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G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1128-1144页

作者： Xiaoli Wei Fan Yin Miaomiao Wu Qianqian Xie Xueqin Zhao cheng Zhu Ruiqian Xie chongqing chen Menghua Liu Xueying Wang Ruixue Ren Guijie Kang chenwen Zhu Jingjing Cong Hua Wang Xuefu Wang Department of Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei 230036China Department of Pharmacy Huainan First People's Hospitalthe First Affiliated Hospital of Anhui University of Science and TechnologyHuainan 232001China School of Pharmacy Anhui Medical UniversityHefei 230032China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province Anhui Medical UniversityHefei 230032China

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Fat accumulation“sensitizes”the liver to insult and leads to nonalcoholic steatohepatitis(NASH).G protein-coupled receptor 35(GPR35)is involved in metabolic stresses,but its role in NAFLD is unknown.We report that hepatocyte GPR35 mitigates NASH by regulating hepatic cholesterol homeostasis.Specifically,we found that GPR35 overexpression in hepatocytes protected against high-fat/cholesterol/fructose(HFCF)diet-induced steatohepatitis,whereas loss of GPR35 had the opposite effect.Administration of the GPR35 agonist kynurenic acid(Kyna)suppressed HFCF diet-induced steatohepatitis in mice.Kyna/GPR35 induced expression of StAR-related lipid transfer protein 4(STARD4)through the ERK1/2 signaling pathway,ultimately resulting in hepatic cholesterol esterification and bile acid synthesis(BAS).The overexpression of STARD4 increased the expression of the BAS rate-limiting enzymes cytochrome P450 family 7 subfamily A member 1(CYP7A1)and CYP8B1,promoting the conversion of cholesterol to bile acid.The protective effect induced by GPR35 overexpression in hepatocytes disappeared in hepatocyte STARD4-knockdown mice.STARD4 overexpression in hepatocytes reversed the aggravation of HFCF diet-induced steatohepatitis caused by the loss of GPR35 expression in hepatocytes in mice.Our findings indicate that the GPR35–STARD4 axis is a promising therapeutic target for NAFLD.

关键词： G protein-coupled receptor 35 Kynurenic acid Steatohepatitis Cholesterol Bile acid STARD4 ACAT2 CYP7A1

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海洋船舶通信网络安全综述

计算机应用 2024年第7期44卷 2123-2136页

作者：吴中岱韩德志蒋海豹冯程韩冰陈重庆上海船舶运输科学研究所有限公司上海200135 水路交通控制全国重点实验室上海200135 上海海事大学信息工程学院上海201306

海上运输是人类最重要的运输方式之一,海上船舶通信网络安全对一个涉海国家的经济发展至关重要。由于海上船舶通信网络基础设施建设远不如陆地互联网络基础设施建设完善,其通信网络存在很多安全漏洞,导致多起船舶在海洋航行时遭受网络... 详细信息

海上运输是人类最重要的运输方式之一,海上船舶通信网络安全对一个涉海国家的经济发展至关重要。由于海上船舶通信网络基础设施建设远不如陆地互联网络基础设施建设完善,其通信网络存在很多安全漏洞,导致多起船舶在海洋航行时遭受网络攻击。近几年,国内外已有大量有关海上通信网络安全的研究文献,但缺乏海洋船舶通信网络安全研究综述文献发表。为此,针对海洋船舶通信网络结构、存在的网络安全风险及其应对安全措施等研究文献进行系统的梳理和综合讨论。在此基础上,对海上船舶通信网络安全威胁提出应对的策略和建议。

关键词：海洋船舶通信网络船舶网络安全网络攻击攻击防御

Low-Carbon Dispatching for Virtual Power Plant with Aggregated Distributed Energy Storage Considering Spatiotemporal Distribution of Cleanness Value

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 346-358页

作者： Hongchao Gao Tai Jin Guanxiong Wang Qixin chen chongqing Kang Jingkai Zhu State Key Laboratory of Power System Operation and Control Department of Electrical EngineeringTsinghua UniversityBeijing 100084China Sichuan Energy Internet Research Institute Tsinghua University Chengdu 200016China Power Dispatching and Control Center of Shanghai Municipal Electric Power Company Shanghai 200122China IEEE

The scale of distributed energy resources is increasing,but imperfect business models and value transmission mechanisms lead to low utilization ratio and poor responsiveness.To address this issue,the concept of cleanness value of distributed energy storage(DES)is proposed,and the spatiotemporal distribution mechanism is discussed from the perspectives of electrical energy and cleanness.Based on this,an evaluation system for the environmental benefits of DES is constructed to balance the interests between the aggregator and the power system operator.Then,an optimal low-carbon dispatching for a virtual power plant(VPP)with aggregated DES is constructed,where-in energy value and cleanness value are both considered.To achieve the goal,a green attribute labeling method is used to establish a correlation constraint between the nodal carbon potential of the distribution network(DN)and DES behavior,but as a cost,it brings multiple nonlinear relationships.Subsequently,a solution method based on the convex envelope(CE)linear re-construction method is proposed for the multivariate nonlinear programming problem,thereby improving solution efficiency and feasibility.Finally,the simulation verification based on the IEEE 33-bus DN is conducted.The simulation results show that the multidimensional value recognition of DES motivates the willingness of resource users to respond.Meanwhile,resolving the impact of DES on the nodal carbon potential can effectively alleviate overcompensation of the cleanness value.

关键词： Distributed energy storage virtual power plant(VPP) spatiotemporal distribution low-carbon dispatching

Nuclear transcription factors and lipid homeostasis in liver

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Chinese Medical Journal 2007年第24期120卷 2290-2296页

作者： chen Ya-xi HUANG Ai-long RUAN Xiong-zhong Centre for Lipid Research,Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education Second Affiliated Hospital,chongqing Medical University,chongqing 400010,China(chen YX,Huang AL and Ruan XZ) Centre for Lipid Research Key Laboratory of Molecular Biology on Infectious DiseasesMinistry of Education

The liver plays a major role in the regulation , glucose, lipid and energy metabolism. Increasd hepatic fat deposit is a very common feature in obese, insulin-resistant patients, in metabolic syndrome, alcoholic steatohepatitis （ASH） and nonalchoholic fatty liver disaseas （NAFLD）. As a central organ for whole body lipid metabolism, disruption of the normal mechanisms for synthesis, transport and removal/ metabolism of long-chain fatty acids and triglycerides are the basis for the development of fatty liver. The exact mechanisms that link hepatic lipid accumulation, impaired glucose metabolism, and insulin resistance are unknown, but increasing evidence suggest that nuclear transcription factors play important roles. Members of the nuclear receptor superfamily, especially the peroxisome proliferator-activated receptors （PPARs） and the liver X receptor （LXR）, other factors such as sterol regulatory element binding proteins （SREBPs）, carbohydrate- response element-binding protein （ChREBP）, and nuclear transcription fator-κB （NF-κB） have emerged as dominant regulators of these processes, but the relative role of each of these factors in fatty liver disease is still undefined.

关键词： nuclear transcription factors lipid homeostasis fatty liver

一种协同仿真方法及其在SOFC数值模拟中的应用

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系统仿真学报 2010年第3期22卷 771-776页

作者：张雨英杨晨重庆大学动力工程学院重庆400030

针对当今复杂能源系统数值模拟的两大常用分析工具—Matlab和Fluent,提出了一种基于TCP/IP的协同仿真方法,并将其应用于SOFC的多尺度仿真。该方法以WinSock为框架,采用文件I/O函数访问共享数据的方式,完成两种工具之间的信息通讯。在SOF... 详细信息

针对当今复杂能源系统数值模拟的两大常用分析工具—Matlab和Fluent,提出了一种基于TCP/IP的协同仿真方法,并将其应用于SOFC的多尺度仿真。该方法以WinSock为框架,采用文件I/O函数访问共享数据的方式,完成两种工具之间的信息通讯。在SOFC多尺度仿真中,利用Fluent建立SOFC单体的宏观尺度模型,利用Matlab建立电化学反应扩散现象的介观尺度模型,通过二者的协同仿真实现两个尺度模型的耦合模拟。结果表明,该方法能有效地完成两种软件之间的协同仿真,且结果较真实地反映了对象的实际特性。

关键词：多尺度模拟 TCP/IP Fluent Matlab SOFC 协同仿真

LEVITIN-POYAK WELL-POSEDNESS OF GENERALIZED VECTOR EQUILIBRIUM PROBLEMS WITH FUNCTIONAL CONSTRAINTS

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Acta Mathematica Scientia 2010年第5期30卷 1400-1412页

作者：王刚黄学祥张杰陈光亚 School of Management Fudan University Institute of Applied Mathematics Chongqing University of Posts and Telecommunications Academy of Mathematics and Systems Science CAS

In this article, we study Levitin-Polyak type well-posedness for generalized vector equilibrium problems with abstract and functional constraints. Criteria and characterizations for these types of well-posednesses are... 详细信息

关键词： generalized vector equilibrium problems well-posedness set-valued map approximating solution sequence

Microstructure Evolution and Mechanical Properties of Friction Stir Welded Al-Cu-Li Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 855-871页

作者： Peng chen Wenhao chen Jiaxin chen Zhiyu chen Yang Tang Ge Liu Bensheng Huang Zhiqing Zhang School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Sichuan Provincial Engineering Research Center of Advanced Materials Manufacturing Technology for Shale Gas High-Efficient Exploitation Southwest Petroleum UniversityChengdu 610500China College of Materials Science and Engineering Chongqing UniversityChongqing 400045China School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China School of Robot Engineering Yangtze Normal UniversityChongqing 408100China

The investigation concentrates on friction stir welded(FSW)Al-Cu-Li alloy concerning its local microstructural evolution and mechanical properties.The grain features were characterized by electron back scattered diffraction(EBSD)technology,while precipitate characterization was conducted by using transmission electron microscopy(TEM)aligned along[011]Al and[001]Al zone axes.The mechanical properties are evaluated through micro-hardness and tensile testing.It can be found that nugget zones exhibit finely equiaxed grains evolved through complete dynamic recrystallization(DRX),primarily occurring in continuous dynamic recrystallization(CDRX)and discontinuous dynamic recrystallization(DDRX).In the thermal-mechanically affected zone(TMAZ),numerous sub-structured grains,exhibiting an elongated morphology,were created due to partial DRX,signifying the dominance of CDRX,DDRX,and geometric dynamic recrystallization(GDRX)in this region.T_(1)completely dissolves in the nugget zone(NZ)leading to the formation of Guinier-Preston zones and increase ofδ′,β′and S′.Conversely,T_(1)partially solubilizes in TMAZ,the lowest hardness zone(LHZ)and heat affected zone(HAZ),and the residual T_(1)undergoes marked coarsening,revealing various T_(1)variants.The solubilization and coarsening of T_(1)are primary contributors to the degradation of hardness and strength.θ′primarily dissolves and coarsens in NZ and TMAZ,whilst this precipitate largely coarsens in HAZ and LHZ.σ,TB,grain boundary phases(GBPs)and precipitate-free zone(PFZ)are newly generated during FSW.σexists in the TMAZ,LHZ and HAZ,whereas TB nucleates in NZ.GBPs and PFZ mostly develop in LHZ and HAZ,which can cause strain localization during tensile deformation,potentially leading to LHZ joint fracture.

关键词： Al-Cu-Li alloy Friction stir welding Microstructure evolution Mechanical properties

From dichotomy to diversity:deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy

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Cancer Biology & Medicine 2024年第2期21卷 132-138页

作者： Xiumei Wang Jun chen Guangshuai Jia Department of Immunology and Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Jinfeng Laboratory Chongqing 401329China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510182China

Macrophages are innate immune cells that are ubiquitously distributed throughout the vertebrate body.Macrophages orchestrate sophisticated processes in development,homeostasis,immunity,and disease1.Macrophages residing in tumor tissues are commonly known as tumor-associated macrophages(TAMs)and promote or inhibit tumor growth depending on the activation state2.

关键词： immunity homeostasis tumor

Mirizzi syndrome:Problems and strategies

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 234-240页

作者： Jun Wu Shuang-Yong Cai Xu-Liang chen Zhi-Tao chen Shao-Hua Shi Department of Hepatobiliary and Pancreatic Surgery People’s Hospital of Jiulongpo DistrictChongqing 400050China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical CollegeHangzhou 310003China

Mirizzi syndrome is a serious complication of gallstone disease.It is caused by the impacted stones in the gallbladder neck or cystic duct.One of the features of Mirizzi syndrome is severe inflammation or dense fibrosis at the Calot’s triangle.In our clinical practice,bile duct,branches of right hepatic artery and right portal vein clinging to gallbladder infundibulum are often observed due to gallbladder infundibulum adhered to right hepatic hilum.The intraoperative damage of branches of right hepatic artery occurs more easily than that of bile duct,all of which are hidden pitfalls for surgeons.Magnetic resonance cholangiopancreatography(MRCP)and endoscopic retrograde cholangiopancreatography(ERCP)are the preferable tools for the diagnosis of Mirizzi syndrome.Anterograde cholecystectomy in Mirizzi syndrome is easy to damage branches of right hepatic artery and bile duct due to gallbladder infundibulum adhered to right hepatic hilum.Subtotal cholecystectomy is an easy,safe and definitive approach to Mirizzi syndrome.When combined with the application of ERCP,a laparoscopic management of Mirizzi syndrome by well-trained surgeons is feasible and safe.The objective of this review was to highlight its existing problems:(1)low preoperative diagnostic rate,(2)easy to damage bile duct and branches of right hepatic artery,and(3)high concomitant gallbladder carcinoma.Meanwhile,the review aimed to discuss the possible therapeutic strategies:(1)to enhance its preoperative recognition by imaging findings,and(2)to avoid potential pitfalls during surgery.

关键词： Mirizzi syndrome Bile duct injury Artery injury Surgical treatment Subtotal cholecystectomy