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American Journal of Analytical Chemistry 2013年第12期4卷 725-731页

作者： Hssaine Amamou Belkacem Ferhat André bois Laboratoire PROTEE-ISO Université du Sud Toulon-VarLa GardeFrance Laboratoire d’Electronique Quantique Faculty of PhysiqueUniversity of Sciences and Technology Houari BoumedieneAlgerAlgérie

The Voigt function is the convolution of a Lorentzian and a Guaussian density. The computation of these functions is required in several problems arising in a variety of physicochemical subjects;such as nuclear reactors, atmospheric transmittance and spectroscopy. In this work we suggest using a new formula for the calculation of the Voigt function. Our formula is a new integral representation for the Voigt function that gives the perfect results for the Voigt function calculation and is easily calculable. We give also a comparison between our results of calculation of Voigt function for the very small values of the parameter a, where the calculation is notoriously difficult, with those of the various algorithms of other authors.

关键词： Convolution Line Profile Voigt Function Lorentz Profile Doppler Profile and Spectral Lines

The Sensible and Identity Crisis of Healthcare Workers： The Perspective of Physiotherapists Practicing Fasciatherapy

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Sociology Study 2018年第1期8卷 1-20页

作者： Christian Courraud Anne Lieutaud Danis bois Centre for Applied Research and Study in Perceptional Psychoeducation/University Fernando Pessoa(CERAP/UFP) Portugal University Fernando Pessoa (UFP) Portugal

The identity of paramedic professions is bound to develop in order to adapt to the changes of the world of health. Careproviders＇ identity is based on the interpersonal dimension, yet French massage-physiotherapy bases this interpersonal competence on touch. This is why many practitioners try to develop this aspect of their practice through continuing professional education. Danis bois Method （MOthode Danis bois： MDB） of fasciatherapy, characterized by its relational and sensitive approach to care and touch, stands in this field. This paper will present the impacts of this manual therapy on the professional identity of 446 masseurs-physiotherapists who took part in a self-assessment survey. The results show that, in spite of the few difficulties they meet within their duties, practicing fasciatherapy integrates perfectly well into the framework of massage-physiotherapy. It largely reinforces the feeling of therapeutical efficacy and the capacity to meet the evolution in health needs （chronic diseases, mental suffering, and patients＇ quality of life）. It also restores meaning and value to the profession and boosts motivation as well as it fosters the congruence of both considered as an added value to masso-physiotherapy, a means to accom professional identity pets plish onal and professional identities. It is thus oneself and an essential component of

关键词： Danis bois Method fasciatherapy professionnal identity physiotherapy crisis of healthcare workers sociological inquiry

Rank-Ordering of Topographic Variables Correlated with Temperature

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Atmospheric and Climate Sciences 2012年第2期2卷 139-147页

作者： Daniel Joly Benjamin bois Klemen Zaksek Universite de Franche-Comte BesanconFrance Universite de Bourgogne DijonFrance University of Hamburg Institute of GeophysicsHamburgGermany Centre of excellence Space-SI LjubljanaSlovenia

Spatial variations in temperature may be ascribed to many variables. Among these, variables pertaining to topography are prominent. Thus various topographic variables were calculated from 50 m-resolution digital terrain models (DTMs) for three study areas in France and for Slovenia. The “classic” geomatic variables (altitude, aspect, gradient, etc.) are supplemented by the description of landforms (amplitude of humps and hollows). Special care is taken in managing collinearity among variables and building windows with different dimensions. Statistical processing involves linear regressions of daily temperatures taken as the response variables and six topographic variables (explanatory variables). Altitude accounts significantly for the spatial variation in temperatures in 90% of cases, except in the Gironde, a lowlying area (50%). The scale of landforms also appears to be highly correlated to the measured temperature. Variations in the frequency with which topographic descriptors account for temperatures are examined from several standpoints. Altitude is less frequently taken as an explanatory variable for spatial variation of temperatures in winter (75%) than in spring (80%) and late summer (85%). Minimum temperatures are influenced on average much more by the amplitude of humps and hollows (56%) than maximum temperatures (38%) are. The frequency with which these two landforms account for the spatial variation of temperature is reversed between the minima and maxima.

关键词： Explanatory Variables Temperature Topography Collinearity Linear Regression

2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling

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World Journal of Gastroenterology 2014年第48期20卷 18207-18215页

作者： Emilien Loeuillard Julien Bertrand Anni Herranen chloé Melchior Charlène Guérin Mo?se Co?ffier Moutaz Aziz Pierre Déchelotte Guillaume Savoye Rachel Marion-Letellier INSERM UnitUMR1073 Rouen University and Rouen University HospitalRouen Cedex 76183 France Institute for Research and Innovation in Biomedicine University of Rouen Rouen Cedex 76183 France Department of Gastroenterology Rouen University Hospital Rouen Cedex 76183 France Nutrition Unit Rouen University Hospital Rouen Cedex 76183 France Department of Pathology Rouen UniversityHospital Rouen Cedex 76183 France

AIM:To investigate whether targeting proteasome might reverse intestinal fibrosis in ***:Chronic colitis was induced in rats by repeated administration of increasing dose of2,4,6-trinitrobenzene sulfonic acid(TNBS,15,30,45,60,60,60 mg)by rectal injection for 6 wk(from day0 to day 35),while control rats received the ***+bortezomib(BTZ)rats received intraperitoneal injections of BTZ twice weekly(from day 37 to day44)at a dose of 25 mg/kg,whereas the control and TNBS groups received the same amount of the *** scoring of inflammation and fibrosis was *** production of transforming growth factor(TGF)-βwas measured by *** fibrosisrelated proteins such as phospho-p38,phosphoSMAD2/3,Akt and peroxisome proliferator activated receptorγ(PPARγ)were studied by western *** of the tight junction proteins,occludin and claudin-1,were assessed by Western *** proteasome activities(chymotrypsin-like and trypsinlike activities)were ***:TNBS-treated rats had a higher colon weight/length ratio compared to control rats(P0.05).In contrast,bortezomib had no effect on other studied parameters such as fibrosis score,TGF-βsignaling,or tight junction expression(P>0.05 for all).CONCLU

关键词： Bortezomib Colitis Fibrosis Proteasome

An ethically guided preclinical device for phenotyping H_(2)production in laboratory rodents

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Animal Models and Experimental Medicine 2024年第4期7卷 553-561页

作者： Victor Pascal-Moussellard Emilie Boucher Stéphane Tanguy Philippe Cinquin Pierre-Alain Barraud chloéDavin Cordélia Salomez-Ihl Dalil Hannani François Boucher Jean-Pierre Alcaraz University Grenoble Alpes CNRSUMR 5525VetAgro SupGrenoble INPTIMCGrenobleFrance

Background:Dihydrogen(H_(2))is produced endogenously by the intestinal microbiota through the fermentation of diet *** the past few years,numer-ous studies have demonstrated the significant therapeutic potential of H_(2)in various pathophysiological contexts,making the characterization of its production in labora-tory species of major preclinical ***:This study proposes an innovative solution to accurately monitor H_(2)pro-duction in free-moving rodents while respecting animal welfare *** devel-oped device consisted of a wire rodent cage placed inside an airtight chamber in which the air quality was maintained,and the H_(2)concentration was continuously *** the airtightness and efficiency of the systems used to control and maintain air quality in the chamber were checked,tests were carried out on rats and mice with different metabolic phenotypes,over 12 min to 1-h experiments and repeatedly.H_(2)production rates(HPR)were obtained using an easy calculation algorithm based on a first-order moving ***:HPR in hyperphagic Zucker rats was found to be twice as high as in control Wistar rats,respectively,2.64 and 1.27 nmol.s^(−1)per *** addition,the ingestion of inulin,a dietary fiber,stimulated H_(2)production in *** were 0.46 nmol.s^(−1)for animals under control diet and 1.99 nmol.s^(−1)for animals under inulin ***:The proposed device coupled with our algorithm enables fine analysis of the metabolic phenotype of laboratory rats or mice with regard to their endogenous H_(2)production.

关键词： hydrogen therapy laboratory rodents microbiota molecular hydrogen noninvasive monitoring device

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公众参与和社会治理

A rodent model of NMD A receptor hypofunction for the study of schizophrenia

2018年

作者： (法)柯蕾(chloe Froissart)

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A rodent model of NMD A receptor hypofunction for the study ...

Blockage and distortion effects on a vane-island type diffuser performance of centrifugal pumps for various flow rates

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： TM du bois KA NEWELL K ZAVITSANOU Centre for Translational Neuroscience School of Health ScienceUniversity of WollongongAustralia

＜正＞Background NMDA receptor antagonist potently elicits symptoms similar to those seeing in schizophrenia ***,it can disrupt brain development by increasing apoptosis and can cause behavioral alterations in later life. Purpose:The aim of this study was to investigate apoptosis,dopamine system and behavioural alterations in rats treated with phencyclidine（PCP） before or after brain *** In one experiment,apoptotic cells were quantified following PCP（10 mg/kg） treatment in perinatal,adolescent or adult *** another experiment,PCP was administered to female rat pups on postnatal day（PN）7,9 and *** PN12,18,32 and 96 brain tissue was collected for biochemical *** cohort of rats underwent behavioural testing 10 weeks after their last perinatal PCP *** Perinatal PCP treatment significantly increased the number of apoptotic cells primarily in cingulate and frontal *** contrast,adolescent and adult PCP treatment did not cause *** PCP treatment also caused a hyperdopaminergic state upon maturation as evidenced by increased tyrosine hydroxylase and dopamine transporter, and decreased D2 receptor expression in specific regions of the mesolimbic/striatal *** PCP-treated rats displayed increased spontaneous locomotion and increased climbing time in the forced swim *** This study has demonstrated that early brain development interruption by NMDA receptor antagonism can alter chemically coded neural network formation in the adult *** only mild behavioural alterations were found,it is likely that this early treatment has left the brain more susceptible to future challenges.

关键词： schizophrenia brain development dopamine receptor glutamate receptor behaviour

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排灌机械工程学报 2016年第12期34卷 1013-1021页

作者： SI Qiaorui DAZIN Antoine DUPONT Patrick ROUSSETTE Olivier bois Gérard National Research Center of Pumps Jiangsu University Laboratoire de Mécanique de Lille (UMR CNRS 8107) Arts et Métiers ParisTech Laboratoire de Mécanique de Lille(UMR CNRS 8107) Ecole Centrale de Lille

Experimental investigation of mean flow velocity and pressure inside the vane-island type diffuser passage of a test centrifugal pump model is presented.A directional three-hole probe was used to investigate hub-to-shroud flow properties at diffuser leading and trailing edge *** addition,the mid-section between suction and pressure sides along the diffuser passage was also *** these measurements were performed at five different flow *** flow structures at the inlet section of the diffuser and along with the passage were analyzed in detail,with a focus on the flow distribution and the pressure recovery evolution of different diffuser *** and distortion effects were analyzed by using existing published particle image velocimetry(PIV)measurements in the outer part of the impeller and around the diffuser throat in order to get a better understanding of the overall performances and local flow structures of such a diffuser *** results show that back flows occur on the shroud region from impeller exit plane up to the semi-vaneless part of the diffuser at low flow *** blockage effects combining with blade thickness geometrical blockage tend to diminish the effects of theoretical high positive *** high flow rates,negative incidence effects induce high local velocity on the pressure side of the diffuser just after the *** aerodynamic blockage associated with low flow distortions are found to have a beneficial effect on pressure recovery for low flow *** the contrary,high flow distortions are found for increased flow rates,resulting in a low pressure recovery inside the semi-vane less part of the diffuser and after the throat.

关键词： vane island diffuser flow structure pressure recovery three-hole probe particle image velocimetry

Numerical Study of the Transition Between Reentrant Jet and Twin Vortex Flow Regimes in Ventilated Cavitation

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Journal of Marine Science and Application 2018年第1期17卷 38-44页

作者： Mahamadou Adama Maiga Olivier Coutier-Delgosha Gérard bois Arts et Métiers ParisTech Laboratoire de Mécanique des Fluides de Lille-Kampéde Fériet8 Boulevard Louis XIV59046 LilleFrance Kevin T.Crofton Aerospace and Ocean Engineering Department Virginia Tech460 Old Turner StreetBlacksburgVA 24061USA

Contrary to natural cavitation,ventilated cavitation is controllable and is not *** is particularly used to reduce the drag of the hydraulic *** ventilated cavitation is characterized by various gas *** mechanisms of ventilated cavitation are investigated in the present work with CFD based on a 2D *** attention is especially focused on the transition between the reentrant jet and twin vortex *** results confirmthat the product of ventilated cavitation number and Froude number is lower than 1(σcFr1)in the reentrant jet regime,as reported in the *** analysis shows that ventilated cavitation is significantly influenced by the natural cavitation number.

关键词： Ventilated and natural cavitation Instability Reentrant jet and twin vortex regimes CFD

Targeting stem cells by radiation: From the biological angle to clinical aspects

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World Journal of Stem Cells 2016年第8期8卷 243-250页

作者： Alexis Vallard Sophie Espenel Jean-Baptiste Guy Peng Diao Yaoxiong Xia Anis El Meddeb Hamrouni Majed Ben Mrad Alexander Tuan Falk Claire Rodriguez-Lafrasse chloé Rancoule Nicolas Magné Department of Radiotherapy Lucien Neuwirth Cancer Institute Laboratoire de Radiobiologie Cellulaire et Moléculaire CNRS UMR 5822 Institut de Physique Nucléaire de Lyon Department of Radiation Oncology Sichuan Cancer Hospital Department of Radiotherapy Centre Antoine Lacassagne

Radiotherapy is a cornerstone of anticancer treatment. However in spite of technical evolutions, important rates of failure and of toxicity are still reported. Although numerous pre-clinical data have been published, we address the subject of radiotherapy-stem cells interaction from the clinical efficacy and toxicity perspective. On one side, cancer stem cells(CSCs) have been recently evidenced in most of solid tumor primary locations and are thought to drive radio-resistance phenomena. It is particularly suggested in glioblastoma, where CSCs were showed to be housed in the subventricular zone(SVZ). In recent retrospective studies, the radiation dose to SVZ was identified as an independent factor significantly influencing overall survival. On the other side, healthy tissue stem cells radio-destruction has been recently suggested to cause two of the most quality of life-impacting side effects of radiotherapy, namely memory disorders after brain radiotherapy, and xerostomia after head and neck radiotherapy. Recent publications studying the impact of a radiation dose decrease on healthy brain and salivary stem cells niches suggested significantly reduced long term toxicities. Stem cells comprehension should be a high priority for radiation oncologists, as this particular cell population seems able to widely modulate the efficacy/toxicity ratio of radiotherapy in real life patients.

关键词： Cancer Neoplastic stem cells Radiation therapy Efficacy Toxicity