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Promoting hepatic growth factor in the treatment of heavy type hepatitis and severe chronic hepatitis: a multicenter clinical study

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Hepatobiliary & Pancreatic Diseases International 2004年第3期3卷 381-385页

作者： Jing-Hang Xu, Yan-Yan Yu, chong-wen si, Zheng Zeng, Qin-Huan Wang, Duan-De Luo,Yong-Xing Zhou, Min-De Zeng, Guang-Yan Qiao, Ji-Lu Yao and Wei-Lun Lu Department of Infectious Diseases, First Hospital ofBeijing University, Beijing 100034, China Department of Gastroenterology, Wuhan UnionHospital, Wuhan 430022, China Department of Gastroentero-logy , Affiliated Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China Department of Gastroenterology, RenjiHospital, Shanghai 200001 , China Department of InfectiousDiseases, Second Affiliated Hospital, China Medical University, Shenyang110004, China Department of Gastroenterology, Third Affilia-ted Hospital, China Medical University, Shenyang 110004 , China Department of Infectious Diseases First Hospital of Beijing University Beijing 100034 China. ddcatjh@***

BACKGROUND: The mortality rate of heavy type hepatitisis high. No special treatment is available except generaltreatment. This multicenter clinical study was designed toobserve the safety and efficacy of promoting hepatic growthfactor (PHGF) in the treatment of heavy type hepatitis andsevere chronic ***: 347 patients with heavy type hepatitis and 324with severe chronic hepatitis were subjected to administra-tion of 120 μg of PHGF per day for 4 weeks on the basis ofgeneral treatment. Those who were being effectively treat-ed would last additional 2 to 4 weeks. Blood routine, urineroutine, blood urea nitrogen (BUN), blood creatinine(Cr), blood ammonia, alpha fetoprotein (AFP), electro-lyte, alanine transaminase (ALT), aspartate transaminase(AST), serum total bilirubin (TBIL), serum direct biliru-bin (DBIL), prothrombin time activity (PTA), total pro-tein (TP) and albumin (ALB) were detected in the pa-tients before treatment, 2 weeks after treatment, and at theend of the treatment. Any side-effect would be ***: In the patients with severe chronic hepatitis, thetotal effective rate of the treatment was 88. 9% The levelsof ALT, AST and TBIL decreased significantly (Psignificantly (P side-effect was ***: PHGF is effective and safe in the treat-ment of patients with heavy type hepatitis and severe chro-nic hepatitis. But it should be administered early in patientswith heavy type hepatitis so as to get better curative effects.

关键词： promoting hepatic growth factor hepatitis safety efficacy

科学数据伦理治理:政策框架与路径——以英国为例

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现代情报 2025年第1期45卷 112-123,134页

作者：刘先瑞司莉武汉大学信息管理学院湖北武汉430072

[目的/意义]完善科学数据伦理治理有助于规范科学数据收集、共享和使用,发挥数据作为科研的关键资源与要素的功能,优化科学数据管理服务。[方法/过程]本研究基于扎根理论分析英国科学数据伦理政策,总结其政策框架与内容,并通过矩阵编码... 详细信息

[目的/意义]完善科学数据伦理治理有助于规范科学数据收集、共享和使用,发挥数据作为科研的关键资源与要素的功能,优化科学数据管理服务。[方法/过程]本研究基于扎根理论分析英国科学数据伦理政策,总结其政策框架与内容,并通过矩阵编码与社会网络分析方法揭示治理特征,提出我国优化科学数据伦理治理的建议。[结果/结论]研究发现,伦理政策框架包括治理环境、主体与策略3层面。伦理治理环境内容分为适用领域、适用主体、概念定义、问题分析与现有政策;伦理治理主体内容涉及治理主体界定与促进主体协作;伦理治理策略内容涵盖治理指导与各阶段治理措施。其治理特征有3维度:注重定义概念,明确分配主体权责与促进协作,全面厘定治理策略与加强伦理风险防控。据此提出4条治理路径:形成治理体系,规范治理理论,明确各方权责与协作方式,细化各阶段治理措施。

关键词：科学数据数据伦理数据治理政策分析英国

Unveiling human impacts on pollinators and pollination in the urbanization era

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Integrative Zoology 2023年第6期18卷 1108-1110页

作者： si-chong CHEN Zhi-An HU Can DAI Wuhan Botanical Garden Chinese Academy of SciencesWuhanChina University of Chinese Academy of Sciences BeijingChina Hubei Key Laboratory of Regional Development and Environmental Response School of Resources and Environmental ScienceHubei UniversityWuhanChina

Among the trademarks of global change and the Anthropocene,the relentless trend of urbanization has the most profound impact on driving rapid declines in biodiversity,species interactions,and ecosystem services(Grimm et al.2008).Of particular concern is the decline of pollinators and pollination services,which occurs globally at an unprecedented rate(Kevan&Viana 2003;Tylianakis 2013).

关键词： services globally

Degradation behavior of 17α-ethinylestradiol by ozonation in the synthetic secondary effluent

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Journal of Environmental Sciences 2012年第2期24卷 228-233页

作者： Zheyun Zhang Hongtao Zhu Xianghua wen Xiurong si Environmental simulation and Pollution Control State Key Joint Laboratory School of Environment Tsinghua University Beijing 100084 China School of Chemical ＆ Environmental Engineering China University of Mining and Technology Beijing 100083 China

Endocrine disrupting chemicals（EDCs） in the secondary effluent discharged from wastewater treatment plants（WWTPs） are of great concern in the process of water *** has been reported as a powerful oxidation technology to eliminate micropollutants in water *** to the complexity of the wastewater matrix,orthogonal experiments and single factor experiments were conducted to study the influence of operational parameters on the degradation of 17α-ethinylestradiol（EE2） in the synthetic secondary *** results of the orthogonal experiments indicated that the initial ozone and natural organic matter（NOM） concentration significantly affected EE2 degradation efficiency,which was further validated by the single factor confirmation ***2 was shown to be effectively degraded by ozonation in the conditions of low pH（6）,NOM（10 mg/L）,carbonate（50 mg/L）,but high suspended solid（20 mg/L） and initial ozone concentration（9 mg/L）.The study firstly revealed that the lower pH resulted in higher degradation of EE2 in the synthetic secondary effluent,which differed from EDCs ozonation behavior in pure ***2 degradation by ozone molecule instead of hydroxyl radical was proposed to play a key role in the degradation of EDCs by ozonation in the secondary *** ratio between O3 and TOC was identified as an appropriate index to assess the degradation of EE2 by ozonation in the synthetic secondary effluent.

关键词： ozonation EE2 pH natural organic matter secondary effluent

Studies on the Electronic Structures and Spectra of C_(78)(CH_2)_3

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Chinese Journal of Structural Chemistry 2007年第3期26卷 314-320页

作者： TENG Qi-wen WU Shi CHEN si-Cong Department of Chemistry Zhejiang University Hangzhou 310027. China Department of Biomedicine-engineering Zhejiang University Hangzhou 310027 China

The structures and spectra of 20 possible isomers of C78（CH2）3 have been studied by using AMI, INDO/CIS and DFT methods. The results show that the most stable isomer is 1,2,3,4,5,6-C78（CH2）3 （A） with annulene structures, where three -CH2 groups are added to the 6/6 bonds located at the same hexagon passed by the shortest axis of C78 （C2v）. Compared with that of C78 （C2v）, the first absorption in the electronic spectrum of C78（CH2）3 （A） iS blue-shifted because of its wider LUMO-HOMO energy gap. While the IR frequencies of the C-C bonds on the carbon cage are red-shifted owing to the formation of annulene structures and the extension of the conjugated system. The chemical shifts of the carbon atoms in 13C NMR spectra are moved upfield upon the addition.

关键词： C78(CH2)3 DFT electronic spectra IR spectra NMR spectra

Effect of Age and Sex on Stroke Mortality of Young and Middle-aged Adults in China,2002–2019,and Predictions to 2030

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Biomedical and Environmental Sciences 2023年第4期36卷 305-312页

作者： ZHAI Yi si Xiang WANG wen Zhi ZHAO wen Hua China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Division of Non-communicable Disease and Ageing Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China

Objective This study aimed to examine the trends in stroke mortality among young and middle-aged adults in *** Data were obtained from the China national vital registration *** changes in mortality were assessed by Joinpoint ***-period-cohort analysis was used to explain the reasons for the *** mortality and counts were predicted by the Bayesian age-period-cohort *** Between 2002 and 2019,a total of 6,253,951 stroke mortality in young and middle-aged adults were *** age-adjusted mortality rates(AAMRs)of women showed a downward *** annual percent changes(APC)were-3.5%(-5.2%,-1.7%)for urban women and-2.8%(-3.7%,-1.9%)for rural *** contrast,the AAMRs per 100,000 for rural men aged 25–44 years continued to rise from 9.40 to *** AAMRS for urban men aged 25–44 years and urban and rural men aged 45–64years did not change *** 2020 and 2030,the projected stroke deaths are 1,423,584 in men and 401,712 in *** significant sex and age disparities in the trends of stroke mortality among young and middle-aged adults were identified in *** health policy measures are needed to address the burden of stroke in the young generation,especially for rural men,with a focus on the prevention and management of high risk factors.

关键词： Stroke Mortality Young and middle-aged Joinpoint regression Age-period-cohort analysis

Enhancement of Ising superconductivity in monolayer NbSe_(2) via surface fluorination

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Science China(Technological Sciences) 2024年第7期67卷 2099-2106页

作者： WU JiZheng SHI WuJun WANG chong DUAN wenHui XU Yong si Chen School of Materials Science and Engineering Beihang UniversityBeijing 100191China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China Shanghai High Repetition Rate XFEL and Extreme Light Facility(SHINE) ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing 100084China Frontier Science Center for Quantum Information Beijing 100084China

Recently discovered Ising superconductors have garnered considerable interest due to their anomalously large in-plane upper critical fields(B_(c2)). However, the requisite strong spin-orbital coupling in the Ising pairing mechanism generally renders these superconductors heavy-element dominant with notably low superconducting transition temperatures(Tc). Here, based on the Migdal-Eliashberg theory and the mean-field Bogoliubov-de Gennes Hamiltonian, we demonstrate a significant enhancement of Ising superconductivity in monolayer NbSe_(2) through surface fluorination, as evidenced by concomitant improvements in Tcand Bc_(2). This enhancement arises from three predominant factors. Firstly, fluorine atoms symmetrically and stably adhere to both sides of the monolayer NbSe_(2), thereby maintaining the out-of-plane mirror symmetry and locking carrier spins ***, fluorination suppresses the charge density wave in monolayer NbSe_(2) and induces a van Hove singularity in the vicinity of the Fermi level, leading to a marked increase in the number of carriers and, consequently, strengthening the electron-phonon coupling(EPC). Lastly, the appearance of fluorine-related, low-frequency phonon modes further augments the EPC. Our findings suggest a promising avenue to elevate Tcin two-dimensional Ising superconductors without compromising their Ising pairing.

关键词： Ising superconductivity surface functionalization upper critical field NbSe_(2) first-principles calculations

Chemosensitization of HepG2 cells by suppression of NF-κB/p65 gene transcription with specific-si RNA

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World Journal of Gastroenterology 2015年第45期21卷 12814-12821页

作者： Yun Shi si-Ye Wang Min Yao wen-Li Sai Wei Wu Jun-Ling Yang Yin Cai wen-Jie Zheng Deng-Fu Yao Research Center of Clinical Medicine Affiliated Hospital of Nantong University Department of Immunology Medical School of Nantong University Department of Oncology Affiliated Hospital of Nantong University

AIM: To investigate small interfering RNA(si RNA)-mediated inhibition of nuclear factor-kappa B(NF-κB) activation and multidrug-resistant(MDR) phenotype formation in human Hep G2 cells. METHODS: Total RNA was extracted from human Hep G2 or LO2 cells. NF-κB/p65 m RNA was amplified by nested reverse transcription polymerase chain reaction and confirmed by sequencing. NF-κB/p65 was analyzed by immunohistochemistry. Specific-si RNA was transfected to Hep G2 cells to knock down NF-κB/p65 expression. The effects on cell proliferation, survival, and apoptosis were assessed, and the level of NF-κB/p65 or P-glycoprotein(P-gp) was quantitatively analyzed by enzyme-linked immunosorbent ***: Hep G2 cells express NF-κB/p65 and express relatively less phosphorylated p65(P-p65) and little P-gp. After treatment of Hep G2 cells with different doses of doxorubicin, the expression of NF-κB/p65, P-p65, and especially P-gp were dose-dependently upregulated. After Hep G2 cells were transfected with NF-κB/p65 si RNA(100 nmol/L), the expression of NF-κB/p65, P-p65, and P-gp were downregulatedsignificantly and dose-dependently. The viability of Hep G2 cells was decreased to 23% in the combination NF-κB/p65 si RNA(100 nmol/L) and doxorubicin(0.5 μmol/L) group and 47% in the doxorubicin(0.5 μmol/L) group(t = 7.043, P siON: Knockdown of NF-κB/p65 with si RNA is an effective strategy for inhibiting Hep G2 cell growth by downregulating P-gp expression associated chemosensitization and apoptosis induction.

关键词： Hepatocellular carcinoma Nuclear factorκB Multidru

Skin tissue engineering advances in severe burns:review and therapeutic applications

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Burns & Trauma 2016年第1期4卷 13-26页

作者： Alvin wen Choong Chua Yik Cheong Khoo Bien Keem Tan Kok Chai Tan Chee Liam Foo si Jack chong singapore General Hospital Department of PlasticReconstructive andAesthetic Surgery20 College RoadAcademia Level 4Singapore 169845Singapore. singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore. Transplant TissueCentre c/o Skin Bank UnitSingapore General HospitalBlock 4 Level 3 RoomA7Outram RoadSingapore 169608Singapore. singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore. Transplant TissueCentre c/o Skin Bank UnitSingapore General HospitalBlock 4 Level 3 RoomA7Outram RoadSingapore 169608Singapore. singapore General Hospital Department of PlasticReconstructive andAesthetic Surgery20 College RoadAcademia Level 4Singapore 169845Singapore. singapore General Hospital Skin Bank UnitBlock 4 Level 3Room 15Outram RoadSingapore 169608Singapore.

Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes:a class of products that is still fraught with limitations for clinical *** the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium(within 3 to 4 weeks)helped alleviate the problem of insufficient donor site for extensive burn,many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn *** offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly *** the availability of these commercial products,they all suffer from the same problems of extremely high cost,sub-normal skin microstructure and inconsistent engraftment,especially in full thickness *** practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes,usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results *** review seeks to bring the reader through the beginnings of skin tissue engineering,the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.

关键词： Burns Skin tissue engineering Stem cells Cultured epithelial autografts Dermal substitutes Microskin grafting