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Construction and evaluation of a liver cancer risk prediction model based on machine learning

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3839-3850页

作者： Ying-Ying Wang Wan-Xia Yang Qia-Jun Du Zhen-Hua Liu Ming-Hua Lu chong-ge you Laboratory Medicine Center The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina

BACKGROUND Liver cancer is one of the most prevalent malignant tumors worldwide,and its early detection and treatment are crucial for enhancing patient survival rates and quality of ***,the early symptoms of liver cancer are often not obvious,resulting in a late-stage diagnosis in many patients,which significantly reduces the effectiveness of *** a highly targeted,widely applicable,and practical risk prediction model for liver cancer is crucial for enhancing the early diagnosis and long-term survival rates among affected *** To develop a liver cancer risk prediction model by employing machine learning techniques,and subsequently assess its *** In this study,a total of 550 patients were enrolled,with 190 hepatocellular carcinoma(HCC)and 195 cirrhosis patients serving as the training cohort,and 83 HCC and 82 cirrhosis patients forming the validation *** regression(LR),support vector machine(SVM),random forest(RF),and least absolute shrinkage and selection operator(LASSO)regression models were developed in the training *** performance was assessed in the validation ***,this study conducted a comparative evaluation of the diagnostic efficacy between the ASAP model and the model developed in this study using receiver operating characteristic curve,calibration curve,and decision curve analysis(DCA)to determine the optimal predictive model for assessing liver cancer *** Six variables including age,white blood cell,red blood cell,platelet counts,alpha-fetoprotein and protein induced by vitamin K absence or antagonist II levels were used to develop LR,SVM,RF,and LASSO regression *** RF model exhibited superior discrimination,and the area under curve of the training and validation sets was 0.969 and 0.858,*** values significantly surpassed those of the LR(0.850 and 0.827),SVM(0.860 and 0.803),LASSO regression(0.845 and 0.831),and ASAP(0.866 and 0.813)model

关键词： Hepatocellular carcinoma Cirrhosis Prediction model Machine learning Random forest

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Laboratory and field evaluation of a low-cost optical particle sizer

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Journal of Environmental Sciences 2024年第8期142卷 215-225页

作者： Mingzhen Tang Yicheng Shen Yanzhen ge Jian Gao chong Wang Liqing Wu Shuchun Si State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Jinan Grid-Based Supervision Center of Ecological and Environmental Protection Jinan 250100China Tai’an Ecological Environment Protection Control Center Tai’an 271000China School of Physics Shandong UniversityJinan 250013China

Low-cost sensors are widely used to collect high-spatial-resolution particulate matter data that traditional reference monitoring devices *** addition to the mass concentration,the number concentration and size distribution are also fundamental in determining the origin and hazard level of particulate ***,low-cost optical sensors have been improved to establish optical particle sizers(OPSs).In this study,a low-cost OPS,the Nova SDS029,is introduced,and it is evaluated in comparison to two reference instruments—the GRIMM 11-D and the TSI *** first tested the sizing accuracy using polystyrene latex ***,we assessed the mass and number size distribution accuracy in three application scenarios:indoor smoking,ambient air quality,and mobile *** evaluations suggest that the low-cost SDS029 rivals research-grade optical sizers in many *** example,(1)the particle diameters obtained with the SDS029 are close to the reference instruments(usuallyge;(2)the number of particles and mass concentration are highly correlated(r≥0.99)with the values obtained with the reference instruments;and(3)the SDS029 slightly underestimates the number concentration,but the derived PM_(2.5)values are closer to monitoring station than the reference *** successful application of the SDS029 in multiple scenarios suggests that a plausible particle size distribution can be obtained in an easy and cost-efficient *** believe that low-cost OPSs will increasingly be used to map the sources and risk levels of particles at the city scale.

关键词： Optical particle sizer Particle size distribution Low-cost sensor Evaluation Field application

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Observation and Analysis of VLF Nocturnal Multimode Interference Phenomenon based on Waveguide Mode Theory

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Research in Astronomy and Astrophysics 2024年第1期24卷 78-86页

作者： Sai Yang you-Tian Niu Zhe Wang Xiu-Kun Zhao Bei Li Yu-Ling Ding ge-ge Zhao An-Qi Zhang College of Electronic and Electrical Engineering Henan Normal UniversityXinxiang 453007China Academician Workstation of Electromagnetic Wave Engineering of Henan Province Xinxiang 453007China Key Laboratory of Optoelectronic Sensing Integrated Application of Henan Province Xinxiang 453007China Engineering Laboratory of Intelligent Additive Manufacturing of Henan Province Xinxiang 453007China

Very low frequency(VLF)signals are propagated between the *** interference will cause the phase to show oscillatory changes with distance while propagating at night,leading to abnormalities in the received VLF *** study uses the VLF signal received in Qingdao City,Shandong Province,from the Russian Alpha navigation system to explore the multimode interference problem of VLF signal *** characteristics of the effect of multimode interference phenomena on the phase are analyzed according to the variation of the phase of the VLF ***,the phase of VLF signals will also be affected by the X-ray and energetic particles that are released during the eruption of solar flares,therefore the two phenomena are studied in this *** is concluded that the X-ray will not affect the phase of VLF signals at night,but the energetic particles will affect the phase change,and the influence of energetic particles should be excluded in the study of multimode interference *** VLF signals for navigation positioning in degraded or unavailable GPS conditions is of great practical significance for VLF navigation systems as it can avoid the influence of multimode interference and improve positioning accuracy.

关键词： waves methods:data analysis Sun:flares Sun:X-rays gamma-rays

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Design study of charge-stripping scheme of heavy ion beams for HIAF-BRing

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Nuclear Science and Techniques 2024年第5期35卷 30-41页

作者： Jun-Jie Zhang Zhi-you Xu Jin-Quan Zhang Wen-Wen ge Liang-Ting Sun Huan-Yu Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Charge strippers play an essential role in heavy-ion accelerators by stripping the projectile ions to higher charge states to enhance the acceleration efficiency downstream of the *** the high-energy mode of the booster ring(BRing)of the high-intensity heavy-ion accelerator facility,the pre-accelerated ions from the iLinac will be stripped by a carbon foil to higher charge states and then injected into the *** key parameters of the stripper and stripped ions were calculated,and the influence of stripping on the beam quality was *** get high stripping efficiencies,the foil thicknesses and resultant charge state distributions for the typical ions were determined by the code *** equilibrium thickness was obtained for the U beam,while the stripper thicknesses for the Xe and Kr beams were determined based on a compromise between the stripped charge states and the stripping *** energy loss,energy straggling,and emittance growth due to stripping have a non-negligible impact on the transport of the stripped beams and the injection of the ***,these parameters were simulated by *** addition,the foil’s temperature evolution,which greatly affects the foil lifetime,was simulated by *** maximum temperature of the foil bombarded by the U and Xe beams with the nominal parameters will exceed the safe value in terms of the impact of evaporation on the foil’s *** the foil temperature constraint,the highest tolerable beam intensity and the injected ion number into the ring were derived for different beam *** results of this paper will present important reference data for the optimization design and commissioning of the beamline and injection to the BRing for the stripped ions.

关键词： High-intensity heavy-ion accelerator facility Charge stripper Energy spread Thermal analysis Emittance growth Injection turns

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Correlation analysis of gene polymorphisms and β-lactam allergy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第7期16卷 632-639页

作者： Jing LI Xin-yue LIU Lin-jing LI chong-ge you Lei SHI Shang-di ZHANG Qian LIU Jun WANG Ze-jing LIU Ting-hong LV Centre of Laboratory Medicine Lanzhou University Second Hospital School of Basic Medical Science Lanzhou University

A total of 64 patients with β-lactam allergy and 30 control subjects were enrolled in a case-control study. This study is aimed to analyze the relationship between β-lactam allergy and 10 single nucleotide polymorphisms（SNPs） in interleukin-10（IL-10）, IL-13, IL-4Rα, high-affinity immunoglobulin E-receptor β chain（FcεRIβ）, interferon γ receptor 2（IFNGR2）, and CYP3A4, and within the Han Chinese population of Northwest China. genotyping for the SNPs was conducted using the Sequenom Mass ARRAY platform. SPSS 17.0 was employed to analyze the statistical data and SHEsis was used to perform the haplotype reconstruction and analyze linkage disequilibrium of SNPs of IL-10 and IL-13. The results showed that the genotype distribution of CYP3A4 rs2242480/CT differed significantly between case and control groups of males（P=0.022; odds ratio（OR）=0.167, 95% confidence interval（CI）： 0.032–0.867）. Further analysis showed that CCA, CCG, and TAA haplotypes of IL-10 had no significant correlation in patients with β-lactam allergy. The correlation between CCT and CAC haplotypes of IL-13 and β-lactam allergy needs to be further studied. The analysis did not reveal any differences in the distribution of others gene polymorphisms between cases and controls.

关键词： Allergy β-Lactam Interleukin(IL) Pharmacogenomics Single nucleotide polymorphism(SNP)

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Controllability of Semilinear Integrodifferential Degenerate Sobolev Equations

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Journal of Systems Science & Complexity 2024年第5期37卷 1923-1936页

作者： ge Zhaoqiang School of Mathematics and Statistics Xi’an Jiaotong University

In this paper, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions is investigated in the sense of integral solution in Hilbert spaces. Some sufficient and necessary conditions are obtained. Firstly, the existence and uniqueness of integral solutions of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions are considered by ge-evolution operator theory and Sadovskii's fixed point theorem, the existence and uniqueness theorem of solutions is given. Secondly, the approximate controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions is studied in the sense of integral solution. The criterion for approximate controllability is provided. The obtained results have important theoretical and practical value for the study of controllability of semilinear integrodifferential degenerate Sobolev equations with nonlocal conditions.

关键词： Approximate controllability ge-evolution operator integral solution Sadovskii’s fixed point theorem semilinear integrodifferential degenerate Sobolev equations

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A comparative study of the pore characteristics and phenol adsorption performance of activated carbons prepared from oil-palm shell wastes by steam and combined steam-chemical activation

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Green Chemical Engineering 2024年第1期5卷 85-96页

作者： Aik chong Lua School of Mechanical and Aerospace Engineering Nanyang Technological University50 Nanyang AvenueSingapore639798Republic of Singapore

Oil-palm shell wastes were successfully converted into useful activated carbons in a systematic and novel approach by optimizing the pyrolysis conditions and subsequent steam activation conditions to maximize the BET surface *** optimal activation conditions were a steam flow rate of 1.13 kg/h,hold time of 1.5 h and temperature of 950℃,yielding BET areas of 1432.94 and 1382.95 m^(2)/g for nitrogen-pyrolyzed and vacuumpyrolyzed chars,*** steam-chemical activation,one-step activation of oil-palm shell in steam with potassium carbonate(K_(2)CO_(3)),sodium carbonate(Na_(2)CO_(3))or potassium chloride(KCl)was conducted,resulting in BET area output order of shell/K_(2)CO_(3)(710.56 m^(2)/g)>shell/KCl(498.55 m^(2)/g)>shell(366.7 m^(2)/g)>shell/Na_(2)CO_(3)(326.62 m^(2)/g).This study reported the first use of KCl and Na_(2)CO_(3)as chemical reagents in one-step steam-chemical activation of ***-activated carbon exhibited retardation of tar formation property,resulting in better pore development than pure steam activated *** adsorption of activated carbon is not only a function of the BET surface area but also the type of pyrolysis used prior to physical *** carbon(BET area of 1192.29 m^(2)/g)pyrolyzed under vacuum could adsorb 87%more phenol than that pyrolyzed in nitrogen flow which had a higher BET area of 1432.94 m^(2)/*** adsorption capacities of activated carbons are:shell pyrolyzed under vacuum(275.5 mg/g)>shell pyrolyzed in N_(2)flow(147.1 mg/g)>shell/K_(2)CO_(3)(145.7 mg/g)>shell without pyrolysis(12.1 mg/g).These activated carbons would be highly suitable in industry processes to remove phenolic contaminants.

关键词： Pore surface area Oil-palm shell Activated carbon Steam activation Phenol adsorption

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Sparse Reconstructive Evidential Clustering for Multi-View Data

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 459-473页

作者： Chaoyu Gong Yang you School of Computing National University of SingaporeSingapore

Although many multi-view clustering(MVC) algorithms with acceptable performances have been presented, to the best of our knowledge, nearly all of them need to be fed with the correct number of clusters. In addition, these existing algorithms create only the hard and fuzzy partitions for multi-view objects,which are often located in highly-overlapping areas of multi-view feature space. The adoption of hard and fuzzy partition ignores the ambiguity and uncertainty in the assignment of objects, likely leading to performance degradation. To address these issues, we propose a novel sparse reconstructive multi-view evidential clustering algorithm(SRMVEC). Based on a sparse reconstructive procedure, SRMVEC learns a shared affinity matrix across views, and maps multi-view objects to a 2-dimensional humanreadable chart by calculating 2 newly defined mathematical metrics for each object. From this chart, users can detect the number of clusters and select several objects existing in the dataset as cluster centers. Then, SRMVEC derives a credal partition under the framework of evidence theory, improving the fault tolerance of clustering. Ablation studies show the benefits of adopting the sparse reconstructive procedure and evidence theory. Besides,SRMVEC delivers effectiveness on benchmark datasets by outperforming some state-of-the-art methods.

关键词： Evidence theory multi-view clustering(MVC) optimization sparse reconstruction

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Non-Deterministic Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 240-248页

作者： Dan you Shouguang Wang IEEE the School of Information and Electronic Engineering Sussex Artificial Intelligence InstituteZhejiang Gongshang UniversityHangzhou 310018China

In this paper, we study the supervisory control problem of discrete event systems assuming that cyber-attacks might occur. In particular, we focus on the problem of liveness enforcement and consider a sensor-reading modification attack(SM-attack) that may disguise the occurrence of an event as that of another event by intruding sensor communication channels. To solve the problem, we introduce non-deterministic supervisors in the paper, which associate to every observed sequence a set of possible control actions offline and choose a control action from the set randomly online to control the system. Specifically, given a bounded Petri net(PN) as the reference formalism and an SMattack, an algorithm that synthesizes a liveness-enforcing nondeterministic supervisor tolerant to the SM-attack is proposed for the first time.

关键词： Cyber-attacks cyber-physical system(CPS) liveness non-deterministic supervisors Petri net(PN)

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Remote estimates of suspended particulate matter in global lakes using machine learning models

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International Soil and Water Conservation Research 2024年第1期12卷 200-216页

作者： Zhidan Wen Qiang Wang Yue Ma Pierre Andre Jacinthe ge Liu Sijia Li Yingxin Shang Hui Tao chong Fang Lili Lyu Baohua Zhang Kaishan Song Northeast Institute of geography and Agroecology CASChangchunJilin130102China Department of geology Indiana University∼Purdue UniversityIndianapolisIN44602USA University of Chinese Academy of Sciences Beijing100100China College of geography and Urban Planning Liaocheng UniversityLiaochengChina

Suspended particulate matter(SPM)in lakes exerts strong impact on light propagation,aquatic ecosystem productivity,which co-varies with nutrients,heavy metal and micro-pollutant in *** lakes,SPM exerts strong absorption and backscattering,ultimately affects water leaving signals that can be detected by satellite *** regression models based on specific band or hand ratios have been widely used for SPM estimate in the past with moderate *** are still rooms for model accuracy improvements,and machine learning models may solve the non-linear relationships between spectral variable and SPM in *** assembled more than 16,400 in situ measured SPM in lakes from six continents(excluding the Antarctica continent),of which 9640 samples were matched with Landsat overpasses within±7 *** machine learning algorithms and two simple regression methods(linear and partial least squares models)were used to estimate SPM in lakes and the performance were *** overcome the problem of imbalance datasets in regression,a Synthetic Minority Over-Sampling technique for regression with Gaussian Noise(SMOGN)was adopted in this *** comparison,we found that gradient boosting decision tree(GBDT),random forest(RF),and extreme gradient boosting(XGBoost)models demonstrated good spatiotemporal transferability with SMOGN processed dataset,and has potential to map SPM at different year with good quality of Landsat land surface reflectance *** all the tested modeling approaches,the GBDT model has accurate calibration(n=6428,R^(2)=0.95,MAPE=29.8%)from SPM collected in 2235 lakes across the world,and the validation(n=3214,R^(2)=0.84,MAPE=38.8%)also exhibited stable ***,the good performances were also exhibited by RF model with calibration(R^(2)=0.93)and validation(R^(2)=0.86,MAPE=24.2%)*** applied GBDT and RF models to map SPM of typical lakes,and satisfactory result was *** addition,the GBDT model was evaluated b

关键词： Landsat imagery Remote estimation SPM Transferability

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