extremity ***,this association was *** prospective studies are needed to elucidate the complex relationship between arterial stiffness and gait dysfunction.

关键词： stiffness sectional pulse

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ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia

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Cellular & Molecular Immunology 2024年第2期21卷 203-204页

作者： Sujin lee tae Jin Kim Department of Immunology Sungkyunkwan University School of MedicineSuwon16419Republic of Korea

B cells have an essential immunoregulatory function,which is mediated by the secretion of IL-10 and TGFβand interaction with activated CD4^(+)T *** antibody-independent function of B cells contributes to ameliorating autoimmune diseases or infection-induced tissue *** this Cellular and Molecular Immunology issue,Fu et *** that regulatory B(Breg)cells play a critical role in resolving Pseudomonas aeruginosa-induced pneumonia[1].

关键词： metabolism pneumonia Immunology

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Endoscopic prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis

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World Journal of Gastroenterology 2014年第44期20卷 16582-16595页

作者： tae Hoon lee Do Hyun Park Division of Gastroenterology Department of Internal Medicine Soonchunhyang University School of Medicine Cheonan Hospital Division of Gastroenterology Department of Internal Medicine University of Ulsan College of Medicine Asa Medical Center

Post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP) is not an uncommon adverse event but may be an avoidable complication. Although pancreatitis of severe grade is reported in 0.1%-0.5% of ERCP patients, a serious clinical course may be lethal. For prevention of severe PEP, patient risk stratification, appropriate selection of patients using noninvasive diagnostic imaging methods such as magnetic resonance cholangiopancreatography or endoscopic ultrasonography(EUS), and avoidance of unnecessary invasive procedures, are important measures to be taken before any procedure. Pharmacological prevention is also commonly attempted but is usually ineffective. No ideal agent has not yet been found and the available data conflict. Currently, rectal non-steroidal anti-inflammatory drugs are used to prevent PEP in high-risk patients, but additional studies using larger numbers of subjects are necessary to confirm any prophylactic effect. In this review, we focus on endoscopic procedures seeking to prevent or decrease the severity of PEP. Among various cannulation methods, wire-guided cannulation,precut fistulotomy,and transpancreatic septostomy are *** pancreatic stent placement,which is the best-known prophylactic method,is reviewed with reference to the ideal stent type,adequate duration of stent placement,and stentrelated ***,we comment on other treatment alternatives,and make the point that further advances in EUS-guided techniques may afford useful PEP prophylaxis.

关键词： Endoscopic retrograde cholangiopancreatography Prevention Pancreatitis Pancreas stent Cannulation Fistulotomy

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