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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan juan Alec C.Bancroft ji Hae choi Chase A.Pagani Aysel A.Fernandes Michael Woodard juhoon Lee Sowmya Ramesh Aaron W.james David Hudson Kevin N.Dalby Lin Xu Robert j.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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采用LI-RADS 2018版的钆塞酸二钠增强MRI诊断<1.0 cm肝细胞癌

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国际医学放射学杂志 2023年第5期 628-628页

作者： H.j.jang S.H.choi S.j.choi W.M.choi j.H.Byun H.j.Won 张晓涵

摘要目的旨在通过包括具有明显有价值的钆塞酸二钠增强MRI次要征象诊断<1 cm肝细胞癌（HCC），提出肝脏成像报告和数据系统2018版（LI-RADS v2018）修正方案并

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替诺福韦相比恩替卡韦可显著改善HBV相关肝细胞癌患者肝切除术后复发

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临床肝胆病杂志 2020年第9期36卷 2106-2106页

作者：江梦捷赵婧菲 choi j jO C LIM YS 广西医科大学附属肿瘤医院肝胆外科不详

【据Hepatology 2020年4月报道】题:替诺福韦与恩替卡韦对HBV相关肝细胞癌肝切除术后复发的影响(作者choi j等)替诺福韦(TDF)和恩替卡韦(ETV)均为目前慢性乙型肝炎(CHB)临床指南中的一线治疗药物,有较高的抗病毒疗效和较低的耐药性。韩... 详细信息

【据Hepatology 2020年4月报道】题:替诺福韦与恩替卡韦对HBV相关肝细胞癌肝切除术后复发的影响(作者choi j等)替诺福韦(TDF)和恩替卡韦(ETV)均为目前慢性乙型肝炎(CHB)临床指南中的一线治疗药物,有较高的抗病毒疗效和较低的耐药性。韩国蔚山大学医学院峨山医学中心研究团队的既往研究表明,使用TDF治疗的CHB患者相比于ETV治疗能显著降低肝细胞癌(HCC)的发生风险。该团队进行了一项回顾性队列分析,探讨了TDF与ETV治疗对HBV相关HCC根治性肝切除术后肿瘤复发及总生存率的影响。

关键词：替诺福韦抗病毒疗效一线治疗药物肝细胞癌患者临床指南肝切除术后恩替卡韦总生存率

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灌注偏度及峰度百分比变化:初诊为胶质母细胞瘤病人的早期治疗反应的一项潜在影像学生物指标

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国际医学放射学杂志 2012年第6期 581-582页

作者： H.j.Baek H.S.Kim N.Kim Y.j.choi Y.j.Kim 胡丽丽郭琪 Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan medical Center86 Asan byeongwon-GilSongpa-GuSeoul 138-736Korea

摘要目的检测治疗早期正常脑血容量(nCBV)偏度及峰度变化对鉴别初诊为胶质母细胞瘤病人的早期肿瘤进展与假性进展的预测价值。材料与方法本回顾性研究经伦理委员会批准。本研究对135例初诊为胶质母细胞瘤且术后同时接受化疗和放疗(CCRT... 详细信息

摘要目的检测治疗早期正常脑血容量(nCBV)偏度及峰度变化对鉴别初诊为胶质母细胞瘤病人的早期肿瘤进展与假性进展的预测价值。材料与方法本回顾性研究经伦理委员会批准。本研究对135例初诊为胶质母细胞瘤且术后同时接受化疗和放疗(CCRT)的病人进行评估。

关键词：胶质母细胞瘤生物指标早期治疗假性进展病人峰度偏度反应

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简化LI-RADS在钆塞酸增强MRI诊断肝细胞癌中的应用

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国际医学放射学杂志 2023年第1期46卷 110-110页

作者： M.Kwag S.H.choi S.j.choi j.H.Byun H.j.Won Y.M.Shin 符小花

摘要尽管对钆塞酸增强MRI的肝脏影像报告和数据系统(LI-RADS)进行各种修改,但LI-RADS对肝细胞癌(HCC)的敏感度并不理想,且过于复杂。目的评估简化LI-

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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So Yung choi Susan Win Yoo jin Lee Shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres j Yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and choi SY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee Yj and Yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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Surface-functionalized hole-selective monolayer for high efficiency single-junction wide-bandgap and monolithic tandem perovskite solar cells

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journal of Energy Chemistry 2024年第1期88卷 317-326,I0008页

作者： Devthade Vidyasagar Yeonghun Yun jae Yu Cho Hyemin Lee Kyung Won Kim Yong Tae Kim Sung Woong Yang jina jung Won Chang choi Seonu Kim Rajendra Kumar Gunasekaran Seok Beom Kang Kwang Heo Dong Hoe Kim jaeyeong Heo Sangwook Lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering and Optoelectronics Convergence Research CenterChonnam National UniversityGwangju 61186Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea

Carbazole moiety-based 2PACz([2-(9H-carbazol-9-yl)ethyl]phosphonic acid)self-assembled monolayers(SAMs)are excellent hole-selective contact(HSC)materials with abilities to excel the charge-transferdynamics of perovskite solar cells(PSCs).Herein,we report a facile but powerful method to functionalize the surface of 2PACz-SAM,by which reproducible,highly stable,high-efficiency wide-bandgap PSCs can be *** 2PACz surface treatment with various donor number solvents improves assembly of 2PACz-SAM and leave residual surface-bound solvent molecules on 2PACz-SAM,which increases perovskite grain size,retards halide segregation,and accelerates hole *** surface functionalization achieves a high power conversion efficiency(PCE)of 17.62%for a single-junction wide-bandgap(~1.77 e V)*** also demonstrate a monolithic all-perovskite tandem solar cell using surfaceengineered HSC,showing high PCE of 24.66%with large open-circuit voltage of 2.008 V and high fillfactor of 81.45%.Our results suggest this simple approach can further improve the tandem device,when coupled with a high-performance narrow-bandgap sub-cell.

关键词： Perovskite solar cells 2PACz Monolithic tandem solar cells Wide bandgap

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比较使用钆塞酸二钠与钆喷酸葡胺进行MRI增强检查时的短暂剧烈运动:改良屏气技术的影响

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国际医学放射学杂志 2018年第3期 363-363页

作者： j.S.Song E.j.choi E.H.Park j.H.Lee 贺思健 Department of Radiology Chonbuk National University Medical School and Hospital

摘要目的比较使用钆塞酸二钠与钆喷酸葡胺进行MRI增强检查时短暂剧烈运动(TSM)的发生率以及钆塞酸二钠MRI增强检查有无应用改良屏气技术时的TSM发生

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Polymer donors with hydrophilic side-chains enabling efficient and thermally-stable polymer solar cells by non-halogenated solvent processing

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Nano Research Energy 2024年第1期3卷 19-29页

作者： Soodeok Seo jun-Young Park jin Su Park Seungjin Lee Do-Yeong choi Yun-Hi Kim Bumjoon j.Kim Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea Department of Materials Engineering and Convergence Technology and ERI Gyeongsang National UniversityJinju 52828Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea Department of Chemistry and ERI Gyeongsang National UniversityJinju 52828Republic of Korea

Polymer solar cells(PSCs)with high power conversion efficiency(PCE)and environment-friendly fabrication are the main requirements enabling their production in industrial *** the use of non-halogenated solvent processing is inevitable for the PSC fabrication,it significantly reduces the processability of polymer donors(PDS)and small-molecule acceptors(SMAs).This often results in unoptimized blend morphology and limits the device *** address this issue,hydrophilic oligoethylene glycol(OEG)side-chains are introduced into a PD(2EG)to enhance the molecular compatibility between the PD and L8-BO *** 2EG PD induces higher crystallinity and alleviates phase separation with the SMA compared to the reference PD(PM7)with hydrocarbon ***,the 2EG-based PSCs exhibit a higher PCE(15.8%)than the PM7-based PSCs(PCE=14.4%)in the ortho-xylene based ***,benefitted from the reduced phase separation and increased crystallinity of 2EG PDS,the 2EG-based PSCs show enhanced thermal stability(84%of initial PCE after 120 h heating)compared to that of the PM7-based PSCs(60%of initial PCE after 120 h heating).This study demonstrates the potential of OEG side-chain-incorporated materials in developing efficient,stable,and eco-friendly PSCs.

关键词： polymer solar cell polymer donor OEG side-chain non-halogenated solvent process side-chain engineering

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胎儿脑MRI显示正常生长、性别二型性和侧向不对称

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国际医学放射学杂志 2022年第3期 360-360页

作者： F.Machado-Rivas j.Gandhi j.j.choi C.Velasco-Annis O.Afacan S.K.Warfield 张玉

摘要 MRI的影像重建、运动校正和分割工具使得胎儿脑发育的精确体积界定成为可能。目的利用胎儿大脑发育的时空MRI图谱，评估健康胎儿颅内结构的体积生长，并考

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