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Therapeutic efficacy and bone marrow protection of the mdr1 gene and over-dose chemotherapy with doxorubicin for rabbits with VX2 hepatocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 545-551页

作者： Yi Wang, Xian-Qing Jin, Shan Wang, Qiao Wang, Qing Luo and Xiao-Ji Luo Department of General Surgery Department of Ultrasound , chongqing Children’s Hospital, chongqing University of Medical Sciences, chongqing 400014, China Department of General Surgery Chongqing Children's Hospital Chongqing University of Medical Sciences Chongqing 400014 China.

BACKGROUND : Malignant tumors are common diseases threatening to the health and life of human being. Clinically, the multidrug resistance of tumor cells and bone marrow depression caused by chemotherapeutic agents are the main obstacles to the treatment of tumors, and both are related to the mdr1 gene. The over expression of the mdr1 gene in tumor cells contributes to the multidrug resistance of malignant tumor cells. With little expression of the mdr1 gene, bone marrow cells particularly susceptible to multidrug resistance-sensitive agents, which cause serious toxicity in bone marrow. This study was undertaken to assess therapeutic efficacy of transplantation of bone marrow mononuclear cells transferred with the mdr1 gene and over-dose chemotherapy with doxorubicin for VX2 hepatocarcinoma of rabbits. METHODS: The mdr1 gene was transferred into the bone marrow mononuclear cells of rabbits, which was co- cultured with retroviral vector-containing supernatant, and the cells were autotransplanted into a rabbit model with VX2 hepatocarcinoma. After chemotherapy with doxorubicin, the protective effects of the mdr1 gene and therapeutic efficacy of over-dose chemotherapy were observed. RESULTS: The mdr1 gene was transferred successfully into the bone marrow mononuclear cells, with a transduction efficiency of 35%. After autotransplantation, the mdr1 gene was expressed functionally in bone marrow with a positive rate of 8%, indicating that the gene played animportant role in bone marrow protection. The rabbits with VX2 hepatocarcinoma, which had received the mdr1 gene-transduced cells, survived after chemotherapy with a 3-fold dose of adriamycin, and their white blood cell counts were (4.26±1.03)×104/L. Since hepatocarcinoma cells were eradicated, the survival time (97.00±46.75 d) of the rabbits was extended (P<0.05) and the healing rate of the tumor was increased (P<0.05). CONCLUSIONS: The transferring of the mdr1 gene into bone marrow mononuclear cells could confer chemop

关键词： multidrug resistance gene transfection mononuclear cell chemotherapy hepatocarcinoma

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《图书馆论坛》与《四川图书馆学报》载文、作者比较分析

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图书馆论坛 2003年第6期23卷 107-112,120页

作者：王志昆重庆图书馆重庆400014

文章选取《图书馆论坛》与《四川图书馆学报》作为东西部图书馆学期刊的代表 ,分别对两刊的基本情况以及 2 0 0 1- 2 0 0 2年的载文、作者进行统计 ,以了解该刊作者在各地的分布、发展情况和作者的发展潜力以及学科的发展前景 ,寻求促... 详细信息

文章选取《图书馆论坛》与《四川图书馆学报》作为东西部图书馆学期刊的代表 ,分别对两刊的基本情况以及 2 0 0 1- 2 0 0 2年的载文、作者进行统计 ,以了解该刊作者在各地的分布、发展情况和作者的发展潜力以及学科的发展前景 ,寻求促进图书馆学期刊事业繁荣与发展的方法。

关键词：《图书馆论坛》《四川图书馆学报》期刊评价作者研究文献计量

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The Distribution about Infectious Diseases of Children’s in chongqing for 10 yeas

The Distribution about Infectious Diseases of Children’s in...

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第五届亚洲儿科研究大会

作者： Xiaoxuan Qing Chaomin Zhu Yuanyuan Xie Division of Infectious Disease and Gastroenterology Children’s Hospital chongqing University of Medical Sciences chongqing 400014 China Division of Infectious Disease and Gastroenterology Children''s Hospital chongqing University of Medical Sciences Chongqing 400014China

＜正＞Objective To find out the overall trends in the prevalence of infectious diseases in the last 10 years about chongqing,including the popular features of its time distribution,urban and rural distribution,age distribution,sex distribution,seasonal distribution,hope to give some suggestion for management of infectious diseases in hospitals.

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TNF-a Up Regulate Frequency of Regulatory T Cells and Foxp3 Expression in Vitro but Showed Indirect Relationship in Patient with JIA

TNF-a Up Regulate Frequency of Regulatory T Cells and Foxp3 ...

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第五届亚洲儿科研究大会

作者： Yunfei An Yini Wen Xiaodong Zhao chongqing Children’s Hospital of chongqing Medical University 400014 chongqing Children''s Hospital of chongqing Medical University 400014

＜正＞Objective The aim of this study was to investigate the relationship between TNF-a and the CD4+CD25+FOXP3+regulatory T cells（Tregs） in and ex vivo,to determine if and how they are involved in the immunoregulation of JIA. Methods From July 2006 to October 2008,67 JIA patients and 20 healthy controls were enrolled in this

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Analysis of Risk Factos Affecting the Trauma Victims after Earthquake

Analysis of Risk Factos Affecting the Trauma Victims after E...

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第五届亚洲儿科研究大会

作者： Yilong Fu Feng Xu Chidrens Hospital of chongqing Medical University 400014 Chidrens Hospital of chongqing Medical University 400014

＜正＞Objective To analyze the factors affecting the occurrence of crush syndrome（CS） after crush injury（CI） and impacting on its severity about pediatric trauma victims in the Wenchuan earthquake. Methods Retrosp...

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Role of P38 MAP Kinase in NAC Protection Effect on Hyperoxia-induced Lung Injury

Role of P38 MAP Kinase in NAC Protection Effect on Hyperoxia...

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第五届亚洲儿科研究大会

作者： Liping Tan Feng Xu Childrens Hospital of chongqing Medical University 400014 Childrens Hospital of chongqing Medical University 400014

＜正＞Objective To explore the protective effect of N-Acetylcysteine（NAC） on hyperoxia-induced lung injury and change of p38 MAP kinase expression caused by NAC treatment. Methods Fourty Wistar rats aged 3 weeks old were randomized to 5 groups with 8 rats in each:room-air group（A）,hyperoxia injury group（B）,hyperoxia +NAC group（C）,hyperoxia +SB203580 group（D）,

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小儿危重心律失常的识别判断与治疗对策

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实用儿科临床杂志 2008年第13期23卷 975-977页

作者：田杰重庆医科大学附属儿童医院心内科重庆400014

心律失常对个体是否构成危重或急诊取决于患儿的心功能状况、频率快速或缓慢的程度、持续的时间、对血压和心肌灌注的影响、年龄和精神状态等因素。正确识别和判断心律失常的危重性,并选择合理、及时的治疗措施,是挽救危重心律失常患儿... 详细信息

心律失常对个体是否构成危重或急诊取决于患儿的心功能状况、频率快速或缓慢的程度、持续的时间、对血压和心肌灌注的影响、年龄和精神状态等因素。正确识别和判断心律失常的危重性,并选择合理、及时的治疗措施,是挽救危重心律失常患儿生命的关键。

关键词：危重心律失常诊断治疗

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High proportion of CD34+/CD38- expression is correlated with poor prognostic factors for childhood acute leukemia

High proportion of CD34+/CD38- expression is correlated with...

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中华医学会第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议

作者： Zou Lin,Long Juan,Li Kang,Zhou Xiaoyan Children Hospital,chongqing Medical University 400014

Purpose The human leucocyte surface phenotype CD34/CD38 is a relatively specific immunologic maker for leukemia stem ***,the clinical and prognostic significance of CD34/CD38 expression in childhood acute leukemia(AL) is not well established. Experimental Design Utilizing 168 childhood ALs,including 112 acute lymphoblastic leukemia (ALL) and 56 acute myeloid leukemia(AML),with

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Guest Editorial:Special Section on Battery Energy Storage Systems for Net-zero Power Systems and Markets

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 321-322页

作者： Pierluigi Mancarella Nikos Hatziargyriou chongqing Kang The University of Melbourne MelbourneAustralia The University of Manchester ManchesterUK National Technical University of Athens(NTUA) AthensGreece Tsinghua University BeijingChina IEEE

Battery energy storage technologies have witnessed both dramatic cost reduction and technical evolution in recent *** is leading to widespread deployment of battery energy storage systems(BESSs)worldwide,particularly to support operation of power grids with already deep penetration of *** the development of new battery technologies with different power-to-energy ratios and for various engineering applications,BESSs could play a strategic role towards a net-zero energy *** opportunities are emerging for BESSs to participate in several markets,provide different grid services,and perform“value stacking”,eventually allowing development of new business cases and improved BESS *** configurations that are“behind the meter”,“in front of the meter”,hybrid plants co-located with renewables,and so forth,are only some of the exciting propositions that are being seen in different countries and at different scales,from highly distributed(virtual power plants),to neighbourhood-level(community batteries),to utility scale.

关键词： Battery battery eventually

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过敏性紫癜肾炎的临床与病理分析

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实用儿科临床杂志 2004年第9期19卷 739-740页

作者：杨晓李秋重庆医科大学儿童医院肾内科重庆400014

目的　回顾性分析经肾活检证实为紫癜肾炎 (HSPN) 2 0例患儿临床、病理特点。方法　根据不同肾小球或肾小管间质病理分型将 2 0例过敏性紫癜性肾炎患儿分组 ,并比较、分析临床特点。结果　肾小球病理改变为Ⅱ、Ⅲ级 2型 ,病例在起病年... 详细信息

目的　回顾性分析经肾活检证实为紫癜肾炎 (HSPN) 2 0例患儿临床、病理特点。方法　根据不同肾小球或肾小管间质病理分型将 2 0例过敏性紫癜性肾炎患儿分组 ,并比较、分析临床特点。结果　肾小球病理改变为Ⅱ、Ⅲ级 2型 ,病例在起病年龄、性别、临床分型、肾外症状等方面差异无显著性意义 ,但Ⅲ级组蛋白尿排出显著多于Ⅱ级组、肾小管间质病变程度也显著重于Ⅱ级组 ,此外HSPN组尿微量蛋白、血浆IgA、C3 浓度等较正常对照组显著增高。结论　紫癜肾炎大部分患儿均同时存在肾小球及肾小管病变 ,两者基本病变相平行。

关键词：肾炎紫癜,过敏性病理临床

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