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A new osteogenic protein isolated from Dioscorea opposita Thunb accelerates bone defect healing through the mTOR signaling axis

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Bioactive Materials 2023年第9期27卷 429-446页

作者： John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Yin lau Lee Kai-fai Lee Stephen cho Wing Sze Wei Qiao Kelvin Wai-Kwok Yeung Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong Kong(HKU)Hong Kong S.A.R.PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma HKU-Shenzhen HospitalShenzhen518053PR China Department of Obstetrics and Gynaecology Li Ka Shing Faculty of MedicineHKU21 Sassoon RoadHong Kong S.A.RPR China Shenzhen Key Laboratory of Fertility Regulation Reproductive Medicine CenterHKU-Shenzhen HospitalShenzhenPR China Department of Biology Faculty of ScienceHong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Golden Meditech Center for NeuroRegeneration Sciences Hong Kong Baptist UniversityKowloon TongHong Kong S.A.RPR China Applied Oral Sciences and Community Dental Care Faculty of DentistryHong Kong S.A.RPR China

Delayed bone defect repairs lead to severe health and socioeconomic impacts on patients. Hence, there are increasing demands for medical interventions to promote bone defect healing. Recombinant proteins such as BMP-2 have been recognized as one of the powerful osteogenic substances that promote mesenchymal stem cells (MSCs) to osteoblast differentiation and are widely applied clinically for bone defect repairs. However, recent reports show that BMP-2 treatment has been associated with clinical adverse side effects such as ectopic bone formation, osteolysis and stimulation of inflammation. Here, we have identified one new osteogenic protein, named ‘HKUOT-S2’ protein, from Dioscorea opposita Thunb. Using the bone defect model, we have shown that the HKUOT-S2 protein can accelerate bone defect repair by activating the mTOR signaling axis of MSCs-derived osteoblasts and increasing osteoblastic biomineralization. The HKUOT-S2 protein can also modulate the transcriptomic changes of macrophages, stem cells, and osteoblasts, thereby enhancing the crosstalk between the polarized macrophages and MSCs-osteoblast differentiation to facilitate osteogenesis. Furthermore, this protein had no toxic effects in vivo. We have also identified HKUOT-S2 peptide sequence TKSSLPGQTK as a functional osteogenic unit that can promote osteoblast differentiation in vitro. The HKUOT-S2 protein with robust osteogenic activity could be a potential alternative osteoanabolic agent for promoting osteogenesis and bone defect repairs. We believe that the HKUOT-S2 protein may potentially be applied clinically as a new class of osteogenic agent for bone defect healing.

关键词： Dioscorea spp protein Mesenchymal stem cells(MSCs) Osteoblast differentiation Bone mineral density(BMD) Bone defect repair mTOR signaling pathway

Late retroperitoneal recurrence of hepatocellular carcinoma 12 years after initial diagnosis

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World Journal of Gastroenterology 2010年第17期16卷 2187-2189页

作者： Tiffany cho-Lam Wong Ka-fai To Simon See-Ming Hou Sidney Kam-Hung Yip Chi-fai Ng Department of Surgery Prince of Wales HospitalThe Chinese University of Hong Kong Department of Anatomical and Cellular Pathology The Chinese University of Hong Kong

Hepatocellular carcinoma (HCC) is an aggressive tumor with poor long-term ***,we present an unusual patient with a solitary recurrence of HCC in the right kidney 12 years after the initial *** illustrates the importan... 详细信息

关键词： Hepatocellular carcinoma Late recurrence Metastasis Retroperitoneal

The combined role of MRI prostate and prostate health index in improving detection of significant prostate cancer in a screening population of Chinese men

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Asian Journal of Andrology 2023年第6期25卷 674-679页

作者： Peter KF Chiu Thomas YT Lam Chi-fai Ng Jeremy YC Teoh Carmen CM cho Hiu-Yee Hung Cindy Hong Monique J Roobol Winnie CW Chu Samuel YS Wong Joseph JY Sung SH Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong Kong SARChina The Jockey Club School of Public Health and Primary Care The Chinese University of Hong KongHong Kong SARChina Department of Imaging and Interventional Radiology The Chinese University of Hong KongHong Kong SARChina Erasmus MC Cancer Institute Erasmus Medical UniversityRotterdam 3015The Netherlands Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Using prostate-specific antigen(PSA)for prostate cancer(PCa)screening led to overinvestigation and overdiagnosis of indolent *** aimed to investigate the value of prostate health index(PHI)and magnetic resonance imaging(MRI)prostate in an Asian PCa screening *** aged 50–75 years were prospectively recruited from a community-based PSA screening *** with PSA 4.0–10.0 ng ml^(−1) had PHI result *** prostate was offered to men with PSA 4.0–50.0 ng ml−1.A systematic prostate biopsy was offered to men with PSA 4.0–9.9 ng ml^(−1) and PHI≥35,or PSA 10.0–50.0 ng ml^(−1).Additional targeted prostate biopsy was offered if they had PI-RADS score≥*** significant PCa(csPCa)was defined as the International Society of Urological Pathology(ISUP)grade group(GG)≥2 or ISUP GG 1 with involvement of≥30%of total systematic *** total,12.8%(196/1536)men had PSA≥4.0 ng ml^(−1).Among 194 men with PSA 4.0–50.0 ng ml^(−1),187(96.4%)received MRI *** them,28.3%(53/187)had PI-RADS≥3 ***,7.0%(107/1536)men were indicated for biopsy and 94.4%(101/107)men received *** the men received biopsy,PCa,ISUP GG≥2 PCa,and csPCa was diagnosed in 42(41.6%),24(23.8%),and 34(33.7%)men,*** with PSA/PHI pathway in men with PSA 4.0–50.0 ng ml^(−1),additional MRI increased diagnoses of PCa,ISUP GG≥2 PCa,and csPCa by 21.2%(from 33 to 40),22.2%(from 18 to 22),and 18.5%(from 27 to 32),*** benefit of additional MRI was only observed in PSA 4.0–10.0 ng ml^(−1),and the number of MRI needed to diagnose one additional ISUP GG≥2 PCa was 20 in PHI≥35 and 94 in PHI<*** them,45.4%(89/196)men with PSA≥4.0 ng ml^(−1) avoided unnecessary biopsy with the use of PHI and MRI.A screening algorithm with PSA,PHI,and MRI could effectively diagnose csPCa while reducing unnecessary *** benefit of MRI prostate was mainly observed in PSA 4.0–9.9 ng ml^(−1) and PHI≥35 *** was an important risk stratification step for PCa

关键词： magnetic resonance imaging prostate prostate cancer prostate health index prostate-specific antigen screening

Anti-onchocerca Metabolites from Cyperus articulatus:Isolation,In Vitro Activity and In Silico‘Drug-Likeness’

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Natural Products and Bioprospecting 2014年第4期4卷 243-249页

作者： jonathan Alunge Metuge Smith B.Babiaka James A.Mbah Fidele Ntie-Kang Godfred A.Ayimele Fidelis cho-Ngwa ANDI Centre of Excellence Department of Biochemistry and Molecular BiologyFaculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Department of Chemistry Faculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon Chemical and Bioactivity Information Centre Chemistry DepartmentFaculty of ScienceUniversity of BueaP.O.Box 63BueaCameroon

The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy of the metabolites on the Onchocerca *** antifilarial activity was evaluated in vitro on microfilariae(Mfs)and adult worms of the bovine derived Onchocerca ochengi,a close relative of Onchocerca *** was assessed in vitro on monkey kidney epithelial *** structures of the active compounds were determined using spectroscopic methods and their drug-likeness evaluated using Lipinski *** secondary metabolites,AMJ1[containing mustakone(1)as the major component]and linoleic acid or(9Z,12Z)-octadeca-9,12-dienoic acid(2)were *** compounds were found to kill both the microfilariae and adult worms of *** in a dose dependent *** IC50s for AMJ1 were 15.7 lg/mL for Mfs,17.4 lg/mL for adult males and 21.9 lg/mL for adult female worms while for linoleic acid the values were,15.7 lg/mL for Mfs,31.0 lg/mL for adult males and 44.2 lg/mL for adult *** present report provides the first ever evidence of the anti-Onchocerca efficacy of AMJ1 and linoleic ***,these secondary metabolites may provide a lead for design and development of new antifilarial agents.

关键词： Cyperus articulates Linoleic acid Microfilariae Mustakone Onchocerca ochengi Onchocerca volvulus

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置换:重新定义东京2030年的公墓

城市环境设计 2016年第6期 392-393页

作者： CHAN cho fai ANDERSON LO HEI TING HAYDN 香港大学

东京在过去10年以来,一直面临生育率降低、城市空间紧张以及墓地价格的突飞猛涨的困境,这些都是城市化的负面后果。由此,这座大都市必须重新理解埋葬与缅怀死者的方式。本项目以当下东京为背景,亦是为未来此类问题做预先设计;批判地审... 详细信息

东京在过去10年以来,一直面临生育率降低、城市空间紧张以及墓地价格的突飞猛涨的困境,这些都是城市化的负面后果。由此,这座大都市必须重新理解埋葬与缅怀死者的方式。本项目以当下东京为背景,亦是为未来此类问题做预先设计;批判地审视当下城市墓葬的严峻处境,提出2030年在东京最拥挤的区域——新宿——修建一座垂直墓地,希望以此解决先关社会问题,通过设计的手段将丧葬转变为意蕴丰富、利于环境、永久性的生命礼赞。

关键词：东京日本新宿骨灰

An unprecedented outbreak investigation for nosocomial and community-acquired legionellosis in Hong Kong

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Chinese Medical Journal 2012年第23期125卷 4283-4290页

作者： CHENG Vincent Chi-chung WONG Samson Sai-yin CHEN jonathan Hon-kwan CHAN Jasper Fuk-woo TO Kelvin Kai-wang POON Rosana Wing-shan WONG Sally Cheuk-ying CHAN Kwok-hung TAI Josepha Wai-ming HO Pak-leung TSANG Thomas Ho-fai YUEN Kwok-yung Department of Microbiology Queen Mary Hospital Hong Kong China Infection Control Team Queen Mary Hospital Hong Kong China Centre for Health Protection Department of Health Hong Kong China

Background The environmental sources associated with community-acquired or nosocomial legionellosis were not always detectable in the mainland of China and Hong Kong, China. The objective of this study was to illustrate the control measures implemented for nosocomial and community outbreaks of legionellosis, and to understand the environmental distribution of legionella in the water system in Hong Kong, China. Methods We investigated the environmental sources of two cases of legionellosis acquired in the hospital and the community by extensive outbreak investigation and sampling of the potable water system using culture and genetic testing at the respective premises. Results The diagnosis of nosocomial legionellosis was suspected in a patient presenting with nosocomial pneumonia not responsive to multiple beta-lactam antibiotics with subsequent confirmation by Legionella pneumophila serogroup 1 antigenuria. High counts of Legionella pneumophila were detected in the potable water supply of the 70-year-old hospital building. Another patient on continuous ambulatory peritoneal dialysis presenting with acute community-acquired pneumonia and severe diarrhoea was positive for Legionella pneumophila serogroup 1 by polymerase chain reaction （PCR） testing on both sputum and nasopharyngeal aspirate despite negative antigenuria. Paradoxically the source of the second case was traced to the water system of a newly commissioned office building complex. No further cases were detected after shock hyperchlorination with or without superheating of the water systems. Subsequent legionella counts were drastically reduced. Point-of-care infection control by off-boiled or sterile water for mouth care and installation of water filter for showers in the hospital wards for immunocompromised patients was instituted. Territory wide investigation of the community potable water supply showed that 22.1% of the household water supply was positive at a mean legionella count of 108.56 CFU/ml （rang

关键词： outbreak nosocomial legionellosis community-acquired legionellosis

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瘢痕子宮陰道分娩硬膜外鎮痛的臨床分析

镜湖医学 2018年第1期18卷 66-67页

作者：李濤錢曉暉陳明輝曹麗勤澳門鏡湖醫院麻醉科中國

目的探討瘢痕子宮婦女再次妊娠經陰道試產時施行硬膜外分娩鎮痛的結局。方法回顧分析2015年6月~2017年6月共2年間本院瘢痕子宫婦女再次妊娠經陰道分娩的記錄資料,按是否實施硬膜外分娩鎮痛分為2組,活躍期開始實施硬膜外分娩鎮痛的25例... 详细信息

目的探討瘢痕子宮婦女再次妊娠經陰道試產時施行硬膜外分娩鎮痛的結局。方法回顧分析2015年6月~2017年6月共2年間本院瘢痕子宫婦女再次妊娠經陰道分娩的記錄資料,按是否實施硬膜外分娩鎮痛分為2組,活躍期開始實施硬膜外分娩鎮痛的25例為觀察組,無分娩鎮痛的135例為對照組。結果活躍期開始實施分娩鎮痛的產婦順產率與對照組產婦順產率相若(P>0.05),但其第二產程較對照組長(P0.05)。結論瘢痕子宫婦女再次妊娠經陰道分娩時施行硬膜外分娩鎮痛安全可行,但其第二產程較長。

关键词：瘢痕子宫分娩鎮痛順產率

Human Rights and Social Stigma Review for Leprosy Patients in Korea

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Advances in Infectious Diseases 2021年第1期11卷 73-83页

作者： Seungshin Lee David Ahn Justin Kim Cathy Park Kunmin Kim Alice Kim Chae Eun Kim Jisu Shin Timothy cho jonathan Jo David Park Tae Youn Kim Paul S. Chung School of Medicine University of California Irvine CA USA Youth with Talents Fairfax VA USA Fuzbien Technology Institute Rockville MD USA

Leprosy is a chronic disease caused by a low multiplying bacillus, Mycobacterium leprae, which primarily affects the skin and the extremities. Multidrug therapy (MDT) and Bacillus Calmette-Guérin (BCG) vaccinations are effective at treatment of the disease, but social misconceptions about the disease inhibit efficient health care for affected individuals. In South Korea, leprosy patients face social, economic, and political discrimination. Korean leprosy patients are isolated into Sorokdo island and face challenges such as difficulty receiving education and limited job opportunities. Leprosy cognitively, emotionally, and socially impacts patients’ lives, and represents a serious social inequality issue. To raise awareness, dispel myths about the disease, and to end patient discrimination that destroys families, we conducted case studies based on scientific journals. The paper specifically focuses on difficulties faced by Korean leprosy patients, and subsequent initiatives by the government to aid patients. To reach the WHO’s target of health and wellbeing for all by 2030, we need to educate the masses about leprosy and address relevant social inequality issues.

关键词： Leprosy Sorokdo

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腾讯滨海大厦

建筑学报 2019年第3期 75-80页

作者： jonathan Ward 高泉顾锋叶宇同 NBBJ 深圳市同济人建筑设计有限公司

地点/深圳南山设计/2011年/竣工/2017年Design Stage 2011 Completion 2017设计团队NBBJ:jonathan Ward, Pascal Suh, Wei Hu, Sung cho,Kerry Hegedus, Vivian Ngo深圳市同济人建筑设计有限公司:高泉、顾锋、叶宇同、李陈、李任达、逄辉、张晓飞(建筑);孙平、莫文峰、王喜堂(结构);朱国权(给排水);赵铁钢(电气);王慧中(暖通)基地面积1.87 hm^2建筑面积34.

关键词：备餐间电话间

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