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Intelligent diagnosis of retinal vein occlusion based on color fundus photographs

International Journal of Ophthalmology(English edition) 2024年第1期17卷 1-6页

作者： Yu-Ke Ji Rong-Rong Hua Sha Liu Cui-Juan Xie Shao-chong zhang Wei-Hua Yang Eye Hospital Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina College of Electronic Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210000Jiangsu ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518000Guangdong ProvinceChina

AIM:To develop an artificial intelligence(AI)diagnosis model based on deep learning(DL)algorithm to diagnose different types of retinal vein occlusion(RVO)by recognizing color fundus photographs(CFPs).METHODS:Totally 914 CFPs of healthy people and patients with RVO were collected as experimental data sets,and used to train,verify and test the diagnostic model of *** the images were divided into four categories[normal,central retinal vein occlusion(CRVO),branch retinal vein occlusion(BRVO),and macular retinal vein occlusion(MRVO)]by three fundus disease *** Transformer was used to build the RVO diagnosis model,and different types of RVO diagnosis experiments were *** model’s performance was compared to that of the ***:The accuracy of the model in the diagnosis of normal,CRVO,BRVO,and MRVO reached 1.000,0.978,0.957,and 0.978;the specificity reached 1.000,0.986,0.982,and 0.976;the sensitivity reached 1.000,0.955,0.917,and 1.000;the F1-Sore reached 1.000,0.9550.943,and 0.887 *** addition,the area under curve of normal,CRVO,BRVO,and MRVO diagnosed by the diagnostic model were 1.000,0.900,0.959 and 0.970,*** diagnostic results were highly consistent with those of fundus disease experts,and the diagnostic performance was ***:The diagnostic model developed in this study can well diagnose different types of RVO,effectively relieve the work pressure of clinicians,and provide help for the follow-up clinical diagnosis and treatment of RVO patients.

关键词： deep learning artificial intelligence Swin Transformer diagnostic model retinal vein occlusion color fundus photographs

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Ultrahigh-throughput screening of antagonistic bacteria against Erwinia carotovora Ecc15 based on droplet microfluidics

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Food Science and Human Wellness 2024年

作者： Longfeng Wei Shuang Li Hang Pan Xingjin Jian Renli Ai Zhu Li chong zhang Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education)， College of Life Sciences/Institute of Agro-bioengineering， Guizhou University Guizhou Key Laboratory of Agricultural Biotechnology Department of Chemical Engineering， Institute of Biochemical Engineering， Tsinghua University Key Laboratory of Industrial Biocatalysis， Ministry of Education， Tsinghua University

Soft rot is a destructive disease that inflicts significant losses on agricultural production and the economy post-harvest. Biocontrol strategies based on antagonistic microorganisms have a broad application prospect to fight against plant pathogens. This study utilized fluorescence-activated droplet sorting （FADS） technology as an alternative to traditional plate culture methods to isolate microorganisms with antagonistic activity against the soft rot pathogen Erwinia carotovora Ecc15. Initially， the culture performance of the FADS platform was evaluated by analyzing bacterial diversity in droplet culture samples and agar plate culture samples， our data showed that droplet culture exhibited higher species richness and diversity than plate culture， and more than 95% of the OTUs in the droplet samples belonged to the rare biosphere. Additionally， we developed a GFP-Ecc15-based FADS screening system， which achieved an enrichment ratio of up to 148. Using this system， we successfully screened 32 antagonistic bacteria from rhizosphere soil sample of healthy konjac plants， and some may be novel microbial resources， including the genera Lelliottia， Buttiauxella and Leclercia. Notably， strain D-62 exhibited the strongest antibacterial ability against Ecc15， with an inhibition zone diameter of （20.86 ± 1.56） mm. In vivo experiments conducted on the corms of Amorphophallus konjac demonstrated that strain D-62 could effectively reduce the infection ability of Ecc15 to the corms， indicating that strain D-62 has the potential to be developed as a biocontrol agent. Our findings suggested that the FADS screening system showed a screening efficiency approximately 3 × 103times higher than plate screening system， while significantly reducing costs of infrastructure， labor and consumables， it provides theoretical guidance for the screening of other plant pathogen biocontrol bacteria.

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Increased Expression of Serum Monocyte Chemoattractant Protein-1,Chemokine(C-C motif)Ligand 3,and Interleukins in Patients With Vitiligo

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International Journal of Dermatology and Venereology 2024年第1期7卷 40-43页

作者： Xiao-Ling Zhao Ya-Lan Li Zi-Han Li Xiao-chong zhang Li-Hui An Yu-Jiao Sun Deng-Xiang Liu Fang Cheng Cancer Laboratory Xingtai People’s HospitalXingtaiHebei 054001China Endocrine Department Xingtai People’s HospitalXingtaiHebei 130500China Dermatological Department Xingtai People’s HospitalXingtaiHebei 054001China

Objective:Vitiligo is a chronic,acquired depigmentation of the skin,which can be divided into active and stable *** stable and active stages are not immutable and often *** of internal markers would help to diagnose the active stage of vitiligo,and the purpose of this study was to find potential active markers in the progression of ***:We compared 30 healthy controls to 60 patients with vitiligo(30 with active disease and 30 with stable disease)regarding the expression of serum monocyte chemoattractant protein(MCP)-1,chemokine(C-C motif)ligand(CCL)3,CCL5,CCL21,interleukin(IL)-6,and *** were collected from May 2017 to December *** detection was carried out by enzyme-linked immunosorbent *** difference between groups was compared by Kruskal-Wallis H test and Mann-Whitney U ***:We found that the serum levels of MCP-1,CCL3,IL-6,and IL-17 were significantly higher in patients with vitiligo than in healthy controls(P<0.01)and that IL-17 was higher in patients with active vitiligo than in those with stable vitiligo(P<0.01).After 3months of treatment,the serum IL-17 level of patients with active vitiligo was not significantly different from that before treatment(P=0.526);after 6months of treatment,however,the serum IL-17 level had significantly decreased(P<0.01).Conclusion:These findings suggest that the serum IL-17 level can be used as a marker of vitiligo disease activity giving it certain guiding significance for clinical treatment.

关键词： clinical marker serum cytokines vitiligo

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基于硫化铅量子点可饱和吸收体的锁模光纤激光器

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光子学报 2024年第6期53卷 145-152页

作者：高博峰王路张贺张崇长春理工大学高功率半导体激光国家重点实验室长春130022 陆军驻长春地区第一军事代表室长春130033

通过优化后的热注入法制备得到硫化铅胶体量子点,再利用匀胶机两步旋涂的方法使材料平铺在小块羧甲基纤维素薄膜上,并将其作为可饱和吸收体应用于光纤激光器中,实现稳定的锁模。制备的硫化铅量子点可饱和吸收薄膜的调制深度和饱和强度... 详细信息

通过优化后的热注入法制备得到硫化铅胶体量子点,再利用匀胶机两步旋涂的方法使材料平铺在小块羧甲基纤维素薄膜上,并将其作为可饱和吸收体应用于光纤激光器中,实现稳定的锁模。制备的硫化铅量子点可饱和吸收薄膜的调制深度和饱和强度分别约为26.46%和6.75 MW/cm^(2),非饱和损耗为6.42%。测试结果表明该薄膜具有更小的非饱和损耗以及更好的重复性和一致性。采用该薄膜作为可饱和吸收体的光纤激光器能在47 mW的泵浦功率处开始实现自启动锁模,且能够实现长时间稳定的锁模激光输出。研究结果为硫化铅量子点可饱和吸收体在光纤激光器中的后续应用奠定了基础。

关键词：光纤激光器锁模热注入法硫化铅量子点可饱和吸收体自启动

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Screening of Chinese giant salamander meat hydrolysates with DPP-IV inhibitory activity and systematic elucidation of their hypoglycemic functions in mouse model

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Food Science and Human Wellness 2024年

作者： Shucheng Li Changge Guan Yi Wang Haihong Chen Wei Li Songjun Wang chong zhang Xin-Hui Xing Key Laboratory for Industrial Biocatalysis， Ministry of Education of China， Department of Chemical Engineering， Tsinghua University School of Life Science and Technology， Tokyo Institute of Technology Institute of Biopharmaceutical and Health Engineering， Tsinghua Shenzhen International Graduate School Henan Giant Salamander Protection and Development Association Center for Synthetic and Systems Biology， Tsinghua University Institute of Biomedical Health Technology and Engineering， Shenzhen Bay Laboratory

Type 2 diabetes (T2D) presents a significant health challenge， underscoring the need for functional foods and nutraceutical hypoglycemic bioactive peptides for its prevention. This study investigates the potential of proteolytic hydrolysate from artificially cultivated Chinese giant salamander (CGS) meat， a rich protein source， as a preventive strategy for T2D. We produced a CGS meat hydrolysate (CGSh) and demonstrated its ability to inhibit the T2D drug target DPP-IV through in vitro assays. We identified five peptides (WRPPDH， WAPPSKD， IPDSPF， IPEMIF， and VPIAVPT) with high DPP-IV inhibitory activity in CGSh， suggesting its potential antidiabetic effects. In vivo experiments showed that CGSh effectively reduced insulin resistance in mice induced with a high-fat diet， as evidenced by a slower increase in blood glucose levels and a decreased HOMA-IR index. 16S rRNA sequencing analysis revealed that CGSh improved gut microbial homeostasis， promoting beneficial microorganisms and reducing harmful bacteria. Metabolomic analyses identified an increase in valeric acid levels and highlighted nine potential biomarker metabolites. By inhibiting metabolic pathways such as AGE-RAGE， CGSh may also prevent diabetic complications and reduce inflammation. These findings suggest that CGSh has a promising hypoglycemic effect， making it a potential functional food ingredient for T2D prevention and treatment.

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健康老龄化视角下互联网使用与老年人认知功能的关系研究

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中国卫生事业管理 2024年第7期41卷 834-840页

作者：张冲熊娟电子科技大学马克思主义学院网络社会治理研究所四川成都611731

目的:随着我国老龄化的深入,老年人认知障碍和老年痴呆发病率的攀升,已成为实现中国健康老龄化目标的主要障碍,而互联网的广泛运用为促进老年人认知训练、提高认知水平创造了条件,其与老年人认知功能的关系有待进一步研究,进而为解决老... 详细信息

目的:随着我国老龄化的深入,老年人认知障碍和老年痴呆发病率的攀升,已成为实现中国健康老龄化目标的主要障碍,而互联网的广泛运用为促进老年人认知训练、提高认知水平创造了条件,其与老年人认知功能的关系有待进一步研究,进而为解决老年人认知能力下降问题提供多样化的经验证据。方法:基于2014年、2016年和2018年CFPS数据,研究互联网使用、使用时长以及使用目的与老年人认知功能的关系。结果:互联网使用及使用时长与老年人认知功能具有显著的正向关系,使用互联网的老年人相对于未使用互联网的老年人具有更高的认知水平,使用时长较久的老年人相对于使用时长较短的老年人能获得更积极的认知促进效应;使用互联网进行工作对老年人认知功能促进作用最为显著。结论:发挥互联网的健康促进功能,鼓励老年人进行积极、适度、多样化的互联网使用是不断促进和培育老年人健康认知功能的有效举措。

关键词：互联网使用认知功能老年人健康老龄化

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Acute primary angle closure during the Omicron outbreak

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1337-1343页

作者： Dong Fang Wang-Ting Li Jia Liang Lu Chen Ning-Xin Dou Hui-Yan Zheng Can-Feng Huang Ting Xie Yi-Jing Zhuang Peng-Feng Li Xing-Xing Mao Shao-chong zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Key Laboratory of OphthalmologyShenzhen 518040Guangdong ProvinceChina

AIM:To investigate Omicron’s impact on clinical presentation of acute primary angle closure(APAC)in ***:A consecutive case series with historical controls was conducted at Shenzhen Eye Hospital,the largest specialized hospital in Shenzhen,*** records from a two-month period during the Omicron pandemic(December 1,2022,to January 31,2023)were compared with records from two control groups(12/2018–1/2019 and 12/2021–1/2022)before *** with APAC were included,and the prevalence of APAC and demographic characteristics in Omicron-infected and noninfected patients were ***:Seventy-one(23.43%)out of 303 patients were diagnosed with APAC in the pandemic cohort,which was 2.98 and 2.61 times higher than that in control cohorts(7.87%in 2019,8.96%in 2022,P<0.001).The pandemic cohort has significantly higher Omicron-infected rate(78.87%vs 0 vs 0;P<0.001),lower proportion of glaucoma history(16.90%vs 42.86%vs 41.67%,P=0.005),higher surgical rate(95.77%vs 83.33%vs 78.57%,P=0.024),higher total medical costs and larger pupil diameter(5.63±0.15 vs 4.68±0.15 vs 4.69±0.22 mm,P<0.01).In 83%Omicron-infected patients,ocular symptoms appeared within 3d after systemic symptoms *** multivariate analysis,Omicron infection(P<0.001)was the only independent predictor of pupil ***:In the Omicron epidemic in China,there is an increase of prevalence and severity of APAC,particularly focusing on the first 3d following infection.

关键词： Omicron acute primary angle closure ocular symptoms

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Association analysis of an anti-obesity mechanism and key ripened Pu-erh tea bioactive components by mimicking human general tea drinking

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Food Science and Human Wellness 2024年

作者： Junyu Liu Zhengyang Song Haihong Chen Wen Zeng Guirong Han Wei Li Bing Xu Yuan Lu Canyang zhang Zhenglian Xue Bin Lü chong zhang Song Yang Yi Wang Xinhui Xing Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory MOE Key Laboratory for Industrial Biocatalysis， Centre for Synthetic and Systems Biology， Department of Chemical Engineering， Tsinghua University Shenzhen International Graduate School， Tsinghua University Shandong Province Key Laboratory of Applied Mycology， Qingdao International Center on Microbes Utilizing Biogas， School of Life Sciences， Qingdao Agricultural University Anhui University of Technology Yunnan Shujian Tea Co.， Ltd.

Pu-erh tea， a traditional Chinese beverage， performs an anti-obesity function， but the correlation between its components and efficacy remains unknown. Here， we screened two Pu-erh teas with significant anti-obesity efficacies from 11 teas. In vitro experiments revealed that lipid accumulation in L02 cells and lipid synthesis in 3T3-L1 cells were significantly better inhibited by Tea-B than Tea-A. Further in vivo experiments using model mice revealed that the differences in chemical components generated two pathways in the anti-obesity efficacy and mechanism of Pu-erh teas. Tea-A changes the histomorphology of brown adipose tissue (BAT) and increases the abundance of Coriobacteriaceae＿UCG＿002 and cyclic AMP in guts through high chemical contents of cyclopentasiloxane， decamethyl， tridecane and 1，2，3-trimethoxybenzene， eventually increasing BAT activation and fat browning gene expression; the high content of hexadecane and 1，2-dimethoxy-benzene in Tea-B reduces white adipose tissue (WAT) accumulation and the process of fatty liver， increases the abundance of Odoribacter and sphinganine 1-phosphate， inhibits the expression of lipid synthesis and transport genes. These mechanistic findings on the association of the representative bioactive components in Pu-erh teas with the anti-obesity phenotypes， gut microbes， gut metabolite structure and anti-obesity pathways， which were obtained for the first time， provide foundations for developing functional Pu-erh tea.

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风险冲击、金融行为与农户可持续生计

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山西财经大学学报 2024年第6期46卷 53-67页

作者：张崇梅汪为中南财经政法大学工商管理学院湖北武汉430073 四川农业大学管理学院四川成都611130

选取2010—2020年中国家庭追踪调查数据,基于DFID可持续生计框架,运用Tobit模型研究风险冲击对农户可持续生计的影响,并探讨不同金融行为在其中的作用机制。结果显示:自然风险和大病风险冲击会对农户的可持续生计产生显著的负向影响;农... 详细信息

选取2010—2020年中国家庭追踪调查数据,基于DFID可持续生计框架,运用Tobit模型研究风险冲击对农户可持续生计的影响,并探讨不同金融行为在其中的作用机制。结果显示:自然风险和大病风险冲击会对农户的可持续生计产生显著的负向影响;农业保险行为在自然风险对可持续生计的负向冲击中具有正向调节作用,医疗保险行为在大病风险对农户可持续生计的负向影响中具有负向调节作用,但农户储蓄行为和借贷行为的调节作用没有得到验证;不同地区农户所遭受的风险冲击类型存在显著差异。

关键词：风险冲击可持续生计保险行为储蓄行为借贷行为

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关中地区土壤干湿变化及对气候的响应

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干旱区研究 2024年第2期41卷 261-271页

作者：杨雅青张翀张婕王玉丹宝鸡文理学院陕西省灾害监测与机理模拟重点实验室陕西宝鸡721013

关中地区是陕西省主要的农业生产基地,但频发的旱灾严重阻碍了社会经济的发展。土壤湿度作为反映旱灾的一个重要指标,进行土壤湿度对气候因子响应的研究,可为科学认识干旱规律及制定政策提供依据。以关中地区为研究区,采用2001—2020年... 详细信息

关中地区是陕西省主要的农业生产基地,但频发的旱灾严重阻碍了社会经济的发展。土壤湿度作为反映旱灾的一个重要指标,进行土壤湿度对气候因子响应的研究,可为科学认识干旱规律及制定政策提供依据。以关中地区为研究区,采用2001—2020年的MODIS-NDVI与MODIS-LST长时间序列数据,构建了关中地区地表土壤干湿状况(TVDI)特征空间,采用线性趋势法、相关性分析、敏感性分析等统计方法对关中地区土壤干湿状况的空间分布特征及其对气候的响应进行分析。结果表明:(1)TVDI能够较为准确的反演出关中地区的土壤湿度状况。近20 a来,关中地区土壤干湿状况存在变干趋势;其中,春季最旱、冬季次之。(2)土壤干湿状况的空间分布存在明显的空间异质性,整体上呈现西南向东北干旱递增的趋势。(3)土壤干湿状况与降水和气温存在相关性。与降水呈正相关关系,随着降水量增加,土壤湿度增加;与气温呈负相关关系,随着气温升高,土壤湿度降低。(4)降水对土壤干湿状况的敏感性较高,而气温对土壤干湿状况的变化程度起着较大的影响。降水决定了土壤湿度值的增加或减少的方向,而气温则决定了增加或减少的程度。土壤干湿状况是一个综合指标,其值受降水和气温的影响。降水是决定增减趋势的主要因素,而气温则决定了增减的幅度。因此,仅研究气温和降水的影响时,降水是控制土壤干湿状况增减趋势的主要因素,而气温则调节了这种增减的幅度。

关键词：土壤干湿状况地表温度-植被指数降水气温关中地区

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