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Points regarding cell transplantation for the treatment of spinal cord injury

Neural Regeneration Research 2016年第7期11卷 1046-1049页

作者： chizuka ide Kenji Kanekiyo Institute of Regeneration and Rehabilitation Aino University School of Health Science

Transplantation of somatic cells,including bone marrow stromal cells（BMSCs）,bone marrow mononuclear cells（BMNCs）,and choroid plexus epithelial cells（CPECs）,enhances the outgrowth of regenerating axons and promotes locomotor *** are not integrated into the host spinal cord,but disappear within 2-3 weeks after *** axons extend at the spinal cord lesion through the astrocyte-devoid area that is filled with connective tissue *** axons have characteristics of peripheral nerves：they are associated with Schwann cells,and embedded in connective tissue *** has been suggested that neurotrophic factors secreted from BMSCs and CPECs promote “intrinsic” ability of the spinal cord to *** Schwann cells survive long-term,and are integrated into the host spinal cord,serving as an effective scaffold for the outgrowth of regenerating axons in the spinal *** disadvantage that axons are blocked to extend through the glial scar at the border of the lesion is *** cells have been approved for clinical *** stem/progenitor cells（NSPCs） survive long-term,proliferate,and differentiate into glial cells and/or neurons after *** method is available at present to manipulate and control the behaviors of NPSCs to allow them to appropriately integrate into the host spinal *** transplantation is not necessarily effective for locomotor improvement.

关键词： Schwann progenitor glial astrocyte neurotrophic differentiate scaffold connective survive proliferate

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Cell transplantation for the treatment of spinal cord injury–bone marrow stromal cells and choroid plexus epithelial cells

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Neural Regeneration Research 2016年第9期11卷 1385-1388页

作者： chizuka ide Norihiko Nakano Kenji Kanekiyo Central Research Laboratory Aino University School of Health Science

Transplantation of bone marrow stromal cells （BMSCs） enhanced the outgrowth of regenerating axons and promoted locomotor improvements of rats with spinal cord injury （SCI）. BMSCs did not survive long-term, disappearing from the spinal cord within 2-3 weeks after transplantation. Astrocyte-devoid areas, in which no astrocytes or oligodendrocytes were found, formed at the epicenter of the lesion. It was remarkable that numerous regenerating axons extended through such astrocyte-devoid areas. Regenerating axons were associated with Schwann cells embedded in extracellular matrices. Transplantation of choroid plexus epithelial cells （CPECs） also enhanced axonal regeneration and locomotor improvements in rats with SCI. Although CPECs disappeared from the spinal cord shortly after transplantation, an extensive outgrowth of regenerating axons occurred through astrocyte-devoid areas, as in the case of BMSC transplantation. These findings suggest that BMSCs and CPECs secret neurotrophic factors that promote tissue repair of the spinal cord, including axonal regeneration and reduced cavity formation. This means that transplantation of BMSCs and CPECs promotes ＂intrinsic＂ ability of the spinal cord to regenerate. The treatment to stimu- late the intrinsic regeneration ability of the spinal cord is the safest method of clinical application for SCI. It should be emphasized that the generally anticipated long-term survival, proliferation and differentiation of transplanted cells are not necessarily desirable from the clinical point of view of safety.

关键词： bone marrow stromal cell choroid plexus epithelial cell spinal cord injury axonal regeneration locomotor improvement intrinsic regeneration ability

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