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Journal of Environmental Sciences 2024年第8期142卷 11-20页

作者： Guodong Zhao chong tian Peidong Wu Xuguang Zhang Zhikang Wang Xiaoxiang Chen Zhuo Xiong Yongchun Zhao Junying Zhang State Key Laboratory of Coal Combustion School of Energy and Power EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China National Environmental Protection Engineering Technology Center for Trace Elements Pollution Control and Low Carbon Utilization of Coal Huazhong University of Science and TechnologyWuhan 430074China School of Environmental Engineering Wuhan Textile UniversityWuhan 430200China

Chromium released during municipal solid waste incineration(MSWI)is toxic and *** removal of chromium from simulated MSWI flue gas by four sorbents(CaO,bamboo charcoal(BC),powdered activated carbon(PAC),and Al_(2)O_(3))and the effects of four oxides(SiO_(2),Al_(2)O_(3),Fe_(2)O_(3),and CaO)on chromium speciation transformationwere *** results showed that the removal rates of total Cr by the four sorbents were Al_(2)O_(3)

关键词： Cr(Ⅵ)reduction Cr(Ⅲ)oxidation Alkali oxides Acidic oxides Municipal solid waste incineration

Successful treatment of severe hepatic impairment in erythropoietic protoporphyria:A case report and review of literature

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World Journal of Hepatology 2024年第6期16卷 966-972页

作者： Tao Zeng Shu-Ru Chen Hao-Qiang Liu Yu-tian chong Xin-Hua Li Department of Infectious Diseases Key Laboratory of Liver Disease of Guangdong ProvinceThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Blood Transfusion The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Erythropoietic protoporphyria(EPP)is a rare genetic disorder stemming from ferrochelatase gene mutations,which leads to abnormal accumulation of protoporphyrin IX primarily in erythrocytes,skin,bone marrow and *** porphyria-related severe liver damage is rare,its consequences can be severe with limited treatment *** SUMMARY This case study highlights a successful intervention for a 35-year-old male with EPP-related liver impairment,employing a combination of red blood cell(RBC)exchange and therapeutic plasma exchange(TPE).The patient experienced significant symptom relief and a decrease in bilirubin levels following multiple PE sessions and an RBC *** The findings suggest that this combined approach holds promise for managing severe hepatic impairment in EPP.

关键词： Erythropoietic protoporphyria Red blood cell exchange Plasma exchange Delta-aminolevulinic acid Ferrochelatase Case report

Prognostic value of neutrophil-to-lymphocyte ratio in end-stage liver disease:A meta-analysis

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World Journal of Hepatology 2024年第3期16卷 477-489页

作者： Xiang-Hao Cai Yun-Ming Tang Shu-Ru Chen Jia-Hui Pang Yu-tian chong Hong Cao Xin-Hua Li Department of Infectious Disease Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)is commonly utilized as a prognostic indicator in end-stage liver disease(ESLD),encompassing conditions like liver failure and decompensated ***,some studies have contested the prognostic value of NLR in *** To investigate the ability of NLR to predict *** Databases,such as Embase,PubMed,Web of Science,Cochrane Library,China National Knowledge Infrastructure,Weipu,and Wanfang,were comprehensively searched to identify studies published before October 2022 assessing the prognostic ability of NLR to predict mortality in patients with *** sizes were calculated using comprehensive meta-analysis software and SATAT *** A total of thirty studies involving patients with end-stage liver disease(ESLD)were included in the *** the pooled results of eight studies,it was observed that the Neutrophil-to-Lymphocyte Ratio(NLR)was significantly higher in non-survivors compared to survivors(random-effects model:standardized mean difference=1.02,95%confidence interval=0.67-1.37).Additionally,twenty-seven studies examined the associations between NLR and mortality in ESLD patients,reporting either hazard ratios(HR)or odds ratios(OR).The combined findings indicated a link between NLR and ESLD mortality(randomeffects model;univariate HR=1.07,95%CI=1.05-1.09;multivariate HR=1.07,95%CI=1.07-1.09;univariate OR=1.29,95%CI=1.18-1.39;multivariate OR=1.29,95%CI=1.09-1.49).Furthermore,subgroup and meta-regression analyses revealed regional variations in the impact of NLR on ESLD mortality,with Asian studies demonstrating a more pronounced *** Increased NLR in patients with ESLD is associated with a higher risk of mortality,particularly in Asian *** is a useful prognostic biomarker in patients with ESLD.

关键词： Neutrophil-to-lymphocyte ratio End stage liver diseases Prognosis Meta-analysis Mortality

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城市医疗集团建设公共利益与经济利益探析

中国医院管理 2024年第1期44卷 6-9页

作者：田翀甘恬方鹏骞华中科技大学同济医学院护理学院湖北武汉430030 华中科技大学健康政策与管理研究院(智库) 湖北武汉430030

城市医疗集团建设是我国城市卫生服务体系的重要供给侧改革探索。分析探讨了城市医疗集团建设中的利益产生机制,公共利益和经济利益的辩证关系及平衡策略,提出城市医疗集团建设主要通过综合医疗、规模化发展、同质化服务、数字化建设和... 详细信息

城市医疗集团建设是我国城市卫生服务体系的重要供给侧改革探索。分析探讨了城市医疗集团建设中的利益产生机制,公共利益和经济利益的辩证关系及平衡策略,提出城市医疗集团建设主要通过综合医疗、规模化发展、同质化服务、数字化建设和技术创新来产生新的价值,能够带来优化医疗救治资源配置、提升区域医疗服务同质化水平和创新能力、强化区域基层医疗服务等公共利益,同时也能够带来服务效率、服务能力和服务量的提升,进而产生经济效益。城市医疗集团建设中的公共利益和经济利益的追求在服务定位和成本的可及性、有效性、合理性方面存在潜在价值冲突,同时也在履行社会责任、优化医疗资源利用、推动医疗创新和高质量发展方面存在协同机制。在城市医疗集团建设试点中应辩证看待公共利益和经济利益,探索发挥地方政府的政策引导、监管和激励作用,聚焦资源优化、创新驱动或高质量发展推进公共利益与经济利益协同,同时强化公众参与,并建立绩效评估机制。

关键词：城市医疗集团医疗联合体公共利益经济利益

我国紧密型城市医疗集团建设关键要素与发展趋向

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中国医院管理 2024年第1期44卷 1-5页

作者：方鹏骞田翀李畅华中科技大学健康政策与管理研究院(智库) 湖北武汉430030 华中科技大学同济医学院护理学院湖北武汉430030 湖北中医药大学公共管理学院湖北武汉430030

我国紧密型城市医疗集团建设工作已在81个试点城市展开,试点工作能否形成可推广的有益经验取决于对关键要素和发展趋势的把握。提出紧密型城市医疗集团建设成功与否的关键要素,包括医疗集团的法律地位、医疗集团与地方卫生健康行政部门... 详细信息

我国紧密型城市医疗集团建设工作已在81个试点城市展开,试点工作能否形成可推广的有益经验取决于对关键要素和发展趋势的把握。提出紧密型城市医疗集团建设成功与否的关键要素,包括医疗集团的法律地位、医疗集团与地方卫生健康行政部门的权责分配、医疗集团的架构、一体化运行机制、医疗集团与一院多区的分界和医疗集团健康效益评价6个方面。在健康中国和数字中国建设相叠加的大背景下,紧密型城市医疗集团存在数字化革命引领全新发展模式、面向需求的多元化发展、合作机制逐渐基于价值共融和利益共享、医防融合进一步加强和成效评价向结果性指标转变5个显著发展趋势。

关键词：紧密型城市医疗集团医疗联合体关键要素发展趋向

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河南汤阴方言古知庄章组声母的今读及演变

现代语文 2024年第1期 16-22页

作者：田冲支建刚天津师范大学国际教育交流学院天津300387 南开大学文学院天津300071

今天的汤阴方言中,古知庄章组声母与精组洪音声母合流,读为[■]或[■]。结合周边方言的共时考察,可以发现,汤阴方言知庄章组与精组洪音合一,是在知庄章组开合口归为一组并与精组对立的前提下演变而来的。通过梳理《中原音韵》《青郊杂... 详细信息

今天的汤阴方言中,古知庄章组声母与精组洪音声母合流,读为[■]或[■]。结合周边方言的共时考察,可以发现,汤阴方言知庄章组与精组洪音合一,是在知庄章组开合口归为一组并与精组对立的前提下演变而来的。通过梳理《中原音韵》《青郊杂著》《交泰韵》等韵书知庄章组声母的情况,大致确定知庄章组声母合一发生在明代。汤阴方言知庄章精(洪)组声母合一,可能是因为受到了周边合一型方言的影响。

关键词：汤阴方言知庄章组声母今读演变

藤黄健骨胶囊对膝骨关节炎鼠骨代谢指标及PI3K/Akt/Nrf2/HO-1信号通路的影响

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世界中西医结合杂志 2024年第4期19卷 694-698,704页

作者：张晏宁朱崇田潍坊医学院康复医学院山东潍坊261053 临沂市人民医院康复医学科山东临沂276007

目的探讨藤黄健骨胶囊对膝骨关节炎鼠骨代谢指标及PI3K/Akt/Nrf2/HO-1信号通路的影响。方法采用木瓜蛋白酶构建膝骨关节炎大鼠(KOA)模型,将造模成功的40只大鼠按随机数字表法分为模型组、阳性药物组、低剂量组和高剂量组,每组各10只... 详细信息

目的探讨藤黄健骨胶囊对膝骨关节炎鼠骨代谢指标及PI3K/Akt/Nrf2/HO-1信号通路的影响。方法采用木瓜蛋白酶构建膝骨关节炎大鼠(KOA)模型,将造模成功的40只大鼠按随机数字表法分为模型组、阳性药物组、低剂量组和高剂量组,每组各10只。未造模的10只大鼠作为对照组。建模4周后,阳性药物组、低剂量组和高剂量组分别以美洛昔康水溶液、0.09 g/kg以及0.36 g/kg藤黄健骨胶囊干预,模型组和对照组以等量生理盐水灌胃,1次/d。给药4周后,观察比较各组大鼠Mankin评分及关节肿胀程度,酶联免疫吸附(Enzyme-linked immunosorbent assay,ELISA)检测白介素-1β(Interleukin 1β,IL-1β)、肿瘤坏死因子-α(Tumor necrosis factor alpha,TNF-α)、金属基质蛋白酶3(Metallomatrix proteinase 3,MMP3)、组织金属蛋白酶抑制因子-1(Tissue metalloproteinase inhibitor 1,TIMP-1)、骨钙素(Bone gamma-carboxyglutamic-acid-containing proteins,BGP)、抗洒石酸酸性磷酸酶(Tartrate-resistant acid phosphatase,TRACP)、I型胶原C端肽(Type I collagen carboxy-terminal peptide,CTX),Western blot法检测软骨组织PI3K/Akt/Nrf2/HO-1信号通路蛋白表达情况。结果 HE染色结果显示,对照组大鼠关节面、关节软骨和软骨细胞均正常;而模型组关节面呈不规则,关节软骨含少量软骨细胞或软骨细胞坏死,且关节软骨被纤维组织取代阳性药物组和高剂量组关节表面不规则,软骨细胞数量减少,而低剂量组显示软骨细胞中度坏死。与对照组比较,模型组Mankin评分、关节肿胀程度均升高,差异有统计学意义(P高剂量组>低剂量组,差异有统计学意义(P高剂量组>低剂量组,差异有统计学意(P<0.05)。结论藤黄健骨胶囊可显著改善膝骨关节炎鼠骨代谢水平,缓解膝骨关节炎症状,其可能机制与激活PI3K/Akt/Nrf2/HO-1信号通路有关。

关键词：藤黄健骨胶囊膝骨关节炎骨代谢 PI3K/Akt/Nrf2/HO-1

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公路隧道初期支护变形特性分析

工程建设与设计 2024年第11期 89-91页

作者：田冲冲刘浏贾占胜北京交科公路勘察设计研究院有限公司北京100191

为研究公路隧道开挖初期支护阶段的变形特性,论文以云南宁永高速公路哨坪隧道为工程背景,采用有限元计算软件Midas GTS对哨坪隧道初期支护变形段进行数值模拟,并结合隧道监控量测数据,分析其变形规律,提出初期支护变形段处治方案并评价... 详细信息

为研究公路隧道开挖初期支护阶段的变形特性,论文以云南宁永高速公路哨坪隧道为工程背景,采用有限元计算软件Midas GTS对哨坪隧道初期支护变形段进行数值模拟,并结合隧道监控量测数据,分析其变形规律,提出初期支护变形段处治方案并评价其支护效果。

关键词：隧道工程围岩变形数值模拟处治方案

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UCat: heterogeneous memory management for unikernels

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Frontiers of Computer Science 2023年第1期17卷 51-61页

作者： chong tian Haikun LIU Xiaofei LIAO Hai JIN National Engineering Research Center for Big Data Technology and System Services Computing Technology and System Lab/Cluster and Grid Computing LabSchool of Computing Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

Unikernels provide an efficient and lightweight way to deploy cloud computing services in application-specialized and single-address-space virtual machines (VMs). They can efficiently deploy hundreds of unikernel-based VMs in a single physical server. In such a cloud computing platform, main memory is the primary bottleneck resource for high-density application deployment. Recently, non-volatile memory (NVM) technologies has become increasingly popular in cloud data centers because they can offer extremely large memory capacity at a low expense. However, there still remain many challenges to utilize NVMs for unikernel-based VMs, such as the difficulty of heterogeneous memory allocation and high performance overhead of address *** this paper, we present UCat, a heterogeneous memory management mechanism that support multi-grained memory allocation for unikernels. We propose front-end/back-end cooperative address space mapping to expose the host memory heterogeneity to unikernels. UCat exploits large pages to reduce the cost of two-layer address translation in virtualization environments, and leverages slab allocation to reduce memory waste due to internal memory fragmentation. We implement UCat based on a popular unikernel--OSv and conduct extensive experiments to evaluate its efficiency. Experimental results show that UCat can reduce the memory consumption of unikernels by 50% and TLB miss rate by 41%, and improve the throughput of real-world benchmarks such as memslap and YCSB by up to 18.5% and 14.8%, respectively.

关键词： unikernel virtualization non-volatile memory heterogeneous memory large page slab allocation

3D-pCASL评估单侧大脑中动脉慢性重度狭窄患者脑血流动力学可行性研究

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中国CT和MRI杂志 2024年第3期22卷 22-24页

作者：代斌刘远成田冲贵州省人民医院医学影像科(贵州省智能医学影像分析与精准诊断重点实验室) 贵州贵阳550002

目的探讨3D-pCASL评估单侧大脑中动脉重度狭窄患者脑血流动力学改变的可行性。方法收集CTA或M R A检查提示一侧大脑中动脉重度狭窄(血管腔狭窄70%-99%)患者32例,分别行3D-pCASL(PLD选择1.5s、2.5s)及DSC-PWI检查;在患侧DSC-达峰时间(T... 详细信息

目的探讨3D-pCASL评估单侧大脑中动脉重度狭窄患者脑血流动力学改变的可行性。方法收集CTA或M R A检查提示一侧大脑中动脉重度狭窄(血管腔狭窄70%-99%)患者32例,分别行3D-pCASL(PLD选择1.5s、2.5s)及DSC-PWI检查;在患侧DSC-达峰时间(TTP)异常最显著层面及镜面对照区分别测量两个PLD脑血流量(CBF)及DSC-PWI的CBF、脑血容量(CBV)、平均通过时间(MTT)和TTP,采用配对t检验比较两侧脑区各参数的差异。计算血管狭窄侧与镜面对照脑区相对值,采用Pearson相关检验分析各参数间相关性。同时测量AS L-PLD 1.5s CBF和DSC-TTP灌注异常区域的面积并行配对t检验。结果与对照脑区比较,32例患者异常灌注脑区ASL-PLD 1.5s及2.5s CBF、DSC-CBF、 DSC-MTT、DSC-TTP参数值间差异具有统计学意义(t值分别为-29.94、-20.07、-11.83、14.33、13.48,P值均0.05)。DSC-TTP与ASL-PLD 1.5s CBF灌注减低区域面积差异无统计学意义(t=1.834,P>0.05)。结论3D-pCASL(PLD 1.5s及2.5s)灌注成像可以评价单侧大脑中动脉重度狭窄患者脑血流动力学的改变情况,并且具有定量及无需注射钆对比剂的优点。

关键词：动脉自旋标记(ASL) 标记后延迟时间(PLD) 动态磁敏感对比-灌注加权成像(DSC-PWI) 大脑中动脉狭窄卒中

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