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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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骨科机器人在临床应用中的分类及优缺点

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中国组织工程研究 2025年第15期29卷 3271-3279页

作者：孙成劼张德强大连医科大学附属第一医院辽宁省大连市116000

背景:步入智能时代以来,人们对应用于医疗方面的人工智能技术的研究热情越发高涨。在骨科领域,机器人辅助技术是最具吸引力的人工智能技术之一。经过近40年的发展,机器人辅助技术逐渐成熟,可参与的骨科手术种类逐渐增多,且起到至关重要... 详细信息

背景:步入智能时代以来,人们对应用于医疗方面的人工智能技术的研究热情越发高涨。在骨科领域,机器人辅助技术是最具吸引力的人工智能技术之一。经过近40年的发展,机器人辅助技术逐渐成熟,可参与的骨科手术种类逐渐增多,且起到至关重要的作用。目的:总结到目前为止骨科机器人在临床的应用情况,并分析其优缺点。方法:通过对PubMed数据库和中国知网已收录的相关文献进行检索,英文检索词为“robot-assisted technology,surgical robots,orthopaedic robots,robotic arm,orthopaedic,orthopaedic surgery,joint,spine,trauma,bone tumor”,中文检索词为“机器人辅助技术,手术机器人,骨科机器人,机械臂,骨科,骨科手术,关节,脊柱,创伤,骨肿瘤”。按照入选标准进行筛选共得到82篇相关性高的文献。结果与结论:目前机器人辅助技术在临床中的应用比较成熟,可用于大多数骨科手术中,有着不错的临床表现;骨科机器人主要优点包括缓解临床医生的工作压力、减少术中副损伤、缩短辐射暴露时间等,但同时也可能存在手术操作时间延长和术后并发症增加的情况。未来骨科机器人的发展将沿着高智能、低成本、更快捷等方向发展。

关键词：机器人辅助技术机械臂骨科智能技术传统术式

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Molecule‑Level Multiscale Design of Nonflammable Gel Polymer Electrolyte to Build Stable SEI/CEI for Lithium Metal Battery

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Nano-Micro Letters 2025年第1期17卷 404-423页

作者： Qiqi sun Zelong Gong Tao Zhang Jiafeng Li Xianli Zhu Ruixiao Zhu Lingxu Wang Leyuan Ma Xuehui Li Miaofa Yuan Zhiwei Zhang Luyuan Zhang Zhao Qian Longwei Yin Rajeev Ahuja Chengxiang Wang Key Laboratory for Liquid‑Solid Structural Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061People’s Republic of China Condensed Matter Theory Department of Physics and AstronomyUppsala UniversityUppsala 75120Sweden

The risk of flammability is an unavoidable issue for gel polymer electrolytes(GPEs).Usually,flameretardant solvents are necessary to be used,but most of them would react with anode/cathode easily and cause serious interfacial instability,which is a big challenge for design and application of nonflammable ***,a nonflammable GPE(SGPE)is developed by in situ polymerizing trifluoroethyl methacrylate(TFMA)monomers with flame-retardant triethyl phosphate(TEP)solvents and LiTFSI–LiDFOB dual lithium *** is strongly anchored to PTFMA matrix via polarity interaction between-P=O and-CH_(2)CF_(3).It reduces free TEP molecules,which obviously mitigates interfacial reactions,and enhances flame-retardant performance of TEP *** TEP molecules are also inhibited in solvation of Li^(+),leading to anion-dominated solvation sheath,which creates inorganic-rich solid electrolyte interface/cathode electrolyte interface *** coordination structure changes Li^(+)transport from sluggish vehicular to fast structural transport,raising ionic conductivity to 1.03 mS cm^(-1) and transfer number to 0.41 at 30℃.The Li|SGPE|Li cell presents highly reversible Li stripping/plating performance for over 1000 h at 0.1 mA cm^(−2),and 4.2 V LiCoO_(2)|SGPE|Li battery delivers high average specific capacity>120 mAh g^(−1) over 200 *** study paves a new way to make nonflammable GPE that is compatible with Li metal anode.

关键词： Anchoring effect Nonflammable gel electrolyte In situ cross-linked Electrode-electrolyte interface Li metal battery

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刃宽对硬岩掘进影响的仿真及试验研究

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工程科学学报 2025年第1期47卷 13-24页

作者：尚勇孙靖东姜海峰许顺海段红磊孙朝阳北京科技大学机械工程学院北京100083 中铁工程装备集团隧道设备制造有限公司河南453000

滚刀在硬岩掘进中极易发生崩刃、偏磨等异常失效,研究硬岩掘进条件下刃型参数对滚刀破岩载荷和破岩效率的影响十分重要.本文采用滚刀破岩试验和仿真分析相结合的方法,从载荷曲线、破岩体积、破岩比能等方面分析了刃宽对滚刀破岩的影响.... 详细信息

滚刀在硬岩掘进中极易发生崩刃、偏磨等异常失效,研究硬岩掘进条件下刃型参数对滚刀破岩载荷和破岩效率的影响十分重要.本文采用滚刀破岩试验和仿真分析相结合的方法,从载荷曲线、破岩体积、破岩比能等方面分析了刃宽对滚刀破岩的影响.基于双线性本构模型及Benzeggagh–Kenane损伤断裂准则建立了岩石材料的内聚力本构模型,通过单轴抗压试验及巴西劈裂试验对内聚力本构模型的微观参数进行了校准,并进一步建立了滚刀破岩的内聚力仿真模型.结果表明:内聚力本构模型可以准确的模拟破岩过程中岩石裂纹的萌生和扩展过程.依据裂纹的萌生和扩展情况,滚刀破岩过程主要分为三个阶段:弹性阶段、裂纹萌生–扩展阶段及岩石破坏卸载阶段.滚刀破岩载荷和破岩体积随着贯入度、刀间距和刃宽的增加而增加;破岩比能随刃宽的增加呈先减小后增大的趋势.对于所选取的硬岩,采用13 mm刃宽滚刀破岩时比能最小,破岩效率最高;7 mm刃宽滚刀破岩时无法形成贯通岩片,相邻滚刀之间仍存在岩脊,破岩效率较低.

关键词：滚刀刃宽 Cohesive模型线切割试验破岩载荷破岩效率

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基于相似理论的飞机实际着陆距离预测方法

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中国安全科学学报 2021年第3期31卷 13-18页

作者：孙瑞山陈雄李重锋中国民航大学飞行技术学院天津300300 中国民航大学民航安全科学研究所天津300300

为防止飞机着陆时冲出跑道事件的发生,提出一种基于相似理论的飞机实际着陆距离预测方法。首先,通过量纲分析法结合影响飞机实际着陆距离的主要因素,推导出表征实际着陆距离的无量纲方程;然后,利用真实飞行数据,得出不同接地俯仰角条件... 详细信息

为防止飞机着陆时冲出跑道事件的发生,提出一种基于相似理论的飞机实际着陆距离预测方法。首先,通过量纲分析法结合影响飞机实际着陆距离的主要因素,推导出表征实际着陆距离的无量纲方程;然后,利用真实飞行数据,得出不同接地俯仰角条件下飞机实际着陆距离的预测方程;最后,对比分析方程预测结果与由真实数据所得的飞机实际着陆距离。结果表明:采用该方法能够在不同接地俯仰角条件下预测飞机实际着陆距离;在小接地俯仰角条件下,预测值与实际值吻合度最高,最大绝对误差在50 m范围内,最大相对误差约为3%。

关键词：相似理论飞机实际着陆距离量纲分析飞行数据着陆过程

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Novel approach to GPS/SINS integration for IMU alignment

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Journal of Systems Engineering and Electronics 2011年第3期22卷 513-518页

作者： Wei sun Feng sun School of Geomatics Liaoning Technical UniversityFuxin 123000P.R.China College of Automation Harbin Engineering UniversityHarbin 150001P.R.China

Strapdown inertial navigation system（SINS） requires an initialization process that establishes the relationship between the body frame and the local geographic *** process,called alignment,is generally used to estimate the initial attitude *** is possible because an accurate determination of the inertial measurement unit（IMU） motion is available based on the measurement obtained from global position system（GPS）.But the update frequency of GPS is much lower than *** to the non-synchronous data streams from GPS and SINS,the initial attitude angles may not be computed accurately *** addition,the estimated initial attitude angles may have relatively large uncertainties that can affect the accuracy of other navigation *** paper presents an effective approach of matching the velocities which are provided by GPS and *** this approach,a digital high-pass filter,which implements a pre-filtering scheme of the measured signal,is used to filter the Schuler cycle of discrete velocity difference between the SINS and *** results show that this approach improves the accuracy greatly and makes the convergence time satisfy the required accuracy.

关键词： strapdown inertial navigation system(SINS) global position system(GPS) integration alignment high-pass filter.

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Single-Walled Carbon Nanotubes for Flexible Electronics and Sensors

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Journal of Materials Science & Technology 2008年第4期24卷 569-577页

作者： Xiuyun sun Yugang sun Department of Mechanical and Electronic Engineering Dezhou University Dezhou 253023 China Center for Nanoscale Materials Argonne National Laboratory 9700 South Cass Avenue Argonne Illinois 60439 USA

This article reviews the use of electronic quality single-walled carbon nanotubes grown via chemical vapor deposition （CVD） approaches at high temperatures as building blocks for fabricating flexible field-effect devices, such as thin-film transistors （TFTs） and chemical sensors. Dry transfer printing technique is developed for forming films of CVD nanotubes on low-temperature plastic substrates. Examples of TFTs with the use of nanotubes and thin dielectrics and hydrogen sensors with the use of nanotubes decorated with palladium nanoparticles are discussed in detail to demonstrate the promising potentiality of single-walled carbon nanotubes for building high performance flexible devices, which can find applications where traditional devices on rigid substrates are not suitable.

关键词： Single-walled carbon nanotubes Flexible Electronics Sensors

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Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第01期 123-138页

作者： Chentong GAO Huiyu sun Jianping GU W.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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知识基础调节下合作网络对绿色技术创新的影响

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科技进步与对策 2021年第2期38卷 38-46页

作者：王崇锋孙靖青岛大学商学院山东青岛266000

绿色技术创新是绿色发展的重要动力,使用1985—2017年中国绿色技术专利数据,基于创新组织微观视角,运用负二项回归分析方法探究中心度、结构洞与聚集性3类合作网络特征对绿色技术创新的直接影响,以及知识广度、知识深度与知识融合性3类... 详细信息

绿色技术创新是绿色发展的重要动力,使用1985—2017年中国绿色技术专利数据,基于创新组织微观视角,运用负二项回归分析方法探究中心度、结构洞与聚集性3类合作网络特征对绿色技术创新的直接影响,以及知识广度、知识深度与知识融合性3类知识基础特征在上述影响中的调节作用。结果表明:①中心度与结构洞对绿色技术创新具有正向影响,聚集性对其具有负向影响;②知识广度削弱了中心度与结构洞的正向影响,同时削弱了聚集性的负向影响;知识深度强化了中心度与结构洞的正向影响,削弱了聚集性的负向影响;知识融合性在合作网络特征对不同类型绿色技术专利申请数的影响中具有不同的调节机制。最后,基于合作网络特征与知识基础特征优化视角,为我国企业、高校及科研院所等创新组织进行绿色技术创新提出相关政策建议。

关键词：合作网络知识基础绿色技术创新绿色技术专利

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Assessment of advanced RANS turbulence models for prediction of complex flows in compressors

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Chinese Journal of Aeronautics 2023年第9期36卷 162-177页

作者： Wei sun China Academy of Aerospace Science and Innovation Beijing 100176China

Reynolds-Averaged Navier-Stokes(RANS) Computational Fluid Dynamics(CFD) has been widely used in compressor design and analysis. However, reasonable prediction of compressor flow and its impact on compressor performance remains challenging. In this study, Menter’s Shear Stress Transport(SST) model and its variants, as well as the ω-based Reynolds stress model(Stress-BSL) are assessed. For a single rotor(Rotor 67), under the peak efficiency operating condition, all studied turbulence models predict its performance with reasonable accuracy;under the off-design conditions, SST with Helicity correction(SST-Helicity) shows superiority in predicting the effect of flow on the spanwise distribution of aerodynamic parameters. For Darmstadt’s 1.5-stage transonic axial compressor, SST-Helicity outperforms SST, SST with the Quadratic Constitutive Relation(SST-QCR) and Stress-BSL in predicting the performance as well as the spanwise distribution of aerodynamic parameters. At the design rotating speed, the stall margin given by SST-Helicity(20.90%) is the closest to the experimental measurement(24.81%), which is more than twice that by SST(8.71%) and 1.5 times that by SST-QCR(14.14%). This paper demonstrates that SSTHelicity model, together with a good quality and sufficiently refined grid, can capture the compressor flow features with reasonable accuracy, which results in a credible prediction of compressor performance and stage matching.

关键词： Compressor flow Computational Fluid Dynamics(CFD) Reynolds-Averaged Navier-Stokes(RANS) Reynolds stress model Stall margin Shear Stress Transport(SST)model Turbulence modelling

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