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A Survey on Mixed Spin P-Fields

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Chinese Annals of Mathematics,Series B 2017年第4期38卷 869-882页

作者： Huai-Liang CHANG Jun LI Wei-Ping LI chiu-chu melissa liu Department of Mathematics Hong Kong University of Science and Technology Hong Kong China. Shanghai Center for Mathematical Sciences Fudan University Shanghai 200433 China Department of Mathematics Stanford University Stanford CA 94305-2125 USA. Department of Mathematics Columbia University New York NY 10027 USA.

The mixed spin P-fields （MSP for short） theory sets up a geometric platform to relate Gromov-Witten invariants of the quintic three-fold and Fan-Jarvis-Ruan-Witten invariants of the quintic polynomial in five variables. It starts with Wittens vision and the P-fields treatment of GW invariants and FJRW invaxiants. Then it briefly discusses the master space technique and its application to the set-up of the MSP moduli. Some key results in MSP theory are explained and some examples are provided.

关键词： Mixed Spin P-fields GW invariants FJRW invariants P-fields Cosection localization

Trust in ESG reporting:The intelligent Veri-Green solution for incentivized verification

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Blockchain(Research and Applications) 2024年第2期5卷 126-139页

作者： Liyuan liu Zhiguo Ma Yiyun Zhou melissa Fan Meng Han Saint Joseph’s University 5600 City AvePhiladelphia19131PAUSA Zhejiang University 866 Yuhangtang RdHangzhou310027ZhejiangChina National Board of Medical Examiners 3750 Market StreetPhiladelphia19104PAUSA

In today’s corporate environment,Environmental,Social,and Governance(ESG)reports crucially reflect an orga-nization’s commitment to sustainability,environmental preservation,and social *** corporations share these detailed reports,the responsibility to validate and assure adherence to respected ESG benchmarks critically lies with third-party assurance ***,the essential verification process often encoun-ters challenges related to authenticity,credibility,and fairness,underscoring the need for a new *** selection of verifiers is a crucial aspect of this process,as their expertise and impartiality directly impact the validity and trustworthiness of the ***,“Veri-Green,”an innovative blockchain-based in-centive mechanism,has been introduced to improve the ESG data verification *** potential risks in verification systems,such as reputational damage due to oversight or inadvertent approval of inaccurate data,and data security risks involving the management of sensitive organizational information,the verifier se-lection process needs to be thoroughly considered and *** the utilization of advanced machine learning algorithms,potential verification candidates are precisely identified,followed by the deployment of the Vickrey Clarke Groves(VCG)auction *** approach ensures the strategic selection of verifiers and cultivates an ecosystem marked by truthfulness,rationality,and computational efficiency throughout the ESG data verification *** this framework,verifiers are not only encouraged but also properly incentivized,developing a more transparent and equitable verification process,thereby driving the ESG agenda towards a future defined by genuine,impactful corporate responsibility and sustainability.

关键词： Incentive mechanism ESG Artificial intelligence Truthfulness

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Fine-scale activity patterns of large-and medium-sized mammals in a deciduous broadleaf forest in the Qinling Mountains,China

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Journal of Forestry Research 2021年第6期32卷 2709-2717页

作者： Yuke Zhang Xiangbo He Xuehua liu melissa Songer Haishan Dang Quanfa Zhang State Key Joint Laboratory of Environmental Simulation and Pollution Control and School of Environment Tsinghua UniversityBeijing 100084People’s Republic of China Foping Nature Reserve Foping CountyShaanxi 723400People’s Republic of China Conservation Ecology Center Smithsonian Conservation Biology InstituteFront RoyalVA 22630USA Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical Garden of the Chinese Academy of SciencesWuhan 430074People’s Republic of China

The composition of animal species and interactions among them are widely known to shape ecological communities and fine-scale(e.g.,<1 km)monitoring of animal communities is essential for understanding the relationships among animals and *** the co-existence of large-and medium-sized species has been studied across different scales,research on fine-scale interactions of herbivores in deciduous broadleaf forests is *** trapping of large-and medium-sized mammals was carried out over a 1 year period within a 25 ha deciduous broadleaf forest dynamics plot in the Qinling Mountains,*** species of large-and medium-sized mammals,including six carnivores,six ungulates,one primate and one rodent species were *** density estimations were used to analyse the diel or 24 h activity patterns of all species with more than 40 independent detections and general linear models were developed to explore the spatial relationships among the *** combination of overlapping diel activity patterns and spatial associations showed obvious niche separation among six species:giant panda(Ailuropoda melanoleuca David),takin(Budorcas taxicolor Hodgson),Reeves’s muntjac(Muntiacus reevesi Ogilby),tufted deer(Elaphodus cephalophus Milne-Edwards),Chinese serow(Capricornis milneedwardsii David)and wild boar(Sus scrofa Linnaeus).Long-term fine-scale monitoring is useful for providing information about the co-existence of species and their *** results demonstrate the importance for fine-scale monitoring of animals and plants for improving understanding of species interactions and community dynamics.

关键词： Large-and medium-sized mammals Fine-scale interaction Camera trapping Spatiotemporal patterns Forest dynamics plots Qinling mountains

Spatiotemporal variation of agricultural patterns in different geomorphologic and climatic environments in the eastern Loess Plateau,north-central China during the late Neolithic and Bronze Ages

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Science China Earth Sciences 2022年第5期65卷 934-948页

作者： Haiming LI Yifu CUI Nathaniel JAMES melissa RITCHEY Fengwen liu Junna ZHANG Minmin MA Guanghui DONG College of Humanities&Social Development Nanjing Agricultural UniversityNanjing 210095China Institution of Chinese Agricultural Civilization Nanjing Agricultural UniversityNanjing 210095China Agricultural Archaeology Research Center Nanjing Agricultural UniversityNanjing 210095China College of Tourism Huaqiao UniversityQuanzhou 362021China Ministry of Education Key Laboratory of Western China’s Environmental System College of Earth&Environmental SciencesLanzhou UniversityLanzhou 730000China Department of Anthropology University of California San DiegoSan DiegoCA 92093USA Department of Anthropology Washington University in St.LouisSt.LouisMO 63130USA Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environment ScienceYunnan UniversityKunming 650504China Laboratory for Environmental Archaeology Archaeological Research CenterBeijing Union UniversityBeijing 100191China

Human settlement and agricultural development are closely linked to local geomorphological and climatic ***,the variation in agricultural systems in different environmental and prehistoric contexts remains *** report new archaeobotanical and radiocarbon dates from 34 Neolithic and Bronze Age sites in the Hutuo River Valley(HTRV)in north-central China and compare them with updated archaeobotanical studies in the Sushui River Valley(SSRV)and Henan Province(HNP),to explore the similarities and differences of agricultural patterns under different geomorphologic and climatic environments in north-central *** results reveal that humans consistently cultivated foxtail and broomcorn millet in the HTRV from the Miaodigou(6000–5700 cal.a BP)to the Shang-Zhou(3600–2256 cal.a BP)period,despite the introduction of wheat and barley into the area around 4000 a *** conditions and hilly landforms in the HTRV,SSRV and some parts of the HNP led people to develop foxtail and broomcorn millet dry land farming practices between 7000 and 3000 a ***,in other areas of the HNP,the climate conditions and alluvial plains enabled people to develop a mixed agriculture of millets,soybeans,and rice from 7000 to 4000 a BP,with the addition of wheat between 4000 and 3000 a ***’different agricultural technologies and interactions with foreign cultures may have also influenced the formation of different agricultural patterns in the three regions between 7000 and 3000 a *** growth during 7000–3000 a BP can explain the overall propensity of the higher-yield foxtail millet rather than broomcorn millet as the main cultivated *** the HTRV,however,higher proportions of broomcorn millet(as compared to the SSRV and HNP),may reflect the greater drought and heat tolerance of broomcorn millet,representing an adaptive agricultural strategy in the river valley.

关键词： Archaeobotanical Agricultural patterns Climate conditions Hilly area Alluvial plains

Human-carnivore conflict in China: a review of current approaches with recommendations for improved management

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Integrative Zoology 2012年第2期7卷 210-226页

作者： melissa PETTIGREW Yan XIE Aili KANG Madhu RAO John GOODRICH Tong liu Joshua BERGER School of Biological Sciences Flinders UniversityAdelaideSouth Australia Wildlife Conservation Society China Program BeijingChina Institute of Zoology Chinese Academy of SciencesBeijingChina Wildlife Conservation Society New YorkUSA AgroParisTech Paris Institute of Technology for LifeFood and Environmental SciencesParisFrance

Human-wildlife conflict(HWC)is a conservation concern that increasingly threatens the continued existence of some of the world’s most endangered *** an increase in human population,urban sprawl and subsequent encroachment on wild land,human and wildlife interaction has become *** the majority of cases,this interaction results in a negative outcome for humans,wildlife or *** China,these key elements,along with a decrease in wild prey species,have resulted in the expansion of HWC encounters,and the need for alleviating this conflict has become a conservation *** of human life,livestock and/or crops is most often the catalysts that fuel *** to alleviate conflict around the world have included preventative measures and mitigation techniques,such as financial compensation and other incentive *** types of measures have had variable *** review the current status of human-carnivore conflict management in China,and,drawing lessons from around the globe,we make recommendations for improving conservation management in *** example,an increase in law enforcement in nature reserves is vital to reducing human disturbance in prime carnivore habitat,thereby reducing conflict ***,modifications to current wildlife compensation programs,so that they are linked with preventative measures,will ensure that moral hazards are ***,investigating the potential for a community self-financed insurance scheme to fund compensation and increasing efforts to restore wild prey populations will improve the outcome for wildlife ***,HWC management in China will greatly benefit from an integrative approach.

关键词： China human-wildlife conflict wildlife compensation

Influence of chelator and near-infrared dye labeling on biocharacteristics of dual-labeled trastuzumab-based imaging agents

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Chinese Journal of Cancer Research 2016年第3期28卷 362-369页

作者： Xuejuan Wang melissa B Aldrich Zhi Yang Nina Zhou Qing Xie Chen liu Eva Sevick-Muraca Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing 100142China Center for Molecular Imaging the Brown Foundation Institute of Molecular MedicineUniversity of Texas Health Science Center at HoustonHouston TX 77030USA

Objective： To investigate the effect of fluorescent dye labeling on the targeting capabilities of 111 In- （DTPA）.-trastuzumab-（IRDye 800）m. Methods： Trastuzumab-based conjugates were synthesized and conjugated with diethylenetriaminepentaacetic acid （DTPA） at molar ratios of I, 2, 3 and 5 and with a fluorescent dye （IRDye 800CW） at molar ratios of 1, 3 and 5. Immunoreactivity and internalization were assessed on SKBR-3 cells, overexpressing human epidermal growth factor receptor 2. The stability in human serum and phosphate-buffered saline （PBS） was evaluated. The biodistribution of dual-labeled conjugates was compared with that of 111In-（DTPA）2-trastuzumab in a SKBR-3 xenograft model to evaluate the effect of dye-to-protein ratio. Results： All trastuzumab-based conjugates exhibited a high level of chemical and optical purity. Flow cytometry results showed that increasing dye-to-protein ratios were associated with decreased immunoreactivity. Stability studies revealed that the conjugate was stable in PBS, while in human serum, increased degradation and protein precipitation were observed with increasing dye-to-protein ratios. At 4 h, the percentages of internalization of dual-labeled conjugates normalized by dye-to-protein ratio （m） were 24.88%±2.10%, 19.99%±0.59%, and 17.47%±1.26% for ＂m＂ equal to 1, 3, and 5, respectively. A biodistribution study revealed a progressive decrease in tumor uptake with an increase in the dye-to-protein ratios. The liver, spleen and kidney showed a marked uptake with increased dye-to-protein ratios, particularly in the latter. Conclusions： With non-specific-site conjugation of the fluorescent dye with a protein based on imaging agent, the increase in dye-to-protein ratios negatively impacted the immunoreactivity and stability, indicating a reduced tumor uptake.

关键词： Influence near infrared dye trastuzumab human epidermal growth factor receptor 2 dual-labeled

Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds

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Neural Regeneration Research 2020年第5期15卷 790-795页

作者： melissa Schepers Nikita Martens Assia Tiane Kenneth Vanbrabant Hong-Bing liu Dieter Lütjohann Monique Mulder Tim Vanmierlo Department of Neuroimmunology Biomedical Research InstituteHasselt UniversityEuropean Graduate School of Neuroscience (EURON)HasseltBelgium Department of Psychiatry & Neuropsychology Division of Translational NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityEuropean Graduate School of Neuroscience (EURON)MaastrichtThe Netherlands Department of Internal Medicine Laboratory of Vascular MedicineErasmus MC University Medical CenterRotterdamthe Netherlands Institue for Clinical Chemistry and Clinical Pharmacology BonnGermany Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong ProvinceChina

Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and *** the last decades,seaweed-derived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological ***,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative *** particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory ***,the anti-inflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more *** this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

关键词： algae carotenoids neuro-active phenols phytosterols polysaccharides seaweed

Corrigendum:Edible seaweed-derived constituents:an undisclosed source of neuroprotective compounds

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Neural Regeneration Research 2021年第12期16卷 2564-2568页

作者： melissa Schepers Nikita Martens Assia Tiane Kenneth Vanbrabant Hong-Bing liu Dieter Lütjohann Monique Mulder Tim Vanmierlo Department of Neuroimmunology Biomedical Research InstituteHasselt UniversityEuropean Graduate School of Neuroscience(EURON)HasseltBelgium Department of Psychiatry&Neuropsychology Division of Translational NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityEuropean Graduate School of Neuroscience(EURON)MaastrichtThe Netherlands Department of Internal Medicine Laboratory of Vascular MedicineErasmus MC University Medical CenterRotterdamthe Netherlands Institue for Clinical Chemistry and Clinical Pharmacology BonnGermany Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong ProvinceChina

Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and *** the last decades,seaweedderived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological ***,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative *** particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory ***,the antiinflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more *** this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

关键词： algae carotenoids neuro-active phenols phytosterols polysaccharides seaweed