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Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents

Food Science and Human Wellness 2024年第5期13卷 2445-2455页

作者： chongshan dai Erjie Tian Hui Li Subhajit Das Gupta Zhihui Hao Zhanhui Wang Tony Velkov Jianzhong Shen National Key Laboratory of Veterinary Public Health and Safety Beijing Key Laboratory of Detection Technology for Animal-Derived Food SafetyCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China College of Animal Science and Technology Henan University of Science and TechnologyLuoyang 471023China Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijing 100013China Department of Internal Medicine University of Texas Southwestern Medical CenterDallas 75230USA Monash Biomedicine Discovery Institute Department of PharmacologyMonash UniversityVictoria 3800Australia

Aflatoxins(AFTs)represent one of the most notorious classes of deadly mycotoxins produced by certain fungi that are found on agricultural *** are highly toxic to mammals and are known to cause a series of detrimental effects,including neuro-,hepato-,nephron-,and *** this original review we summarize the mechanisms of aflatoxin-induced neurotoxicity and the clinical potential of novel neuroprotective *** B1(AFB1)is the most toxic congener among the 21 identified *** studies have shown that food borne exposure to AFB1 and/or its metabolites often leads to fatal neurotoxicity in animals and *** studies indicated that AFB1 exposure could induce abnormal behavioral changes,including anxiety,lethargy disorders,depression-like behavior,cognitive,learning and memory defects,and decreased feeding ***,AFB1 exposure has been associated with lipid peroxidation,ablation of non-enzymatic and enzymatic antioxidant defense systems and decreased neurotransmitter ***1 exposure has also been shown to induce DNA damage,apoptosis,pyroptosis,and mitochondrial dysfunction in the brain *** signaling pathways,including gasdermin D,toll like receptor 2(TLR2),TLR4,Akt,NF-κB,ERK/MAPK,protein kinase C(PKC),and mitochondrial apoptotic pathways have been shown to participate in AFB1-induced neuronal or astrocyte cell *** these pathways by small molecules(e.g.,quercetin,curcumin,and gallic acid,and dimethyl fumarate),Chinese herbal extracts(e.g.,Artichoke leaf extract,Chelidonium majus ethanolic extract,pumpkin extract,and Crocus sativus ***),and probiotic supplements could effectively improve AFB1-induced neurobehavioral abnormalities and *** date,the precise molecular mechanisms of AFB1-induced neurotoxicity and potential neuroprotective agents remain *** the present review,the clinical manifestations,molecular mechanisms,and potential neuroprotective agents of AFB1

关键词： Aflatoxin B1(AFB1) Neurotoxicity Molecular mechanisms Chemical preventions

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应对可转移多黏菌素耐药性--饲料添加剂来源的白屈菜红碱具有双重效应

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Engineering 2024年第1期32卷 163-173页

作者： Huangwei Song Xueyang Wang Muchen Zhang Zhiyu Zou Siyuan Yang Tian Yi Jianfeng Wang Dejun Liu Yingbo Shen chongshan dai Zhihai Liu Timothy R.Walsh Jianzhong Shen Congming Wu Yang Wang National Key Laboratory of Veterinary Public Health and Safety College ofVeterinary MedicineChina Agricultural UniversityBeijing 100193China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China State Key Laboratory for Zoonotic Diseases Key Laboratory of Zoonosis ResearchMinistry of EducationInstitute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun 130015China College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University.Qingdao 266109China Ineos-Oxford Institute of Antimicrobial Research Department of BiologyUniversity of OxfordOxford OX13SZUK

The emergence and spread of the mobile colistin-resistance gene,mcr-1,and its variants pose achallenge to the use of colistin,a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant(XDR)Gram-negative *** adjuvants are a promising strategy to enhance the efficacy of colistin against colistin-resistant pathogens;however,few studies have considered the effects of adjuvants on limiting resistance-gene *** found that chelerythrine(4 mg·L^(-1))derived from Macleaya cordata extract,which is used as an animal feed additive,reduced the minimal inhibitory concentration(MIC)of colistin against an mcr-1 positive Escherichia coli(***)strain by 16-fold(from 2.000 to 0.125 mg·L^(-1)).eliminated approximately 10^(4) colony-forming units(CFUs)of an mcr-1-carrying strain in a murine intestinal infection model,and inhibited the conjugation of an mcr-1-bearing plasmid in vitro(by>100-fold)and in a mouse model(by up to 5-fold).A detailed analysis revealed that chelery-thrine binds to phospholipids on bacterial membranes and increases cytoplasmic membrane fluidity,thereby impairing respiration,disrupting proton motive force(PMF),generating reactive oxygen species(ROS),and decreasing intracellular adenosine triphosphate(ATP)levels,which subsequently downregu-lates mcr-1 and conjugation-associated *** dual effects of chelerythrine can expand the use of antibiotic adjuvants and may provide a new strategy for circumventing mobile colistin resistance.

关键词： Chelerythrine Antibiotic adjuvant Conjugation inhibitor Colistin mcr-1 Dual effects

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Morphological Characteristics of the Dorsal Skin of Two Hynobiids and Their Adaptive Role in Aquatic and Terrestrial Habitats

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Asian Herpetological Research 2013年第1期4卷 62-67页

作者： Jianli XIONG chongshan dai Mengyun LI Wen DENG Jichang LI Animal Science and Technology College Henan University of Science and Technology College of Animal Medicine Northeast Agriculture University

The morphological characteristics of the dorsal skin of trunk in two species of hynobiid salamanders, Batrachuperus pinchonii and Hynobius chinensis were examined by light microscopy. The basic structures of the skin in the two species are similar and consist of two layers： epidermis and dermis. The epidermis consists of stratum corneum, stratum intermedium and stratum germinativum, while the dermis is composed of a stratum spongiosum and stratum compactum. However, some species-specific variation has been identified （e.g., the distribution of capillary vessels and gland cells, and the thickness of skin）. H. chinensis is a terrestrial species and only lives in water during breeding period, but B. pinchonii is aquatic and remains aquatic throughout its lifetime. The differences in the distribution of capillary vessels and gland cells are related to their different habitats, and show a morphological adaptation.

关键词： hynobiid salamander skin morphology adaptation habitat

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Osthole ameliorates myonecrosis caused by Clostridium perfringens type A infection in mice

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One Health Advances 2023年第1期1卷 52-61页

作者： Xueyong Zhang Yue Liu Zhangqi Shen Shaolin Wang Congming Wu Dejun Liu Shusheng Tang chongshan dai National Key Laboratory of Veterinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

This study aimed to investigate the protective effect of the nature product osthole(OST)against Clostridium perfrin-gens type A infection-caused myonecrosis in a mouse *** mice were divided into(1)control,(2)infected,(3)OST50 and(4)OST100 treatment *** the infected groups,mice were intramuscularly injected with 1×108 CFU of *** per day for 6 *** in the OST50 and OST100 groups were administrated intraperitoneally with OST at the doses of 50 or 100 mg/kg per day post *** *** results showed that *** infection caused marked necrosis and inflammatory cell infiltration in the muscle tissues of *** in the OST50 and OST100 treatment groups displayed significantly attenuated *** infection-induced lipid peroxida-tion,oxidative stress,and apoptosis in their muscle ***,OST treatment significantly downregulated the expressions of NF-κB,IL-1β,and TNF-αmRNA and protein levels,while concomitantly upregulating the expressions of Nrf2 and HO-1 mRNA and *** treatments also inhibited the expression of phosphorylation(p)-p38,p-mTOR,and p-Erk1/2 proteins,and upregulated LC3II and Beclin1 *** summary,our results reveal that OST therapy confers a protective effect against *** infection-induced oxidative stress and inflammation in muscle tissue,via activation of Nrf2/HO-1 and autophagy pathways and inhibition of p38,Erk1/2 and NF-κB pathways.

关键词： C.perfringens Myonecrosis Osthole Nrf2/HO-1 pathway NF-κB pathway

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β-桧木醇联合替加环素对tet(X4)阳性大肠杆菌的体外协同抗菌作用

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生物工程学报 2023年第4期39卷 1621-1632页

作者：张慕琛宋黄威邹之宇杨思源李会代重山刘德俊邵兵吴聪明沈建忠汪洋中国农业大学动物医学院农业农村部动物源细菌耐药性监测重点实验室北京100193 岭南现代农业科学与技术广东省实验室广东广州510642 北京市疾病预防控制中心北京100013

质粒介导tet(X4)基因的出现和流行,严重影响替加环素(tigecycline)对临床多重耐药细菌感染的治疗效果,急需寻找有效的佐剂遏制替加环素耐药性。本研究采用微量棋盘稀释法、时间-杀菌曲线测定β-桧木醇(β-thujaplicin)和替加环素的体外... 详细信息

质粒介导tet(X4)基因的出现和流行,严重影响替加环素(tigecycline)对临床多重耐药细菌感染的治疗效果,急需寻找有效的佐剂遏制替加环素耐药性。本研究采用微量棋盘稀释法、时间-杀菌曲线测定β-桧木醇(β-thujaplicin)和替加环素的体外联合抗菌表征,通过测定细菌细胞膜通透性、细菌胞内活性氧(reactive oxygen species,ROS)含量、铁含量以及替加环素含量等指标,来探究β-桧木醇和替加环素联合使用对tet(X4)基因阳性大肠杆菌(Escherichia coli)的抗菌作用机制。结果表明,β-桧木醇联合替加环素对tet(X4)基因阳性大肠杆菌具有体外协同抗菌效果,且β-桧木醇在抗菌作用浓度范围内无显著溶血性和细胞毒性。机制研究发现,β-桧木醇能显著增大细菌细胞膜的通透性,降低细菌胞内铁含量,干扰铁稳态,诱导细胞内ROS显著增加,从而发挥抗菌效果。进一步研究发现,β-桧木醇可通过干扰细菌铁代谢和增大细菌细胞膜通透性,协同增强替加环素的抗菌效果。本研究结果为β-桧木醇联合替加环素治疗tet(X4)基因阳性大肠杆菌感染提供了理论和实践基础。

关键词： β-桧木醇替加环素 tet(X4) 协同抗菌铁稳态

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黏菌素对小鼠神经传导速率及运动单元动作电位的影响

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东北农业大学学报 2013年第3期44卷 1-4页

作者：李继昌代重山马晶蒋红李睿张德显林巍东北农业大学动物医学学院哈尔滨150030 东北农业大学校医院哈尔滨150030 沈阳农业大学畜牧兽医学院沈阳110866

为探讨黏菌素对小鼠感觉神经传导速率(SNCV)、运动神经传导速率(MNCV)及运动单元动作电位(MUAP)的影响,对50只昆明系小鼠单次尾静脉注射硫酸黏菌素7.5 ***-1,每12 h 1次,连续给药7 d。分别于第1、3、7、14天(以初次给药当天为第1天计)... 详细信息

为探讨黏菌素对小鼠感觉神经传导速率(SNCV)、运动神经传导速率(MNCV)及运动单元动作电位(MUAP)的影响,对50只昆明系小鼠单次尾静脉注射硫酸黏菌素7.5 ***-1,每12 h 1次,连续给药7 d。分别于第1、3、7、14天(以初次给药当天为第1天计)测定小鼠坐骨神经SNCV、MNCV及MUAP,并对腓肠肌进行病理学检查。结果表明,与对照组相比,黏菌素给药3 d后,SNCV降低至(30.67±1.15)m.s-(1P<0.05)。给药7 d后,神经传导速率(NCV)显著降低,MNCV降低至(24.47±0.41)m.s-(1P<0.05),SNCV降低至(29.67±2.89)m.s-(1P<0.05);此外,腓肠肌MUAP降低至(0.26±0.0153)mV(P<0.05),运动单元动作电位持续时间(MUAPD)降低至(0.3±0.046)s(P<0.01)。表明黏菌素可影响小鼠的神经感觉及运动功能,并可导致小鼠肌肉无力。SNCV变化较为敏感,可作为黏菌素诱发神经毒性的早期诊断指标。

关键词：黏菌素小鼠 SNCV MNCV MUAP

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基于混合特征和CFOA-GRNN的行星齿轮箱故障诊断研究

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机床与液压 2022年第6期50卷 186-191页

作者：许家才吕亮陆崇山代劲国能云南新能源有限公司云南昆明650200 武汉大学动力与机械学院湖北武汉430072

针对行星齿轮传动系统典型故障的识别,提出一种基于信号混合特征和混沌果蝇优化算法-广义回归神经网络(CFOA-GRNN)的故障诊断方法。计算信号的几种典型时域统计特征,并通过小波包分解获取信号频域能量特征,得到信号混合特征向量作为广... 详细信息

针对行星齿轮传动系统典型故障的识别,提出一种基于信号混合特征和混沌果蝇优化算法-广义回归神经网络(CFOA-GRNN)的故障诊断方法。计算信号的几种典型时域统计特征,并通过小波包分解获取信号频域能量特征,得到信号混合特征向量作为广义回归神经网络(GRNN)的输入;采用混沌扰动改进的果蝇优化算法对GRNN进行参数寻优,构建最优诊断模型;利用采集的行星齿轮箱实验台不同工况数据进行实验和对比。结果表明:所提方法能够有效识别不同工况下齿轮箱的不同故障;与其他模型相比,它具有参数设置简便、主观因素影响小、寻优速度快等优势,具有较好的实用性。

关键词：行星齿轮箱故障诊断混合特征混沌果蝇优化算法广义回归神经网络

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川中致密砂岩油藏表面活性剂驱油机理数值模拟

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石油与天然气化工 2017年第2期46卷 85-88页

作者：代宸宇王重善陈青松付晓中国石油大学(北京) 中国石油西南油气田公司中国石油川庆钻探工程公司

针对致密砂岩油藏开发过程中采收率较低的难题,以川中地区上三叠统须家河组致密砂岩油藏为例,结合油藏数值模拟,分析了注入速率、注入表面活性剂浓度、注入PV数对致密砂岩油藏采收率的定性和定量的影响,预测分析不同表面活性剂驱方案实... 详细信息

针对致密砂岩油藏开发过程中采收率较低的难题,以川中地区上三叠统须家河组致密砂岩油藏为例,结合油藏数值模拟,分析了注入速率、注入表面活性剂浓度、注入PV数对致密砂岩油藏采收率的定性和定量的影响,预测分析不同表面活性剂驱方案实施效果,给出在当前油藏条件下的最佳方案,得出了影响表面活性剂驱的主控因素。

关键词：表面活性剂数值模拟采收率致密油藏

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