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Ethanol extract from Gynostemma pentaphyllum ameliorates dopaminergic neuronal cell death in transgenic mice expressing mutant A53T human alpha-synuclein

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Neural Regeneration Research 2020年第2期15卷 361-368页

作者： Hyun Jin Park Ting Ting Zhao Seung Hwan Kim chong kil lee Bang Yeon Hwang Kyung Eun lee Myung Koo lee Department of Pharmacy College of PharmacyChungbuk National UniversityCheongjuRepublic of Korea 2Research Center for Bioresource and Health College of PharmacyChungbuk National UniversityCheongjuRepublic of Korea Department of Social Physical Education Songwon UniversityGwangjuRepublic of Korea

Gynostemma(G.) pentaphyllum(Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum(GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal models of Parkinson’s disease(PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-and 6-hydroxydopamine. PD patients exhibit multiple symptoms, so PD-related research should combine neurotoxin models with genetic models. In the present study, we investigated the ameliorative effects of GP-EX, including gypenosides, on the cell death of dopaminergic neurons in the midbrain of A53 T α-synuclein transgenic mouse models of PD(A53 T). Both GP-EX and gypenosides at 50 mg/kg per day were orally administered to the A53 T mice for 20 weeks.α-Synuclein-immunopositive cells and α-synuclein phosphorylation were increased in the midbrain of A53 T mice, which was reduced following treatment with GP-EX. Treatment with GP-EX modulated the reduced phosphorylation of tyrosine hydroxylase, extracellular signal-regulated kinase(ERK1/2), Bcl-2-associated death promoter(Bad) at Ser112, and c-Jun N-terminal kinase(JNK1/2) due to α-synuclein overexpression. In the A53 T group, GP-EX treatment prolonged the latency of the step-through passive avoidance test and shortened the transfer latency of the elevated plus maze test. Gypenosides treatment exhibited the effects and efficacy similar to those of GP-EX. Taken together, GP-EX, including gypenosides, has ameliorative effects on dopaminergic neuronal cell death due to the overexpression of α-synuclein by modulating ERK1/2, Bad at Ser112, and JNK1/2 signaling in the midbrain of A53 T mouse model of PD. Further studies are needed to investigate GP-EX as a treatment for neurodegenerative synucleinopathies, including PD. This study was approved by the Animal Ethics Committee of Chungbuk National University(approval No. CBNUA-956-16-01) on September 21, 2016.

关键词： A53T α-synuclein genetic mice ERK1/2 gynostemma pentaphyllum gypenosides Parkinson’s disease retention transfer latency time

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Experience of Mental Health Professionals Collaborating with Peer Supporters in a Community Mental Health Service Team

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International Journal of Mental Health Promotion 2024年第4期26卷 251-260页

作者： Sowon lee Boyoung Kim Chung kil Park College of Nursing Chonnam National UniversityGwangju61469South Korea College of Oriental Medicine Wonkwang UniversityIksan54538South Korea

This study explored how mental health professionals collaborate with peer supporters with mental disabilities in a community mental health *** January 19 to February 23,2021,three 60 min interviews were conducted with six mental health professionals working at a Korean community *** results were qualitatively analyzed and divided into four themes and eight *** four themes were the perceptions of and challenges in working with peer supporters with mental disabilities,conflict and confusion about working with peer supporters,forming partnerships with peer supporters,and policy support for peer supporters’job *** reported vague anxiety about working with a peer supporter and difficulties with the trial-and-error process of adjusting to the role as *** time,however,they realized that they needed to make an effort to develop meaningful relationships with peer supporters and mental health ***,through this study,we realized that there was a need to improve the system,such as building infrastructure for job stability for peer support workers and capacity building tailored to the mental *** peer supporters play various roles while working with mental health professionals,this study showed the possibility of mutual growth through communication and *** findings will help prepare systems necessary for collaboration between the two teams amidst the increasing institutionalization of peer support for mental disorders.

关键词： Peer supporters mental health mental health professionals collaborating

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Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-Il Park Deug-chan lee Kyung-Min Choi WonWoo lee Ji-Won Park Bohyun Yun Su-Hyeon Cho kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

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Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： Eric Tzyy Jiann chong Joveen Wan Fen Neoh Tiek Ying Lau Kek Heng Chua Yvonne Ai-Lian Lim Ping-Chin lee Biotechnology Research Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of Biomedical Science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Centre of Excellence for Research in AIDS(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of Science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and ***:Thirty-nine blood samples infected with *** were collected in Sabah,Malaysian Borneo and Peninsular *** S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and *** natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK *** study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA ***:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of *** isolates from different areas in Malaysia based on the S-type SSU rRNA gene *** S-type SSU rRNA gene sequences were relatively conserved and with a purifying *** sharing of the S-type SSU rRNA gene was observed between the *** isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular ***:This study suggests that the S-type SSU rRNA gene of *** isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the *** features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among *** species.

关键词： Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection Haplotype

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Model algorithm control using neural networks for input delayed nonlinear control system

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Journal of Systems Engineering and Electronics 2015年第1期26卷 142-150页

作者： Yuanliang Zhang kil To chong School of Mechanical Engineering Huaihai Institute of Technology School of Electronics and Information Chonbuk National University

The performance of the model algorithm control method is partially based on the accuracy of the system＇s model. It is difficult to obtain a good model of a nonlinear system, especially when the nonlinearity is high. Neural networks have the ability to ＂learn＂the characteristics of a system through nonlinear mapping to represent nonlinear functions as well as their inverse functions. This paper presents a model algorithm control method using neural networks for nonlinear time delay systems. Two neural networks are used in the control scheme. One neural network is trained as the model of the nonlinear time delay system, and the other one produces the control inputs. The neural networks are combined with the model algorithm control method to control the nonlinear time delay systems. Three examples are used to illustrate the proposed control method. The simulation results show that the proposed control method has a good control performance for nonlinear time delay systems.

关键词： model algorithm control neural network nonlinear system time delay

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Adaptive network fuzzy inference system based navigation controller for mobile robotAdaptive network fuzzy inference system based navigation controller for mobile robot

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Frontiers of Information Technology & Electronic Engineering 2019年第2期20卷 141-151页

作者： Panati SUBBASH kil To chong Department of Electronics and Information Engineering Chonbuk National University Advanced Electronics and Information Research Center Chonbuk National University

Autonomous navigation of a mobile robot in an unknown environment with highly cluttered obstacles is a fundamental issue in mobile robotics research. We propose an adaptive network fuzzy inference system(ANFIS) based navigation controller for a differential drive mobile robot in an unknown environment with cluttered obstacles. Ultrasonic sensors are used to capture the environmental information around the mobile robot. A training data set required to train the ANFIS controller has been obtained by designing a fuzzy logic based navigation controller. Additive white Gaussian noise has been added to the sensor readings and fed to the trained ANFIS controller during mobile robot navigation, to account for the effect of environmental noise on sensor readings. The robustness of the proposed navigation controller has been evaluated by navigating the mobile robot in three different environments. The performance of the proposed controller has been verified by comparing the travelled path length/efficiency and bending energy obtained by the proposed method with reference mobile robot navigation controllers, such as neural network, fuzzy logic, and ANFIS. Simulation results presented in this paper show that the proposed controller has better performance compared with reference controllers and can successfully navigate in different environments without any collision with obstacles.

关键词： Adaptive network fuzzy inference system Additive white Gaussian noise Autonomous navigation Mobile robot

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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

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Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige Hu Michael H Perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur Hazlin Hazrin-chong Soojin Jang Haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K H lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal High Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).However,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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Fast global kernel fuzzy c-means clustering algorithm for consonant/vowel segmentation of speech signal

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第7期15卷 551-563页

作者： Xian ZANG Felipe P. VISTA IV kil To chong Department of Electronic Engineering Jeonbuk National University Advanced Electronics and Information Research Center Jeonbuk National University

We propose a novel clustering algorithm using fast global kernel fuzzy c-means-F(FGKFCM-F), where F refers to kernelized feature space. This algorithm proceeds in an incremental way to derive the near-optimal solution by solving all intermediate problems using kernel-based fuzzy c-means-F(KFCM-F) as a local search procedure. Due to the incremental nature and the nonlinear properties inherited from KFCM-F, this algorithm overcomes the two shortcomings of fuzzy c-means(FCM): sen- sitivity to initialization and inability to use nonlinear separable data. An accelerating scheme is developed to reduce the compu-tational complexity without significantly affecting the solution quality. Experiments are carried out to test the proposed algorithm on a nonlinear artificial dataset and a real-world dataset of speech signals for consonant/vowel segmentation. Simulation results demonstrate the effectiveness of the proposed algorithm in improving clustering performance on both types of datasets.

关键词： Fuzzy c-means clustering Kernel method Global optimization Consonant/vowel segmentation

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Virtual reconfigurable architecture for evolving combinational logic circuits

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Journal of Central South University 2014年第5期21卷 1862-1870页

作者：王进 lee chong-Ho chongqing Key Laboratory of Computational Intelligence(chongqing University of Posts and Telecommunications) Department of Information&Communication Engineering Inha University

A virtual reconfigurable architecture(VRA)-based evolvable hardware is proposed for automatic synthesis of combinational logic circuits at *** proposed VRA is implemented by a Celoxica RC1000 peripheral component interconnect(PCI)board with an Xilinx Virtex xcv2000E field programmable gate array(FPGA).To improve the quality of the evolved circuits,the VRA works through a two-stage evolution: finding a functional circuit and minimizing the number of logic gates used in a feasible *** optimize the algorithm performance in the two-stage evolutionary process and set free the user from the time-consuming process of mutation parameter tuning,a self-adaptive mutation rate control(SAMRC)scheme is *** the evolutionary process,the mutation rate control parameters are encoded as additional genes in the chromosome and also undergo evolutionary *** efficiency of the proposed methodology is tested with the evolutions of a 4-bit even parity function,a 2-bit multiplier,and a 3-bit *** obtained results demonstrate that our scheme improves the evolutionary design of combinational logic circuits in terms of quality of the evolved circuit as well as the computational effort,when compared to the existing evolvable hardware approaches.

关键词： evolutionary algorithm evolvable hardware self-adaptive mutation rate control virtual reconfigurable architecture

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Endoscopic submucosal dissection for undifferentiated-type early gastric cancer: Do we have enough data to support this?

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World Journal of Gastroenterology 2014年第14期20卷 3938-3949页

作者： Choong Nam Shim Sang kil lee Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine

Although endoscopic submucosal dissection (ESD) is now accepted for treatment of early gastric cancers (EGC) with negligible risk of lymph node (LN) metastasis, ESD for intramucosal undifferentiated type EGC without ulceration and with diameter ≤ 2 cm is regarded as an investigational treatment according to the Japanese gastric cancer treatment guidelines. This consideration was largely based on the analysis of surgically resected EGCs that contained undifferentiated type EGCs; however, results from several institutes showed some discrepancies in sample size and incidence of LN metastasis. Recently, some reports about the safety and efficacy of ESD for undifferentiated type EGC meeting the expanded criteria have been published. Nonetheless, only limited data are available regarding long-term outcomes of ESD for EGC with undifferentiated histology so far. At the same time, endoscopists cannot ignore the patients’ desire to guarantee quality of life after the relatively non-invasive endoscopic treatment when compared to conventional surgery. To satisfy the needs of patients and provide solid evidence to support ESD for undifferentiated EGC, we need more delicate tools to predict undetected LN metastasis and more data that can reveal predictive factors for LN metastasis.

关键词： Early gastric cancer Endoscopic submucosal dissection Undifferentiated histology Indications

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