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Landscape of human organoids:Ideal model in clinics and research

The Innovation 2024年第3期5卷 146-164页

作者： Xinxin han Chunhui Cai Wei Deng Yanghua Shi Lanyang Li Chen Wang Jian Zhang Mingjie Rong Jiping Liu Bangjiang fang Hua He Xiling Liu Chuxia Deng Xiao He Xin Cao Organ Regeneration X Lab Lisheng East China Institute of BiotechnologyPeking UniversityJiangsu 226200China Shanghai Lisheng Biotech Shanghai 200092China LongHua Hospital Shanghai University of Traditional Chinese Medicine725 Wanping South RoadXuhui DistrictShanghai 200032China Department of Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Neurosurgery Third Affiliated HospitalNaval Medical UniversityShanghai 200438China Shanghai Key Laboratory of Forensic Medicine Shanghai Forensic Service PlatformAcademy of Forensic ScienceMinistry of JusticeShanghai 200063China Cancer Center Faculty of Health SciencesUniversity of MacaoTaipaMacao SARChina Ministry of Education Frontiers Science Center for Precision Oncology University of MacaoTaipaMacao SAR 999078China CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Zhongshan Hospital Institute of Clinical Science Fudan University Shanghai Medical CollegeShanghai 200032China

In the last decade,organoid research has entered a golden era,signifying a pivotal shift in the biomedical *** year 2023 marked a milestone with the publication of thousands of papers in this arena,reflecting exponential ***,amid this burgeoning expansion,a comprehensive and accurate overview of the field has been conspicuously *** review is intended to bridge this gap,providing a panoramic view of the rapidly evolving organoid *** meticulously analyze the organoid field from eight distinctive vantage points,harnessing our rich experience in academic research,industrial application,and clinical *** present a deep exploration of the advances in organoid technology,underpinned by our long-standing involvement in this *** narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors,including oncology,toxicology,and drug *** delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine,enhancing high-throughput drug screening,and constructing physiologically pertinent disease *** comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid *** spotlight technological innovations,methodological evolution,and the broadening spectrum of applications,emphasizing the revolutionary influence of organoids in personalized medicine,oncology,drug discovery,and other *** ahead,we cautiously anticipate future developments in the field of organoid research,especially its potential implications for personalized patient care,new avenues of drug discovery,and clinical *** trust that our comprehensive review will be an asset for researchers,clinicians,and patients with keen interest in personalized medical *** offer a broad view of the

关键词： landscape intended advances

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Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 43-56页

作者： Chao Li Bingchun Chen Suo Langda Peng Pu Xiaojia Zhu Shiwei Zhou Peter Kalds Ke Zhang Meenu Bhati Alexander Leonard Shuhong Huang Ran Li Awang Cuoji Xiran Wang Haolin Zhu Yujiang Wu Renqin Cuomu Ba Gui Ming Li Yutao Wang Yan Li Wenwen fang Ting Jia Tianchun Pu Xiangyu Pan Yudong Cai chong He Liming Wang Yu Jiang Jian-Lin han Yulin Chen Ping Zhou Hubert Pausch Xiaolong Wang International Joint Agriculture Research Center for Animal Bio-Breeding Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal GeneticsBreeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Animal Genomics ETH ZürichZürich 8092Switzerland Institute of Animal Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China School of Biological and Pharmaceutical Engineering Lanzhou Jiaotong UniversityLanzhou 730070China College of Life Sciences Shaanxi Normal UniversityXi’an 710119China Zoology and Evolutionary Biology Department of BiologyUniversity of Konstanz78457 KonstanzGermany College of Life and Geographic Sciences Kashi UniversityKashi 844000China Beijing Key Laboratory of Captive Wildlife Technologies Beijing ZooBeijing 100044China Department of Medical Research Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural Affairs/Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent ServiceCollege of Information EngineeringNorthwest A&F UniversityYangling 712100China Institute of Animal Husbandry and Veterinary Medicine Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation SciencesShihezi 832000China CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China Livestock Genetics Program International Livestock Research InstituteNairobi 00100Kenya

Sheep were domesticated in the Fertile Crescent and then spread globally,where they have been encountering various environmental *** Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 *** explore genomic variants associated with high-altitude adaptation in Tibetan sheep,we analyzed Illumina short-reads of 994 whole genomes representing∼60 sheep breeds/populations at varied altitudes,PacBio High fidelity(HiFi)reads of 13 breeds,and 96 transcriptomes from 12 sheep *** testing between the inhabited altitudes and 34,298,967 variants was conducted to investigate the genetic architecture of altitude *** accurate HiFi reads were used to complement the current ovine reference assembly at the most significantly associatedβ-globin locus and to validate the presence of two haplotypes A and B among 13 sheep *** haplotype A carried two homologous gene clusters:(1)HBE1,HBE2,HBB-like,and HBBC,and(2)HBE1-like,HBE2-like,HBB-like,and HBB;while the haplotype B lacked the first *** high-altitude sheep showed highly frequent or nearly fixed haplotype A,while the low-altitude sheep dominated by haplotype *** further demonstrated that sheep with haplotype A had an increased hemoglobin–O2 affinity compared with those carrying haplotype *** highly associated genomic region contained the EGLN1 gene which showed varied expression between high-altitude and low-altitude *** results provide evidence that the rapid adaptive evolution of advantageous alleles play an important role in facilitating the environmental adaptation of Tibetan sheep.

关键词： Environmental adaptation High altitude Hypoxia Selection signature Sheep

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Donor-acceptor modulation of coordination polymers for effective photothermal conversion

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Science China Chemistry 2024年

作者： Bo Zhang Xing-Wang Li han fang Chang-Tai Li Si-Jia Yu Mei-Hui Yu Ze Chang Xian-He Bu School of Materials Science and Engineering Nankai University State Key Laboratory of Elemento-Organic Chemistry Nankai University

The targeted construction of donor-acceptor（D-A） materials featuring efficient photothermal（PT） conversion properties has been an attractive but challenging goal. Herein, a new series of coordination polymers（CPs） featuring different PT performances were constructed with flexible linker 1,1′-Ferrocenedicarboxylic acid（FCA） and 2,4,6-tri（pyridin-4-yl）-1,3,5-triazine（TPT） as acceptor and donor molecules including coronene and tetrathiafulvalene（TTF）. Based on the flexible configurations of FCA ligand and the directing of donor dependent D-A interactions, the structures of TF-1 to TF-3 featuring distinctive dimension were obtained based on Cd（II） ions for investigating the PT property in configurational perspectives. A systematic investigation of the PT properties of the CPs was performed. Notably, TF-3 exhibits the finest PT conversion effect under the irradiation of 560 nm laser, while TF-2 shows optimal PT conversion under 808 nm laser irradiation required for biological PT therapy,illustrating the correlation between the structural and component features of the CPs and their PT performances. Furthermore,Zn（II） as bio-friendly ion was utilized to construct hypotoxic TF-4 that reveals similar structure to that of TF-2 for potential application. Polydimethylsiloxane（PDMS） patches doped with TF-4 exhibits considerable NIR PT conversion effect under808 nm, represented by the nearly 80 °C temperature increased in 120 s for TF-4@PDMS patch（1.2 wt%） under 0.9 W cm-2irradiation, the results of which herein indicate the potential of D-A CPs as versatile platform for the modulation of PT materials.

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马克思世界市场理论视域下新发展格局构建研究

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技术经济与管理研究 2024年第5期 44-50页

作者：朱芳菡南开大学马克思主义学院天津300350

面对国内外复杂的经济环境变化,作为发展中国家的我国在当前的世界市场中面临着三重困境:逆全球化潮流甚嚣尘上、资本霸权危害日益严重、多项产业缺乏国际竞争力。为应对这三重困境,在马克思世界市场理论指导下,我国提出构建新发展格局... 详细信息

面对国内外复杂的经济环境变化,作为发展中国家的我国在当前的世界市场中面临着三重困境:逆全球化潮流甚嚣尘上、资本霸权危害日益严重、多项产业缺乏国际竞争力。为应对这三重困境,在马克思世界市场理论指导下,我国提出构建新发展格局的重大战略布局。这一重大战略布局要求我们,注重发挥世界市场的运行机制作为有力支撑,重视利用世界市场推动的国际分工体系这一关键要点,时刻注意世界市场的“双刃剑”作用这一影响因素。新时代新征程科学构建新发展格局应对世界市场困境,应从三个方面着力:推动供给侧和需求侧动态平衡,增强国内大循环内生动力;国内国际双循环相互促进,建设更高水平开放型经济体制;努力打造合作共赢的世界市场,推动构建人类命运共同体。

关键词：马克思世界市场理论新发展格局国内国际双循环

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用于激光频率参数测量的飞秒光学频率梳

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仪器仪表学报 2024年第2期45卷 31-46页

作者：韩羿曹士英宋文霞左娅妮房芳中国计量科学研究院时间频率计量科学研究所北京100029 国家市场监管重点实验室(时间频率与重力计量基准) 北京100029

近年来随着光纤制造技术和飞秒激光技术的成熟,以掺铒(Er)光纤光学频率梳为代表的频率梳技术,逐步突破了光学频率测量领域,在长度测量、精密光谱分析、超低相位噪声微波频率产生、精密时间频率传递、温度测量等领域发挥出越来越重要的作... 详细信息

近年来随着光纤制造技术和飞秒激光技术的成熟,以掺铒(Er)光纤光学频率梳为代表的频率梳技术,逐步突破了光学频率测量领域,在长度测量、精密光谱分析、超低相位噪声微波频率产生、精密时间频率传递、温度测量等领域发挥出越来越重要的作用,已成为许多高端科研领域的基础性工具。但飞秒光学频率梳所解决的重要问题是对激光频率进行测量。本文主要面向激光频率参数测量的需求,研制基于掺Er光纤飞秒激光器的光学频率梳,在实现光学频率梳稳定运转的前提下,通过非线性光学频率变换技术,实现光谱范围从掺Er光纤光学频率梳的中心波长向各个待测激光波长的转换,并完成与多个不同波长激光的拍频信号探测。目前已验证的飞秒光梳可测频率范围为500~2000 nm;频率稳定度和准确度为10^(-16)量级;线宽为Hz量级。该指标满足了激光频率特性参数测量的需求,为激光绝对频率、频率漂移、线宽等参数的测量提供了基础性的测量工具。

关键词：光学频率梳频率测量拍频稳定度线宽绝对频率

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Elimination of GGTA1,CMAH,β4GalNT2 and CIITA genes in pigs compromises human versus pig xenogeneic immune reactions

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Animal Models and Experimental Medicine 2024年第4期7卷 584-590页

作者： Jing Xu Jilong Ren Kai Xu Minghui fang Meina Ka Fei Xu Xin Wang Jing Wang Zhiqiang han Guihai Feng Ying Zhang Tang Hai Wei Li Zheng Hu State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Key Laboratory of Organ Regeneration and Reconstruction Chinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First HospitalJilin UniversityChangchunChina Beijing Farm Animal Research Center Institute of ZoologyChinese Academy of SciencesBeijingChina

Background:Pig organ xenotransplantation is a potential solution for the severe organ shortage in clinic,while immunogenic genes need to be eliminated to im-prove the immune compatibility between humans and *** knockout strat-egies are mainly aimed at the genes causing hyperacute immune rejection(HAR)that occurs in the first few hours while adaptive immune reactions orchestrated by CD4 T cell thereafter also cause graft failure,in which process the MHC II molecule plays critical ***:Thus,we generate a 4-gene(GGTA1,CMAH,β4GalNT2,and CIITA)knockout pig by CRISPR/Cas9 and somatic cell nuclear transfer to compromise HAR and CD4 T cell reactions ***:We successfully obtained 4KO piglets with deficiency in all alleles of genes,and at cellular and tissue ***,the safety of our animals after gene editing was verified by using whole-genome sequencing and *** have survived for more than one year in the barrier,and also survived for more than 3 months in the conventional environment,suggesting that the piglets without MHC II can be raised in the barrier and then gradually mated in the conventional ***:4KO piglets have lower immunogenicity,are safe in genomic level,and are easier to breed than the model with both MHC I and II deletion.

关键词： CD4 T cell genetically edited pig immune rejection major histocompatibility complex II xenotransplantation

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Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-Ling Lin Ying Zhao Sheng-Bo Wang Jian Shen Jie Deng Yu-Feng Ye Ze-Ping han fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde Vocational and Technical College Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation Chinese population

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An improved method for edge detection based on neighbor distance for processing hemispheric photography

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JOURNAL OF PLANT ECOLOGY 2024年第2期17卷 134-145页

作者： Liu, Yasi Fan, Dayong Sun, han Wang, Xiangping Beijing Forestry Univ Sch Ecol & Nat Conservat State Key Lab Efficient Prod Forest Resources Beijing 100083 Peoples R China Beijing Forestry Univ Key Lab Silviculture & Conservat Minist Educ Beijing 100083 Peoples R China

Hemisphere photos are now widely applied to provide information about solar radiation dynamics, canopy structure and their contribution to biophysical processes, plant productivity and ecosystem properties. The present study aims to improve the original 'edge detection' method for binary classification between sky and canopy, which works not well for closed canopies. We supposed such inaccuracy probably is due to the influence of sky pixels on their neighbor canopy pixels. Here, we introduced a new term 'neighbor distance', defined as the distance between pixels participated in the calculation of contrast at the edges between classified canopy and sky, into the 'edge detection' method. We showed that choosing a suitable neighbor distance for a photo with a specific gap fraction can significantly improve the accuracy of the original 'edge detection' method. We developed an ND-IS (Neighbor Distance-Iteration Selection) method that can automatically determine the threshold values of hemisphere photos with high accuracy and reproductivity. It combines the modified 'edge detection' method and an iterative selection method, with the aid of an empirical power function for the relationship between neighbor distance and manually verified gap fraction. This procedure worked well throughout a broad range of gap fractions (0.019-0.945) with different canopy compositions and structures, in five forest biomes along a broad gradient of latitude and longitude across Eastern China. Our results highlight the necessity of integrating neighbor distance into the original 'edge detection' algorithm. The advantages and limitations of the method, and the application of the method in the field were also discussed.

关键词： hemisphere photos 'edge detection' method neighbor distance gap fraction forest AREA INDEX EXPOSURE FORESTS

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Thrombopoietin ameliorates doxorubicin-induced toxicities in H9c2 myocardiocytes by inhibiting oxidative stress through the SIRT1/p38 MAPK signaling pathway

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 410-416页

作者： Xu-han Zuo Yu Huang Bo-Cen Chen Ming-Yue Zhu Cai-Cai Zhang han-Yi Jiao Li-fang Lu Man Xiao han Wang Key Laboratory of Tropical Translational Medicine of Ministry of Education School of Basic Medicine and Life SciencesHainan Medical UniversityHaikouHainanChina Experiment and Teaching Center for Clinical Skills Hainan Medical UniversityHaikouHainanChina

Objective:To explore whether thrombopoietin can exert a protective effect against doxorubicin-induced cardiotoxicity by modulating the sirtuin 1(SIRT1)signaling ***:H9c2 cell viability was determined by CCK-8 and cardiomyocyte apoptosis was detected by TUNEL *** protein expressions of SIRT1 and p38 MAPK were measured by Western ***-qPCR was also used to determine SIRT1 mRNA *** addition,intracellular reactive oxygen species levels and antioxidant enzyme activities were ***:Thrombopoietin treatment reversed doxorubicin-induced decline in H9c2 cell *** also increased SIRT1 and decreased p-p38 MAPK protein *** addition,thrombopoietin significantly attenuated doxorubicin-induced apoptosis and oxidative stress,and enhanced antioxidant enzyme ***,silencing SIRT1 abrogated the protective effects of thrombopoietin,as evidenced by reduced cell viability and increased oxidative stress and reactive oxygen species ***:Thrombopoietin alleviates doxorubicin-induced cardiomyocyte injury by reducing oxidative stress and apoptosis via the SIRT1/p38 MAPK ***,its protective effects need to be further verified in animal tests.

关键词： Doxorubicin Thrombopoietin Oxidative stress Sirtuin 1 Cardiotoxicity

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架空隔热屋面的研究进展及发展趋势

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太阳能学报 2024年第5期45卷 441-449页

作者：方振雷张晗孙勇北京金茂绿建科技有限公司北京100012 天津大学APEC可持续能源中心天津300072

屋面热工性能的提升对于降低室内空调采暖能耗和改善室内热舒适性具有重大意义,该文详细介绍建筑节能领域的架空隔热技术的研究进展及发展趋势,分析不同架空隔热技术的隔热原理及对室内热舒适度的影响,对传统与新型架空隔热屋面的研究... 详细信息

屋面热工性能的提升对于降低室内空调采暖能耗和改善室内热舒适性具有重大意义,该文详细介绍建筑节能领域的架空隔热技术的研究进展及发展趋势,分析不同架空隔热技术的隔热原理及对室内热舒适度的影响,对传统与新型架空隔热屋面的研究进展分别进行阐述。传统架空隔热屋面具有改善隔热的优势,但其结构未将优势达到最大化,目前学者们在此基础上广泛研究各类新型架空隔热屋面,意在从结构优化、使用新型材料、复合型屋面等方式进一步提高架空隔热屋面的热工性能。该文还对光伏与架空隔热结合的光伏架空隔热屋面相关研究进行重点讨论和比较,光伏架空隔热屋面具有改善屋面隔热性能和利用太阳能为建筑供电的两种优势。在当前中国倡导绿色发展,加快能源结构转型的背景下,新型光伏架空隔热屋面更符合建筑节能和光伏建筑一体化的发展趋势。

关键词：隔热太阳能建筑光伏发电架空屋面建筑节能

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