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Can hyperthermic intraperitoneal chemotherapy effectively control gastric cancer-associated peritoneal carcinomatosis?

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World Journal of Surgical Procedures 2019年第1期9卷 7-11页

作者： chong-chi chiu Chao-Jung Tsao Jhi-Joung Wang Yutaka Yonemura Department of General Surgery Chi Mei Medical CenterLiouying 73657 and Tainan 71004Taiwan Department of Electrical Engineering Southern Taiwan University of Science and TechnologyTainan 71005Taiwan Department of Oncology Chi Mei Medical CenterLiouying 73657Taiwan Department of Medical Research Chi Mei Medical CenterTainan 71004 Taiwan AI Biomed Center Southern Taiwan University of Science and Technology Tainan 71005Taiwan Peritoneal Surface Malignancy Center Kishiwada Tokushukai Hospital KishiwadaOsaka 596-8522Japan

Gastric cancer-associated peritoneal carcinomatosis leads to a poor prognosis and low quality of life. The current systemic chemotherapy processes cannot effectively improve survival. Hyperthermic intraperitoneal chemotherapy (HIPEC) has been used as an alternative treatment to control this disease through recurrence prevention, definitive therapeutic modality, and symptom palliation. Although HIPEC has been demonstrated to yield favorable results mainly in some Asian studies, widespread adoption of this treatment is still debatable before larger prospective randomized controlled clinical trials confirm its effectiveness.

关键词： Hyperthermic intraperitoneal chemotherapy Gastric cancer Peritoneal carcinomatosis

Mesentery solitary fibrous tumor with postoperative recurrence and sarcomatosis: A case report and review of literature

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World Journal of Clinical Oncology 2022年第4期13卷 303-313页

作者： chong-chi chiu Haruaki Ishibashi Satoshi Wakama Yang Liu Yuan Hao Chao-Ming Hung Po-Huang Lee Kun-Ming Rau Hui-Ming Lee Yutaka Yonemura Department of General Surgery E-Da Cancer HospitalKaohsiung 82445Taiwan School of Medicine College of MedicineIShou UniversityKaohsiung 82445Taiwan Department of Medical Education and Research E-Da Cancer HospitalKaohsiung 82445Taiwan Peritoneal Surface Malignancy Center Kishiwada Tokushukai HospitalOsaka 596-8522Japan Department of General Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery E-Da HospitalKaohsiung 82445Taiwan College of Medicine I-Shou UniversityKaohsiung 82445Taiwan Department of Hematology&Oncology E-Da Cancer HospitalKaohsiung 82445Taiwan

BACKGROUND Solitary fibrous tumors are rare neoplasms of mesenchymal origin. They are often of low malignant potential and rarely metastasize. They frequently arise from the pleura and can occur at any soft tissue site in the body. However, these tumors rarely develop in the mesentery, peritoneal cavity or *** SUMMARY We report on a scarce case of solitary fibrous tumor of the rectal mesentery showing sarcomatosis about 4 years after previous tumor resection. This 69-yearold male had no clinical symptoms but was transferred to our hospital because of a suspected tumor recurrence from follow-up abdominal computed *** markers(CEA, CA 19-9 and CA 125) were within the normal range. Open laparotomy showed sarcomatosis, and pathology confirmed its mesenchymal origin and diagnosis as the solitary fibrous tumor. Our case may be the second recurrent mesentery solitary fibrous tumor reported to date, and the only one with progression to sarcomatosis. There has been no evidence of recurrence in follow-up at the 28 th mo after extensive intra-operative peritoneal lavage and cytoreductive *** Although there are few risk factors of cancer recurrence in this patient, careful long-term followup after cytoreductive surgery is necessary.

关键词： Solitary fibrous tumor of rectum mesentery Recurrence Sarcomatosis Extensive intra-operative peritoneal lavage Cytoreductive surgery Case report

Potential and role of artificial intelligence in current medical healthcare

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Artificial Intelligence in Cancer 2022年第1期3卷 1-10页

作者： Chao-Ming Hung Hon-Yi Shi Po-Huang Lee Chao-Sung Chang Kun-Ming Rau Hui-Ming Lee Cheng-HaoTseng Sung-Nan Pei Kuen-Jang Tsai chong-chi chiu Department of General Surgery E-Da Cancer HospitalKaohsiung 82445Taiwan College of Medicine I-Shou UniversityKaohsiung 82445Taiwan Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708Taiwan Department of Business Management National Sun Yat-Sen UniversityKaohsiung 80420Taiwan Department of Medical Research Kaohsiung Medical University HospitalKaohsiung 80708Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402Taiwan Department of Surgery E-Da HospitalKaohsiung 82445Taiwan Department of Hematology&Oncology E-Da Cancer HospitalKaohsiung 82445Taiwan School of Medicine for International Students College of MedicineI-Shou UniversityKaohsiung 82445Taiwan School of Medicine College of MedicineI-Shou UniversityKaohsiung 82445Taiwan Department of Gastroenterology and Hepatology E-Da Cancer HospitalKaohsiung 82445Taiwan Department of Gastroenterology and Hepatology E-Da HospitalKaohsiung 82445Taiwan Department of Medical Education and Research E-Da Cancer HospitalKaohsiung 82445Taiwan

Artificial intelligence(AI)is defined as the digital computer or computer-controlled robot's ability to mimic intelligent conduct and crucial thinking commonly associated with intelligent *** application of AI technology and machine learning in medicine have allowed medical practitioners to provide patients with better quality of services;and current advancements have led to a dramatic change in the healthcare ***,many efficient applications are still in their initial stages,which need further evaluations to improve and develop these *** must recognize and acclimate themselves with the developments in AI technology to improve their delivery of healthcare services;but for this to be possible,a significant revision of medical education is needed to provide future leaders with the required *** article reviews the potential and limitations of AI in healthcare,as well as the current medical application trends including healthcare administration,clinical decision assistance,patient health monitoring,healthcare resource allocation,medical research,and public health policy ***,future possibilities for further clinical and scientific practice were also summarized.

关键词： Artificial intelligence Machine learning Potential Limitation Medical healthcare application Coronavirus disease 19

Medium-term surgical outcomes and health-related quality of life after laparoscopic vs open colorectal cancer resection: SF-36 health survey questionnaire

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World Journal of Gastrointestinal Endoscopy 2023年第3期15卷 163-176页

作者： Chao-Ming Hung Kuo-Chuan Hung Hon-Yi Shi Shih-Bin Su Hui-Ming Lee Meng-Che Hsieh Cheng-Hao Tseng Shung-Eing Lin chih-Cheng Chen Chao-Ming Tseng Ying-Nan Tsai chi-Zen Chen Jung-Fa Tsai chong-chi chiu Department of General Surgery E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina School of Medicine College of MedicineI-Shou UniversityKaohsiung 82445TaiwanChina Department of Anesthesiology Chi Mei Medical CenterTainan 71004TaiwanChina Department of Hospital and Health Care Administration College of Recreation and Health ManagementChia Nan University of Pharmacy and ScienceTainan 71710TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina Department of Business Management National Sun Yat-Sen UniversityKaohsiung 80424TaiwanChina Department of Medical Research Kaohsiung Medical University HospitalKaohsiung 80756TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina Department of Occupational Medicine Chi Mei Medical CenterLiouying 73657TaiwanChina Department of Occupational Medicine Chi Mei Medical CenterTainan 71004TaiwanChina Department of Leisure Recreation and Tourism ManagementSouthern Taiwan University of Science and TechnologyTainan 71005TaiwanChina College of Medicine I-Shou UniversityKaohsiung 82445TaiwanChina Department of Hematology-Oncology E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Gastroenterology and Hepatology E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Gastroenterology and Hepatology E-Da HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Colon and Rectal Surgery E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Gastroenterology and Hepatology E-Da Dachang HospitalI-Shou UniversityKaohsiung 80794TaiwanChina Department of Medical Education and Research E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of General Surgery Chi Mei Medical CenterLiouying 73657TaiwanChina

BACKGROUND Previous studies that compared the postoperative health-related quality of life(HRQoL)outcomes after receiving laparoscopic resection(LR)or open resection(OR)in patients with colorectal cancer(CRC)have different *** To explore the medium-term effect of postoperative HRQoL in such *** This study randomized 567 patients undergoing non-metastatic CRC surgery managed by one surgeon to the LR or OR *** was assessed during the preoperative period and 3,6,and 12 mo postoperative using a modified version of the 36-Item Short Form(SF-36)Health Survey questionnaire,emphasizing eight specific *** This cohort randomly assigned 541 patients to receive LR(n=296)or OR(n=245)surgical *** episodes of postoperative urinary tract infection(P<0.001),wound infection(P<0.001),and pneumonia(P=0.048)were encountered in the OR *** results demonstrated that the LR group subjectively gained mildly better general health(P=0.045),moderately better physical activity(P=0.006),and significantly better social function recovery(P=0.0001)3 mo *** the aspect of social function recovery was claimed at 6 mo,with a significant advantage in the LR group(P=0.001).No clinical difference was found in HRQoL during the 12 *** Our results demonstrated that LR resulted in better outcomes,including intra-operative blood loss,surgery-related complications,course of recovery,and especially some health domains of HRQoL at least within 6 mo *** should undergo LR if there is no contraindication.

关键词： Health-related quality of life Medium-term result Laparoscopic Open surgery Non-metastatic colorectal cancer

Large-vessel thrombosis in intestinal Behet's disease complicated with myelodysplastic syndrome and trisomy 8

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World Journal of Gastroenterology 2012年第10期18卷 1137-1140页

作者： Huang-chi Chen Ying-Ming chiu Division of Critical Care Medicine Department of Internal Medicine Changhua Christian Hospital 500 Changhua Taiwan China Division of Allergy Immunology and Rheumatology Department of Internal Medicine Changhua Christian Hospital 500 Changhua Taiwan China

Behet's disease is characterized by recurrent oral ulcers, genital ulcers, uveitis and skin lesions. Myelodysplastic syndrome (MDS) is characterized by problems due to ineffective hematopoiesis. Several studies have identified a relationship between MDS and Behet's disease, especially intestinal Behet's disease. Trisomy 8 seems to play an important role in these disorders as well. The present case was a 24-year-old woman who had a huge tonsil ulcer with initial symptoms of odynophagia and intermittent fever. We also noted folliculitis on her upper back. Five days later, she began to experience diarrhea and abdominal pain. Abdominal computed tomography and subsequent surgery revealed ileum perforation and enterocolitis with multiple ulcers. Later, she was admitted again for a vulvar suppurative ulcer and suspicious Bartholin's cyst infection. The patient's clinical presentations met the criteria for Behet's disease. Six months after the bowel perforation event, we noted the development of pancytopenia in a routine laboratory examination. All the examinations led to the diagnosis of MDS with trisomy 8. The most unusual finding was that multiple large vessel thrombi developed during follow-up. Previous studies have suggested that trisomy 8 in MDS leads to concurrent intestinal Behet's disease. Moreover, the inflammatory and immune genes related to thrombus formation are overexpressed in cases of MDS with trisomy 8. Trisomy 8 must play a role in thrombosis. Further studies are needed to help clarify the pathophysiology and pathogenesis of these disorders.

关键词： Behcet's disease Myelodysplastic syndrome Trisomy 8 Intestinal ulcers Thrombosis

Neuroprotective action of lithium in disorders of the central nervous system

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中南大学学报（医学版） 2011年第6期36卷 461-475页

作者： chi-Tso chiu De-Maw CHUANG Section on Molecular Neurobiology National Institute of Mental HealthNational Institutes of Health

Substantial in vitro and in vivo evidence of neurotrophic and neuroprotective effects of lithium suggests that it may also have considerable potential for the treatment of neurodegenerative ***'s main mechanisms of action appear to stem from its ability to inhibit glycogen synthase kinase-3 activity and also to induce signaling mediated by brain-derived neurotrophic *** in turn alters a wide variety of downstream effectors,with the ultimate effect of enhancing pathways to cell *** addition,lithium contributes to calcium *** inhibiting N-methyl-D-aspartate receptor-mediated calcium influx,for instance,it suppresses the calcium-dependent activation of pro-apoptotic signaling *** inhibiting the activity of phosphoinositol phosphatases,it decreases levels of inositol 1,4,5-trisphosphate,a process recently identified as a novel mechanism for inducing *** mechanisms allow therapeutic doses of lithium to protect neuronal cells from diverse insults that would otherwise lead to massive cell ***,moreover,has been shown to improve behavioral and cognitive deficits in animal models of neurodegenerative diseases,including stroke,amyotrophic lateral sclerosis,fragile X syndrome,and Huntington's,Alzheimer's,and Parkinson's *** lithium is already FDA-approved for the treatment of bipolar disorder,our conclusions support the notion that its clinical relevance can be expanded to include the treatment of several neurological and neurodegenerative-related diseases.

关键词：《中南大学学报:医学版》期刊摘要编辑部

Harnessing and honing mesenchymal stem/stromal cells for the amelioration of graft-versus-host disease

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World Journal of Stem Cells 2023年第4期15卷 221-234页

作者： Tang-Her Jaing Tsung-Yen Chang chia-chi chiu Division of Hematology OncologyDepartment of PediatricsChang Gung Children’s HospitalChang Gung UniversityTaoyuan 333TaiwanChina Department of Pediatrics Chang Gung University College of MedicineTaoyuan 333TaiwanChina Department of Nursing Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

Allogeneic hematopoietic stem cell transplantation is a deterministic curative procedure for various hematologic disorders and congenital *** its increased use,the mortality rate for patients undergoing this procedure remains high,mainly due to the perceived risk of exacerbating graft-versushost disease(GVHD).However,even with immunosuppressive agents,some patients still develop *** mesenchymal stem/stromal cell(MSC)strategies have been proposed to achieve better therapeutic outcomes,given their immunosuppressive ***,the efficacy and trial designs have varied among the studies,and some research findings appear contradictory due to the challenges in characterizing the in vivo effects of *** review aims to provide real insights into this clinical entity,emphasizing diagnostic,and therapeutic considerations and generating pathophysiology hypotheses to identify research *** indications and timing for the clinical application of MSCs are still subject to debate.

关键词： Mesenchymal stem/stromal cells Graft-versus-host disease Immunomodulatory Adaptive immunity Exosomes

Some features of effective radius and variance of dust particles in numerical simulations of the dust climate on Mars

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Earth and Planetary Physics 2021年第1期5卷 11-18页

作者： chi-Fong Wong Kim-chiu Chow Kwing LChan Jing Xiao Yemeng Wang Space Science Institute/State Key Laboratory of Lunar and Planetary Science Macao University of Science and TechnologyTaipaMacaoChina

Airborne dust is an important constituent in the Martian atmosphere because of its radiative interaction with the atmospheric *** size is one crucial factor in determining this *** reality dust sizes are varied;however,in numerical modeling of dust processes,dust size has usually been described by choice of a particular size distribution function,or by use of fixed values of effective radius(ER)and effective variance(EV).In this work,we present analytical expressions that have been derived to specify ER and EV for Nbin dust schemes,based on a model-calculated dust mixing *** simulations based on this approach thus would consider the effects of variable ER on the atmospheric radiation and their *** have revealed some interesting features of the dust distribution parameters,such as seasonal and spatial variation of ER and EV,which are generally consistent with some previous observational and modeling *** with the usual approach of using a fixed ER,simulation results from the present approach suggest that the variability of ER can have significant effects on the simulated thermal field of the Martian atmosphere.

关键词： Mars dust effective radius effective variance general circulation model

Successful management of delirium with dexmedetomidine in a patient with haloperidol-induced neuroleptic malignant syndrome:A case report

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World Journal of Clinical Cases 2022年第2期10卷 625-630页

作者： chi-Ju Yang ching-Tang chiu Yu-Chang Yeh Anne Chao Department of Pharmacy National Taiwan University HospitalTaipei 100220Taiwan Department of Anesthesiology National Taiwan University HospitalTaipei 100220Taiwan

BACKGROUND We report a case of lorazepam-induced agitated delirium treated with haloperidol,which in turn triggered the onset of neuroleptic malignant syndrome(NMS).The latter condition,a medical emergency,was effectively treated with medical treatment and dexmedetomidine,a versatile and highly selective shortacting alpha-2 adrenergic agonist with sedative-hypnotic and anxiolytic *** SUMMARY A 65-year-old man with a history of bipolar disorder presented to the emergency department with severe abdominal discomfort after binge *** his hospital stay,he received intravenous lorazepam for *** the next day,he became delirious and was thus treated with seven doses(5 mg each)of haloperidol over a 48 h *** of NMS(hyperthermia,rigidity,myoclonus of upper limbs,impaired consciousness,tachypnea,and dark urine)became apparent and haloperidol was immediately suspended and brisk diuresis was *** intensive care unit admission,he was confused,disoriented,and markedly *** infusion was started with the goal of achieving a Richmond Agitation-Sedation Scale score of-1 or *** was resolved gradually and the patient stabilized,permitting discontinuation of dexmedetomidine after 3 *** Dexmedetomidine may be clinically helpful for the management of NMS,most likely because of its sympatholytic activity.

关键词： Haloperidol Dexmedetomidine Delirium Neuroleptic malignant syndrome Alpha-2 adrenergic agonists Case report