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Redox-sensitive colorimetric polyaniline nanoprobes synthesized by a solvent=shift process

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Nano Research 2013年第5期6卷 356-364页

作者： jihye choi Yoochan Hong Eugene Lee Myeong-Hoon Kim Dae Sung Yoon Jinsuck Suh Yongmin Huh Seungjoo Haam Jaemoon Yang Department of Chemical and Biomolecular Engineering Yonsei University Seou1120-749 Republic of Korea Department of Biomedical Engineering Yonsei University Wonju 220-710 Republic of Korea epartment of Radiology College of Medicine Yonsei University Seou1120- 752 Republic of Korea YUHS-KRIBB Medical Convergence Research Institute Seou1120-752 Republic of Korea Severance Biomedical Science Institute (SBSI) Seou1120-752 Republic of Korea Severance Integrative Research Institute for Cerebral and Cardiovascular Diseases Yonsei University Health System Seou1120-752 Republic of Korea

We have synthesized water-stable polyaniline nanoparticles coated with tri- armed polyethylene glycol chains using a solvent-shift method and confirmed their colloidal size and aqueous solubility. Furthermore, we have demonstrated that the polyaniline nanoparticles can be doped with biological dopants to produce distinct color changes allowing the detection of live cancer cells.

关键词： polyaniline solvent-shifting cancer colorimetric nanoprobe

Colourimetric redox-polyaniline nanoindicator for in situ vesicular trafficking of intracellular transport

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Nano Research 2015年第4期8卷 1169-1179页

作者： Eun Bi choi jihye choi Seo Ryung Bae Hyun-Ouk Kim EunjiJang Byunghoon Kang Myeong-Hoon Kim Byeongyoon Kim Jin-Suck Suh Kwangyeol Lee Yong-Min Huh Seungjoo Haam Department of Chemical and Biomolecular Engineering College of Engineering Yonsei University Seou1120-749 Republic of Korea Department of Radiology College of Medicine Yonsei University Seou1120-752 Republic of Korea Department of Chemistry Korea University Seou1136-701 Republic of Korea

Vesicular pH modulates the function of many organelles and plays a pivotal role in cell metabolism processes such as proliferation and apoptosis. Here, we introduce a simple colorimetric redox-polyaniline nanoindicator, which can detect and quantify a broader biogenic pH range with superior sensitivity compared to pre-established trafficking agents employing one-dimensional turn-on of the fluorescence resonance-energy-transfer （FRET） signal. We fabricated polyaniline- based nanoprobes, which exhibited convertible transition states according to the proton levels, as an in situ indicator of vesicular transport pH. Silica-coated Fe304-MnO heterometal nanoparticles were synthesised and utilised as a metal oxidant to polymerise the aniline monomer. Finally, silica-coated polyaniline nanoparticles with adsorbed cyanine dye fluorophores Cy3 and Cy7 （FPSNIcyB and FPSNIcy7） were fabricated as proton-sensitive nanoindicators. Owing to the selective quenching induced by the local pH variations of vesicular transport, FPSNIcy3 and FPSNIcy7 demonstrated excellent intracellular trafficking and provided sensitive optical indication of minute proton levels.

关键词： redox pH intraceUular compartments organic quencher conducting polymer nanoindicator

Microsphere-assisted hyperspectral imaging:super-resolution,non-destructive metrology for semiconductor devices

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Light(Science & Applications) 2024年第6期13卷 1098-1111页

作者： Jangryul Park Youngsun choi Soonyang Kwon Youngjun Lee Jiwoong Kim Jae-joon Kim jihye Lee Jeongho Ahn Hidong Kwak Yusin Yang Taeyong Jo Myungjun Lee Kwangrak Kim Metrology and Inspection Equipment R&D Team Mechatronics ResearchSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department DRAM Process Development TeamSemiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea Process Development Department Semiconductor R&D CenterSamsung Electronics Co.Ltd.1-1 Samsungjeonja-rohwaseong-siGyeonggi-do18848Republic of Korea

As semiconductor devices shrink and their manufacturing processes advance,accurately measuring in-cell critical dimensions(CD)becomes increasingly *** test element group(TEG)measurements are becoming inadequate for representing the fine,repetitive patterns in cell *** non-destructive metrology technologies like optical critical dimension(OCD)are limited due to their large spot diameter of approximately 25μm,which impedes their efficacy for detailed in-cell structural ***,there is a pressing need for small-spot and non-destructive metrology *** address this limitation,we demonstrate a microsphere-assisted hyperspectral imaging(MAHSI)system,specifically designed for small spot optical metrology with *** microsphere-assisted super-resolution imaging,this system achieves an optical resolution of 66 nm within a field of view of 5.6μm×5.6μ*** approach effectively breaks the diffraction limit,significantly enhancing the magnification of the *** MAHSI system incorporating hyperspectral imaging with a wavelength range of 400–790 nm,enables the capture of the reflection spectrum at each camera *** achieved pixel resolution,which is equivalent to the measuring spot size,is 14.4 nm/pixel and the magnification is *** MAHSI system enables measurement of local uniformity in critical areas like corners and edges of DRAM cell blocks,areas previously challenging to inspect with conventional OCD *** our knowledge,this approach represents the first global implementation of microsphere-assisted hyperspectral imaging to address the metrology challenges in complex 3D structures of semiconductor devices.

关键词： metrology resolution enable

Zircon U-Pb ages and O-Hf isotopes of Quaternary trachytes from the East Sea:Implications for the genesis of low-δ^(18)O magmas

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Geoscience Frontiers 2024年第2期15卷 41-54页

作者： Hyun-Ok choi jihye Oh Chang Hwan Kim Soon Young choi Won Hyuck Kim Chan Hong Park Dokdo Research Center East Sea Research InstituteKorea Institute of Ocean Science and TechnologyUljin 36315Republic of Korea Deep-Sea and Seabed Mineral Resources Research Center Korea Institute of Ocean Science and TechnologyBusan 49111Republic of Korea Division of Science Education Kangwon National University1 Gangwondaehak-gilChuncheon-siGangwon-do 24341Republic of Korea

Quaternary intraplate magmatism formed several volcanic islands and seamounts,including Dokdo(DD),Ulleungdo(UD),Simheungtack(ST),Anyongbok,and Isabu in the southwest of the East Sea back-arc *** this study,we present whole-rock geochemical,zircon U–Pb age,and in situ O–Hf isotope data for the submerged volcanic rocks from DD,UD,and ST to provide new insights into the eruption timing of these volcanoes and constrain the magma evolution *** samples used in this study were trachytes and exhibited ferroan,alkalic,and metaluminous to weakly peraluminous *** showed light rare earth element(REE)-enriched patterns with(La/Yb)N ratios of 25.3–31.7 and mostly negative Eu anomalies in a chondrite-normalized REE *** addition,they were enriched in large-ion lithophile elements and high field strength elements;they exhibited positive Pb anomalies and strongly negative Ba,Sr,P,and Ti *** zircons yielded a weighted-mean 206Pb/238U age of 2.61,0.348–0.704,and 2.76–2.94 Ma for the DD,UD,and ST trachytes,*** zircons exhibited lowerδ^(18)O values than normal depleted mantle values,regardless of the crystallization age and spatial distribution of ***δ^(18)O values showed no correlation with U contents or Th/U ratios,indicating that the lowδ^(18)O signatures were of primary magmatic *** Hf isotopic compositions of the zircons were relatively heterogeneous but predominately characterized by positive eHf *** O–Hf mixing modeling revealed that low-δ^(18)O rocks with positive eHf values from the UD and ST volcanoes were derived from a hybrid source of recycled juvenile crustal materials with low-δ^(18)O and positive eHf signatures and an enriched mantle source with normalδ^(18)O and negative eHf *** juvenile oceanic crust in the source was likely metasomatized by seawater at high temperatures prior to *** contrast,the felsic magma that formed the DD volcanoes may have assimilated with regional

关键词： Quaternary intraplate volcanism East Sea Zircon O-Hf isotopes Low-δ^(18)O magma Recycled juvenile oceanic crust

Compositional dependence of thermal and elastic properties of Cu-Ti-Zr-Ni bulk metallic glasses

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International Journal of Minerals,Metallurgy and Materials 2010年第3期17卷 318-322页

作者： jihye An Hyunjune Yim choi-Yim Haein Department of Physics Sookmyung Women's University Department of Mechanical & System Design Engineering Hongik University

Starting from the quaternary Cu47Ti34Zr11Ni8 alloy, the compositional dependence of thermal and elastic properties of Cu-Ti-Zr-Ni alloys was systematically investigated. Quaternary Cu-Ti-Zr-Ni alloys can be cast directly from the melt into copper molds to form fully amorphous strips or rods with the thickness of 3-6 mm. The evidence of the amorphous nature of the cast rods was provided by X-ray spectra. The measured glass transition temperature （Tg） and crystallization temperature （Tx） were obtained for the alloys using differential scanning calorimetry （DSC） at the heating rate of 20 K/s. In the results, the differences between the glass temperature and the crystallization temperature （△Tx=Tx-Tg） are measured with values ranging up to 33-55 K. The reduced glass transition temperature （Trg）, which is the ratio of the glass temperature to the liquidus temperature （T3, is often used as an indication of the glass-forming ability of metallic alloys. For the present Cu-Ti-Zr-Ni alloys, this ratio is typically in the range of 0.5838-0.5959, characteristic of metallic alloys with good glass-forming ability. The elastic constants for several selected alloys were measured using ultrasonic methods. The values of the elastic shear modulus, bulk modulus, and Poisson＇s ratio were also given.

关键词： bulk metallic glasses (BMGs) quatemary alloys elastic constants glass-forming ability

Characterization of MAGEG2 with testis-specific expression in mice

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Asian Journal of Andrology 2017年第6期19卷 659-665页

作者： Juri Jeong Sora Jin Heejin choi Jun Tae Kwon jihye Kim Jaehwan Kim Zee Yong Park Chunghee Cho School of Life Sciences Gwangju Institute of Science and Technology Gwangju 61005 South Korea.

Male germ cell development is a well-defined process occurring in numerous seminiferous tubules of the testis. Uncovering testicular novel genes related to intrinsic regulation of spermatogenesis is essential for the understanding of spermatogenesis. In the present study, we investigated mouse Mageg2, which belongs to a group of melanoma-associated antigens （MAGEs）. Mageg2 is transcribed in the testis specifically, and its expression level is increased at the pachytene spermatocyte stage, indicating that Mageg2 is expressed predominantly in germ cells. We generated an antibody against mouse MAGEG2 for further characterization at the protein level. Immunoblot analysis suggested that MAGEG2 has specific testicular expression and the expression primarily occurred in pachytene spermatocytes. Proteomic analyses demonstrated that mouse MAGEG2 binded to testicular germ cell-specific serine/threonine-protein kinase 31 （STK31） and heat shock protein 9 （HSPA9）. Direct binding with both interaction partners was confirmed by co-immunoprecipitation. We found that STK31 and HSPA9 bind MAGEG2 directly but not with each other. Interestingly, MAGEG2 reduced the kinase activity of STK31. Our study suggests that mouse MAGEG2 has at least two functions, including chaperone activity related to HSPA9 and regulation of pachytene spermatocyte-specific kinase, STK31. Altogether, our results provide the first information about MAGEG2 at the transcript and protein levels and suggest its potential molecular functions.

关键词： heat shock proteins serine/threonine kinase spermatogenesis testis

Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study

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World Journal of Gastroenterology 2019年第42期25卷 6354-6364页

作者： Jooyoung Lee Jong Pil Im Kyungdo Han Seona Park Hosim Soh Kukhwan choi jihye Kim Jaeyoung Chun Joo Sung Kim Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam CenterSeoul National University HospitalSeoul 06236South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Biostatics College of MedicineCatholic University of KoreaSeoul 06591South Korea Department of Internal Medicine CHA Gangnam Medical CenterCHA UniversitySeoul 06135South Korea Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273South Korea

BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway *** To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of *** A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were *** COPD group was divided into the severe and the mild COPD group according to diagnostic *** risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression *** cumulative incidences of IBD were compared between the *** The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased.

关键词： Claim data Inflammatory bowel disease Chronic obstructive pulmonary disease Crohn’s disease Ulcerative colitis

Simple techniques to preconcentrate samples for capillary electrophoresis/mass spectrometry

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Simple techniques to preconcentrate samples for capillary el...

Dual-light emitting 3D encryption with printable fluorescent-phosphorescent metal-organic frameworks

第21届全国色谱学术报告会及仪器展览会

作者： Joon Yup Kwon jihye Kim Kihwan choi Doo Soo Chung Department of Chemistry Seoul National University Division of Methodology for Quality of Life Korea Research Institute of Standards and Science

＜正＞Sample preconcentration for capillary electrophoresis （CE） can be done either before or after sample injection. Large volume sample stacking using an electroosmotic flow pump （LVSEP） is a widely used after-injection preconcentration technique removing the long sample matrix into the inlet side. However, due to the lack of an outlet vial, it was difficult to apply LVSEP to CE with electrospray ionization mass spectrometry （ESI-MS）. We solved this difficulty by placing a vial supplying a run buffer during the matrix

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Light(Science & Applications) 2023年第10期12卷 2172-2186页

作者： Jin Woo Oh Seokyeong Lee Hyowon Han Omar Allam Ji Il choi Hyeokjung Lee Wei Jiang jihye Jang Gwanho Kim Seungsoo Mun Kyuho Lee Yeonji Kim Jong Woong Park Seonju Lee Seung Soon Jang Cheolmin Park Department of Materials Science and Engineering Yonsei UniversitySeoul 03722Republic of Korea The George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology801 Ferst DriveAtlantaGA 30332-0405USA School of Materials Science and Engineering Georgia Institute of Technology771 Ferst DriveAtlantaGA 30332-0245USA Om Spin Convergence Research Center Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea

Optical encryption technologies based on room-temperature light-emitting materials are of considerable ***,we present three-dimensional(3D)printable dual-light-emitting materials for high-performance optical pattern *** are based on fluorescent perovskite nanocrystals(NCs)embedded in metal-organic frameworks(MOFs)designed for phosphorescent host-guest ***,perovskite-containing MOFs emit a highly efficient blue phosphorescence,and perovskite NCs embedded in the MOFs emit characteristic green or red fluorescence under ultraviolet(UV)*** dual-light-emitting MOFs with independent fluorescence and phosphorescence emissions are employed in pochoir pattern encryption,wherein actual information with transient phosphorescence is efficiently concealed behind fake information with fluorescence under UV ***,a 3D cubic skeleton is developed with the dual-light-emitting MOF powder dispersed in 3D-printable polymer filaments for 3D dual-pattern *** article outlines a universal principle for developing MOF-based room-temperature multi-light-emitting materials and a strategy for multidimensional information encryption with enhanced capacity and security.

关键词： perovskite light pattern