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Qinzhi Zhudan formula improves memory and alleviates neuroinflammation in vascular dementia rats partly by inhibiting the TNFR1-mediated TNF pathway

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Journal of Traditional Chinese Medical Sciences 2022年第3期9卷 298-310页

作者： Shuling Liu Fafeng Cheng Beida Ren Wenxiu Xu Congai Chen chongyang ma Xiaole Zhang Feifei Tang Qingguo Wang Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Dongzhizmen Hospital Beijing University of Chinese MedicineBeijing100700China Institute for Brain Disorders Beijing University of Chinese MedicineBeijing100700China School of Traditional Chinese Medicine Capital Medical UniversityBeijing100069China

Objective: The Qinzhi Zhudan formula(QZZD) exhibits a prominent therapeutic effect in the treatment of vascular dementia(VaD). This study combined a network pharmacology approach and experimental validation to identify the underlying biological mechanism of QZZD against VaD.Methods: male Wistar rats received bilateral common carotid artery occlusion(BCCAO) surgery, and after4 weeks of intragastric administration of QZZD, the therapeutic effect was assessed using the Morris water maze test and cerebral blood flow(CBF) assessment. Hematoxylin and eosin staining, Nissl staining, and electron microscopy were used to measure the histopathological changes in the neurons of rats. The effect of QZZD treatment on hippocampal neurotransmitters was assessed by high-performance liquid chromatography with electrochemical detection and liquid chromatography mass spectrometry.Immunofluorescence was used to observe VaD-induced microglia activation. The inflammatory cytokine levels were assessed by enzyme linked immunosorbent assay. Western blot was used to examine the TNFR1-mediated TNF pathway, which was screened out by network pharmacology analysis.Results: QZZD treatment alleviated pathological changes and neuronal damage in VaD rats and attenuated their cognitive impairment. In addition, QZZD increased CBF and the expression of acetylcholine and 5-hydroxytryptamine in the hippocampal region. Notably, QZZD inhibited microglial activation and the expression of IL-6 and TNF-a. Network pharmacology and western blot indicated that QZZD inhibited the levels of TNFR1, NF-κBp65, p-ERK, TNF-a, and IL-6, which are related to the TNFR1-mediated TNF signaling pathway.Conclusion: QZZD clearly improved learning and memory function, reduced brain pathological damage,elevated CBF and hippocampal neurotransmitter levels, and alleviated neuroinflammation of VaD rats partly by inhibiting the TNFR1-mediated TNF pathway, indicating its potential value in the clinical therapy of VaD.

关键词： Vascular dementia Neuroinflammation Inflammatory cytokines Microglia TNF signaling Pathway Network pharmacology Cerebral blood flow Chronic cerebral ischemia

Learning to assess visual aesthetics of food images

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Computational Visual Media 2021年第1期7卷 139-152页

作者： Kekai Sheng Weiming Dong Haibin Huang Menglei Chai Yong Zhang chongyang ma Bao-Gang Hu Youtu Lab TencentShanghai 200233China NLPR Institute of AutomationChinese Academy of SciencesBeijing 100190China Kuaishou Technology Beijing 100085China Snap Inc. Santa Monica90405USA AI Lab Tencent Inc.Shenzhen 518000China

Distinguishing aesthetically pleasing food photos from others is an important visual analysis task for social media and ranking systems related to food.Nevertheless,aesthetic assessment of food images remains a challenging and relatively unexplored task,largely due to the lack of related food image datasets and practical knowledge.Thus,we present the Gourmet Photography Dataset(GPD),the first largescale dataset for aesthetic assessment of food photos.It contains 24,000 images with corresponding binary aesthetic labels,covering a large variety of foods and scenes.We also provide a non-stationary regularization method to combat over-fitting and enhance the ability of tuned models to generalize.Quantitative results from extensive experiments,including a generalization ability test,verify that neural networks trained on the GPD achieve comparable performance to human experts on the task of aesthetic assessment.We reveal several valuable findings to support further research and applications related to visual aesthetic analysis of food images.To encourage further research,we have made the GPD publicly available at https://***/Openning07/GPA.

关键词： image aesthetic assessment food image analysis dataset regularization

网络思维在中医临床经典课程教学中的价值浅谈

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中国中医药现代远程教育 2024年第4期22卷 14-16页

作者：马重阳高源首都医科大学中医药学院北京100069

中医临床经典课程是中医学传承创新人才培养的重要环节,学好中医临床经典,既能有效指导临床实践,又有助于深层次凝练中医科研思路,真正做到守正创新。网络思维是一种具有交叉学科特点的、站在系统视域下的、以研究对象之间关系为主要内... 详细信息

中医临床经典课程是中医学传承创新人才培养的重要环节,学好中医临床经典,既能有效指导临床实践,又有助于深层次凝练中医科研思路,真正做到守正创新。网络思维是一种具有交叉学科特点的、站在系统视域下的、以研究对象之间关系为主要内容的新型思维范式。通过描绘思维导图、构建方剂或中药网络、介绍网络药理学研究进展,能够梳理并直观展示概念之间的层级关系,解析中医临床经典课程中蕴含的隐性知识,揭示中药配伍及复方治病的科学内涵,培养学生网络思维,进一步提高学生传承创新能力。

关键词：中医临床经典网络思维思维导图网络药理学

基于网络药理学及分子对接技术研究夏枯草-猫爪草药对治疗桥本氏甲状腺炎的药效物质基础及作用机制

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甘肃中医药大学学报 2024年第2期41卷 55-61页

作者：李鸣付黎韵闫凯马重阳京东中美医院内分泌科河北廊坊065201 成都市龙泉驿区第一人民医院中医科四川成都610100 首都医科大学附属北京朝阳医院中医科北京100020 首都医科大学中医药学院北京100069

目的基于网络药理学及分子对接技术研究夏枯草-猫爪草药对治疗桥本氏甲状腺炎(HT)的药效物质基础及潜在作用机制。方法采用中药系统药理学数据库和分析平台(TCMSP)筛选夏枯草-猫爪草药对的活性成分及靶点,利用DisGeNET数据库筛选疾病相... 详细信息

目的基于网络药理学及分子对接技术研究夏枯草-猫爪草药对治疗桥本氏甲状腺炎(HT)的药效物质基础及潜在作用机制。方法采用中药系统药理学数据库和分析平台(TCMSP)筛选夏枯草-猫爪草药对的活性成分及靶点,利用DisGeNET数据库筛选疾病相关靶点,将药物与疾病靶点相互映射取交集得夏枯草-猫爪草药对治疗HT的潜在作用靶点;采用Cytoscape 3.8.2软件构建“药物-活性成分-靶点”相互作用网络;采用STRING数据库和Cytoscape 3.8.2软件对交集靶点进行蛋白质-蛋白质相互作用(PPI)网络分析;利用R语言ClusterProfiler包对交集靶点进行基因本体(GO)富集分析和京都基因与基因组百科全书(KEGG)通路分析;利用CB-DOCK在线平台对关键活性成分和重要靶点进行分子对接验证。结果共获得药物活性成分23个,对应靶点197个,疾病靶点335个,二者交集靶点38个。GO富集发现主要涉及对脂多糖的反应、活性氧代谢过程的调节、T细胞活化等生物过程。KEGG通路富集分析主要涉及晚期糖基化终产物及其受体(AGE-RAGE)信号通路在糖尿病并发症中的作用、肿瘤坏死因子信号通路、白细胞介素(IL)-17信号通路、流体剪切应力和动脉粥样硬化、Toll样受体信号通路、T辅助细胞17(Th17)分化等信号通路。分子对接结果显示,槲皮素及木犀草素与核转录因子-κB抑制因子α(NFKBIA)均具有较好的结合活性。结论夏枯草-猫爪草药对可能是通过槲皮素及木犀草素作用于NFKBIA等靶点来调控Th17细胞分化和激活,从而发挥治疗HT的作用。

关键词：桥本氏甲状腺炎夏枯草猫爪草网络药理学分子对接物质基础作用机制

基于数据挖掘研究钱英辨治慢性乙型肝炎用药规律

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中国中医药信息杂志 2024年第4期31卷 59-64页

作者：胡文涵马重阳姜雪娇梁嘉俊张秋云首都医科大学中医药学院中医络病研究北京市重点实验室北京100069

目的通过数据挖掘方法分析全国名中医钱英教授治疗慢性乙型肝炎的用药规律及学术思想。方法回顾性收集钱英教授2000年3月-2020年12月治疗慢性乙型肝炎医案168则,采用名医传承辅助平台多维度分析其处方用药的性味归经、核心方药及药物群... 详细信息

目的通过数据挖掘方法分析全国名中医钱英教授治疗慢性乙型肝炎的用药规律及学术思想。方法回顾性收集钱英教授2000年3月-2020年12月治疗慢性乙型肝炎医案168则,采用名医传承辅助平台多维度分析其处方用药的性味归经、核心方药及药物群组。结果168则医案涉及患者168例,中药227味,总频次为2158。性味归经特点显示,药性以寒性最多,药味以苦味居前,归经以肝经为主。挖掘得到34味高频药物(以补虚药、清热药、活血化瘀药为主),28味核心药物,10对高共现药对,10类潜在药物群组。结论钱英教授针对慢性乙型肝炎本虚标实病机,治疗尤重补虚;常从肝论治,同时强调肝脾肾同调;以补虚、清热、活血化瘀为主要治法,随证佐以祛湿、行气、化痰、开郁、解表等治法;重视体用同调;善多法联用。

关键词：慢性乙型肝炎钱英用药经验数据挖掘

Molecular mechanism of non-alcoholic fatty liver disease induced and aggravated by chronic stress through HSL/ATGL-FFA which promotes fat mobilization

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Journal of Traditional Chinese Medical Sciences 2019年第4期6卷 315-324页

作者： Jie Mu Xueqian Wang Qingguo Wang Fafeng Cheng Wenxiang Zhu Changxiang Li chongyang ma Changming Zhai Yajun Lian Xin Du School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China

Objective:To study the effects of social stress(CS)and social stress combined with high-fat diet on fat mobilization as a candidate mechanism for the induction or aggravation of non-alcoholic fatty liver disease(NAFLD).Methods:Thirty-two male Wistar rats(250±10 g)were randomly allocated to a blank control group(BC),a high-fat diet group(HFD),a CS group,and a combined CS and high-fat diet group(CS t HFD).Rats were sacrificed and tissues were collected after 8 weeks.Liver and body mass were measured and used to calculate the liver index.Serum aspartate aminotransferase(AST),alanine aminotransferase(ALT),and free fatty acids(FFAs)were measured.Liver sections were examined microscopically after oil red O and hematoxylin and eosin staining.The relative mRNA expression of acetyl-CoA carboxylase(ACCase),hydroxymethylglutaryl coenzyme A(HMG-CoA)reductase in liver,and hormone-sensitive lipase(HSL),and adipose triglyceride lipase(ATGL)in subcutaneous adipose tissue,were measured by real-time PCR.The liver concentrations of triglyceride,reactive oxygen species,and ACCase were measured by ELISA and HSL activity was determined using turbidimetry.Results:NAFLD developed in the CS,HFD,and CS t HFD groups,with the most severe NAFLD being in the CS t HFD group.Serum AST,ALT,and FFA,liver index,and hepatic triglyceride,FFA,and tumor necrosis factor-a were significantly higher in both the CS and CS t HFD groups.However,food intake and ACCase mRNA expression were lower.The mRNA expression of HSL and ATGL in adipose tissue was much higher,and HSL activity was higher in the CS group than in the BC group,and in the CS t HFD group than in the HFD group.Conclusion:We have successfully established two models of stress-induced NAFLD,suggesting stress can induce and aggravate NAFLD by promoting fat mobilization through upregulation of HSL and ATGL.

关键词： Non-alcoholic fatty liver disease Chronic stress Fat mobilization Free fatty acid

基于网络药理学探讨仙鹤草治疗慢性疲劳综合征作用机制

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中国中医药图书情报杂志 2024年第4期48卷 47-53页

作者：鲁昕怡马重阳王佳佳张玉雯迟莉北京工业大学环境与生命学部北京100124 首都医科大学中医药学院北京100069

目的采用网络药理学方法研究仙鹤草治疗慢性疲劳综合征潜在作用机制。方法通过Symmap、HERB数据库获取仙鹤草化学成分和潜在靶点,通过DisGeNET数据库获取慢性疲劳综合征疾病靶点,将化学成分对应靶点与疾病相关靶点去重后获得交集靶点... 详细信息

目的采用网络药理学方法研究仙鹤草治疗慢性疲劳综合征潜在作用机制。方法通过Symmap、HERB数据库获取仙鹤草化学成分和潜在靶点,通过DisGeNET数据库获取慢性疲劳综合征疾病靶点,将化学成分对应靶点与疾病相关靶点去重后获得交集靶点,采用Cytoscape3.9.1软件绘制仙鹤草-化学成分-交集靶点网络,采用STRING数据库并结合Cytoscape3.9.1软件绘制交集靶点相互作用图,DAVID数据库进行GO功能和KEGG通路富集分析,采用CB-Dock平台对关键成分及核心靶点进行分子对接。结果获得仙鹤草化学成分21个,潜在靶点360个,慢性疲劳综合征相关靶点118个,仙鹤草和慢性疲劳综合征交集靶点22个。GO功能和KEGG通路富集分析显示,仙鹤草调节慢性疲劳综合征涉及181个生物过程、9个细胞组分、10个分子功能及58条信号通路。分子对接结果表明,槲皮素、蛇床子素、木犀草素、β-谷甾醇与核心靶点IL1B、IL6、TNF、PTGS2有一定结合力。结论仙鹤草抗慢性疲劳综合征可能通过蛇床子素、β-谷甾醇、山柰酚、槲皮素、木犀草素等成分,作用于IL1B、IL6、TNF等靶点,作用机制有调节炎症及免疫反应、改善肠道免疫网络及作用于糖尿病和癌症相关通路等。

关键词：仙鹤草慢性疲劳综合征网络药理学分子对接

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非酒精性脂肪性肝炎内生热毒探讨

辽宁中医杂志 2024年第6期51卷 46-50页

作者：徐甜吉静陈丹孙资金马重阳王雪茜程发峰王庆国北京中医药大学中医学院北京100029 首都医科大学中医药学院北京100069

非酒精性脂肪性肝炎以肝脏脂肪变性、炎症、肝细胞凋亡和纤维化为特征,但发病机制仍未完全阐明。中医认为内生热毒损伤肝体,败坏肝络是非酒精性脂肪性肝炎的显著病变特征。文章系统梳理了内生热毒的理论源流,阐明了非酒精性脂肪性肝炎... 详细信息

非酒精性脂肪性肝炎以肝脏脂肪变性、炎症、肝细胞凋亡和纤维化为特征,但发病机制仍未完全阐明。中医认为内生热毒损伤肝体,败坏肝络是非酒精性脂肪性肝炎的显著病变特征。文章系统梳理了内生热毒的理论源流,阐明了非酒精性脂肪性肝炎内生热毒的四大特征:乖张暴戾、病情焦灼、兼相为患和深入肝络。饮食偏嗜,痰湿盘踞;情志抑郁,痰瘀搏结;正气不足,虚火旺盛是内生热毒的三大引动因素。内生热毒与代谢性炎症具有一定的通约性,清热解毒中药能够干预非酒精性脂肪性肝炎的脂质堆积和炎症连锁反应。关注内生热毒在非酒精性脂肪性肝炎发生发展过程中的重要作用,能够拓展中医药防治非酒精性脂肪性肝炎的思路。

关键词：非酒精性脂肪性肝炎内生热毒代谢性炎症清热解毒

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牛黄-人参药对发展源流与配伍特征探析

辽宁中医杂志 2024年第7期51卷 137-140页

作者：厉赢吉静邵奇徐甜陈丹马重阳王雪茜王庆国程发峰北京中医药大学中医学院北京100029 首都医科大学中医药学院北京100069

自《神农本草经》首次提出“牛黄,人参为使”以来,历代医家对牛黄-人参配伍多有应用与发挥,内外妇儿各科均能找到应用痕迹。但关于牛黄-人参药对的发展源流及配伍特征尚待梳理与明确。通过对历代医籍相关记载的梳理,分析和总结牛黄-人... 详细信息

自《神农本草经》首次提出“牛黄,人参为使”以来,历代医家对牛黄-人参配伍多有应用与发挥,内外妇儿各科均能找到应用痕迹。但关于牛黄-人参药对的发展源流及配伍特征尚待梳理与明确。通过对历代医籍相关记载的梳理,分析和总结牛黄-人参药对的历史沿革、配伍特征和临床应用,以期为更好地发挥其临床价值和现代开发提供文献参考。

关键词：牛黄人参药对配伍特征发展源流临床应用