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Drug-Target Interactions Prediction Based on Signed Heterogeneous Graph Neural Networks

Chinese Journal of Electronics 2024年第1期33卷 231-244页

作者： Ming CHEN Yajian jiang Xiujuan LEI yi PAN Chunyan JI Wei jiang College of Information Science and Engineering Hunan Normal University School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Computer Science Department BNU-HKBU United International College

Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.

关键词： Drugs Training Proteins Measurement Message passing Prediction methods Graph neural networks

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Initial alignment of compass based on genetic algorithm-particle swarm optimization

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Defence Technology（防务技术） 2020年第1期16卷 257-262页

作者： yi-feng Liang Peng-fei jiang jiang-ning Xu Wen An Miao Wu College of Electrical Engineering Naval Univ.of EngineeringWuhan 430033China

The rapidity and accuracy of the initial alignment influence the performance of the strapdown inertial navigation system(SINS),compass alignment is one of the most important methods for initial *** selection of the parameters of the compass alignment loop directly affects the result of ***,the optimal parameters of the compass loop of different SINS are also different Traditionally,the alignment parameters are determined by experience and trial-and-error,thus it cannot ensure that the parameters are *** this paper,the Genetic Algorithm-Particle Swarm Optimization(GA-PSO) algorithm is proposed to optimize the compass alignment parameters so as to improve the performance of the initial alignment of strapdown *** experiment results showed that the GA-PSO algorithm can find out the optimal parameters of the compass alignment circuit quickly and accurately and proved the effectiveness of the proposed method.

关键词： Inertial alignment Genetic algorithm SINS Compass alignment

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Numerical modeling method on the movement of water flow and suspended solids in two-dimensional sedimentation tanks in the wastewater treatment plant

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Journal of Environmental Sciences 2003年第1期15卷 31-37页

作者： ZENGGuang－ming jiang－yi－min 等 DepartmentofEnvironmentalSciencesandEngineeeringofHumanUniversity Changsha410082China

Taking the distributing calculation of velocity and concentration as an example, the paper established a series of governing equations by the vorticity stream function method, and dispersed the equations by the finite differencing method. After figuring out the distribution field of velocity, the paper also calculated the concentration distribution in sedimentation tank by using the two dimensional concentration transport equation. The validity and feasibility of the numerical method was verified through comparing with experimental data. Furthermore, the paper carried out a tentative exploration into the application of numerical simulation of sedimentation tanks.

关键词： sedimentation tank numerical simulation vorticity stream function

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The Chinese Understanding of Wittgenstein’s Mysticism in the Tractatus

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Frontiers of Philosophy in China 2021年第1期16卷 6-25页

作者： jiang yi School of Philosophy and Sociology and Research Center for the Philosophy of Science and TechnologyShanxi UniversityTaiyuan 030006China

Wittgenstein’s mysticism has been one of the focuses of critics and commentators of Tractatus *** prevailing readings hold different attitudes towards *** classical reading commits to the mysticism in the Tractatus,while the therapeutic reading rejects it amid its interpretation of Wittgenstein’s later *** this paper,I will argue against both by discussing how the Chinese reading understands the Tractatus.I will show that the ineffable in the Tractatus is not any type of mysticism,and that the Chinese reading of the Tractatus is a metaphysical one without any mysticism.

关键词： Tractatus classic reading therapeutic reading Chinese reading mysticism Wittgenstein Zhang Shenfu

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Self-enhanced targeted delivery of a cell wall– and membrane-active antibiotics,daptomycin, against staphylococcal pneumonia

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Acta Pharmaceutica Sinica B 2016年第4期6卷 319-328页

作者： Hong jiang Meimei Xiong Qiuyan Bi ying Wang chong Li College of Pharmaceutical Sciences Southwest University

Considering that some antibacterial agents can identify the outer structure of pathogens like cell wall and/or cell membrane, we explored a self-enhanced targeted delivery strategy by which a small amount of the antibiotic molecules were modified on the surface of carriers as targeting ligands of certain bacteria while more antibiotic molecules were loaded inside the carriers, and thus has the potential to improve the drug concentration at the infection site, enhance efficacy and reduce potential toxicity. In this study, a novel targeted delivery system against methicillin-resistant Staphylococcus aureus(MRSA)pneumonia was constructed with daptomycin, a lipopeptide antibiotic, which can bind to the cell wall of *** via its hydrophobic tail. Daptomycin was conjugated with N-hydroxysuccinimidyl–polyethylene glycol–1,2-distearoyl-sn-glycero-3-phosphoethanolamine to synthesize a targeting compound(Dapt–PEG–DSPE) which could be anchored on the surface of liposomes, while additional daptomycin molecules were encapsulated inside the liposomes. These daptomycin-modified, daptomycin-loaded liposomes(DPD-L[D]) showed specific binding to MRSA as detected by flow cytometry and good targeting capabilities in vivo to MRSA-infected lungs in a pneumonia model. DPD-L[D] exhibited more favorable antibacterial efficacy against MRSA than conventional PEGylated liposomal daptomycin both in vitro and in vivo. Our study demonstrates that daptomycin-modified liposomes can enhance MRSAtargeted delivery of encapsulated antibiotic, suggesting a novel drug delivery approach for existing antimicrobial agents.

关键词： Daptomycin Liposome Targeted drug delivery Lung infection Staphylococcus aureus

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Mobile Network Computer Can Better Describe The Future of Information Society

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China Communications 2016年第12期13卷 90-96页

作者： Zhaoming Guo yi jiang Shihua Bi Beijing Institute of Technology China

In the paper, we illustrate the importance of the concept of mobile network computer from a technological perspective. Because of the usefulness of mobile network computers, with the growth of the Internet of things, mobile network computers may include not only TV box audio-visual equipment, wireless household appliances, and mobile communication equipment, but may also include devices such as intelligent foot rings, smart watches, smart glasses, smart shoes and smart coats. Considering the different types of networks, e.g. IP multimedia Subsystem(IMS), we explain why some network elements are inaccurate and misleading from a technological perspective. We aim to popularize the concept of mobile network computers for its accuracy and importance, which better define modern mobile terminals and reflects the nature of multiple mobile terminals based on the structure of their integrated computers and the capabilities of processing multimedia. In the computer and Internet age, network computers and mobile network computers are the main terminals of fixed and mobile networks, respectively. Therefore, based on the concept of mobile network computers, we discuss the future of information society.

关键词： mobile computer network mobile network computer mobile communication network WAP IMS

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PARAMETERS OF WATER CIRCULATION NETWORK FOR A DISTRICT HEATING AND COOLING SYSTEM

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Journal of Hydrodynamics 2000年第1期12卷 87-95页

作者： Fu, Lin Pan, Jihong jiang, yi Shandong Univ of Technology Jinan China

In a district heating and cooling system, i.e. Beijing combined heating cooling and power (CHCP) system studied here, the high temperature water generated by two cogeneration plants circulates through a network between the plants and heat substations. At heat substations, the supply water of high temperature from the network drives absorption chillers for air-conditioning in summer and meets space heating demands in winter or domestic hot water demands by heat exchangers in the whole year. The parameters, i.e. supply/return water temperatures in the network, have a great impact on primary energy consumption (PEC) of the absorption chillers, circulation pumps and domestic hot water (DHW), which is studied in this paper.

关键词： Boiler circulation Energy utilization Hot water heating Parameter estimation Water cooling systems

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VARIATIONAL ANALYSIS FOR THE MAXIMAL TIME FUNCTION IN NORMED SPACES

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Acta Mathematica Scientia 2024年第5期44卷 1696-1706页

作者： Ziyi ZHOU yi jiang School of Mathematical Sciences Visual Computing and Virtual Reality Key LaboratorySichuan Normal UniversityChengdu610066China

For a general normed vector space,a special optimal value function called a maximal time function is *** covers the farthest distance function as a special case,and has a close relationship with the smallest enclosing ball *** properties of the maximal time function are proven,including the convexity,the lower semicontinuity,and the exact characterizations of its subdifferential formulas.

关键词： maximal time function subdifferential normal cone nonsmooth analysis

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Effects of vegetation cover on recruitment of Ulmus pumila L. in Horqin Sandy Land, northeastern China

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Journal of Arid Land 2014年第3期6卷 343-351页

作者： DeMing jiang yi TANG Carlos A BUSSO Institute of Applied Ecology Chinese Academy of Sciences Agronomy Department National University of the South and CERZOS (CONICET)

Understanding the effects of vegetation cover on seedling survival is helpful for promoting vegetation restoration in environmentally fragile zones. This study was conducted in the desertified, moving sand dunes of Horqin Sandy Land, Inner Mongolia, northeastern China. We hyphothesized that （1） seed density （i.e., number/m2） increases as vegetation cover increases, and （2） there will be more surviving seedlings in locations with higher vegetation covers. Total vegetation cover and initial densities of seeds, germinated seeds and surviving seedlings of Ulmus pumilia were evaluated under various vegetation covers in trying to clarify the effects of vegetation cover on the early stages of the plant life history. In agreement with the first hypothesis, initial seed densities were greater （P〈0.05） under higher vegetation covers. The relationship between vegetation cover and initial seed density was represented by a quadratic regression, where a threshold occurred with a vegetation cover of 36% （P〈0.05）. The higher total vegetation covers, however, did not result in increased densities of germinated seeds （P〉0.05）, which on average represented 16.7% of initial seed densities. Even more, three months after the study initiation, total vegetation covers were similar （P〉0.05） at all positions in the dunes, and they determined a similar number （P〉0.05） of surviving seedlings at those positions （i.e. the second hypothesis had to be rejected）. The mean number of seedlings that survived at all positions was only 4.5% of germinated seeds. The number of surviving elm seedlings （0 to 1.7 seedlings/m2） under various vegetations covers （12.2% to 20.8%） at all dune positions by late summer would most likely not contribute to vegetation restoration in the study area.

关键词： arid and semiarid zones elm seed dispersal seed germination seedling survival

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New type of spherical pore Al alloy foam with low porosity and high strength

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Science China Chemistry 2004年第5期47卷 407-413页

作者： ZOU yi HE Deping jiang Jiaqiao Department of Material Science and Engineering Southeast University Nanjing 210096 China Department of Material Science and Engineering Southeast University Nanjing 210096 China Department of Material Science and Engineering Southeast University Nanjing 210096 China

A computer system for displacement sensor is developed to obtain the real-time curve of the liquid porosity of molten Al alloy foam. The relationship between the curve ofP I-t and the change of the shape of the cells (spherical, similar spherical and polygonal) in the foaming process is analyzed. The changes of cell diameter and cell wall thickness are studied. And the the controlling methods of a new Al alloy foam with spherical pores, low porosity and high strength are developed on this basis. Also, the stress-strain curve during compressive deformation and energy absorption characteristics are investigated and compared with polygonal pore Al alloy foam with high porosity. Keywords spherical pore - low porosity - high strength - interface shifting - Al alloy foam These authors contributed equally to this work.

关键词： spherical pore, low porosity, high strength, interface shifting, Al alloy foam.

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